Multicellular tumor spheroid model to evaluate spatio-temporal dynamics effect of chemotherapeutics: application to the gemcitabine/CHK1 inhibitor combination in pancreatic cancer
Dufau, Isabelle, Frongia, Céline, Sicard, Flavie, Dedieu, Laure, Cordelier, Pierre, Ausseil, Frédéric, Ducommun, Bernard, Valette, Annie
Published in BMC cancer (13.01.2012)
Published in BMC cancer (13.01.2012)
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Rational Design of Bisubstrate-Type Analogues as Inhibitors of DNA Methyltransferases in Cancer Cells
Halby, Ludovic, Menon, Yoann, Rilova, Elodie, Pechalrieu, Dany, Masson, Véronique, Faux, Celine, Bouhlel, Mohamed Amine, David-Cordonnier, Marie-Hélène, Novosad, Natacha, Aussagues, Yannick, Samson, Arnaud, Lacroix, Laurent, Ausseil, Fréderic, Fleury, Laurence, Guianvarc’h, Dominique, Ferroud, Clotilde, Arimondo, Paola B
Published in Journal of medicinal chemistry (08.06.2017)
Published in Journal of medicinal chemistry (08.06.2017)
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DNA methylation inhibitors in cancer: Recent and future approaches
Gros, Christina, Fahy, Jacques, Halby, Ludovic, Dufau, Isabelle, Erdmann, Alexandre, Gregoire, Jean-Marc, Ausseil, Fréderic, Vispé, Stéphane, Arimondo, Paola B.
Published in Biochimie (01.11.2012)
Published in Biochimie (01.11.2012)
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Properly substituted analogues of BIX-01294 lose inhibition of G9a histone methyltransferase and gain selective anti-DNA methyltransferase 3A activity
Rotili, Dante, Tarantino, Domenico, Marrocco, Biagina, Gros, Christina, Masson, Véronique, Poughon, Valérie, Ausseil, Fréderic, Chang, Yanqi, Labella, Donatella, Cosconati, Sandro, Di Maro, Salvatore, Novellino, Ettore, Schnekenburger, Michael, Grandjenette, Cindy, Bouvy, Celine, Diederich, Marc, Cheng, Xiaodong, Arimondo, Paola B, Mai, Antonello
Published in PloS one (08.05.2014)
Published in PloS one (08.05.2014)
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Journal Article
Development of a universal radioactive DNA methyltransferase inhibition test for high-throughput screening and mechanistic studies
Gros, Christina, Chauvigné, Laura, Poulet, Anaïs, Menon, Yoann, Ausseil, Frédéric, Dufau, Isabelle, Arimondo, Paola B
Published in Nucleic acids research (01.10.2013)
Published in Nucleic acids research (01.10.2013)
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High-throughput bioluminescence screening of ubiquitin-proteasome pathway inhibitors from chemical and natural sources
Ausseil, Frederic, Samson, Arnaud, Aussagues, Yannick, Vandenberghe, Isabelle, Creancier, Laurent, Pouny, Isabelle, Kruczynski, Anna, Massiot, Georges, Bailly, Christian
Published in Journal of biomolecular screening (01.02.2007)
Published in Journal of biomolecular screening (01.02.2007)
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New Insights on the Mechanism of Quinoline-based DNA Methyltransferase Inhibitors
Gros, Christina, Fleury, Laurence, Nahoum, Virginie, Faux, Céline, Valente, Sergio, Labella, Donatella, Cantagrel, Frédéric, Rilova, Elodie, Bouhlel, Mohamed Amine, David-Cordonnier, Marie-Hélène, Dufau, Isabelle, Ausseil, Frédéric, Mai, Antonello, Mourey, Lionel, Lacroix, Laurent, Arimondo, Paola B.
Published in The Journal of biological chemistry (06.03.2015)
Published in The Journal of biological chemistry (06.03.2015)
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Journal Article
Optimization of a homogeneous assay for kinase inhibitors in plant extracts
Dufau, Isabelle, Lazzari, Anne, Samson, Arnaud, Pouny, Isabelle, Ausseil, Frederic
Published in Assay and drug development technologies (01.10.2008)
Published in Assay and drug development technologies (01.10.2008)
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Journal Article
Parthenolide inhibits tubulin carboxypeptidase activity
FONROSE, Xavier, AUSSEIL, Frédéric, LAFANECHERE, Laurence, SOLEILHAC, Emmanuelle, MASSON, Veronique, DAVID, Bruno, POUNY, Isabelle, CINTRAT, Jean-Christophe, ROUSSEAU, Bernard, BARETTE, Caroline, MASSIOT, Georges
Published in Cancer research (Chicago, Ill.) (01.04.2007)
Published in Cancer research (Chicago, Ill.) (01.04.2007)
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The CERT antagonist HPA-12: First practical synthesis and individual binding evaluation of the four stereoisomers
Santos, Cécile, Fleury, Laurence, Rodriguez, Frédéric, Markus, Jozef, Berkeš, Dušan, Daïch, Adam, Ausseil, Frédéric, Baudoin-Dehoux, Cécile, Ballereau, Stéphanie, Génisson, Yves
Published in Bioorganic & medicinal chemistry (01.05.2015)
Published in Bioorganic & medicinal chemistry (01.05.2015)
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Journal Article
Asymmetric Synthesis and Binding Study of New Long-Chain HPA-12 Analogues as Potent Ligands of the Ceramide Transfer Protein CERT
Ďuriš, Andrej, Daïch, Adam, Santos, Cécile, Fleury, Laurence, Ausseil, Frédéric, Rodriguez, Frédéric, Ballereau, Stéphanie, Génisson, Yves, Berkeš, Dušan
Published in Chemistry : a European journal (04.05.2016)
Published in Chemistry : a European journal (04.05.2016)
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Design and synthesis of new non nucleoside inhibitors of DNMT3A
Erdmann, Alexandre, Menon, Yoann, Gros, Christina, Molinier, Nicolas, Novosad, Natacha, Samson, Arnaud, Gregoire, Jean-Marc, Long, Christophe, Ausseil, Frédéric, Halby, Ludovic, Arimondo, Paola B.
