The discovery of the potent aurora inhibitor MK-0457 (VX-680)
Bebbington, David, Binch, Hayley, Charrier, Jean-Damien, Everitt, Simon, Fraysse, Damien, Golec, Julian, Kay, David, Knegtel, Ronald, Mak, Chau, Mazzei, Francesca, Miller, Andrew, Mortimore, Michael, O’Donnell, Michael, Patel, Sanjay, Pierard, Francoise, Pinder, Joanne, Pollard, John, Ramaya, Sharn, Robinson, Daniel, Rutherford, Alistair, Studley, John, Westcott, James
Published in Bioorganic & medicinal chemistry letters (01.07.2009)
Published in Bioorganic & medicinal chemistry letters (01.07.2009)
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Discovery of Selective, Orally Bioavailable Pyrazolopyridine Inhibitors of Protein Kinase Cθ (PKCθ) That Ameliorate Symptoms of Experimental Autoimmune Encephalomyelitis
Collier, Philip N, Twin, Heather C, Knegtel, Ronald M. A, Boyall, Dean, Brenchley, Guy, Davis, Christopher J, Keily, Shazia, Mak, Chau, Miller, Andrew, Pierard, Françoise, Settimo, Luca, Bolton, Clare M, Chiu, Peter, Curnock, Adam, Doyle, Elisabeth, Tanner, Adam J, Jimenez, Juan-Miguel
Published in ACS medicinal chemistry letters (08.08.2019)
Published in ACS medicinal chemistry letters (08.08.2019)
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Synthesis of a stable pyridyl boronate and its reaction with aryl and heteroaryl halides
Durrant, Steven J., Pinder, Joanne L., Charrier, Jean-Damien, Jimenez, Juan-Miguel, Brenchley, Guy, Collier, Philip N., Kay, David, Miller, Andrew, Pierard, Francoise, Ramaya, Sharn, Sadiq, Shazia, Twin, Heather C.
Published in Heterocycles (31.12.2006)
Published in Heterocycles (31.12.2006)
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Development of Dirhodium(II)-Catalyzed Generation and Enantioselective 1,3-Dipolar Cycloaddition of Carbonyl Ylides
Hodgson, David M., Stupple, Paul A., Pierard, Françoise Y. T. M., Labande, Agnès H., Johnstone, Craig
Published in Chemistry : a European journal (15.10.2001)
Published in Chemistry : a European journal (15.10.2001)
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Design and Optimization of Selective Protein Kinase C θ (PKCθ) Inhibitors for the Treatment of Autoimmune Diseases
Jimenez, Juan-Miguel, Boyall, Dean, Brenchley, Guy, Collier, Philip N, Davis, Christopher J, Fraysse, Damien, Keily, Shazia B, Henderson, Jaclyn, Miller, Andrew, Pierard, Francoise, Settimo, Luca, Twin, Heather C, Bolton, Claire M, Curnock, Adam P, Chiu, Peter, Tanner, Adam J, Young, Stephen
Published in Journal of medicinal chemistry (14.03.2013)
Published in Journal of medicinal chemistry (14.03.2013)
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Strategies for the modulation of phase II metabolism in a series of PKC epsilon inhibitors
Clemens, Jeremy J., Coon, Timothy, Busch, Brett B., Asgian, Juliana L., Hudson, Sarah, Termin, Andreas, Flores, Tina B., Tran, Dao, Chiang, Peggy, Sperry, Sam, Gross, Ray, Abt, Jeffrey, Heim, Roger, Lechner, Sandra, Twin, Heather, Studley, John, Brenchley, Guy, Collier, Philip N., Pierard, Francoise, Miller, Andrew, Mak, Chau, Dvornikovs, Vadims, Jimenez, Juan-Miguel, Stamos, Dean
Published in Bioorganic & medicinal chemistry letters (01.08.2014)
Published in Bioorganic & medicinal chemistry letters (01.08.2014)
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RADIOLABELLED DERIVATIVES OF A 2-AMINO-6-FLUORO-N-[5-FLUORO-PYRIDIN-3-YL]- PYRAZOLO[1,5-A]PYRIMIDIN-3-CARBOXAMIDE COMPOUND USEFUL AS ATR KINASE INHIBITOR, PREPARATION OF SAID COMPOUND AND DIFFERENT SOLID FORMS THEREOF
