Design and synthesis of orally bioavailable serum and glucocorticoid-regulated kinase 1 (SGK1) inhibitors
Hammond, Marlys, Washburn, David G., Hoang, Tram H., Manns, Sharada, Frazee, James S., Nakamura, Hiroko, Patterson, Jaclyn R., Trizna, Walter, Wu, Charlene, Azzarano, Leonard M., Nagilla, Rakesh, Nord, Melanie, Trejo, Rebecca, Head, Martha S., Zhao, Baoguang, Smallwood, Angela M., Hightower, Kendra, Laping, Nicholas J., Schnackenberg, Christine G., Thompson, Scott K.
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Journal Article
Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists
Thompson, Scott K., Washburn, David G., Frazee, James S., Madauss, Kevin P., Hoang, Tram H., Lapinski, Leahann, Grygielko, Eugene T., Glace, Lindsay E., Trizna, Walter, Williams, Shawn P., Duraiswami, Chaya, Bray, Jeffrey D., Laping, Nicholas J.
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
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Journal Article
Improving the developability profile of pyrrolidine progesterone receptor partial agonists
Kallander, Lara S., Washburn, David G., Hoang, Tram H., Frazee, James S., Stoy, Patrick, Johnson, Latisha, Lu, Qing, Hammond, Marlys, Barton, Linda S., Patterson, Jaclyn R., Azzarano, Leonard M., Nagilla, Rakesh, Madauss, Kevin P., Williams, Shawn P., Stewart, Eugene L., Duraiswami, Chaya, Grygielko, Eugene T., Xu, Xiaoping, Laping, Nicholas J., Bray, Jeffrey D., Thompson, Scott K.
Published in Bioorganic & medicinal chemistry letters (01.01.2010)
Published in Bioorganic & medicinal chemistry letters (01.01.2010)
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Journal Article
Discovery of orally active, pyrrolidinone-based progesterone receptor partial agonists
Washburn, David G., Hoang, Tram H., Frazee, James S., Johnson, Latisha, Hammond, Marlys, Manns, Sharada, Madauss, Kevin P., Williams, Shawn P., Duraiswami, Chaya, Tran, Thuy B., Stewart, Eugene L., Grygielko, Eugene T., Glace, Lindsay E., Trizna, Walter, Nagilla, Rakesh, Bray, Jeffrey D., Thompson, Scott K.
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
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Journal Article
Multisubstrate inhibitors of dopamine .beta.-hydroxylase. 1. Some 1-phenyl and 1-phenyl-bridged derivatives of imidazole-2-thione
Kruse, Lawrence I, Kaiser, Carl, DeWolf, Walter E, Frazee, James S, Garvey, Eleanor, Hilbert, Eileen L, Faulkner, Wayne A, Flaim, Kathryn E, Sawyer, John L, Berkowitz, Barry A
Published in Journal of medicinal chemistry (01.12.1986)
Published in Journal of medicinal chemistry (01.12.1986)
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Journal Article
Synthesis and antiviral activity of a novel class of HIV-1 protease inhibitors containing a heterocyclic P1′-P2′ amide bond isostere
Thompson, Scott K., Eppley, Alecia M., Frazee, James S., Darcy, Michael G., Lum, Robert T., Tomaszek, Thaddeus A., Ivanoff, Lucinda A., Morris, Jane F., Sternberg, Edmund J., Lambert, Dennis M., Fernandez, Annabellee V., Petteway, Stephen R., Meek, Thomas D, Metcalf, Brian W., Gleason, John G.
Published in Bioorganic & medicinal chemistry letters (01.10.1994)
Published in Bioorganic & medicinal chemistry letters (01.10.1994)
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Journal Article
Some benzyl-substituted imidazoles, triazoles, tetrazoles, pyridinethiones, and structural relatives as multisubstrate inhibitors of dopamine .beta.-hydroxylase. 4. Structure-activity relationships at the copper binding site
Kruse, Lawrence I, Kaiser, Carl, DeWolf, Walter E, Finkelstein, Joseph A, Frazee, James S, Hilbert, Eileen L, Ross, Stephen T, Flaim, Kathryn E, Sawyer, John L
Published in Journal of medicinal chemistry (01.02.1990)
Published in Journal of medicinal chemistry (01.02.1990)
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Journal Article
Orally Active and Potent Inhibitors of γ-Aminobutyric Acid Uptake
Ali, Fadia E, Bondinell, William E, Dandridge, Penelope A, Frazee, James S, Garvey, Eleanor, Girard, Gerald R, Kaiser, Carl, Ku, Thomas W, Lafferty, John J, Moonsammy, George I, Oh, Hye-Ja, Rush, Julia A, Setler, Paulette E, Stringer, Orum D, Venslavsky, Joseph W, Volpe, Beth W, Yunger, Libby M, Zirkle, Charles L
Published in Journal of medicinal chemistry (01.05.1985)
Published in Journal of medicinal chemistry (01.05.1985)
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Journal Article
