Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration
Fragola, Giulia, Mabb, Angela M., Taylor-Blake, Bonnie, Niehaus, Jesse K., Chronister, William D., Mao, Hanqian, Simon, Jeremy M., Yuan, Hong, Li, Zibo, McConnell, Michael J., Zylka, Mark J.
Published in Nature communications (23.04.2020)
Published in Nature communications (23.04.2020)
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Journal Article
Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration
Pearson, Brandon L., Simon, Jeremy M., McCoy, Eric S., Salazar, Gabriela, Fragola, Giulia, Zylka, Mark J.
Published in Nature communications (31.03.2016)
Published in Nature communications (31.03.2016)
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Journal Article
Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication
Piunti, Andrea, Rossi, Alessandra, Cerutti, Aurora, Albert, Mareike, Jammula, Sriganesh, Scelfo, Andrea, Cedrone, Laura, Fragola, Giulia, Olsson, Linda, Koseki, Haruhiko, Testa, Giuseppe, Casola, Stefano, Helin, Kristian, di Fagagna, Fabrizio d’Adda, Pasini, Diego
Published in Nature communications (14.04.2014)
Published in Nature communications (14.04.2014)
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Journal Article
Cell reprogramming requires silencing of a core subset of polycomb targets
Fragola, Giulia, Germain, Pierre-Luc, Laise, Pasquale, Cuomo, Alessandro, Blasimme, Alessandro, Gross, Fridolin, Signaroldi, Elena, Bucci, Gabriele, Sommer, Cesar, Pruneri, Giancarlo, Mazzarol, Giovanni, Bonaldi, Tiziana, Mostoslavsky, Gustavo, Casola, Stefano, Testa, Giuseppe
Published in PLoS genetics (01.02.2013)
Published in PLoS genetics (01.02.2013)
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Journal Article
Cas9 gene therapy for Angelman syndrome traps Ube3a-ATS long non-coding RNA
Wolter, Justin M., Mao, Hanqian, Fragola, Giulia, Simon, Jeremy M., Krantz, James L., Bazick, Hannah O., Oztemiz, Baris, Stein, Jason L., Zylka, Mark J.
Published in Nature (London) (12.11.2020)
Published in Nature (London) (12.11.2020)
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Journal Article
The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome
Yi, Jason J., Paranjape, Smita R., Walker, Matthew P., Choudhury, Rajarshi, Wolter, Justin M., Fragola, Giulia, Emanuele, Michael J., Major, Michael B., Zylka, Mark J.
Published in The Journal of biological chemistry (28.07.2017)
Published in The Journal of biological chemistry (28.07.2017)
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Journal Article
NuMorph: Tools for cortical cellular phenotyping in tissue-cleared whole-brain images
Krupa, Oleh, Fragola, Giulia, Hadden-Ford, Ellie, Mory, Jessica T., Liu, Tianyi, Humphrey, Zachary, Rees, Benjamin W., Krishnamurthy, Ashok, Snider, William D., Zylka, Mark J., Wu, Guorong, Xing, Lei, Stein, Jason L.
Published in Cell reports (Cambridge) (12.10.2021)
Published in Cell reports (Cambridge) (12.10.2021)
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Journal Article
Accurate and High Throughput Cell Segmentation Method for Mouse Brain Nuclei Using Cascaded Convolutional Neural Network
Wang, Qian, Wang, Shaoyu, Zhu, Xiaofeng, Liu, Tianyi, Humphrey, Zachary, Ghukasyan, Vladimir, Conway, Mike, Scott, Erik, Fragola, Giulia, Bradford, Kira, Zylka, Mark J., Krishnamurthy, Ashok, Stein, Jason L., Wu, Guorong
Published in Patch-Based Techniques in Medical Imaging
Published in Patch-Based Techniques in Medical Imaging
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Book Chapter
Cell Reprogramming Requires Silencing of a Core Subset of Polycomb Targets. e1003292
Fragola, Giulia, Germain, Pierre-Luc, Laise, Pasquale, Cuomo, Alessandro, Blasimme, Alessandro, Gross, Fridolin, Signaroldi, Elena, Bucci, Gabriele, Sommer, Cesar, Pruneri, Giancarlo
Published in PLoS genetics (01.02.2013)
Published in PLoS genetics (01.02.2013)
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Journal Article
METHODS AND COMPOSITIONS FOR TREATING ANGELMAN SYNDROME
MAO, Hanqian, WOLTER, Justin Matthew, SIMON, Jeremy Mark, ZYLKA, Mark John, FRAGOLA, Giulia
Year of Publication 01.12.2021
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Year of Publication 01.12.2021
Patent
METHODS AND COMPOSITIONS FOR TREATING ANGELMAN SYNDROME
Mao, Hangqian, Fragola, Giulia, Simon, Jeremy Mark, Wolter, Justin Matthew, Zylka, Mark J
Year of Publication 25.02.2021
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Year of Publication 25.02.2021
Patent
METHODS AND COMPOSITIONS FOR TREATING ANGELMAN SYNDROME
MAO, Hanqian, WOLTER, Justin Matthew, SIMON, Jeremy Mark, ZYLKA, Mark John, FRAGOLA, Giulia
Year of Publication 06.01.2021
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Year of Publication 06.01.2021
Patent
METHODS AND COMPOSITIONS FOR TREATING ANGELMAN SYNDROME
WOLTER, Justin Matthew, SIMON, Jeremy Mark, ZYLKA, Mark John, FRAGOLA, Giulia, MAO, Hangqian
Year of Publication 06.09.2019
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Year of Publication 06.09.2019
Patent
METHODS AND COMPOSITIONS FOR TREATING ANGELMAN SYNDROME
SIMON, JEREMY MARK, MAO, HANGQIAN, FRAGOLA, GIULIA, WOLTER, JUSTIN MATTHEW, ZYLKA, MARK JOHN
Year of Publication 06.09.2019
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Year of Publication 06.09.2019
Patent
NuMorph: tools for cellular phenotyping in tissue cleared whole brain images
Krupa, Oleh, Fragola, Giulia, Hadden-Ford, Ellie, Mory, Jessica T, Liu, Tianyi, Humphrey, Zachary, Rees, Benjamin W, Krishnamurthy, Ashok, Snider, William D, Zylka, Mark J, Wu, Guorong, Xing, Lei, Stein, Jason L
Published in bioRxiv (03.03.2021)
Published in bioRxiv (03.03.2021)
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Paper
METHODS AND COMPOSITIONS FOR TREATING ANGELMAN SYNDROME
FRAGOLA GIULIA, WOLTER JUSTIN MATTHEW, MAO HANGQIAN, ZYLKA MARK JOHN, SIMON JEREMY MARK
Year of Publication 13.10.2020
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Year of Publication 13.10.2020
Patent