Engineering the next-generation of CAR T-cells with CRISPR-Cas9 gene editing
Dimitri, Alexander, Herbst, Friederike, Fraietta, Joseph A
Published in Molecular cancer (18.03.2022)
Published in Molecular cancer (18.03.2022)
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Journal Article
Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication
Kloss, Christopher C., Lee, Jihyun, Zhang, Aaron, Chen, Fang, Melenhorst, Jan Joseph, Lacey, Simon F., Maus, Marcela V., Fraietta, Joseph A., Zhao, Yangbing, June, Carl H.
Published in Molecular therapy (05.07.2018)
Published in Molecular therapy (05.07.2018)
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Journal Article
Decade-long leukaemia remissions with persistence of CD4+ CAR T cells
Melenhorst, J. Joseph, Chen, Gregory M., Wang, Meng, Porter, David L., Chen, Changya, Collins, McKensie A., Gao, Peng, Bandyopadhyay, Shovik, Sun, Hongxing, Zhao, Ziran, Lundh, Stefan, Pruteanu-Malinici, Iulian, Nobles, Christopher L., Maji, Sayantan, Frey, Noelle V., Gill, Saar I., Loren, Alison W., Tian, Lifeng, Kulikovskaya, Irina, Gupta, Minnal, Ambrose, David E., Davis, Megan M., Fraietta, Joseph A., Brogdon, Jennifer L., Young, Regina M., Chew, Anne, Levine, Bruce L., Siegel, Donald L., Alanio, Cécile, Wherry, E. John, Bushman, Frederic D., Lacey, Simon F., Tan, Kai, June, Carl H.
Published in Nature (London) (17.02.2022)
Published in Nature (London) (17.02.2022)
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Journal Article
CRISPR-engineered T cells in patients with refractory cancer
Stadtmauer, Edward A, Fraietta, Joseph A, Davis, Megan M, Cohen, Adam D, Weber, Kristy L, Lancaster, Eric, Mangan, Patricia A, Kulikovskaya, Irina, Gupta, Minnal, Chen, Fang, Tian, Lifeng, Gonzalez, Vanessa E, Xu, Jun, Jung, In-Young, Melenhorst, J Joseph, Plesa, Gabriela, Shea, Joanne, Matlawski, Tina, Cervini, Amanda, Gaymon, Avery L, Desjardins, Stephanie, Lamontagne, Anne, Salas-Mckee, January, Fesnak, Andrew, Siegel, Donald L, Levine, Bruce L, Jadlowsky, Julie K, Young, Regina M, Chew, Anne, Hwang, Wei-Ting, Hexner, Elizabeth O, Carreno, Beatriz M, Nobles, Christopher L, Bushman, Frederic D, Parker, Kevin R, Qi, Yanyan, Satpathy, Ansuman T, Chang, Howard Y, Zhao, Yangbing, Lacey, Simon F, June, Carl H
Published in Science (American Association for the Advancement of Science) (28.02.2020)
Published in Science (American Association for the Advancement of Science) (28.02.2020)
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Journal Article
Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells
Kawalekar, Omkar U., O’Connor, Roddy S., Fraietta, Joseph A., Guo, Lili, McGettigan, Shannon E., Posey, Avery D., Patel, Prachi R., Guedan, Sonia, Scholler, John, Keith, Brian, Snyder, Nathaniel W., Blair, Ian A., Milone, Michael C., June, Carl H.
Published in Immunity (Cambridge, Mass.) (16.02.2016)
Published in Immunity (Cambridge, Mass.) (16.02.2016)
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Journal Article
Adoptive immunotherapy for cancer or viruses
Maus, Marcela V, Fraietta, Joseph A, Levine, Bruce L, Kalos, Michael, Zhao, Yangbing, June, Carl H
Published in Annual review of immunology (01.01.2014)
Published in Annual review of immunology (01.01.2014)
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Journal Article
PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial
Narayan, Vivek, Barber-Rotenberg, Julie S., Jung, In-Young, Lacey, Simon F., Rech, Andrew J., Davis, Megan M., Hwang, Wei-Ting, Lal, Priti, Carpenter, Erica L., Maude, Shannon L., Plesa, Gabriela, Vapiwala, Neha, Chew, Anne, Moniak, Michael, Sebro, Ronnie A., Farwell, Michael D., Marshall, Amy, Gilmore, Joan, Lledo, Lester, Dengel, Karen, Church, Sarah E., Hether, Tyler D., Xu, Jun, Gohil, Mercy, Buckingham, Thomas H., Yee, Stephanie S., Gonzalez, Vanessa E., Kulikovskaya, Irina, Chen, Fang, Tian, Lifeng, Tien, Kyle, Gladney, Whitney, Nobles, Christopher L., Raymond, Hayley E., Hexner, Elizabeth O., Siegel, Donald L., Bushman, Frederic D., June, Carl H., Fraietta, Joseph A., Haas, Naomi B.
