Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells
Grasberger, Bruce L, Lu, Tianbao, Schubert, Carsten, Parks, Daniel J, Carver, Theodore E, Koblish, Holly K, Cummings, Maxwell D, LaFrance, Louis V, Milkiewicz, Karen L, Calvo, Raul R, Maguire, Diane, Lattanze, Jennifer, Franks, Carol F, Zhao, Shuyuan, Ramachandren, Kannan, Bylebyl, Gwendolyn R, Zhang, Marie, Manthey, Carl L, Petrella, Eugene C, Pantoliano, Michael W, Deckman, Ingrid C, Spurlino, John C, Maroney, Anna C, Tomczuk, Bruce E, Molloy, Christopher J, Bone, Roger F
Published in Journal of medicinal chemistry (24.02.2005)
Published in Journal of medicinal chemistry (24.02.2005)
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Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo
Koblish, Holly K, Zhao, Shuyuan, Franks, Carol F, Donatelli, Robert R, Tominovich, Rose M, LaFrance, Louis V, Leonard, Kristi A, Gushue, Joan M, Parks, Daniel J, Calvo, Raul R, Milkiewicz, Karen L, Marugán, Juan José, Raboisson, Pierre, Cummings, Maxwell D, Grasberger, Bruce L, Johnson, Dana L, Lu, Tianbao, Molloy, Christopher J, Maroney, Anna C
Published in Molecular cancer therapeutics (01.01.2006)
Published in Molecular cancer therapeutics (01.01.2006)
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The synthesis and SAR of new 4-(N-alkyl-N-phenyl)amino-6,7-dimethoxyquinazolines and 4-(N-alkyl-N-phenyl)amino-pyrazolo[3,4-d]pyrimidines, inhibitors of CSF-1R tyrosine kinase activity
MYERS, M. R, SETZER, N. N, FRANKS, C. F, MITCHELL, K. J, SPADA, A. P, PERSONS, P. E, LY, C. Q, MAGUIRE, M. P, ZULLI, A. L, CHENEY, D. L, ZILBERSTEIN, A, JOHNSON, S. E
Published in Bioorganic & medicinal chemistry letters (18.02.1997)
Published in Bioorganic & medicinal chemistry letters (18.02.1997)
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Journal Article
The synthesis and SAR of new 4-( N-alkyl- N-phenyl)amino-6,7-dimethoxyquinazolines and 4-( N-alkyl- N-phenyl)aminopyrazolo[3,4- d]pyrimidines, inhibitors of CSF-1R tyrosine kinase activity
Myers, Michael R., Setzer, Natalie N., Spada, Alfred.P., Persons, Paul E., Ly, Cuong Q., Maguire, Martin P., Zulli, Allison L., Cheney, Daniel L., Zilberstein, Asher, Johnson, Susan E., Franks, Carol F., Mitchell, Karen J.
Published in Bioorganic & medicinal chemistry letters (18.02.1997)
Published in Bioorganic & medicinal chemistry letters (18.02.1997)
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