Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease
Ellwanger, Daniel C, Wang, Shoutang, Brioschi, Simone, Shao, Zhifei, Green, Lydia, Case, Ryan, Yoo, Daniel, Weishuhn, Dawn, Rathanaswami, Palaniswami, Bradley, Jodi, Rao, Sara, Cha, Diana, Luan, Peng, Sambashivan, Shilpa, Gilfillan, Susan, Hasson, Samuel A, Foltz, Ian N, van Lookeren Campagne, Menno, Colonna, Marco
Published in Proceedings of the National Academy of Sciences - PNAS (19.01.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (19.01.2021)
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Molecular basis for the loss-of-function effects of the Alzheimer's disease–associated R47H variant of the immune receptor TREM2
Sudom, Athena, Talreja, Santosh, Danao, Jean, Bragg, Eric, Kegel, Rob, Min, Xiaoshan, Richardson, Jason, Zhang, Zhongqi, Sharkov, Nikolai, Marcora, Edoardo, Thibault, Steve, Bradley, Jodi, Wood, Steve, Lim, Ai-Ching, Chen, Hang, Wang, Songli, Foltz, Ian N., Sambashivan, Shilpa, Wang, Zhulun
Published in The Journal of biological chemistry (10.08.2018)
Published in The Journal of biological chemistry (10.08.2018)
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Apo2L/TRAIL and the Death Receptor 5 Agonist Antibody AMG 655 Cooperate to Promote Receptor Clustering and Antitumor Activity
Graves, Jonathan D., Kordich, Jennifer J., Huang, Tzu-Hsuan, Piasecki, Julia, Bush, Tammy L., Sullivan, Timothy, Foltz, Ian N., Chang, Wesley, Douangpanya, Heather, Dang, Thu, O’Neill, Jason W., Mallari, Rommel, Zhao, Xiaoning, Branstetter, Daniel G., Rossi, John M., Long, Alexander M., Huang, Xin, Holland, Pamela M.
Published in Cancer cell (11.08.2014)
Published in Cancer cell (11.08.2014)
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Journal Article
Identification and Characterization of MEDI4736, an Antagonistic Anti-PD-L1 Monoclonal Antibody
Stewart, Ross, Morrow, Michelle, Hammond, Scott A, Mulgrew, Kathy, Marcus, Danielle, Poon, Edmund, Watkins, Amanda, Mullins, Stefanie, Chodorge, Matthieu, Andrews, John, Bannister, David, Dick, Emily, Crawford, Nicola, Parmentier, Julie, Alimzhanov, Marat, Babcook, John S, Foltz, Ian N, Buchanan, Andrew, Bedian, Vahe, Wilkinson, Robert W, McCourt, Matthew
Published in Cancer immunology research (01.09.2015)
Published in Cancer immunology research (01.09.2015)
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Discovery and bio-optimization of human antibody therapeutics using the XenoMouse® transgenic mouse platform
Foltz, Ian N., Gunasekaran, Kannan, King, Chadwick T.
Published in Immunological reviews (01.03.2016)
Published in Immunological reviews (01.03.2016)
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Journal Article
AMG 595, an Anti-EGFRvIII Antibody-Drug Conjugate, Induces Potent Antitumor Activity against EGFRvIII-Expressing Glioblastoma
Hamblett, Kevin J, Kozlosky, Carl J, Siu, Sophia, Chang, Wesley S, Liu, Hua, Foltz, Ian N, Trueblood, Esther S, Meininger, David, Arora, Taruna, Twomey, Brian, Vonderfecht, Steven L, Chen, Qing, Hill, John S, Fanslow, William C
Published in Molecular cancer therapeutics (01.07.2015)
Published in Molecular cancer therapeutics (01.07.2015)
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Journal Article
TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant Trem2R47H on murine myeloid cell function
Cheng, Qingwen, Danao, Jean, Talreja, Santosh, Wen, Paul, Yin, Jun, Sun, Ning, Li, Chi-Ming, Chui, Danny, Tran, David, Koirala, Samir, Chen, Hang, Foltz, Ian N., Wang, Songli, Sambashivan, Shilpa
Published in The Journal of biological chemistry (10.08.2018)
Published in The Journal of biological chemistry (10.08.2018)
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Journal Article
Conatumumab, a fully human agonist antibody to death receptor 5, induces apoptosis via caspase activation in multiple tumor types
Kaplan-Lefko, Paula J., Graves, Jonathan D., Zoog, Stephen J., Pan, Yang, Wall, Jason, Branstetter, Daniel G., Moriguchi, Jodi, Coxon, Angela, Huard, Justin N., Xu, Ren, Peach, Matthew L., Juan, Gloria, Kaufman, Stephen, Chen, Qing, Bianchi, Allison, Kordich, Jennifer J., Ma, Mark, Foltz, Ian N., Gliniak, Brian C.