Published in Nature medicine (01.04.2022)
Published in Nature medicine (01.04.2022)
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Journal Article
Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells
Fraietta, Joseph A., Nobles, Christopher L., Sammons, Morgan A., Lundh, Stefan, Carty, Shannon A., Reich, Tyler J., Cogdill, Alexandria P., Morrissette, Jennifer J. D., DeNizio, Jamie E., Reddy, Shantan, Hwang, Young, Gohil, Mercy, Kulikovskaya, Irina, Nazimuddin, Farzana, Gupta, Minnal, Chen, Fang, Everett, John K., Alexander, Katherine A., Lin-Shiao, Enrique, Gee, Marvin H., Liu, Xiaojun, Young, Regina M., Ambrose, David, Wang, Yan, Xu, Jun, Jordan, Martha S., Marcucci, Katherine T., Levine, Bruce L., Garcia, K. Christopher, Zhao, Yangbing, Kalos, Michael, Porter, David L., Kohli, Rahul M., Lacey, Simon F., Berger, Shelley L., Bushman, Frederic D., June, Carl H., Melenhorst, J. Joseph
Published in Nature (London) (01.06.2018)
Published in Nature (London) (01.06.2018)
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Journal Article
Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell
Ruella, Marco, Xu, Jun, Barrett, David M., Fraietta, Joseph A., Reich, Tyler J., Ambrose, David E., Klichinsky, Michael, Shestova, Olga, Patel, Prachi R., Kulikovskaya, Irina, Nazimuddin, Farzana, Bhoj, Vijay G., Orlando, Elena J., Fry, Terry J., Bitter, Hans, Maude, Shannon L., Levine, Bruce L., Nobles, Christopher L., Bushman, Frederic D., Young, Regina M., Scholler, John, Gill, Saar I., June, Carl H., Grupp, Stephan A., Lacey, Simon F., Melenhorst, J. Joseph
Published in Nature medicine (01.10.2018)
Published in Nature medicine (01.10.2018)
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Journal Article
Antigen-specific B cell depletion for precision therapy of mucosal pemphigus vulgaris
Lee, Jinmin, Lundgren, Daniel K, Mao, Xuming, Manfredo-Vieira, Silvio, Nunez-Cruz, Selene, Williams, Erik F, Assenmacher, Charles-Antoine, Radaelli, Enrico, Oh, Sangwook, Wang, Baomei, Ellebrecht, Christoph T, Fraietta, Joseph A, Milone, Michael C, Payne, Aimee S
Published in The Journal of clinical investigation (01.12.2020)
Published in The Journal of clinical investigation (01.12.2020)
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Journal Article
Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia
Fraietta, Joseph A., Lacey, Simon F., Orlando, Elena J., Pruteanu-Malinici, Iulian, Gohil, Mercy, Lundh, Stefan, Boesteanu, Alina C., Wang, Yan, O’Connor, Roddy S., Hwang, Wei-Ting, Pequignot, Edward, Ambrose, David E., Zhang, Changfeng, Wilcox, Nicholas, Bedoya, Felipe, Dorfmeier, Corin, Chen, Fang, Tian, Lifeng, Parakandi, Harit, Gupta, Minnal, Young, Regina M., Johnson, F. Brad, Kulikovskaya, Irina, Liu, Li, Xu, Jun, Kassim, Sadik H., Davis, Megan M., Levine, Bruce L., Frey, Noelle V., Siegel, Donald L., Huang, Alexander C., Wherry, E. John, Bitter, Hans, Brogdon, Jennifer L., Porter, David L., June, Carl H., Melenhorst, J. Joseph
Published in Nature medicine (01.05.2018)
Published in Nature medicine (01.05.2018)
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Journal Article
IFNγ and CCL2 Cooperate to Redirect Tumor-Infiltrating Monocytes to Degrade Fibrosis and Enhance Chemotherapy Efficacy in Pancreatic Carcinoma
Long, Kristen B, Gladney, Whitney L, Tooker, Graham M, Graham, Kathleen, Fraietta, Joseph A, Beatty, Gregory L
Published in Cancer discovery (01.04.2016)
Published in Cancer discovery (01.04.2016)