Published in Bioorganic & medicinal chemistry (01.09.2015)
Published in Bioorganic & medicinal chemistry (01.09.2015)
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Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells
Zwergel, Clemens, Schnekenburger, Michael, Sarno, Federica, Battistelli, Cecilia, Manara, Maria Cristina, Stazi, Giulia, Mazzone, Roberta, Fioravanti, Rossella, Gros, Christina, Ausseil, Frédéric, Florean, Cristina, Nebbioso, Angela, Strippoli, Raffaele, Ushijima, Toshikazu, Scotlandi, Katia, Tripodi, Marco, Arimondo, Paola B, Altucci, Lucia, Diederich, Marc, Mai, Antonello, Valente, Sergio
Published in Clinical epigenetics (06.05.2019)
Published in Clinical epigenetics (06.05.2019)
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Identification of epigenetic factors regulating the mesenchyme to epithelium transition by RNA interference screening in breast cancer cells
Gregoire, Jean-Marc, Fleury, Laurence, Salazar-Cardozo, Clara, Alby, Frédéric, Masson, Véronique, Arimondo, Paola Barbara, Ausseil, Frédéric
Published in BMC cancer (31.08.2016)
Published in BMC cancer (31.08.2016)
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Identification and optimization of hydrazone-gallate derivatives as specific inhibitors of DNA methyltransferase 3A
Erdmann, Alexandre, Menon, Yoann, Gros, Christina, Masson, Véronique, Aussagues, Yannick, Ausseil, Fréderic, Novosad, Natacha, Schambel, Philippe, Baltas, Michel, Arimondo, Paola B
Published in Future medicinal chemistry (01.03.2016)
Published in Future medicinal chemistry (01.03.2016)
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Development of a CERT START Domain-Ceramide HTRF Binding Assay and Application to Pharmacological Studies and Screening
Fleury, Laurence, Faux, Céline, Santos, Cécile, Ballereau, Stéphanie, Génisson, Yves, Ausseil, Frédéric
Published in Journal of biomolecular screening (01.07.2015)
Published in Journal of biomolecular screening (01.07.2015)
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Journal Article
Design, Synthesis and Biological Evaluation of 4-Amino-N-(4-aminophenyl)benzamide Analogues of Quinoline-Based SGI-1027 as Inhibitors of DNA Methylation
Rilova, Elodie, Erdmann, Alexandre, Gros, Christina, Masson, Véronique, Aussagues, Yannick, Poughon-Cassabois, Valérie, Rajavelu, Arumugam, Jeltsch, Albert, Menon, Yoann, Novosad, Natacha, Gregoire, Jean-Marc, Vispé, Stéphane, Schambel, Philippe, Ausseil, Fréderic, Sautel, François, Arimondo, Paola B., Cantagrel, Frédéric
Published in ChemMedChem (01.03.2014)
Published in ChemMedChem (01.03.2014)
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Alisiaquinones and Alisiaquinol, Dual Inhibitors of Plasmodium falciparum Enzyme Targets from a New Caledonian Deep Water Sponge
Desoubzdanne, Denis, Marcourt, Laurence, Raux, Roselyne, Chevalley, Séverine, Dorin, Dominique, Doerig, Christian, Valentin, Alexis, Ausseil, Frédéric, Debitus, Cécile
Published in Journal of natural products (Washington, D.C.) (01.07.2008)
Published in Journal of natural products (Washington, D.C.) (01.07.2008)
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Physalin B, a novel inhibitor of the ubiquitin-proteasome pathway, triggers NOXA-associated apoptosis
Vandenberghe, Isabelle, Créancier, Laurent, Vispé, Stéphane, Annereau, Jean-Philippe, Barret, Jean-Marc, Pouny, Isabelle, Samson, Arnaud, Aussagues, Yannick, Massiot, Georges, Ausseil, Frédéric, Bailly, Christian, Kruczynski, Anna
Published in Biochemical pharmacology (15.08.2008)
Published in Biochemical pharmacology (15.08.2008)
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Proteasome Inhibitors from Neoboutonia melleri
Long, Christophe, Beck, Joséphine, Cantagrel, Frédéric, Marcourt, Laurence, Vendier, Laure, David, Bruno, Plisson, Fabien, Derguini, Fadila, Vandenberghe, Isabelle, Aussagues, Yannick, Ausseil, Frédéric, Lavaud, Catherine, Sautel, François, Massiot, Georges
Published in Journal of natural products (Washington, D.C.) (27.01.2012)
Published in Journal of natural products (Washington, D.C.) (27.01.2012)
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