Gene expression profiling following NRF2 and KEAP1 siRNA knockdown in human lung fibroblasts identifies CCL11/Eotaxin-1 as a novel NRF2 regulated gene
Fourtounis, Jimmy, Wang, I-Ming, Mathieu, Marie-Claude, Claveau, David, Loo, Tenneille, Jackson, Aimee L, Peters, Mette A, Therien, Alex G, Boie, Yves, Crackower, Michael A
Published in Respiratory research (12.10.2012)
Published in Respiratory research (12.10.2012)
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Journal Article
CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition
Gallo, David, Young, Jordan T. F., Fourtounis, Jimmy, Martino, Giovanni, Álvarez-Quilón, Alejandro, Bernier, Cynthia, Duffy, Nicole M., Papp, Robert, Roulston, Anne, Stocco, Rino, Szychowski, Janek, Veloso, Artur, Alam, Hunain, Baruah, Prasamit S., Fortin, Alexanne Bonneau, Bowlan, Julian, Chaudhary, Natasha, Desjardins, Jessica, Dietrich, Evelyne, Fournier, Sara, Fugère-Desjardins, Chloe, Goullet de Rugy, Theo, Leclaire, Marie-Eve, Liu, Bingcan, Bhaskaran, Vivek, Mamane, Yael, Melo, Henrique, Nicolas, Olivier, Singhania, Akul, Szilard, Rachel K., Tkáč, Ján, Yin, Shou Yun, Morris, Stephen J., Zinda, Michael, Marshall, C. Gary, Durocher, Daniel
Published in Nature (London) (28.04.2022)
Published in Nature (London) (28.04.2022)
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Journal Article
Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306
Szychowski, Janek, Papp, Robert, Dietrich, Evelyne, Liu, Bingcan, Vallée, Frédéric, Leclaire, Marie-Eve, Fourtounis, Jimmy, Martino, Giovanni, Perryman, Alexander L., Pau, Victor, Yin, Shou Yun, Mader, Pavel, Roulston, Anne, Truchon, Jean-Francois, Marshall, C. Gary, Diallo, Mohamed, Duffy, Nicole M., Stocco, Rino, Godbout, Claude, Bonneau-Fortin, Alexanne, Kryczka, Rosie, Bhaskaran, Vivek, Mao, Daniel, Orlicky, Stephen, Beaulieu, Patrick, Turcotte, Pascal, Kurinov, Igor, Sicheri, Frank, Mamane, Yael, Gallant, Michel, Black, W. Cameron
Published in Journal of medicinal chemistry (11.08.2022)
Published in Journal of medicinal chemistry (11.08.2022)
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Journal Article
Abstract A023: Preclinical development of PKMYT1 and WEE1 inhibitor combinations
Gallo, David, Shah, Fenil, Stocco, Rino, Baruah, Prasamit, Fourtounis, Jimmy, Kryczka, Rosie, Hyer, Marc L, Roulston, Anne, Marshall, C Gary, Zimmermann, Michal, Morris, Stephen, Zinda, Michael
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Journal Article
Abstract C163: KRAS alterations combined with TP53 mutations as novel synthetic lethal genomic lesions for PKMYT1 inhibition
Hyer, Marc L., Fourtounis, Jimmy, Gallo, David, Bhaskaran, Vivek, Stocco, Rino, Kryczka, Rosie, Save, Sai, Burston, Helen, Nicolas, Olivier, Morris, Stephen, Roulston, Anne, Young, Jordan T. F., Zimmermann, Michal, Marshall, C. Gary, Veloso, Artur, Aguado-Fraile, Elia
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Journal Article
Abstract B057: Preclinical development of PKMYT1 and ATR inhibitor combinations
Gallo, David, Hyer, Marc L., Martino, Giovanni, Pertrone, Adam, Aguado-Fraile, Elia, Kryczka, Rosie, Fourtounis, Jimmy, Stocco, Rino, Morris, Stephen J., Marshall, C. Gary, Roulston, Anne, Zinda, Michael, Zimmermann, Michal
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Journal Article
Abstract 5650: RP-6306, a novel PKMYT1 inhibitor, demonstrates synthetic lethality as monotherapy and in combination with gemcitabine in CCNE1 amplified cancer cells
Fourtounis, Jimmy, Martino, John, Stocco, Rino, Baruah, Prasamit, Duffy, Nicole, Gallo, David, Fournier, Sarah, Li, JingJing, Li, Li, Aguado, Elia, Petrone, Adam, Roulston, Anne, Mamane, Yael, Morris, Stephen, Szychowski, Janek, Papp, Robert, Zinda, Mike, Marshall, C. Gary