High-affinity leukotriene receptor antagonists. Synthesis and pharmacological characterization of 2-hydroxy-3-[(2-carboxyethyl)thio]-3-[2-(8-phenyloctyl)phenyl]propanoic acid
Gleason, John G, Hall, Ralph F, Perchonock, Carl D, Erhard, Karl F, Frazee, James S, Ku, Thomas W, Kondrad, Karen, McCarthy, Mary E, Mong, Seymour
Published in Journal of medicinal chemistry (01.06.1987)
Published in Journal of medicinal chemistry (01.06.1987)
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Journal Article
Multisubstrate inhibitors of dopamine .beta.-hydroxylase. 2. Structure-activity relationships at the phenethylamine binding site
Kruse, Lawrence I, Kaiser, Carl, DeWolf, Walter E, Frazee, James S, Ross, Stephen T, Wawro, Joyce, Wise, Merrie, Flaim, Kathryn E, Sawyer, John L
Published in Journal of medicinal chemistry (01.03.1987)
Published in Journal of medicinal chemistry (01.03.1987)
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Journal Article
Substituted 1-benzylimidazole-2-thiols as potent and orally active inhibitors of dopamine .beta.-hydroxylase
Kruse, Lawrence I, Kaiser, Carl, DeWolf, Walter E, Frazee, James S, Erickson, Robert W, Ezekiel, Mildred, Ohlstein, Eliot H, Ruffolo, Robert R, Berkowitz, Barry A
Published in Journal of medicinal chemistry (01.06.1986)
Published in Journal of medicinal chemistry (01.06.1986)
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Journal Article
SB 209670, a Rationally Designed Potent Nonpeptide Endothelin Receptor Antagonist
Ohlstein, Eliot H., Nambi, Ponnal, Douglas, Stephen A., Edwards, Richard M., Gellai, Miklos, Lago, Amparo, Leer, Jack D., Cousins, Russell D., Gao, Aiming, Frazee, James S., Peishoff, Catherine E., Bean, John W., Eggleston, Drake S., Elshourbagy, Nabil A., Kumar, Chandrika, Lee, Jonathan A., Yue, Tian-Li, Louden, Calvert, Brooks, David P., Weinstock, Joseph, Feuerstein, Giora, Poste, George, Ruffolo, Robert R., Gleason, John G., Elliott, John D.
Published in Proceedings of the National Academy of Sciences - PNAS (16.08.1994)
Published in Proceedings of the National Academy of Sciences - PNAS (16.08.1994)
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Journal Article
Adrenergic agents. 6. Synthesis and potential .beta.-adrenergic agonist activity of some meta-substituted p-hydroxyphenylethanolamines related to salbutamol
Jen, Timothy, Frazee, James S, Kaiser, Carl, Colella, Donald F, Wardell, Joe R
Published in Journal of medicinal chemistry (01.08.1977)
Published in Journal of medicinal chemistry (01.08.1977)
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Journal Article
Adrenergic agents. 8. Synthesis and .beta.-adrenergic agonist activity of some 3-tert-butylamino-2-(substituted phenyl)-1-propanols
Jen, Timothy, Frazee, James S, Schwartz, Mark S, Erhard, Karl F, Kaiser, Carl, Colella, Donald F, Wardell, Joe R
Published in Journal of medicinal chemistry (01.10.1977)
Published in Journal of medicinal chemistry (01.10.1977)
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Journal Article
3-Phenyl-5-quinolinemethanol antimalarials
Makriyannis, Alexandros, Wilson, James W, Frazee, James S
Published in Journal of medicinal chemistry (01.02.1973)
Published in Journal of medicinal chemistry (01.02.1973)
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Journal Article
Synthesis and antiviral activity of a novel class of HIV-1 protease inhibitors containing a heterocyclic P 1′-P 2′ amide bond isostere
Thompson, Scott K., Eppley, Alecia M., Frazee, James S., Darcy, Michael G., Lum, Robert T., Tomaszek, Thaddeus A., Ivanoff, Lucinda A., Morris, Jane F., Sternberg, Edmund J., Lambert, Dennis M., Fernandez, Annabellee V., Petteway, Stephen R., Meek, Thomas D, Metcalf, Brian W., Gleason, John G.
Published in Bioorganic & medicinal chemistry letters (20.10.1994)
Published in Bioorganic & medicinal chemistry letters (20.10.1994)
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Journal Article
1H-Pyrrolo[2,3-B]Pyridines
THOMPSON SCOTT KEVIN, MANNS SHARADA, HAMMOND MARLYS, FRAZEE JAMES S, KANO KAZUYA, WASHBURN DAVID G, NAKAMURA HIROKO
Year of Publication 20.09.2012
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Year of Publication 20.09.2012
Patent
PYRROLIDINONE ANILINES AS PROGESTERONE RECEPTOR MODULATORS
WASHBURN, DAVID, G, FRAZEE, JAMES, S, THOMPSON, SCOTT, KEVIN, JOHNSON, LATISHA, C, HOANG, TRAM, H, HAMMOND, MARLYS
Year of Publication 19.09.2012
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Year of Publication 19.09.2012
Patent