Application of Conformation Design in Acyclic Stereoselection: Total Synthesis of Borrelidin as the Crystalline Benzene Solvate
Hanessian, Stephen, Yang, Giroux, Simon, Mascitti, Vincent, Ma, Jianguo, Raeppel, Franck
Published in Journal of the American Chemical Society (12.11.2003)
Published in Journal of the American Chemical Society (12.11.2003)
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Journal Article
Discovery of a novel and potent series of thieno[3,2- b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases
Claridge, Stephen, Raeppel, Franck, Granger, Marie-Claude, Bernstein, Naomy, Saavedra, Oscar, Zhan, Lijie, Llewellyn, David, Wahhab, Amal, Deziel, Robert, Rahil, Jubrail, Beaulieu, Normand, Nguyen, Hannah, Dupont, Isabelle, Barsalou, Annie, Beaulieu, Carole, Chute, Ian, Gravel, Serge, Robert, Marie-France, Lefebvre, Sylvain, Dubay, Marja, Pascal, Roussen, Gillespie, Jeff, Jin, Zhiyun, Wang, James, Besterman, Jeffrey M., MacLeod, A. Robert, Vaisburg, Arkadii
Published in Bioorganic & medicinal chemistry (01.05.2008)
Published in Bioorganic & medicinal chemistry (01.05.2008)
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N-(4-(6,7-Disubstituted-quinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: A novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors
Mannion, Michael, Raeppel, Stéphane, Claridge, Stephen, Zhou, Nancy, Saavedra, Oscar, Isakovic, Ljubomir, Zhan, Lijie, Gaudette, Frédéric, Raeppel, Franck, Déziel, Robert, Beaulieu, Normand, Nguyen, Hannah, Chute, Ian, Beaulieu, Carole, Dupont, Isabelle, Robert, Marie-France, Lefebvre, Sylvain, Dubay, Marja, Rahil, Jubrail, Wang, James, Ste-Croix, Hélène, Robert Macleod, A., Besterman, Jeffrey M., Vaisburg, Arkadii
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
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SAR around ( l)- S-adenosyl- l-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes
Saavedra, Oscar M., Isakovic, Ljubomir, Llewellyn, David B., Zhan, Lijie, Bernstein, Naomy, Claridge, Stephen, Raeppel, Franck, Vaisburg, Arkadii, Elowe, Nadine, Petschner, Andrea J., Rahil, Jubrail, Beaulieu, Norman, MacLeod, A. Robert, Delorme, Daniel, Besterman, Jeffrey M., Wahhab, Amal
Published in Bioorganic & medicinal chemistry letters (15.05.2009)
Published in Bioorganic & medicinal chemistry letters (15.05.2009)
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Journal Article
Abstract 930: Preclinical characterization of MG516, a novel inhibitor of receptor tyrosine kinases involved in resistance to targeted therapies
Beaulieu, Normand, Sainte-Croix, Helene, Bonfils, Claire, Mannion, Michael, Raeppel, Stephane, Isakovic, Lubo, Claridge, Stephen, Saavedra, Oscar, Raeppel, Franck, Vaisburg, Arkadii, Wang, James, Fournel, Marielle, Besterman, Jeffrey M., Maroun, Christiane R.