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Assessing protein–RNA interactions using microfluidic capillary mobility shift assays
Fourtounis, Jimmy, Falgueyret, Jean-Pierre, Elie Sayegh, Camil
Published in Analytical biochemistry (01.04.2011)
Published in Analytical biochemistry (01.04.2011)
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Journal Article
COMBINATION THERAPIES INCLUDING MYT1 INHIBITORS
YOUNG, Jordan, HUSTEDT, Nicole, DUROCHER, Daniel, FOURTOUNIS, Jimmy, BERNIER, Cynthia
Year of Publication 27.06.2024
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Year of Publication 27.06.2024
Patent
Targeting CCNE1 amplified ovarian and endometrial cancers by combined inhibition of PKMYT1 and ATR
Xu, Haineng, George, Erin, Gallo, David, Medvedev, Sergey, Wang, Xiaolei, Kryczka, Rosie, Hyer, Marc L, Fourtounis, Jimmy, Stocco, Rino, Aguado-Fraile, Elia, Petrone, Adam, Yin, Shou Yun, Shiwram, Ariya, Anderson, Matthew, Kim, Hyoung, Liu, Fang, Marshall, C Gary, Simpkins, Fiona
Published in Research square (16.02.2024)
Published in Research square (16.02.2024)
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Journal Article
COMBINATION THERAPIES INCLUDING MYT1 INHIBITORS
YOUNG, Jordan, HUSTEDT, Nicole, DUROCHER, Daniel, FOURTOUNIS, Jimmy, BERNIER, Cynthia
Year of Publication 13.10.2022
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Year of Publication 13.10.2022
Patent
METHODS OF USING MYT1 INHIBITORS
YOUNG, Jordan, VALLÉE, Frédéric, VELOSO, Artur, DUROCHER, Daniel, BEAULIEU, Patrick, SICHERI, Frank, PERRYMAN, Alexander, LIU, Bingcan, ZHANG, Theresa, TRUCHON, Jean-François, FOURTOUNIS, Jimmy, SZYCHOWSKI, Janek, DIETRICH, Evelyne, PAPP, Robert
Year of Publication 17.04.2024
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Year of Publication 17.04.2024
Patent
METHODS OF USING MYT1 INHIBITORS
YOUNG, Jordan, VALLÉE, Frédéric, VELOSO, Artur, DUROCHER, Daniel, BEAULIEU, Patrick, SICHERI, Frank, PERRYMAN, Alexander, LIU, Bingcan, ZHANG, Theresa, TRUCHON, Jean-François, FOURTOUNIS, Jimmy, SZYCHOWSKI, Janek, DIETRICH, Evelyne, PAPP, Robert
Year of Publication 25.05.2023
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Year of Publication 25.05.2023
Patent
METHODS OF USING MYT1 INHIBITORS
YOUNG, Jordan, VALLÉE, Frédéric, VELOSO, Artur, DUROCHER, Daniel, BEAULIEU, Patrick, SICHERI, Frank, PERRYMAN, Alexander, LIU, Bingcan, ZHANG, Theresa, TRUCHON, Jean-François, FOURTOUNIS, Jimmy, SZYCHOWSKI, Janek, DIETRICH, Evelyne, PAPP, Robert
Year of Publication 08.02.2023
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Year of Publication 08.02.2023
Patent
METHODS OF USING MYT1 INHIBITORS
YOUNG, Jordan, VALLÉE, Frédéric, VELOSO, Artur, DUROCHER, Daniel, BEAULIEU, Patrick, SICHERI, Frank, PERRYMAN, Alexander, LIU, Bingcan, ZHANG, Theresa, TRUCHON, Jean-François, FOURTOUNIS, Jimmy, SZYCHOWSKI, Janek, DIETRICH, Evelyne, PAPP, Robert
Year of Publication 25.11.2021
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Year of Publication 25.11.2021
Patent
METHODS OF USING MYT1 INHIBITORS
PERRYMAN, ALEXANDER, DUROCHER, DANIEL, DIETRICH, EVELYNE, BEAULIEU, PATRICK, YOUNG, JORDAN, SZYCHOWSKI, JANEK, FOURTOUNIS, JIMMY, VALLEE, FREDERIC, VELOSO, ARTUR, PAPP, ROBERT, SICHERI, FRANK, TRUCHON, JEAN-FRANCOIS, LIU, BINGCAN, ZHANG, THERESA
Year of Publication 07.10.2021
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Year of Publication 07.10.2021
Patent
METHODS OF USING MYT1 INHIBITORS
YOUNG, Jordan, VALLÉE, Frédéric, VELOSO, Artur, DUROCHER, Daniel, BEAULIEU, Patrick, TRUCHON, Jean-françois, SICHERI, Frank, PERRYMAN, Alexander, LIU, Bingcan, ZHANG, Theresa, FOURTOUNIS, Jimmy, SZYCHOWSKI, Janek, DIETRICH, Evelyne, PAPP, Robert
Year of Publication 07.10.2021
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Year of Publication 07.10.2021
Patent