Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory
Fá, M, Puzzo, D, Piacentini, R, Staniszewski, A, Zhang, H, Baltrons, M A, Li Puma, D D, Chatterjee, I, Li, J, Saeed, F, Berman, H L, Ripoli, C, Gulisano, W, Gonzalez, J, Tian, H, Costa, J A, Lopez, P, Davidowitz, E, Yu, W H, Haroutunian, V, Brown, L M, Palmeri, A, Sigurdsson, E M, Duff, K E, Teich, A F, Honig, L S, Sierks, M, Moe, J G, D'Adamio, L, Grassi, C, Kanaan, N M, Fraser, P E, Arancio, O
Published in Scientific reports (20.01.2016)
Published in Scientific reports (20.01.2016)
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Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence
Zraika, S, Hull, R. L, Verchere, C. B, Clark, A, Potter, K. J, Fraser, P. E, Raleigh, D. P, Kahn, S. E
Published in Diabetologia (01.06.2010)
Published in Diabetologia (01.06.2010)
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Islet Amyloid Deposition Limits the Viability of Human Islet Grafts but Not Porcine Islet Grafts
Potter, K. J., Abedini, A., Marek, P., Klimek, A. M., Butterworth, S., Driscoll, M., Baker, R., Nilsson, M. R., Warnock, G. L., Oberholzer, J., Bertera, S., Trucco, M., Korbutt, G. S., Fraser, P. E., Raleigh, D. P., Verchere, C. B., Steiner, Donald F.
Published in Proceedings of the National Academy of Sciences - PNAS (02.03.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (02.03.2010)
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Islet amyloid inhibitors improve glucose homeostasis in a transgenic mouse model of type 2 diabetes
Wijesekara, N., Ahrens, R., Wu, L., Ha, K., Liu, Y., Wheeler, M. B., Fraser, P. E.
Published in Diabetes, obesity & metabolism (01.10.2015)
Published in Diabetes, obesity & metabolism (01.10.2015)
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Proliferation, differentiation and amyloid-β production in neural progenitor cells isolated from TgCRND8 mice
Kanemoto, S, Griffin, J, Markham-Coultes, K, Aubert, I, Tandon, A, George-Hyslop, P.S, Fraser, P.E
Published in Neuroscience (07.03.2014)
Published in Neuroscience (07.03.2014)
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Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
Rogaev, E. I, Sherrington, R, Rogaeva, E. A, Levesque, G, Ikeda, M, Liang, Y, Chi, H, Lin, C, Holman, K, Tsuda, T, Mar, L, Sorbi, S, Nacmias, B, Piacentini, S, Amaducci, L, Chumakov, I, Cohen, D, Lannfelt, L, Fraser, P. E, Rommens, J. M, George-Hyslop, P. H. St
Published in Nature (London) (31.08.1995)
Published in Nature (London) (31.08.1995)
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Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4-10 and inhibit cytotoxicity and fibrillogenesis
McLaurin, J, Przybylski, M, Cecal, R, Kierstead, M.E, Tian, X, Phinney, A.L, Manea, M, French, J.E, Lambermon, M.H.L, Darabie, A.A, Brown, M.E, Janus, C, Chishti, M.A, Horne, P, Westaway, D, Fraser, P.E, Mount, H.T.J, St George-Hyslop, P
Published in Nature medicine (01.11.2002)
Published in Nature medicine (01.11.2002)
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The cellular prion protein binds copper in vivo
Kretzschmar, Hans, Brown, David R, Qin, Kefeng, Herms, Jochen W, Madlung, Axel, Manson, Jean, Strome, Robert, Fraser, Paul E, Kruck, Theo, von Bohlen, Alex, Schulz-Schaeffer, Walter, Giese, Armin, Westaway, David
Published in Nature (London) (18.12.1997)
Published in Nature (London) (18.12.1997)
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Review: Modulating Factors in Amyloid-β Fibril Formation
McLaurin, J., Yang, D.-S., Yip, C.M., Fraser, P.E.