Published in Cancer biology & therapy (15.04.2010)
Published in Cancer biology & therapy (15.04.2010)
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Journal Article
MEDI0639: a novel therapeutic antibody targeting Dll4 modulates endothelial cell function and angiogenesis in vivo
Jenkins, David W, Ross, Sarah, Veldman-Jones, Margaret, Foltz, Ian N, Clavette, Brandon C, Manchulenko, Kathy, Eberlein, Cath, Kendrew, Jane, Petteruti, Philip, Cho, Song, Damschroder, Melissa, Peng, Li, Baker, Dawn, Smith, Neil R, Weir, Hazel M, Blakey, David C, Bedian, Vahe, Barry, Simon T
Published in Molecular cancer therapeutics (01.08.2012)
Published in Molecular cancer therapeutics (01.08.2012)
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Journal Article
Analytical and Functional Similarity of Aflibercept Biosimilar ABP 938 with Aflibercept Reference Product
Seo, Neungseon, Guan, Xiaoyan, Wang, Tian, Chung, Hyo S. Helen, Wikström, Mats, Padaki, Rupa, Kalenian, Kevin, Kuhns, Scott, Matthies, Kelli, Crouse-Zeineddini, Jill, Wong, Helen Y., Ng, Michael, Foltz, Ian N., Cao, Shawn, Liu, Jennifer
Published in Ophthalmology and therapy (01.05.2024)
Published in Ophthalmology and therapy (01.05.2024)
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Journal Article
Evolution and Emergence of Therapeutic Monoclonal Antibodies: What Cardiologists Need to Know
FOLTZ, Ian N, KAROW, Margaret, WASSERMAN, Scott M
Published in Circulation (New York, N.Y.) (04.06.2013)
Published in Circulation (New York, N.Y.) (04.06.2013)
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Journal Article
Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models
Killion, Elizabeth A, Wang, Jinghong, Yie, Junming, Shi, Stone D-H, Bates, Darren, Min, Xiaoshan, Komorowski, Renee, Hager, Todd, Deng, Liying, Atangan, Larissa, Lu, Shu-Chen, Kurzeja, Robert J M, Sivits, Glenn, Lin, Joanne, Chen, Qing, Wang, Zhulun, Thibault, Stephen A, Abbott, Christina M, Meng, Tina, Clavette, Brandon, Murawsky, Christopher M, Foltz, Ian N, Rottman, James B, Hale, Clarence, Véniant, Murielle M, Lloyd, David J
Published in Science translational medicine (19.12.2018)
Published in Science translational medicine (19.12.2018)
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Enhancing Antibody Fc Heterodimer Formation through Electrostatic Steering Effects: APPLICATIONS TO BISPECIFIC MOLECULES AND MONOVALENT IgG
Gunasekaran, Kannan, Pentony, Martin, Shen, Min, Garrett, Logan, Forte, Carla, Woodward, Anne, Ng, Soo Bin, Born, Teresa, Retter, Marc, Manchulenko, Kathy, Sweet, Heather, Foltz, Ian N, Wittekind, Michael, Yan, Wei
Published in The Journal of biological chemistry (18.06.2010)
Published in The Journal of biological chemistry (18.06.2010)
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Journal Article
Development of a potent high-affinity human therapeutic antibody via novel application of recombination signal sequence–based affinity maturation
Kielczewska, Agnieszka, D'Angelo, Igor, Amador, Maria Sheena, Wang, Tina, Sudom, Athena, Min, Xiaoshan, Rathanaswami, Palaniswami, Pigott, Craig, Foltz, Ian N.
