Using human genetics to understand the disease impacts of testosterone in men and women
Ruth, Katherine S, Day, Felix R, Tyrrell, Jessica, Thompson, Deborah J, Wood, Andrew R, Mahajan, Anubha, Beaumont, Robin N, Wittemans, Laura, Martin, Susan, Busch, Alexander S, Erzurumluoglu, A Mesut, Hollis, Benjamin, O'Mara, Tracy A, McCarthy, Mark I, Langenberg, Claudia, Easton, Douglas F, Wareham, Nicholas J, Burgess, Stephen, Murray, Anna, Ong, Ken K, Frayling, Timothy M, Perry, John R B
Published in Nature medicine (01.02.2020)
Published in Nature medicine (01.02.2020)
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Journal Article
Assessing the Pathogenicity, Penetrance, and Expressivity of Putative Disease-Causing Variants in a Population Setting
Wright, Caroline F., West, Ben, Tuke, Marcus, Jones, Samuel E., Patel, Kashyap, Laver, Thomas W., Beaumont, Robin N., Tyrrell, Jessica, Wood, Andrew R., Frayling, Timothy M., Hattersley, Andrew T., Weedon, Michael N.
Published in American journal of human genetics (07.02.2019)
Published in American journal of human genetics (07.02.2019)
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Journal Article
Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits
JIAN YANG, FERREIRA, Teresa, FRAYLING, Timothy M, MCCARTHY, Mark I, HIRSCHHORN, Joel N, EGODDARD, Michael, VISSCHER, Peter M, MORRIS, Andrew P, MEDLAND, Sarah E, MADDEN, Pamela A. F, HEATH, Andrew C, MARTIN, Nicholas G, MONTGOMERY, Grant W, WEEDON, Michael N, LOOS, Ruth J
Published in Nature genetics (01.04.2012)
Published in Nature genetics (01.04.2012)
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Journal Article
Quantification of the overall contribution of gene-environment interaction for obesity-related traits
Sulc, Jonathan, Mounier, Ninon, Günther, Felix, Winkler, Thomas, Wood, Andrew R, Frayling, Timothy M, Heid, Iris M, Robinson, Matthew R, Kutalik, Zoltán
Published in Nature communications (13.03.2020)
Published in Nature communications (13.03.2020)
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Journal Article
Higher adiposity and mental health: causal inference using Mendelian randomization
Casanova, Francesco, O’Loughlin, Jessica, Martin, Susan, Beaumont, Robin N, Wood, Andrew R, Watkins, Edward R, Freathy, Rachel M, Hagenaars, Saskia P, Frayling, Timothy M, Yaghootkar, Hanieh, Tyrrell, Jess
Published in Human molecular genetics (30.11.2021)
Published in Human molecular genetics (30.11.2021)
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Journal Article
Biomarkers for Type 2 Diabetes and Impaired Fasting Glucose Using a Nontargeted Metabolomics Approach
MENNI, Cristina, FAUMAN, Eric, WEI YUAN, MILBURN, Mike, PALMER, Colin N. A, FRAYLING, Timothy M, TRIMMER, Jeff, BELL, Jordana T, GIEGER, Christian, MOHNEY, Rob P, BROSNAN, Mary Julia, SUHRE, Karsten, ERTE, Idil, SORANZO, Nicole, SPECTOR, Tim D, PERRY, John R. B, KASTENMÜLLER, Gabi, SHIN, So-Youn, PETERSEN, Ann-Kristin, HYDE, Craig, PSATHA, Maria, WARD, Kirsten J
Published in Diabetes (New York, N.Y.) (01.12.2013)
Published in Diabetes (New York, N.Y.) (01.12.2013)
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Journal Article
A genome-wide association study identifies 5 loci associated with frozen shoulder and implicates diabetes as a causal risk factor
Green, Harry D, Jones, Alistair, Evans, Jonathan P, Wood, Andrew R, Beaumont, Robin N, Tyrrell, Jessica, Frayling, Timothy M, Smith, Christopher, Weedon, Michael N
Published in PLoS genetics (10.06.2021)
Published in PLoS genetics (10.06.2021)
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Journal Article
Genetic correlates of social stratification in Great Britain
Abdellaoui, Abdel, Hugh-Jones, David, Yengo, Loic, Kemper, Kathryn E, Nivard, Michel G, Veul, Laura, Holtz, Yan, Zietsch, Brendan P, Frayling, Timothy M, Wray, Naomi R, Yang, Jian, Verweij, Karin J H, Visscher, Peter M
Published in Nature human behaviour (01.12.2019)
Published in Nature human behaviour (01.12.2019)
