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Gwynn, Michael N, Bax, Benjamin D, Wohlkonig, Alexandre, Chan, Pan F, Fosberry, Andrew P, Homes, Paul, Huang, Jianzhong, Kranz, Michael, Leydon, Vaughan R, Miles, Timothy J, Pearson, Neil D, Perera, Rajika L, Shillings, Anthony J
Published in Nature structural & molecular biology (01.09.2010)
Published in Nature structural & molecular biology (01.09.2010)
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Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin
Chan, Pan F, Srikannathasan, Velupillai, Huang, Jianzhong, Cui, Haifeng, Fosberry, Andrew P, Gu, Minghua, Hann, Michael M, Hibbs, Martin, Homes, Paul, Ingraham, Karen, Pizzollo, Jason, Shen, Carol, Shillings, Anthony J, Spitzfaden, Claus E, Tanner, Robert, Theobald, Andrew J, Stavenger, Robert A, Bax, Benjamin D, Gwynn, Michael N
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Published in Nature communications (07.12.2015)
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1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI)
Heerding, Dirk A, Chan, George, DeWolf, Walter E, Fosberry, Andrew P, Janson, Cheryl A, Jaworski, Deborah D, McManus, Edward, Miller, William H, Moore, Terrance D, Payne, David J, Qiu, Xiayang, Rittenhouse, Stephen F, Slater-Radosti, Courtney, Smith, Ward, Takata, Dennis T, Vaidya, Kalindi S, Yuan, Catherine C.K, Huffman, William F
Published in Bioorganic & medicinal chemistry letters (20.08.2001)
Published in Bioorganic & medicinal chemistry letters (20.08.2001)
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Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4- b]indoles as potential antibacterial agents
Seefeld, Mark A, Miller, William H, Newlander, Kenneth A, Burgess, Walter J, Payne, David J, Rittenhouse, Stephen F, Moore, Terrance D, DeWolf, Walter E, Keller, Paul M, Qiu, Xiayang, Janson, Cheryl A, Vaidya, Kalindi, Fosberry, Andrew P, Smyth, Martin G, Jaworski, Deborah D, Slater-Radosti, Courtney, Huffman, William F
Published in Bioorganic & medicinal chemistry letters (03.09.2001)
Published in Bioorganic & medicinal chemistry letters (03.09.2001)
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Crystallization and initial crystallographic analysis of covalent DNA-cleavage complexes of Staphyloccocus aureus DNA gyrase with QPT-1, moxifloxacin and etoposide
Srikannathasan, Velupillai, Wohlkonig, Alexandre, Shillings, Anthony, Singh, Onkar, Chan, Pan F., Huang, Jianzhong, Gwynn, Michael N., Fosberry, Andrew P., Homes, Paul, Hibbs, Martin, Theobald, Andrew J., Spitzfaden, Claus, Bax, Benjamin D.
Published in Acta crystallographica. Section F, Structural biology communications (01.10.2015)
Published in Acta crystallographica. Section F, Structural biology communications (01.10.2015)
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Discovery of a Novel and Potent Class of FabI-Directed Antibacterial Agents
PAYNE, David J, MILLER, William H, HEERDING, Dirk A, JANSON, Cheryl A, JAWORSKI, Deborah D, KELLER, Paul M, MANLEY, Peter J, MOORE, Terrance D, NEWLANDER, Kenneth A, PEARSON, Stewart, POLIZZI, Brian J, XIAYANG QIU, BERRY, Valerie, RITTENHOUSE, Stephen F, SLATER-RADOSTI, Courtney, SALYERS, Kevin L, SEEFELD, Mark A, SMYTH, Martin G, TAKATA, Dennis T, UZINSKAS, Irene N, VAIDYA, Kalindi, WALLIS, Nicola G, WINRAM, Scott B, BROSKY, John, YUAN, Catherine C. K, HUFFMAN, William F, BURGESS, Walter J, CHEN, Emile, DEWOLF, Walter E, FOSBERRY, Andrew P, GREENWOOD, Rebecca, HEAD, Martha S
Published in Antimicrobial Agents and Chemotherapy (01.10.2002)
Published in Antimicrobial Agents and Chemotherapy (01.10.2002)
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The antimicrobial natural product chuangxinmycin and Some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase
Brown, Murray J., Carter, Paul S., Fenwick, Ashley E., Fosberry, Andrew P., Hamprecht, Dieter W., Hibbs, Martin J., Jarvest, Richard L., Mensah, Lucy, Milner, Peter H., O'Hanlon, Peter J., Pope, Andrew J., Richardson, Christine M., West, Andrew, Witty, David R.
