Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates
Foster, Donald J., Brown, Christopher R., Shaikh, Sarfraz, Trapp, Casey, Schlegel, Mark K., Qian, Kun, Sehgal, Alfica, Rajeev, Kallanthottathil G., Jadhav, Vasant, Manoharan, Muthiah, Kuchimanchi, Satya, Maier, Martin A., Milstein, Stuart
Published in Molecular therapy (07.03.2018)
Published in Molecular therapy (07.03.2018)
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Journal Article
Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA
Schlegel, Mark K, Foster, Donald J, Kel’in, Alexander V, Zlatev, Ivan, Bisbe, Anna, Jayaraman, Muthusamy, Lackey, Jeremy G, Rajeev, Kallanthottathil G, Charissé, Klaus, Harp, Joel, Pallan, Pradeep S, Maier, Martin A, Egli, Martin, Manoharan, Muthiah
Published in Journal of the American Chemical Society (28.06.2017)
Published in Journal of the American Chemical Society (28.06.2017)
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Journal Article
5′-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates
Parmar, Rubina, Willoughby, Jennifer L. S., Liu, Jingxuan, Foster, Donald J., Brigham, Benjamin, Theile, Christopher S., Charisse, Klaus, Akinc, Akin, Guidry, Erin, Pei, Yi, Strapps, Walter, Cancilla, Mark, Stanton, Matthew G., Rajeev, Kallanthottathil G., Sepp-Lorenzino, Laura, Manoharan, Muthiah, Meyers, Rachel, Maier, Martin A., Jadhav, Vasant
Published in Chembiochem : a European journal of chemical biology (02.06.2016)
Published in Chembiochem : a European journal of chemical biology (02.06.2016)
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Journal Article
4′‑C‑Methoxy-2′-deoxy-2′-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing
Malek-Adamian, Elise, Guenther, Dale C, Matsuda, Shigeo, Martínez-Montero, Saúl, Zlatev, Ivan, Harp, Joel, Burai Patrascu, Mihai, Foster, Donald J, Fakhoury, Johans, Perkins, Lydia, Moitessier, Nicolas, Manoharan, Rajar M, Taneja, Nate, Bisbe, Anna, Charisse, Klaus, Maier, Martin, Rajeev, Kallanthottathil G, Egli, Martin, Manoharan, Muthiah, Damha, Masad J
Published in Journal of the American Chemical Society (18.10.2017)
Published in Journal of the American Chemical Society (18.10.2017)
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Journal Article
Facile Synthesis, Geometry, and 2′-Substituent-Dependent in Vivo Activity of 5′‑(E)- and 5′‑(Z)‑Vinylphosphonate-Modified siRNA Conjugates
Parmar, Rubina Giare, Brown, Christopher R, Matsuda, Shigeo, Willoughby, Jennifer L. S, Theile, Christopher S, Charissé, Klaus, Foster, Donald J, Zlatev, Ivan, Jadhav, Vasant, Maier, Martin A, Egli, Martin, Manoharan, Muthiah, Rajeev, Kallanthottathil G
Published in Journal of medicinal chemistry (08.02.2018)
Published in Journal of medicinal chemistry (08.02.2018)
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Journal Article
RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models
Haase, Nadine, Foster, Donald J, Cunningham, Mark W, Bercher, Julia, Nguyen, Tuyen, Shulga-Morskaya, Svetlana, Milstein, Stuart, Shaikh, Sarfraz, Rollins, Jeff, Golic, Michaela, Herse, Florian, Kräker, Kristin, Bendix, Ivo, Serdar, Meray, Napieczynska, Hanna, Heuser, Arnd, Gellhaus, Alexandra, Thiele, Kristin, Wallukat, Gerd, Müller, Dominik N, LaMarca, Babbette, Dechend, Ralf
Published in The Journal of clinical investigation (01.06.2020)
Published in The Journal of clinical investigation (01.06.2020)
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Journal Article
Structural basis for the synergy of 4′- and 2′-modifications on siRNA nuclease resistance, thermal stability and RNAi activity
Harp, Joel M, Guenther, Dale C, Bisbe, Anna, Perkins, Lydia, Matsuda, Shigeo, Bommineni, Gopal R, Zlatev, Ivan, Foster, Donald J, Taneja, Nate, Charisse, Klaus, Maier, Martin A, Rajeev, Kallanthottathil G, Manoharan, Muthiah, Egli, Martin
Published in Nucleic acids research (19.09.2018)
Published in Nucleic acids research (19.09.2018)
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Journal Article
Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis
Butler, James S., Chan, Amy, Costelha, Susete, Fishman, Shannon, Willoughby, Jennifer L. S., Borland, Todd D., Milstein, Stuart, Foster, Donald J., Gonçalves, Paula, Chen, Qingmin, Qin, June, Bettencourt, Brian R., Sah, Dinah W., Alvarez, Rene, Rajeev, Kallanthottathil G., Manoharan, Muthiah, Fitzgerald, Kevin, Meyers, Rachel E., Nochur, Saraswathy V., Saraiva, Maria J., Zimmermann, Tracy S.
