Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers
Peng, Sheng-Bin, Henry, James R., Kaufman, Michael D., Lu, Wei-Ping, Smith, Bryan D., Vogeti, Subha, Rutkoski, Thomas J., Wise, Scott, Chun, Lawrence, Zhang, Youyan, Van Horn, Robert D., Yin, Tinggui, Zhang, Xiaoyi, Yadav, Vipin, Chen, Shih-Hsun, Gong, Xueqian, Ma, Xiwen, Webster, Yue, Buchanan, Sean, Mochalkin, Igor, Huber, Lysiane, Kays, Lisa, Donoho, Gregory P., Walgren, Jennie, McCann, Denis, Patel, Phenil, Conti, Ilaria, Plowman, Gregory D., Starling, James J., Flynn, Daniel L.
Published in Cancer cell (14.09.2015)
Published in Cancer cell (14.09.2015)
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Novel MET/TIE2/VEGFR2 inhibitor altiratinib inhibits tumor growth and invasiveness in bevacizumab-resistant glioblastoma mouse models
Piao, Yuji, Park, Soon Young, Henry, Verlene, Smith, Bryan D, Tiao, Ningyi, Flynn, Daniel L, de Groot, John F
Published in Neuro-oncology (Charlottesville, Va.) (01.09.2016)
Published in Neuro-oncology (Charlottesville, Va.) (01.09.2016)
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Phase 1 dose-finding study of rebastinib (DCC-2036) in patients with relapsed chronic myeloid leukemia and acute myeloid leukemia
Cortes, Jorge, Talpaz, Moshe, Smith, Hedy P, Snyder, David S, Khoury, Jean, Bhalla, Kapil N, Pinilla-Ibarz, Javier, Larson, Richard, Mitchell, David, Wise, Scott C, Rutkoski, Thomas J, Smith, Bryan D, Flynn, Daniel L, Kantarjian, Hagop M, Rosen, Oliver, Van Etten, Richard A
Published in Haematologica (Roma) (01.03.2017)
Published in Haematologica (Roma) (01.03.2017)
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The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2Hi Macrophages in Breast Cancer and Pancreatic Neuroendocrine Tumors
Harney, Allison S., Karagiannis, George S., Pignatelli, Jeanine, Smith, Bryan D., Kadioglu, Ece, Wise, Scott C., Hood, Molly M., Kaufman, Michael D., Leary, Cynthia B., Lu, Wei-Ping, Al-Ani, Gada, Chen, Xiaoming, Entenberg, David, Oktay, Maja H., Wang, Yarong, Chun, Lawrence, De Palma, Michele, Jones, Joan G., Flynn, Daniel L., Condeelis, John S.
Published in Molecular cancer therapeutics (01.11.2017)
Published in Molecular cancer therapeutics (01.11.2017)
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Multipolymer Solution-Phase Reactions: Application to the Mitsunobu Reaction
Harned, Andrew M, He, Helen Song, Toy, Patrick H, Flynn, Daniel L, Hanson, Paul R
Published in Journal of the American Chemical Society (12.01.2005)
Published in Journal of the American Chemical Society (12.01.2005)
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Monomer-on-Monomer (MoM) Mitsunobu Reaction: Facile Purification Utilizing Surface-Initiated Sequestration
Maity, Pradip K, Rolfe, Alan, Samarakoon, Thiwanka B, Faisal, Saqib, Kurtz, Ryan D, Long, Toby R, Schätz, Alexander, Flynn, Daniel L, Grass, Robert N, Stark, Wendelin J, Reiser, Oliver, Hanson, Paul R
Published in Organic letters (07.01.2011)
Published in Organic letters (07.01.2011)
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High-Load, Oligomeric Dichlorotriazine: A Versatile ROMP-Derived Reagent and Scavenger
