Comparison of the Bioactivation Potential of the Antidepressant and Hepatotoxin Nefazodone with Aripiprazole, a Structural Analog and Marketed Drug
BAUMAN, Jonathan N, FREDERICK, Kosea S, SAWANT, Aarti, WALSKY, Robert L, COX, Loretta M, OBACH, Ronald S, KALGUTKAR, Amit S
Published in Drug metabolism and disposition (01.06.2008)
Published in Drug metabolism and disposition (01.06.2008)
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Role of Transporters in the Disposition of the Selective Phosphodiesterase-4 Inhibitor (+)-2-[4-({[2-(Benzo[1,3]dioxol-5-yloxy)-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic Acid in Rat and Human
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Published in Drug metabolism and disposition (01.11.2007)
Published in Drug metabolism and disposition (01.11.2007)
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Indinavir Increases Midazolam N -Glucuronidation in Humans: Identification of an Alternate CYP3A Inhibitor Using an In Vitro to In Vivo Approach
Tian, Dan-Dan, Leonowens, Cathrine, Cox, Emily J, González-Pérez, Vanessa, Frederick, Kosea S, Scarlett, Yolanda V, Fisher, Michael B, Paine, Mary F
Published in Drug metabolism and disposition (01.07.2019)
Published in Drug metabolism and disposition (01.07.2019)
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Dihydrobenzisoxazole-4-one compounds are novel selective inhibitors of aldosterone synthase (CYP11B2) with in vivo activity
Meyers, Kenneth, Cogan, Derek A., Burke, Jennifer, Arenas, Raquel, Balestra, Michael, Brown, Nicholas F., Chen, Zhidong, Cerny, Matthew A., Clifford, Holly E., Colombo, Federico, Fader, Lee, Frederick, Kosea S., Guo, Xin, Goldberg, Daniel, Hornberger, Keith R., Kugler, Stanley, Lord, John, Marshall, Daniel R., Moss, Neil, Parmentier, Jean-Huges, Richman, Jeremy R., Schmenk, Jennifer, Weldon, Steven M., Yu, Maolin, Zhang, Michael
Published in Bioorganic & medicinal chemistry letters (01.03.2018)
Published in Bioorganic & medicinal chemistry letters (01.03.2018)
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CCR2 receptor blockade alters blood monocyte subpopulations but does not affect atherosclerotic lesions in apoE−/− mice
Aiello, Robert J, Perry, Bret D, Bourassa, Patricia-Ann, Robertson, Andrew, Weng, Weifan, Knight, Delvin R, Smith, Andrew H, Frederick, Kosea S, Kalgutkar, Amit, Gladue, Ronald P
Published in Atherosclerosis (01.02.2010)
Published in Atherosclerosis (01.02.2010)
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NADPH-Dependent Covalent Binding of [3H]Paroxetine to Human Liver Microsomes and S-9 Fractions: Identification of an Electrophilic Quinone Metabolite of Paroxetine
Zhao, Sabrina X, Dalvie, Deepak K, Kelly, Joan M, Soglia, John R, Frederick, Kosea S, Smith, Evan B, Obach, R. Scott, Kalgutkar, Amit S
Published in Chemical research in toxicology (01.11.2007)
Published in Chemical research in toxicology (01.11.2007)
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Identification of a novel, non-tetrahydroquinoline variant of the cholesteryl ester transfer protein (CETP) inhibitor torcetrapib, with improved aqueous solubility
Kalgutkar, Amit S., Frederick, Kosea S., Hatch, Heather L., Ambler, Catherine M., Perry, David A., Garigipati, Ravi S., Chang, George C., Lefker, Bruce A., Clark, Ronald W., Morehouse, Lee A., Francone, Omar, Hu, Xiao
Published in Xenobiotica (01.07.2014)
Published in Xenobiotica (01.07.2014)
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Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors
Bhattacharya, Samit K., Aspnes, Gary E., Bagley, Scott W., Boehm, Markus, Brosius, Arthur D., Buckbinder, Leonard, Chang, Jeanne S., Dibrino, Joseph, Eng, Heather, Frederick, Kosea S., Griffith, David A., Griffor, Matthew C., Guimarães, Cristiano R.W., Guzman-Perez, Angel, Han, Seungil, Kalgutkar, Amit S., Klug-McLeod, Jacquelyn, Garcia-Irizarry, Carmen, Li, Jianke, Lippa, Blaise, Price, David A., Southers, James A., Walker, Daniel P., Wei, Liuqing, Xiao, Jun, Zawistoski, Michael P., Zhao, Xumiao
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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Elucidation of the biochemical basis for a clinical drug-drug interaction between atorvastatin and 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methyl benzoic acid (CP-778 875), a subtype selective agonist of the peroxisome proliferator-activated receptor alpha
Kalgutkar, Amit S., Chen, Danny, Varma, Manthena V., Feng, Bo, Terra, Steven G., Scialis, Renato J., Rotter, Charles J., Frederick, Kosea S., West, Mark A., Goosen, Theunis C., Gosset, James R., Walsky, Robert L., Francone, Omar L.