Published in Bioorganic & medicinal chemistry letters (04.11.2002)
Published in Bioorganic & medicinal chemistry letters (04.11.2002)
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Nuclear magnetic resonance spectroscopy reveals the functional state of the signalling protein CheY in vivo in Escherichia coli
Hubbard, Julia A., MacLachlan, Lesley K., King, Gavin W., Jones, Joanna J., Fosberry, Andrew P.
Published in Molecular microbiology (01.09.2003)
Published in Molecular microbiology (01.09.2003)
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Nanomolar Inhibitors of Staphylococcus aureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens
JARVEST, Richard L., BERGE, John M., BERRY, Valerie, BOYD, Helen F., BROWN, Murray J., ELDER, John S., FORREST, Andrew K., FOSBERRY, Andrew P., GENTRY, Daniel R., HIBBS, Martin J., JAWORSKI, Deborah D., O'HANLON, Peter J., POPE, Andrew J., RITTENHOUSE, Stephen, SHEPPARD, Robert J., SLATER-RADOSTI, Courtney, WORBY, Angela
Published in Journal of medicinal chemistry (09.05.2002)
Published in Journal of medicinal chemistry (09.05.2002)
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Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase
Jarvest, Richard L., Erskine, Symon G., Forrest, Andrew K., Fosberry, Andrew P., Hibbs, Martin J., Jones, Joanna J., O’Hanlon, Peter J., Sheppard, Robert J., Worby, Angela
Published in Bioorganic & medicinal chemistry letters (02.05.2005)
Published in Bioorganic & medicinal chemistry letters (02.05.2005)
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Potential of real-time measurement of GFP-fusion proteins
Jones, Jo J, Bridges, Angela M, Fosberry, Andrew P, Gardner, Sharmila, Lowers, Robert R, Newby, Rachel R, James, Philip J, Hall, Richard M, Jenkins, Owen
Published in Journal of biotechnology (08.04.2004)
Published in Journal of biotechnology (08.04.2004)
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Conference Proceeding
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Jones, Jo J, Bridges, Angela M, Fosberry, Andrew P, Bullock, Jonathan, Hudson, Ian, Hall, Richard M, Jenkins, Owen, Cole, Jeffrey A
Published in Microbial cell factories (10.10.2006)
Published in Microbial cell factories (10.10.2006)
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Clavulanic acid biosynthesis in Streptomyces clavuligerus: gene cloning and characterization
Hodgson, John E, Fosberry, Andrew P, Rawlinson, Nichola S, Ross, Hamish N.M, Neal, Robert J, Arnell, Janice C, Earl, Alison J, Lawlor, Elizabeth J
Published in Gene (01.12.1995)
Published in Gene (01.12.1995)
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Nanomolar Inhibitors of Staphylococcus a ureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens
Jarvest, Richard L, Berge, John M, Berry, Valerie, Boyd, Helen F, Brown, Murray J, Elder, John S, Forrest, Andrew K, Fosberry, Andrew P, Gentry, Daniel R, Hibbs, Martin J, Jaworski, Deborah D, O'Hanlon, Peter J, Pope, Andrew J, Rittenhouse, Stephen, Sheppard, Robert J, Slater-Radosti, Courtney, Worby, Angela
Published in Journal of medicinal chemistry (09.05.2002)
Published in Journal of medicinal chemistry (09.05.2002)
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A Method for Identification of Inhibitors of the Phosphorylation Reactions of Bacterial Response Regulator Proteins Using 31P Nuclear Magnetic Resonance Spectroscopy
Hubbard, Julia A., MacLachlan, Lesley K., Johnson, Peter, Findlow, Stuart C., Ladds, Joanne C., Lewis, Ceri J., Carter, Paul S., Jones, Jo J., Fosberry, Andrew P.
Published in Analytical biochemistry (01.12.2001)
Published in Analytical biochemistry (01.12.2001)
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A method for identification of inhibitors of the phosphorylation reactions of bacterial response regulator proteins using (31)P nuclear magnetic resonance spectroscopy
Hubbard, J A, MacLachlan, L K, Johnson, P, Findlow, S C, Ladds, J C, Lewis, C J, Carter, P S, Jones, J J, Fosberry, A P
Published in Analytical biochemistry (01.12.2001)
Published in Analytical biochemistry (01.12.2001)
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