Rolfe, Alan, Probst, Donald A, Volp, Kelly A, Omar, Iman, Flynn, Daniel L, Hanson, Paul R
Published in Journal of organic chemistry (21.11.2008)
Published in Journal of organic chemistry (21.11.2008)
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High-Load, Soluble Oligomeric Carbodiimide: Synthesis and Application in Coupling Reactions
Zhang, Mianji, Vedantham, Punitha, Flynn, Daniel L, Hanson, Paul R
Published in Journal of organic chemistry (26.11.2004)
Published in Journal of organic chemistry (26.11.2004)
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Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants
Smith, Bryan D., Kaufman, Michael D., Lu, Wei-Ping, Gupta, Anu, Leary, Cynthia B., Wise, Scott C., Rutkoski, Thomas J., Ahn, Yu Mi, Al-Ani, Gada, Bulfer, Stacie L., Caldwell, Timothy M., Chun, Lawrence, Ensinger, Carol L., Hood, Molly M., McKinley, Arin, Patt, William C., Ruiz-Soto, Rodrigo, Su, Ying, Telikepalli, Hanumaiah, Town, Ajia, Turner, Benjamin A., Vogeti, Lakshminarayana, Vogeti, Subha, Yates, Karen, Janku, Filip, Abdul Razak, Albiruni Ryan, Rosen, Oliver, Heinrich, Michael C., Flynn, Daniel L.
Published in Cancer cell (13.05.2019)
Published in Cancer cell (13.05.2019)
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Ripretinib and MEK Inhibitors Synergize to Induce Apoptosis in Preclinical Models of GIST and Systemic Mastocytosis
Gupta, Anu, Singh, Jarnail, García-Valverde, Alfonso, Serrano, César, Flynn, Daniel L, Smith, Bryan D
Published in Molecular cancer therapeutics (01.07.2021)
Published in Molecular cancer therapeutics (01.07.2021)
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A Phase I Study of LY3009120, a Pan-RAF Inhibitor, in Patients with Advanced or Metastatic Cancer
Sullivan, Ryan J, Hollebecque, Antoine, Flaherty, Keith T, Shapiro, Geoffrey I, Rodon Ahnert, Jordi, Millward, Michael J, Zhang, Wei, Gao, Ling, Sykes, Amanda, Willard, Melinda D, Yu, Danni, Schade, Andrew E, Crowe, KrisAnne, Flynn, Daniel L, Kaufman, Michael D, Henry, James R, Peng, Sheng-Bin, Benhadji, Karim A, Conti, Ilaria, Gordon, Michael S, Tiu, Ramon V, Hong, David S
Published in Molecular cancer therapeutics (01.02.2020)
Published in Molecular cancer therapeutics (01.02.2020)
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Vimseltinib: A Precision CSF1R Therapy for Tenosynovial Giant Cell Tumors and Diseases Promoted by Macrophages
Smith, Bryan D, Kaufman, Michael D, Wise, Scott C, Ahn, Yu Mi, Caldwell, Timothy M, Leary, Cynthia B, Lu, Wei-Ping, Tan, Gege, Vogeti, Lakshminarayana, Vogeti, Subha, Wilky, Breelyn A, Davis, Lara E, Sharma, Maitreyi, Ruiz-Soto, Rodrigo, Flynn, Daniel L
Published in Molecular cancer therapeutics (01.11.2021)
Published in Molecular cancer therapeutics (01.11.2021)
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Discovery of vimseltinib (DCC-3014), a highly selective CSF1R switch-control kinase inhibitor, in clinical development for the treatment of Tenosynovial Giant Cell Tumor (TGCT)
Caldwell, Timothy M., Ahn, Yu Mi, Bulfer, Stacie L., Leary, Cynthia B., Hood, Molly M., Lu, Wei-Ping, Vogeti, Lakshminarayana, Vogeti, Subha, Kaufman, Michael D., Wise, Scott C., Le Bourdonnec, Bertrand, Smith, Bryan D., Flynn, Daniel L.