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Genetic evidence for a normal-weight "metabolically obese" phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes
Yaghootkar, Hanieh, Scott, Robert A, White, Charles C, Zhang, Weihua, Speliotes, Elizabeth, Munroe, Patricia B, Ehret, Georg B, Bis, Joshua C, Fox, Caroline S, Walker, Mark, Borecki, Ingrid B, Knowles, Joshua W, Yerges-Armstrong, Laura, Ohlsson, Claes, Perry, John R B, Chambers, John C, Kooner, Jaspal S, Franceschini, Nora, Langenberg, Claudia, Hivert, Marie-France, Dastani, Zari, Richards, J Brent, Semple, Robert K, Frayling, Timothy M
Published in Diabetes (New York, N.Y.) (01.12.2014)
Published in Diabetes (New York, N.Y.) (01.12.2014)
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Journal Article
Common Variation in the DIO2 Gene Predicts Baseline Psychological Well-Being and Response to Combination Thyroxine Plus Triiodothyronine Therapy in Hypothyroid Patients
Panicker, Vijay, Saravanan, Ponnusamy, Vaidya, Bijay, Evans, Jonathan, Hattersley, Andrew T, Frayling, Timothy M, Dayan, Colin M
Published in The journal of clinical endocrinology and metabolism (01.05.2009)
Published in The journal of clinical endocrinology and metabolism (01.05.2009)
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Journal Article
Identification and analysis of individuals who deviate from their genetically-predicted phenotype
Hawkes, Gareth, Yengo, Loic, Vedantam, Sailaja, Marouli, Eirini, Beaumont, Robin N, Tyrrell, Jessica, Weedon, Michael N, Hirschhorn, Joel, Frayling, Timothy M, Wood, Andrew R
Published in PLoS genetics (21.09.2023)
Published in PLoS genetics (21.09.2023)
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Journal Article
Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis
Hazelwood, Emma, Sanderson, Eleanor, Tan, Vanessa Y, Ruth, Katherine S, Frayling, Timothy M, Dimou, Niki, Gunter, Marc J, Dossus, Laure, Newton, Claire, Ryan, Neil, Pournaras, Dimitri J, O'Mara, Tracy A, Davey Smith, George, Martin, Richard M, Yarmolinsky, James
Published in BMC medicine (19.04.2022)
Published in BMC medicine (19.04.2022)
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Journal Article
fat mass-and obesity-associated locus and dietary intake in children
Timpson, Nicholas J, Emmett, Pauline M, Frayling, Timothy M, Rogers, Imogen, Hattersley, Andrew T, McCarthy, Mark I, Davey Smith, George
Published in The American journal of clinical nutrition (01.10.2008)
Published in The American journal of clinical nutrition (01.10.2008)
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Journal Article
Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing
Harries, Lorna W., Hernandez, Dena, Henley, William, Wood, Andrew R., Holly, Alice C., Bradley‐Smith, Rachel M., Yaghootkar, Hanieh, Dutta, Ambarish, Murray, Anna, Frayling, Timothy M., Guralnik, Jack M., Bandinelli, Stefania, Singleton, Andrew, Ferrucci, Luigi, Melzer, David
Published in Aging cell (01.10.2011)
Published in Aging cell (01.10.2011)
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Assessing the Combined Impact of 18 Common Genetic Variants of Modest Effect Sizes on Type 2 Diabetes Risk
Lango, Hana, Palmer, Colin N A, Morris, Andrew D, Zeggini, Eleftheria, Hattersley, Andrew T, McCarthy, Mark I, Frayling, Timothy M, Weedon, Michael N
Published in Diabetes (New York, N.Y.) (01.11.2008)
Published in Diabetes (New York, N.Y.) (01.11.2008)
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Journal Article
A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure
Frayling, Timothy M., Beaumont, Robin N., Jones, Samuel E., Yaghootkar, Hanieh, Tuke, Marcus A., Ruth, Katherine S., Casanova, Francesco, West, Ben, Locke, Jonathan, Sharp, Seth, Ji, Yingjie, Thompson, William, Harrison, Jamie, Etheridge, Amy S., Gallins, Paul J., Jima, Dereje, Wright, Fred, Zhou, Yihui, Innocenti, Federico, Lindgren, Cecilia M., Grarup, Niels, Murray, Anna, Freathy, Rachel M., Weedon, Michael N., Tyrrell, Jessica, Wood, Andrew R.