JOANNE PINDER, PIERRE-HENRI STORCK, DAVIS CHRIS, CHARRIER JEAN-DAMIEN, STUDLEY JOHN, MANINDER PANESAR, FRANCOISE PIERARD, KNEGTEL RONALD, FRAYSSE DAMIEN, NADIA AHMAD, GORKA ETXEBARRIA I JARDI
Year of Publication 29.08.2019
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Year of Publication 29.08.2019
Patent
COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
STEVEN DURRANT, O'DONNELL MICHAEL, MANINDER PANESAR, JIMENEZ JUAN-MIGUEL, GORKA ETXEBARRIA I JARDI, HEATHER TWIN, DEAN BOYALL, JOANNE PINDER, PIERRE-HENRI STORCK, KAY DAVID, DAVIS CHRIS, CHARRIER JEAN-DAMIEN, DONALD MIDDLETON, STUDLEY JOHN, FRANCOISE PIERARD, KNEGTEL RONALD, REBECCA DAVIS, FRAYSSE DAMIEN, NADIA AHMAD, DAVID SHAW
Year of Publication 07.06.2018
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Year of Publication 07.06.2018
Patent
Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, the preparation of said compound and different solid forms thereof
Panesar, Maninder, Davis, Chris, Studley, John, Charrier, Jean-Damien, Storck, Pierre-Henri, Etxebarria I Jardi, Gorka, Knegtel, Ronald, Fraysse, Damien, Pierard, Francoise, Ahmad, Nadia, Pinder, Joanne
Year of Publication 22.12.2023
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Year of Publication 22.12.2023
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Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, the preparation of said compound and different solid forms thereof
Panesar, Maninder, Davis, Chris, Studley, John, Charrier, Jean-Damien, Storck, Pierre-Henri, Etxebarria I Jardi, Gorka, Knegtel, Ronald, Fraysse, Damien, Pierard, Francoise, Ahmad, Nadia, Pinder, Joanne
Year of Publication 22.12.2023
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Year of Publication 22.12.2023
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2-AMINO-6-FLUORO-N-[5-FLUORO-PYRIDIN-3-YL]PYRAZOLO[1,5-A]PYRIMIDIN-3-CARBOXAMIDE COMPOUND USEFUL AS ATR KINASE INHIBITOR, ITS PREPARATION, DIFFERENT SOLID FORMS AND RADIOLABELLED DERIVATIVES THEREOF
SHAW, DAVID MATTHEW, STUDLEY, JOHN, CHARRIER, JEAN-DAMIEN, ETXEBARRIA I JARDI, GORKA, PINDER, JOANNE, PANESAR, MANINDER, ALEM, NAZIHA, PIERARD, FRANCOISE, SANGHVI, TAPAN, PEGG, SIMON, FRAYSSE, DAMIEN, WALDO, MICHAEL, MEDEK, ALES, ZHANG, YUEGANG, DAVIS, CHRISTOPHER JOHN, ZWICKER, CARL
Year of Publication 31.10.2023
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Year of Publication 31.10.2023
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HYDROXY AND (HALO)ALKOXY SUBSTITUTED TETRAHYDROFURANS AS MODULATORS OF SODIUM CHANNELS
SKERRATT, Sarah, CARVALHO MEIRELES, Lidio Marx, PIERARD, Francoise, SHAW, David Matthew, PONTILLO, Joseph, NORTH, Kiri, ETXEBARRIA JARDI, Gorka, HURLEY, Dennis James, HADIDA RUAH, Sara S, NEUBERT, Timothy Donald, GALAN, Bhairavi, BECK, Elizabeth Mary, STAMOS, Dean, THOMSON, Stephen Andrew, VIRANI, Anisa Nizarali, AHMAD, Nadia M, CHUDYK, Ewa Iwona, PULLIN, Robert, DURRANT, Steven John, KNEGTEL, Ronald Marcellus, SCHMIDT, Yvonne, PINDER, Joanne Louise, WRAY, Christopher, SOUSA, Bruno Artur
Year of Publication 05.09.2024
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Year of Publication 05.09.2024
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RADIOLABELLED DERIVATIVES OF A 2-AMINO-6-FLUORO-N-[5-FLUORO-PYRIDIN-3-YL]- PYRAZOLO[1,5-A]PYRIMIDIN-3-CARBOXAMIDE COMPOUND USEFUL AS ATR KINASE INHIBITOR, THE PREPARATION OF SAID COMPOUND AND DIFFERENT SOLID FORMS THEREOF