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Journal Article
Ibrutinib treatment improves T cell number and function in CLL patients
Long, Meixiao, Beckwith, Kyle, Do, Priscilla, Mundy, Bethany L, Gordon, Amber, Lehman, Amy M, Maddocks, Kami J, Cheney, Carolyn, Jones, Jeffrey A, Flynn, Joseph M, Andritsos, Leslie A, Awan, Farrukh, Fraietta, Joseph A, June, Carl H, Maus, Marcela V, Woyach, Jennifer A, Caligiuri, Michael A, Johnson, Amy J, Muthusamy, Natarajan, Byrd, John C
Published in The Journal of clinical investigation (01.08.2017)
Published in The Journal of clinical investigation (01.08.2017)
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Journal Article
Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia
Fraietta, Joseph A., Beckwith, Kyle A., Patel, Prachi R., Ruella, Marco, Zheng, Zhaohui, Barrett, David M., Lacey, Simon F., Melenhorst, Jan Joseph, McGettigan, Shannon E., Cook, Danielle R., Zhang, Changfeng, Xu, Jun, Do, Priscilla, Hulitt, Jessica, Kudchodkar, Sagar B., Cogdill, Alexandria P., Gill, Saar, Porter, David L., Woyach, Jennifer A., Long, Meixiao, Johnson, Amy J., Maddocks, Kami, Muthusamy, Natarajan, Levine, Bruce L., June, Carl H., Byrd, John C., Maus, Marcela V.
Published in Blood (03.03.2016)
Published in Blood (03.03.2016)
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Journal Article
FOXO1 is a master regulator of memory programming in CAR T cells
Doan, Alexander E., Mueller, Katherine P., Chen, Andy Y., Rouin, Geoffrey T., Chen, Yingshi, Daniel, Bence, Lattin, John, Markovska, Martina, Mozarsky, Brett, Arias-Umana, Jose, Hapke, Robert, Jung, In-Young, Wang, Alice, Xu, Peng, Klysz, Dorota, Zuern, Gabrielle, Bashti, Malek, Quinn, Patrick J., Miao, Zhuang, Sandor, Katalin, Zhang, Wenxi, Chen, Gregory M., Ryu, Faith, Logun, Meghan, Hall, Junior, Tan, Kai, Grupp, Stephan A., McClory, Susan E., Lareau, Caleb A., Fraietta, Joseph A., Sotillo, Elena, Satpathy, Ansuman T., Mackall, Crystal L., Weber, Evan W.
Published in Nature (London) (02.05.2024)
Published in Nature (London) (02.05.2024)
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Journal Article
Chronic lymphocytic leukemia cells impair mitochondrial fitness in CD8+ T cells and impede CAR T-cell efficacy
van Bruggen, Jaco A.C., Martens, Anne W.J., Fraietta, Joseph A., Hofland, Tom, Tonino, Sanne H., Eldering, Eric, Levin, Mark-David, Siska, Peter J., Endstra, Sanne, Rathmell, Jeffrey C., June, Carl H., Porter, David L., Melenhorst, J. Joseph, Kater, Arnon P., van der Windt, Gerritje J.W.
Published in Blood (04.07.2019)
Published in Blood (04.07.2019)
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Journal Article
T cell lymphoma and secondary primary malignancy risk after commercial CAR T cell therapy
Ghilardi, Guido, Fraietta, Joseph A., Gerson, James N., Van Deerlin, Vivianna M., Morrissette, Jennifer J. D., Caponetti, Gabriel C., Paruzzo, Luca, Harris, Jaryse C., Chong, Elise A., Susanibar Adaniya, Sandra P., Svoboda, Jakub, Nasta, Sunita D., Ugwuanyi, Ositadimma H., Landsburg, Daniel J., Fardella, Eugenio, Waxman, Adam J., Chong, Emeline R., Patel, Vrutti, Pajarillo, Raymone, Kulikovskaya, Irina, Lieberman, David B., Cohen, Adam D., Levine, Bruce L., Stadtmauer, Edward A., Frey, Noelle V., Vogl, Dan T., Hexner, Elizabeth O., Barta, Stefan K., Porter, David L., Garfall, Alfred L., Schuster, Stephen J., June, Carl H., Ruella, Marco
Published in Nature medicine (01.04.2024)
Published in Nature medicine (01.04.2024)
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