Published in Cell reports (Cambridge) (10.04.2018)
Published in Cell reports (Cambridge) (10.04.2018)
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Mendelian Randomization Analyses Suggest Childhood Body Size Indirectly Influences End Points From Across the Cardiovascular Disease Spectrum Through Adult Body Size
Power, Grace M, Tyrrell, Jessica, Frayling, Timothy M, Davey Smith, George, Richardson, Tom G
Published in Journal of the American Heart Association (07.09.2021)
Published in Journal of the American Heart Association (07.09.2021)
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Journal Article
Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus
Bell, Christopher G, Finer, Sarah, Lindgren, Cecilia M, Wilson, Gareth A, Rakyan, Vardhman K, Teschendorff, Andrew E, Akan, Pelin, Stupka, Elia, Down, Thomas A, Prokopenko, Inga, Morison, Ian M, Mill, Jonathan, Pidsley, Ruth, Deloukas, Panos, Frayling, Timothy M, Hattersley, Andrew T, McCarthy, Mark I, Beck, Stephan, Hitman, Graham A
Published in PloS one (18.11.2010)
Published in PloS one (18.11.2010)
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Journal Article
Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers
Pilling, Luke C, Atkins, Janice L, Duff, Michael O, Beaumont, Robin N, Jones, Samuel E, Tyrrell, Jessica, Kuo, Chia-Ling, Ruth, Katherine S, Tuke, Marcus A, Yaghootkar, Hanieh, Wood, Andrew R, Murray, Anna, Weedon, Michael N, Harries, Lorna W, Kuchel, George A, Ferrucci, Luigi, Frayling, Timothy M, Melzer, David
Published in PloS one (28.09.2017)
Published in PloS one (28.09.2017)
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Journal Article
A genome-wide association study identifies protein quantitative trait loci (pQTLs)
Melzer, David, Perry, John R B, Hernandez, Dena, Corsi, Anna-Maria, Stevens, Kara, Rafferty, Ian, Lauretani, Fulvio, Murray, Anna, Gibbs, J Raphael, Paolisso, Giuseppe, Rafiq, Sajjad, Simon-Sanchez, Javier, Lango, Hana, Scholz, Sonja, Weedon, Michael N, Arepalli, Sampath, Rice, Neil, Washecka, Nicole, Hurst, Alison, Britton, Angela, Henley, William, van de Leemput, Joyce, Li, Rongling, Newman, Anne B, Tranah, Greg, Harris, Tamara, Panicker, Vijay, Dayan, Colin, Bennett, Amanda, McCarthy, Mark I, Ruokonen, Aimo, Jarvelin, Marjo-Riitta, Guralnik, Jack, Bandinelli, Stefania, Frayling, Timothy M, Singleton, Andrew, Ferrucci, Luigi
Published in PLoS genetics (01.05.2008)
Published in PLoS genetics (01.05.2008)
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