Published in Journal of Structural Biology (01.06.2000)
Published in Journal of Structural Biology (01.06.2000)
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Book Review
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Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis
Booth, David R, Sunde, Margaret, Bellotti, Vittorio, Robinson, Carol V, Hutchinson, Winston L, Fraser, Paul E, Hawkins, Philip N, Dobson, Christopher M, Radford, Sheena E, Blake, Colin C. F, Pepys, Mark B
Published in Nature (London) (27.02.1997)
Published in Nature (London) (27.02.1997)
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The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin
Yu, G, Chen, F, Levesque, G, Nishimura, M, Zhang, D M, Levesque, L, Rogaeva, E, Xu, D, Liang, Y, Duthie, M, St George-Hyslop, P H, Fraser, P E
Published in The Journal of biological chemistry (26.06.1998)
Published in The Journal of biological chemistry (26.06.1998)
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Molecular Structure of a Fibrillar Alzheimer's Aβ Fragment
Serpell, Louise C, Blake, Colin C. F, Fraser, Paul E
Published in Biochemistry (Easton) (31.10.2000)
Published in Biochemistry (Easton) (31.10.2000)
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Phosphatidylinositol and inositol involvement in alzheimer amyloid-β fibril growth and arrest
McLaurin, J, Franklin, T, Chakrabartty, A, Fraser, P.E
Published in Journal of molecular biology (24.04.1998)
Published in Journal of molecular biology (24.04.1998)
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pH-dependent structural transitions of Alzheimer amyloid peptides
Fraser, P.E., Nguyen, J.T., Surewicz, W.K., Kirschner, D.A.
Published in Biophysical journal (01.11.1991)
Published in Biophysical journal (01.11.1991)
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Current and future implications of basic and translational research on amyloid-β peptide production and removal pathways
Bohm, C., Chen, F., Sevalle, J., Qamar, S., Dodd, R., Li, Y., Schmitt-Ulms, G., Fraser, P.E., St George-Hyslop, P.H.
Published in Molecular and cellular neuroscience (01.05.2015)
Published in Molecular and cellular neuroscience (01.05.2015)
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Presenilins Interact with Armadillo Proteins Including Neural‐Specific Plakophilin‐Related Protein and β‐Catenin
Levesque, G., Yu, G., Nishimura, M., Zhang, D. M., Levesque, L., Yu, H., Xu, D., Liang, Y., Rogaeva, E., Ikeda, M., Duthie, M., Murgolo, N., Wang, L., VanderVere, P., Bayne, M. L., Strader, C. D., Rommens, J. M., Fraser, P. E., George‐Hyslop, P. St
Published in Journal of neurochemistry (01.03.1999)
Published in Journal of neurochemistry (01.03.1999)
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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
Sherrington, R, Rogaev, E. I, Liang, Y, Rogaeva, E. A, Levesque, G, Ikeda, M, Chi, H, Lin, C, Li, G, Holman, K, Tsuda, T, Mar, L, Foncin, J.-F, Bruni, A. C, Montesi, M. P, Sorbi, S, Rainero, I, Pinessi, L, Nee, L, Chumakov, I, Pollen, D, Brookes, A, Sanseau, P, Polinsky, R. J, Wasco, W, Da Silva, H. A. R, Haines, J. L, Pericak-Vance, M. A, Tanzi, R. E, Roses, A. D, Fraser, P. E, Rommens, J. M, St George-Hyslop, P. H
Published in Nature (London) (29.06.1995)
Published in Nature (London) (29.06.1995)
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Alternate aggregation pathways of the Alzheimer beta-amyloid peptide. An in vitro model of preamyloid
Huang, T H, Yang, D S, Fraser, P E, Chakrabartty, A
Published in The Journal of biological chemistry (17.11.2000)
Published in The Journal of biological chemistry (17.11.2000)
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