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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N-(3-fluoro-4-(2-arylthieno[3,2- b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: A novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors
Raeppel, Stéphane, Claridge, Stephen, Saavedra, Oscar, Gaudette, Frédéric, Zhan, Lijie, Mannion, Michael, Zhou, Nancy, Raeppel, Franck, Granger, Marie-Claude, Isakovic, Ljubomir, Déziel, Robert, Nguyen, Hannah, Beaulieu, Normand, Beaulieu, Carole, Dupont, Isabelle, Robert, Marie-France, Lefebvre, Sylvain, Dubay, Marja, Rahil, Jubrail, Wang, James, Ste-Croix, Hélène, Robert Macleod, A., Besterman, Jeffrey, Vaisburg, Arkadii
Published in Bioorganic & medicinal chemistry letters (01.03.2009)
Published in Bioorganic & medicinal chemistry letters (01.03.2009)
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Journal Article
Design and synthesis of 4-[( s-triazin-2-ylamino)methyl]- N-(2-aminophenyl)-benzamides and their analogues as a novel class of histone deacetylase inhibitors
Paquin, Isabelle, Raeppel, Stéphane, Leit, Silvana, Gaudette, Frédéric, Zhou, Nancy, Moradei, Oscar, Saavedra, Oscar, Bernstein, Naomy, Raeppel, Franck, Bouchain, Giliane, Fréchette, Sylvie, Woo, Soon H., Vaisburg, Arkadii, Fournel, Marielle, Kalita, Ann, Robert, Marie-France, Lu, Aihua, Trachy-Bourget, Marie-Claude, Yan, Pu Theresa, Liu, Jianhong, Rahil, Jubrail, MacLeod, A. Robert, Besterman, Jeffrey M., Li, Zuomei, Delorme, Daniel
Published in Bioorganic & medicinal chemistry (01.02.2008)
Published in Bioorganic & medicinal chemistry (01.02.2008)
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Journal Article
Abstract 3609: MGCD265, an orally active Met/VEGFR multitargeted kinase inhibitor in Phase II clinical development, potently inhibits clinically relevant Met mutants
Beaulieu, Normand, Dupont, Isabelle, Bonfils, Claire, Dubay, Marja, Ste-Croix, Hélène, Isakovic, Lubo, Claridge, Stephen, Saavedra, Oscar, Raeppel, Franck, Raeppel, Stephane, Mannion, Michael, Vaisburg, Arkadii, Besterman, Jeffrey M., Maroun, Christiane R.
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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Abstract 3612: Potent preclinical anti-tumor activity of MGCD265, an orally active Met/VEGFR multitargeted kinase inhibitor in Phase II clinical development, in combination with an EGFR inhibitor
Fournel, Marielle, Dupont, Isabelle, Bonfils, Claire, Dubay, Marja, Ste-Croix, Hélène, Beaulieu, Carole, Beaulieu, Normand, Lemoyne, Christian, Wang, James, Isakovic, Lubo, Claridge, Stephen, Saavedra, Oscar, Raeppel, Franck, Raeppel, Stephane, Mannion, Michael, Vaisburg, Arkadii, Martell, Robert E., Besterman, Jeffrey M., Maroun, Christiane R.
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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Journal Article
N super(3)-Arylmalonamides: A new series of thieno[3,2-b]pyridine based inhibitors of c-Met and VEGFR2 tyrosine kinases
Saavedra, Oscar, Claridge, Stephen, Zhan, Lijie, Raeppel, Franck, Granger, Marie-Claude, Raeppel, Stephane, Mannion, Michael, Gaudette, Frederic, Zhou, Nancy, Isakovic, Ljubomir, Bernstein, Naomy, Deziel, Robert, Nguyen, Hannah, Beaulieu, Normand, Beaulieu, Carole, Dupont, Isabelle, Wang, James, Macleod, ARobert, Besterman, Jeffrey M, Vaisburg, Arkadii
Published in Bioorganic & medicinal chemistry letters (15.12.2009)
Published in Bioorganic & medicinal chemistry letters (15.12.2009)
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Journal Article
N3-Arylmalonamides: A new series of thieno[3,2-b]pyridine based inhibitors of c-Met and VEGFR2 tyrosine kinases
Saavedra, Oscar, Claridge, Stephen, Zhan, Lijie, Raeppel, Franck, Granger, Marie-Claude, Raeppel, Stéphane, Mannion, Michael, Gaudette, Frédéric, Zhou, Nancy, Isakovic, Ljubomir, Bernstein, Naomy, Déziel, Robert, Nguyen, Hannah, Beaulieu, Normand, Beaulieu, Carole, Dupont, Isabelle, Wang, James, Macleod, A. Robert, Besterman, Jeffrey M., Vaisburg, Arkadii
Published in Bioorganic & medicinal chemistry letters (15.12.2009)
Published in Bioorganic & medicinal chemistry letters (15.12.2009)
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