Published in Bioorganic & medicinal chemistry letters (15.10.2022)
Published in Bioorganic & medicinal chemistry letters (15.10.2022)
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The ABL switch control inhibitor DCC-2036 is active against the chronic myeloid leukemia mutant BCR-ABLT315I and exhibits a narrow resistance profile
Eide, Christopher A, Adrian, Lauren T, Tyner, Jeffrey W, Mac Partlin, Mary, Anderson, David J, Wise, Scott C, Smith, Bryan D, Petillo, Peter A, Flynn, Daniel L, Deininger, Michael W N, O'Hare, Thomas, Druker, Brian J
Published in Cancer research (Chicago, Ill.) (01.05.2011)
Published in Cancer research (Chicago, Ill.) (01.05.2011)
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Discovery of acyl ureas as highly selective small molecule CSF1R kinase inhibitors
Caldwell, Timothy M., Kaufman, Michael D., Wise, Scott C., Mi Ahn, Yu, Hood, Molly M., Lu, Wei-Ping, Patt, William C., Samarakoon, Thiwanka, Vogeti, Lakshminarayana, Vogeti, Subha, Yates, Karen M., Bulfer, Stacie L., Le Bourdonnec, Bertrand, Smith, Bryan D., Flynn, Daniel L.
Published in Bioorganic & medicinal chemistry letters (15.10.2022)
Published in Bioorganic & medicinal chemistry letters (15.10.2022)
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Journal Article
Conformational Control Inhibition of the BCR-ABL1 Tyrosine Kinase, Including the Gatekeeper T315I Mutant, by the Switch-Control Inhibitor DCC-2036
Chan, Wayne W., Wise, Scott C., Kaufman, Michael D., Ahn, Yu Mi, Ensinger, Carol L., Haack, Torsten, Hood, Molly M., Jones, Jennifer, Lord, John W., Lu, Wei Ping, Miller, David, Patt, William C., Smith, Bryan D., Petillo, Peter A., Rutkoski, Thomas J., Telikepalli, Hanumaiah, Vogeti, Lakshminarayana, Yao, Tony, Chun, Lawrence, Clark, Robin, Evangelista, Peter, Gavrilescu, L. Cristina, Lazarides, Katherine, Zaleskas, Virginia M., Stewart, Lance J., Van Etten, Richard A., Flynn, Daniel L.
Published in Cancer cell (12.04.2011)
Published in Cancer cell (12.04.2011)
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Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancer
Ghazi, Phaedra C, O'Toole, Kayla T, Srinivas Boggaram, Sanjana, Scherzer, Michael T, Silvis, Mark R, Zhang, Yun, Bogdan, Madhumita, Smith, Bryan D, Lozano, Guillermina, Flynn, Daniel L, Snyder, Eric L, Kinsey, Conan G, McMahon, Martin
Published in eLife (30.08.2024)
Published in eLife (30.08.2024)
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Discovery of 1‑(3,3-Dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3‑d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a Pan-RAF Inhibitor with Minimal Paradoxical Activation and Activity against BRAF or RAS Mutant Tumor Cells
Henry, James R, Kaufman, Michael D, Peng, Sheng-Bin, Ahn, Yu Mi, Caldwell, Timothy M, Vogeti, Lakshminarayana, Telikepalli, Hanumaiah, Lu, Wei-Ping, Hood, Molly M, Rutkoski, Thomas J, Smith, Bryan D, Vogeti, Subha, Miller, David, Wise, Scott C, Chun, Lawrence, Zhang, Xiaoyi, Zhang, Youyan, Kays, Lisa, Hipskind, Philip A, Wrobleski, Aaron D, Lobb, Karen L, Clay, Julia M, Cohen, Jeffrey D, Walgren, Jennie L, McCann, Denis, Patel, Phenil, Clawson, David K, Guo, Sherry, Manglicmot, Danalyn, Groshong, Chris, Logan, Cheyenne, Starling, James J, Flynn, Daniel L
Published in Journal of medicinal chemistry (28.05.2015)
Published in Journal of medicinal chemistry (28.05.2015)
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