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Targeting the Th17 pathway in psoriasis
Elloso, M Merle, Gomez-Angelats, Mireia, Fourie, Anne M
Published in Journal of leukocyte biology (01.12.2012)
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RORγt and RORα signature genes in human Th17 cells
Castro, Glenda, Liu, Xuejun, Ngo, Karen, De Leon-Tabaldo, Aimee, Zhao, Shanrong, Luna-Roman, Rosa, Yu, Jingxue, Cao, Tinghua, Kuhn, Robert, Wilkinson, Patrick, Herman, Krystal, Nelen, Marina I, Blevitt, Jonathan, Xue, Xiaohua, Fourie, Anne, Fung-Leung, Wai-Ping
Published in PloS one (01.08.2017)
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IL-23 regulation of myeloid cell biology during inflammation
Lee, Kevin M.-C., Lupancu, Tanya, Chang, Leon, Manthey, Carl L., Zeeman, Martha, Fourie, Anne M., Hamilton, John A.
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Published in Cytokine (Philadelphia, Pa.) (01.07.2024)
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Xue, Xiaohua, De Leon-Tabaldo, Aimee, Luna-Roman, Rosa, Castro, Glenda, Albers, Michael, Schoetens, Freddy, DePrimo, Samuel, Devineni, Damayanthi, Wilde, Thomas, Goldberg, Steve, Kinzel, Olaf, Hoffmann, Thomas, Fourie, Anne M., Thurmond, Robin L.
Published in Scientific reports (26.05.2021)
Published in Scientific reports (26.05.2021)
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JNJ-77242113, a highly potent, selective peptide targeting the IL-23 receptor, provides robust IL-23 pathway inhibition upon oral dosing in rats and humans
Fourie, Anne M., Cheng, Xiaoli, Chang, Leon, Greving, Carrie, Li, Xinyi, Knight, Beverly, Polidori, David, Patrick, Aaron, Bains, Trpta, Steele, Ruth, Allen, Samantha J., Patch, Raymond J., Sun, Chengzao, Somani, Sandeep, Bhandari, Ashok, Liu, David, Huie, Keith, Li, Shu, Rodriguez, Michael A., Xue, Xiaohua, Kannan, Arun, Kosoglou, Teddy, Sherlock, Jonathan P., Towne, Jennifer, Holland, M. Claire, Modi, Nishit B.
Published in Scientific reports (30.07.2024)
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ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro
Golub, Suzanne B, Rogerson, Fraser M, Campbell, Ian K, East, Charlotte J, Lawlor, Kate E, Little, Christopher B, Fourie, Anne M, Fosang, Amanda J, Meeker, Clare T, Last, Karena, Stanton, Heather, Farmer, Pamela J
Published in Nature (31.03.2005)
Published in Nature (31.03.2005)
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Pharmacologic modulation of RORγt translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis
Xue, Xiaohua, Soroosh, Pejman, De Leon-Tabaldo, Aimee, Luna-Roman, Rosa, Sablad, Marciano, Rozenkrants, Natasha, Yu, Jingxue, Castro, Glenda, Banie, Homayon, Fung-Leung, Wai-Ping, Santamaria-Babi, Luis, Schlueter, Thomas, Albers, Michael, Leonard, Kristi, Budelsky, Alison L., Fourie, Anne M.
Published in Scientific reports (01.12.2016)
Published in Scientific reports (01.12.2016)
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Leukotriene B4 Receptors BLT1 and BLT2: Expression and Function in Human and Murine Mast Cells
Lundeen, Katherine A, Sun, Binggang, Karlsson, Lars, Fourie, Anne M
Published in The Journal of immunology (1950) (01.09.2006)
Published in The Journal of immunology (1950) (01.09.2006)
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Author Correction: Preclinical and clinical characterization of the RORγt inhibitor JNJ-61803534
Xue, Xiaohua, De Leon-Tabaldo, Aimee, Luna-Roman, Rosa, Castro, Glenda, Albers, Michael, Schoetens, Freddy, DePrimo, Samuel, Devineni, Damayanthi, Wilde, Thomas, Goldberg, Steve, Kinzel, Olaf, Hoffmann, Thomas, Fourie, Anne M., Thurmond, Robin L.
Published in Scientific reports (06.04.2022)
Published in Scientific reports (06.04.2022)
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Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt
Gege, Christian, Albers, Michael, Kinzel, Olaf, Kleymann, Gerald, Schlüter, Thomas, Steeneck, Christoph, Hoffmann, Thomas, Xue, Xiaohua, Cummings, Maxwell D., Spurlino, John, Milligan, Cynthia, Fourie, Anne M., Edwards, James P., Leonard, Kristi, Coe, Kevin, Scott, Brian, Pippel, Dan, Goldberg, Steven D.
