Discovery of N‑(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)‑5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)‑2H‑tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis
Ruminski, Peter G, Massa, Mark, Strohbach, Joseph, Hanau, Cathleen E, Schmidt, Michelle, Scholten, Jeffrey A, Fletcher, Theresa R, Hamper, Bruce C, Carroll, Jeffery N, Shieh, Huey S, Caspers, Nicole, Collins, Brandon, Grapperhaus, Margaret, Palmquist, Katherine E, Collins, Joe, Baldus, John E, Hitchcock, Jeffrey, Kleine, H. Peter, Rogers, Michael D, McDonald, Joseph, Munie, Grace E, Messing, Dean M, Portolan, Silvia, Whiteley, Laurence O, Sunyer, Teresa, Schnute, Mark E
Published in Journal of medicinal chemistry (14.01.2016)
Published in Journal of medicinal chemistry (14.01.2016)
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Targeting bone marrow lymphoid niches in acute lymphoblastic leukemia
Uy, Geoffrey L, Hsu, Yen-Michael S, Schmidt, Amy P, Stock, Wendy, Fletcher, Theresa R, Trinkaus, Kathryn M, Westervelt, Peter, DiPersio, John F, Link, Daniel C
Published in Leukemia research (01.12.2015)
Published in Leukemia research (01.12.2015)
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MMP-13 selective isonipecotamide α-sulfone hydroxamates
Kolodziej, Stephen A., Hockerman, Susan L., DeCrescenzo, Gary A., McDonald, Joseph J., Mischke, Debbie A., Munie, Grace E., Fletcher, Theresa R., Stehle, Nathan, Swearingen, Craig, Becker, Daniel P.
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
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Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis
SCHNUTE, Mark E, O'BRIEN, Patrick M, CARROLL, Jeffery N, PATT, William C, SHIEH, Huey S, COLLINS, Brandon, PAVLOVSKY, Alexander G, PALMQUIST, Katherine E, ASTON, Karl W, HITCHCOCK, Jeffrey, ROGERS, Michael D, MCDONALD, Joseph, NAHRA, Joe, JOHNSON, Adam R, MUNIE, Grace E, WITTWER, Arthur J, MAN, Chiu-Fai, SETTLE, Steven L, NEMIROVSKIY, Olga, VICKERY, Lillian E, AGAWAL, Arun, DYER, Richard D, SUNYER, Teresa, MORRIS, Mark, HOWARD ROARK, W, HANAU, Cathleen E, RUMINSKI, Peter G, SCHOLTEN, Jeffrey A, FLETCHER, Theresa R, HAMPER, Bruce C
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Structure-based parallel medicinal chemistry approach to improve metabolic stability of benzopyran COX-2 inhibitors
Xing, Li, Hamper, Bruce C., Fletcher, Theresa R., Wendling, Jay M., Carter, Jeffery, Gierse, James K., Liao, Subo
Published in Bioorganic & medicinal chemistry letters (01.02.2011)
Published in Bioorganic & medicinal chemistry letters (01.02.2011)
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Orally bioavailable dual MMP-1/MMP-14 sparing, MMP-13 selective α-sulfone hydroxamates
Kolodziej, Stephen A., Hockerman, Susan L., Boehm, Terri L., Carroll, Jeffery N., DeCrescenzo, Gary A., McDonald, Joseph J., Mischke, Debbie A., Munie, Grace E., Fletcher, Theresa R., Rico, Joseph G., Stehle, Nathan W., Swearingen, Craig, Becker, Daniel P.
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
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A novel class of apical sodium co-dependent bile acid transporter inhibitors: The 1,2-benzothiazepines
TOLLEFSON, Michael B, KOLODZIEJ, Stephen A, FLETCHER, Theresa R, VERNIER, William F, BEAUDRY, Judith A, KELLER, Bradley T, REITZ, David B
Published in Bioorganic & medicinal chemistry letters (03.11.2003)
Published in Bioorganic & medicinal chemistry letters (03.11.2003)
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Discovery of N -(4-Fluoro-3-methoxybenzyl)-6-(2-(((2 S ,5 R )-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2 H -tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis
Ruminski, Peter G., Massa, Mark, Strohbach, Joseph, Hanau, Cathleen E., Schmidt, Michelle, Scholten, Jeffrey A., Fletcher, Theresa R., Hamper, Bruce C., Carroll, Jeffery N., Shieh, Huey S., Caspers, Nicole, Collins, Brandon, Grapperhaus, Margaret, Palmquist, Katherine E., Collins, Joe, Baldus, John E., Hitchcock, Jeffrey, Kleine, H. Peter, Rogers, Michael D., McDonald, Joseph, Munie, Grace E., Messing, Dean M., Portolan, Silvia, Whiteley, Laurence O., Sunyer, Teresa, Schnute, Mark E.
Published in Journal of medicinal chemistry (14.01.2016)
Published in Journal of medicinal chemistry (14.01.2016)
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PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS
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Year of Publication 03.05.2010
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Year of Publication 03.05.2010
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Discovery of (pyridin-4-yl)-2 H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis
Schnute, Mark E., O’Brien, Patrick M., Nahra, Joe, Morris, Mark, Howard Roark, W., Hanau, Cathleen E., Ruminski, Peter G., Scholten, Jeffrey A., Fletcher, Theresa R., Hamper, Bruce C., Carroll, Jeffery N., Patt, William C., Shieh, Huey S., Collins, Brandon, Pavlovsky, Alexander G., Palmquist, Katherine E., Aston, Karl W., Hitchcock, Jeffrey, Rogers, Michael D., McDonald, Joseph, Johnson, Adam R., Munie, Grace E., Wittwer, Arthur J., Man, Chiu-Fai, Settle, Steven L., Nemirovskiy, Olga, Vickery, Lillian E., Agawal, Arun, Dyer, Richard D., Sunyer, Teresa
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS
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Year of Publication 11.11.2010
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Year of Publication 11.11.2010
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CRICH, JOYCE, Z, FLETCHER, THERESA, R, BONAFOUX, DOMINIQUE, BERGMANIS, ARIJA, A, CLARE, MICHAEL
Year of Publication 21.08.2003
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Year of Publication 21.08.2003
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PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS
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Year of Publication 19.05.2010
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Year of Publication 27.03.2003
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Year of Publication 27.03.2003
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Year of Publication 05.02.2009
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