Published in Amyloid (01.06.2016)
Published in Amyloid (01.06.2016)
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Journal Article
5′-Morpholino modification of the sense strand of an siRNA makes it a more effective passenger
Kumar, Pawan, Parmar, Rubina G, Brown, Christopher R, Willoughby, Jennifer L. S, Foster, Donald J, Babu, I. Ramesh, Schofield, Sally, Jadhav, Vasant, Charisse, Klaus, Nair, Jayaprakash K, Rajeev, Kallanthottathil G, Maier, Martin A, Egli, Martin, Manoharan, Muthiah
Published in Chemical communications (Cambridge, England) (25.04.2019)
Published in Chemical communications (Cambridge, England) (25.04.2019)
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Journal Article
Interleukin-21 inhibits dendritic cell activation and maturation
Brandt, Katja, Bulfone-Paus, Silvia, Foster, Donald C., Rückert, René
Published in Blood (01.12.2003)
Published in Blood (01.12.2003)
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Journal Article
5′‑C‑Malonyl RNA: Small Interfering RNAs Modified with 5′-Monophosphate Bioisostere Demonstrate Gene Silencing Activity
Zlatev, Ivan, Foster, Donald J, Liu, Jingxuan, Charisse, Klaus, Brigham, Benjamin, Parmar, Rubina G, Jadhav, Vasant, Maier, Martin A, Rajeev, Kallanthottathil G, Egli, Martin, Manoharan, Muthiah
Published in ACS chemical biology (15.04.2016)
Published in ACS chemical biology (15.04.2016)
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Journal Article
Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses
Parrish‐Novak, Julia, Foster, Donald C., Holly, Richard D., Clegg, Christopher H.
Published in Journal of leukocyte biology (01.11.2002)
Published in Journal of leukocyte biology (01.11.2002)
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Journal Article
Integrins and proximal signaling mechanisms in cardiovascular disease
Lal, Hind, Verma, Suresh K, Foster, Donald M, Golden, Honey B, Reneau, John C, Watson, Linley E, Singh, Hitesh, Dostal, David E
Published in Frontiers in bioscience (01.01.2009)
Published in Frontiers in bioscience (01.01.2009)
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Journal Article
Structure, function and biology of tissue factor pathway inhibitor-2
Chand, Hitendra S, Foster, Donald C, Kisiel, Walter
Published in Thrombosis and haemostasis (01.12.2005)
Published in Thrombosis and haemostasis (01.12.2005)
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Journal Article
Comprehensive evaluation of canonical versus Dicer-substrate siRNA in vitro and in vivo
Foster, Donald J, Barros, Scott, Duncan, Rick, Shaikh, Sarfraz, Cantley, William, Dell, Amy, Bulgakova, Elena, O'Shea, Jonathan, Taneja, Nate, Kuchimanchi, Satya, Sherrill, Christopher B, Akinc, Akin, Hinkle, Gregory, Seila White, Amy C, Pang, Bo, Charisse, Klaus, Meyers, Rachel, Manoharan, Muthiah, Elbashir, Sayda M
Published in RNA (Cambridge) (01.03.2012)
Published in RNA (Cambridge) (01.03.2012)
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Journal Article
Suppressing Hepatic UGT1A1 Increases Plasma Bilirubin, Lowers Plasma Urobilin, Reorganizes Kinase Signaling Pathways and Lipid Species and Improves Fatty Liver Disease
Bates, Evelyn A, Kipp, Zachary A, Martinez, Genesee J, Badmus, Olufunto O, Soundarapandian, Mangala M, Foster, Donald, Xu, Mei, Creeden, Justin F, Greer, Jennifer R, Morris, Andrew J, Stec, David E, Hinds, Jr, Terry D
Published in Biomolecules (Basel, Switzerland) (29.01.2023)
Published in Biomolecules (Basel, Switzerland) (29.01.2023)
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Journal Article
Rac1 and RhoA differentially regulate angiotensinogen gene expression in stretched cardiac fibroblasts
VERMA, Suresh K, LAL, Hind, GOLDEN, Honey B, GERILECHAOGETU, Fnu, SMITH, Manuela, GULERIA, Rakeshwar S, FOSTER, Donald M, GUANGRONG LU, DOSTAL, David E
Published in Cardiovascular research (01.04.2011)
Published in Cardiovascular research (01.04.2011)
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Journal Article
Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions
Parrish-Novak, Julia, Xu, Wenfeng, Brender, Ty, Yao, Lena, Jones, Crystal, West, Jim, Brandt, Cameron, Jelinek, Laura, Madden, Karen, McKernan, Patricia A, Foster, Donald C, Jaspers, Stephen, Chandrasekher, Yasmin A
Published in The Journal of biological chemistry (06.12.2002)
Published in The Journal of biological chemistry (06.12.2002)
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