Published in Bioorganic & medicinal chemistry letters (15.06.2020)
Published in Bioorganic & medicinal chemistry letters (15.06.2020)
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Discovery and optimization of new oxadiazole substituted thiazole RORγt inverse agonists through a bioisosteric amide replacement approach
Steeneck, Christoph, Gege, Christian, Kinzel, Olaf, Albers, Michael, Kleymann, Gerald, Schlüter, Thomas, Schulz, Andreas, Xue, Xiaohua, Cummings, Maxwell D., Fourie, Anne M., Leonard, Kristi A., Scott, Brian, Edwards, James P., Hoffmann, Thomas, Goldberg, Steven D.
Published in Bioorganic & medicinal chemistry letters (15.06.2020)
Published in Bioorganic & medicinal chemistry letters (15.06.2020)
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Identification and structure activity relationships of quinoline tertiary alcohol modulators of RORγt
Kummer, David A., Cummings, Maxwell D., Abad, Marta, Barbay, Joseph, Castro, Glenda, Wolin, Ronald, Kreutter, Kevin D., Maharoof, Umar, Milligan, Cynthia, Nishimura, Rachel, Pierce, Joan, Schalk-Hihi, Celine, Spurlino, John, Urbanski, Maud, Venkatesan, Hariharan, Wang, Aihua, Woods, Craig, Xue, Xiaohua, Edwards, James P., Fourie, Anne M., Leonard, Kristi
Published in Bioorganic & medicinal chemistry letters (01.05.2017)
Published in Bioorganic & medicinal chemistry letters (01.05.2017)
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IL-23 past, present, and future: a roadmap to advancing IL-23 science and therapy
Krueger, James G, Eyerich, Kilian, Kuchroo, Vijay K, Ritchlin, Christopher T, Abreu, Maria T, Elloso, M Merle, Fourie, Anne, Fakharzadeh, Steven, Sherlock, Jonathan P, Yang, Ya-Wen, Cua, Daniel J, McInnes, Iain B
Published in Frontiers in immunology (2024)
Published in Frontiers in immunology (2024)
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6-Substituted quinolines as RORγt inverse agonists
Barbay, J. Kent, Cummings, Maxwell D., Abad, Marta, Castro, Glenda, Kreutter, Kevin D., Kummer, David A., Maharoof, Umar, Milligan, Cynthia, Nishimura, Rachel, Pierce, Joan, Schalk-Hihi, Celine, Spurlino, John, Tanis, Virginia M., Urbanski, Maud, Venkatesan, Hariharan, Wang, Aihua, Woods, Craig, Wolin, Ronald, Xue, Xiaohua, Edwards, James P., Fourie, Anne M., Leonard, Kristi
Published in Bioorganic & medicinal chemistry letters (01.12.2017)
Published in Bioorganic & medicinal chemistry letters (01.12.2017)
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3-Substituted Quinolines as RORγt Inverse Agonists
Tanis, Virginia M., Venkatesan, Hariharan, Cummings, Maxwell D., Albers, Michael, Kent Barbay, J., Herman, Krystal, Kummer, David A., Milligan, Cynthia, Nelen, Marina I., Nishimura, Rachel, Schlueter, Thomas, Scott, Brian, Spurlino, John, Wolin, Ronald, Woods, Craig, Xue, Xiaohua, Edwards, James P., Fourie, Anne M., Leonard, Kristi
Published in Bioorganic & medicinal chemistry letters (15.06.2019)
Published in Bioorganic & medicinal chemistry letters (15.06.2019)
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Leukotriene A4 Hydrolase Inhibition Attenuates Allergic Airway Inflammation and Hyperresponsiveness
RAO, Navin L, RILEY, Jason P, DUNFORD, Paul J, BANIE, Homayon, XIAOHUA XUE, BINGGANG SUN, CRAWFORD, Shelby, LUNDEEN, Katherine A, FUQU YU, KARLSSON, Lars, FOURIE, Anne M
Published in American journal of respiratory and critical care medicine (01.05.2010)
Published in American journal of respiratory and critical care medicine (01.05.2010)
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Leukotriene A(4) hydrolase inhibition attenuates allergic airway inflammation and hyperresponsiveness
Rao, Navin L, Riley, Jason P, Banie, Homayon, Xue, Xiaohua, Sun, Binggang, Crawford, Shelby, Lundeen, Katherine A, Yu, Fuqu, Karlsson, Lars, Fourie, Anne M, Dunford, Paul J
Published in American journal of respiratory and critical care medicine (01.05.2010)
Published in American journal of respiratory and critical care medicine (01.05.2010)
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