Published in Xenobiotica (01.11.2013)
Published in Xenobiotica (01.11.2013)
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Discovery Tactics To Mitigate Toxicity Risks Due to Reactive Metabolite Formation with 2-(2-Hydroxyaryl)-5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3H)-one Derivatives, Potent Calcium-Sensing Receptor Antagonists and Clinical Candidate(s) for the Treatment of Osteoporosis
Kalgutkar, Amit S, Griffith, David A, Ryder, Tim, Sun, Hao, Miao, Zhuang, Bauman, Jonathan N, Didiuk, Mary T, Frederick, Kosea S, Zhao, Sabrina X, Prakash, Chandra, Soglia, John R, Bagley, Scott W, Bechle, Bruce M, Kelley, Ryan M, Dirico, Kenneth, Zawistoski, Michael, Li, Jianke, Oliver, Robert, Guzman-Perez, Angel, Liu, Kevin K. C, Walker, Daniel P, Benbow, John W, Morris, Joel
Published in Chemical research in toxicology (21.06.2010)
Published in Chemical research in toxicology (21.06.2010)
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Journal Article
Short-acting 5-(trifluoromethyl)pyrido[4,3- d]pyrimidin-4(3 H)-one derivatives as orally-active calcium-sensing receptor antagonists
Didiuk, Mary T., Griffith, David A., Benbow, John W., Liu, Kevin K.C., Walker, Daniel P., Christopher Bi, F., Morris, Joel, Guzman-Perez, Angel, Gao, Hua, Bechle, Bruce M., Kelley, Ryan M., Yang, Xiaojing, Dirico, Kenneth, Ahmed, Syed, Hungerford, William, DiBrinno, Joseph, Zawistoski, Michael P., Bagley, Scott W., Li, Jianke, Zeng, Yuan, Santucci, Stephanie, Oliver, Robert, Corbett, Matthew, Olson, Thanh, Chen, Chiliu, Li, Mei, Paralkar, Vishwas M., Riccardi, Keith A., Healy, David R., Kalgutkar, Amit S., Maurer, Tristan S., Nguyen, Hang T., Frederick, Kosea S.
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
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N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a “chemical knock-out equivalent” to assess the impact of efflux transporters on oral drug absorption in the rat
Kalgutkar, Amit S., Frederick, Kosea S., Chupka, Jonathan, Feng, Bo, Kempshall, Sarah, Mireles, Rochelle J., Fenner, Katherine S., Troutman, Matthew D.
Published in Journal of pharmaceutical sciences (01.12.2009)
Published in Journal of pharmaceutical sciences (01.12.2009)
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ALDOSTERONE SYNTHASE INHIBITORS
FREDERICK KOSEA S, COGAN DEREK, FADER LEE, SURPRENANT SIMON, BURKE JENNIFER, MCKIBBEN BRYAN P, LORD JOHN, MARSHALL DANIEL RICHARD, ZHANG YUNLONG, CERNY MATTHEW A, YU MAOLIN
Year of Publication 22.03.2017
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Year of Publication 22.03.2017
Patent
PHARMACOKINETICS, PHARMACODYNAMICS AND DRUG METABOLISM: N-(3,4-Dimethoxyphenethyl)-4-(6,7-Dimethoxy-3,4-Dihydroisoquinolin-2[1H]-yl)-6,7-Dimethoxyquinazolin-2-Amine (CP-100,356) as a Chemical Knock-out Equivalent to Assess the impact of Efflux Transporters on Oral Drug Absorption in the Rat
KALGUTKAR, Amit S, FREDERICK, Kosea S, CHUPKA, Jonathan, BO FENG, KEMPSHALL, Sarah, MIRELES, Rochelle J, FENNER, Katherine S, TROUTMAN, Matthew D
Published in Journal of pharmaceutical sciences (2009)
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Published in Journal of pharmaceutical sciences (2009)
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Year of Publication 15.11.2022
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Year of Publication 15.11.2022
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Year of Publication 18.06.2022
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Year of Publication 18.06.2022
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Aldosterone synthase inhibitors
Cerny, Matthew A, Marshall, Daniel Richard, Fader, Lee, Zhang, Yunlong, Burke, Jennifer, Mckibben, Bryan P, Frederick, Kosea S, Yu, Maolin, Lord, John, Cogan, Derek, Surprenant, Simon
Year of Publication 31.01.2020
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Year of Publication 31.01.2020
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Aldosterone synthase inhibitors
Cerny, Matthew A, Marshall, Daniel Richard, Fader, Lee, Zhang, Yunlong, Burke, Jennifer, Frederick, Kosea S, Yu, Maolin, Lord, John, McKibben, Bryan P, Cogan, Derek, Surprenant, Simon
Year of Publication 21.11.2019
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Year of Publication 21.11.2019
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ALDOSTERONE SYNTHASE INHIBITORS
LORD, John, MCKIBBEN, Bryan P, ZHANG, Yunlong, CERNY, Matthew A, COGAN, Derek, BURKE, Jennifer, YU, Maolin, FREDERICK, Kosea S, MARSHALL, Daniel Richard, SURPRENANT, Simon, FADER, Lee
Year of Publication 28.02.2019
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Year of Publication 28.02.2019
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ALDOSTERONE SYNTHASE INHIBITORS
FREDERICK, KOSEA S, CERNY, MATTHEW A, SURPRENANT, SIMON, COGAN, DEREK, MARSHALL, DANIEL RICHARD, YU, MAOLIN, BURKE, JENNIFER, MCKIBBEN, BRYAN P, LORD, JOHN, FADER, LEE, ZHANG, YUNLONG
Year of Publication 30.11.2018
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Year of Publication 30.11.2018
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