Published in The Journal of biological chemistry (01.02.2022)
Published in The Journal of biological chemistry (01.02.2022)
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Journal Article
Native SEC and Reversed-Phase LC–MS Reveal Impact of Fab Glycosylation of Anti-SARS-COV‑2 Antibodies on Binding to the Receptor Binding Domain
Woodall, Daniel W., Thomson, Christy A., Dillon, Thomas M., McAuley, Arnold, Green, Lydia B., Foltz, Ian N., Bondarenko, Pavel V.
Published in Analytical chemistry (Washington) (24.10.2023)
Published in Analytical chemistry (Washington) (24.10.2023)
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Journal Article
Treating diabetes and obesity with an FGF21-mimetic antibody activating the βKlotho/FGFR1c receptor complex
Foltz, Ian N, Hu, Sylvia, King, Chadwick, Wu, Xinle, Yang, Chaofeng, Wang, Wei, Weiszmann, Jennifer, Stevens, Jennitte, Chen, Jiyun Sunny, Nuanmanee, Noi, Gupte, Jamila, Komorowski, Renee, Sekirov, Laura, Hager, Todd, Arora, Taruna, Ge, Hongfei, Baribault, Helene, Wang, Fen, Sheng, Jackie, Karow, Margaret, Wang, Minghan, Luo, Yongde, McKeehan, Wallace, Wang, Zhulun, Véniant, Murielle M, Li, Yang
Published in Science translational medicine (28.11.2012)
Published in Science translational medicine (28.11.2012)
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Functional and Nonclinical Similarity of ABP 980, a Biosimilar of Trastuzumab
Jassem, Shea, Wang, Wei, Sweet, Heather, Manoukian, Raffi, Chow, Vincent, Kanakaraj, Palanisamy, Hutterer, Katariina M., Kuhns, Scott, Foltz, Ian N., Chen, Qing, Ferbas, John, McBride, Helen J.
Published in Pharmaceutical research (01.12.2019)
Published in Pharmaceutical research (01.12.2019)
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Journal Article
A Novel Antibody Engineering Strategy for Making Monovalent Bispecific Heterodimeric IgG Antibodies by Electrostatic Steering Mechanism
Liu, Zhi, Leng, Esther C., Gunasekaran, Kannan, Pentony, Martin, Shen, Min, Howard, Monique, Stoops, Janelle, Manchulenko, Kathy, Razinkov, Vladimir, Liu, Hua, Fanslow, William, Hu, Zhonghua, Sun, Nancy, Hasegawa, Haruki, Clark, Rutilio, Foltz, Ian N., Yan, Wei
Published in The Journal of biological chemistry (20.03.2015)
Published in The Journal of biological chemistry (20.03.2015)
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Journal Article
The serum protein transthyretin as a platform for dimerization and tetramerization of antibodies and Fab fragments to enable target clustering
Walker, Kenneth W., Foltz, Ian N., Wang, Tina, Salimi-Moosavi, Hossein, Bailis, Julie M., Lee, Fei, An, Phillip, Smith, Stephen, Bruno, Richele, Wang, Zhulun
Published in The Journal of biological chemistry (24.07.2020)
Published in The Journal of biological chemistry (24.07.2020)
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Journal Article
Impact of antibody subclass and disulfide isoform differences on the biological activity of CD200R and βklotho agonist antibodies
Grujic, Ognjen, Stevens, Jennitte, Chou, Robert Y.-T., Weiszmann, Jennifer V., Sekirov, Laura, Thomson, Christy, Badh, Anita, Grauer, Stephanie, Chan, Brian, Graham, Kevin, Manchulenko, Kathy, Dillon, Thomas M., Li, Yang, Foltz, Ian N.
Published in Biochemical and biophysical research communications (13.05.2017)
Published in Biochemical and biophysical research communications (13.05.2017)
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