AHMAD, NADIA, KNEGTEL, RONALD, STORCK, PIERRE-HENRI, FRAYSSE, DAMIEN, STUDLEY, JOHN, CHARRIER, JEAN-DAMIEN, ETXEBARRIA I JARDI, GORKA, DAVIS, CHRIS, PINDER, JOANNE, PANESAR, MANINDER, PIERARD, FRANCOISE
Year of Publication 28.06.2022
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Year of Publication 28.06.2022
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HYDROXY AND (HALO)ALKOXY SUBSTITUTED TETRAHYDROFURANS AS MODULATORS OF SODIUM CHANNELS
SKERRATT, Sarah, CARVALHO MEIRELES, Lidio Marx, PIERARD, Francoise, SHAW, David Matthew, PONTILLO, Joseph, NORTH, Kiri, ETXEBARRIA JARDI, Gorka, HURLEY, Dennis James, HADIDA RUAH, Sara S, NEUBERT, Timothy Donald, GALAN, Bhairavi, BECK, Elizabeth Mary, STAMOS, Dean, THOMSON, Stephen Andrew, VIRANI, Anisa Nizarali, AHMAD, Nadia M, CHUDYK, Ewa Iwona, PULLIN, Robert, DURRANT, Steven John, KNEGTEL, Ronald Marcellus, SCHMIDT, Yvonne, PINDER, Joanne Louise, WRAY, Christopher, SOUSA, Bruno Artur
Year of Publication 10.04.2024
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Year of Publication 10.04.2024
Patent
HYDROXY AND (HALO)ALKOXY SUBSTITUTED TETRAHYDROFURANS AS MODULATORS OF SODIUM CHANNELS
SKERRATT, Sarah, CARVALHO MEIRELES, Lidio Marx, PIERARD, Francoise, SHAW, David Matthew, PONTILLO, Joseph, NORTH, Kiri, ETXEBARRIA JARDI, Gorka, HURLEY, Dennis James, HADIDA RUAH, Sara S, NEUBERT, Timothy Donald, GALAN, Bhairavi, BECK, Elizabeth Mary, STAMOS, Dean, THOMSON, Stephen Andrew, VIRANI, Anisa Nizarali, AHMAD, Nadia M, CHUDYK, Ewa Iwona, PULLIN, Robert, DURRANT, Steven John, KNEGTEL, Ronald Marcellus, SCHMIDT, Yvonne, PINDER, Joanne Louise, WRAY, Christopher, SOUSA, Bruno Artur
Year of Publication 30.11.2023
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Year of Publication 30.11.2023
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Compounds useful as inhibitors of ATR kinase
Sanghvi, Tapan, Zwicker, Carl, Alem, Naziha, Charrier, Jean-Damien, Fraysse, Damien, Zhang, Yuegang, Shaw, David Matthew, Pegg, Simon, Waldo, Michael, Panesar, Maninder, Studley, John, Davis, Christopher John, Etxebarria I Jardi, Gorka, Pierard, Francoise, Pinder, Joanne, Medek, Ales
Year of Publication 01.11.2022
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Year of Publication 01.11.2022
Patent
COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
PIERARD, Francoise, KAY, David, FRAYSSE, Damien, JIMENEZ, Juan-Miguel, TWIN, Heather, CHARRIER, Jean-Damien, STORCK, Pierre-Henri, AHMAD, Nadia, DURRANT, Steven, PINDER, Joanne, STUDLEY, John, BOYALL, Dean, PANESAR, Maninder, SHAW, David, KNEGTEL, Ronald, MIDDLETON, Donald, O'DONNELL, Michael, ETXEBARRIA I JARDI, Gorka, DAVIS, Chris, DAVIS, Rebecca
Year of Publication 31.08.2023
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Year of Publication 31.08.2023
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PYRAZOLO[1,5-A]PYRIMIDINES USEFUL AS INHIBITORS OF ATR KINASE FOR THE TREATMENT OF CANCER DISEASES
PIERARD, Francoise, KAY, David, JIMENEZ, Juan-Miguel, ODONNELL, Michael, KNEGTEL, Roland, TWIN, Heather, CHARRIER, Jean-Damien, STORCK, Pierre-Henri, AHMAD, Nadia, DURRANT, Steven, PINDER, Joanne, STUDLEY, John, BOYALL, Dean, PANESAR, Maninder, SHAW, David, FRAYSSE, Damine, MIDDLETON, Donald, ETXEBARRIA I JARDI, Gorka, DAVIS, Chris, DAVIS, Rebecca
Year of Publication 28.08.2023
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Year of Publication 28.08.2023
Patent