Identification of aryl dihydrouracil derivatives as palm initiation site inhibitors of HCV NS5B polymerase
Liu, Yaya, Lim, Ben Hock, Jiang, Wen W., Flentge, Charles A., Hutchinson, Douglas K., Madigan, Darold L., Randolph, John T., Wagner, Rolf, Maring, Clarence J., Kati, Warren M., Molla, Akhteruzzaman
Published in Bioorganic & medicinal chemistry letters (01.06.2012)
Published in Bioorganic & medicinal chemistry letters (01.06.2012)
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Discovery of fluorobenzimidazole HCV NS5A inhibitors
Randolph, John T., Flentge, Charles A., Donner, Pamela, Rockway, Todd W., Patel, Sachin V., Nelson, Lissa, Hutchinson, Douglas K., Mondal, Rubina, Mistry, Neeta, Reisch, Thomas, Dekhtyar, Tatyana, Krishnan, Preethi, Pilot-Matias, Tami, Stolarik, Deanne F., Beno, David W.A., Wagner, Rolf, Maring, Clarence, Kati, Warren M.
Published in Bioorganic & medicinal chemistry letters (15.11.2016)
Published in Bioorganic & medicinal chemistry letters (15.11.2016)
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Synthesis and Biological Characterization of B-Ring Amino Analogues of Potent Benzothiadiazine Hepatitis C Virus Polymerase Inhibitors
Randolph, John T, Flentge, Charles A, Huang, Peggy P, Hutchinson, Douglas K, Klein, Larry L, Lim, Hock B, Mondal, Rubina, Reisch, Thomas, Montgomery, Debra A, Jiang, Wen W, Masse, Sherie V, Hernandez, Lisa E, Henry, Rodger F, Liu, Yaya, Koev, Gennadiy, Kati, Warren M, Stewart, Kent D, Beno, David W. A, Molla, Akhteruzzaman, Kempf, Dale J
Published in Journal of medicinal chemistry (28.05.2009)
Published in Journal of medicinal chemistry (28.05.2009)
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Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: Synthesis and characterization of analogs with a fused 5,6-bicyclic ring motif
Krueger, A. Chris, Randolph, John T., DeGoey, David A., Donner, Pamela L., Flentge, Charles A., Hutchinson, Douglas K., Liu, Dachun, Motter, Christopher E., Rockway, Todd W., Wagner, Rolf, Beno, David W.A., Koev, Gennadiy, Lim, Hock B., Beyer, Jill M., Mondal, Rubina, Liu, Yaya, Kati, Warren M., Longenecker, Kenton L., Molla, Akhteruzzaman, Stewart, Kent D., Maring, Clarence J.
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
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Kv7 채널 활성제로서 피라졸로[1,5-a]피리딘-2,3-일 아미드
MARESKA DAVID A, HALE JAMES S, RESNICK LYNN, BELARDI JUSTIN K, FLENTGE CHARLES A, BOYD STEVEN A, TOPALOV GEORGE T
Year of Publication 03.09.2024
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Year of Publication 03.09.2024
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2-Pyridyl P1′-Substituted Symmetry-Based Human Immunodeficiency Virus Protease Inhibitors (A-792611 and A-790742) with Potential for Convenient Dosing and Reduced Side Effects
DeGoey, David A, Grampovnik, David J, Flentge, Charles A, Flosi, William J, Chen, Hui-ju, Yeung, Clinton M, Randolph, John T, Klein, Larry L, Dekhtyar, Tatyana, Colletti, Lynn, Marsh, Kennan C, Stoll, Vincent, Mamo, Mulugeta, Morfitt, David C, Nguyen, Bach, Schmidt, James M, Swanson, Sue J, Mo, Hongmei, Kati, Warren M, Molla, Akhteruzzaman, Kempf, Dale J
Published in Journal of medicinal chemistry (23.04.2009)
Published in Journal of medicinal chemistry (23.04.2009)
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Hepatitis C NS5B polymerase inhibitors: Functional equivalents for the benzothiadiazine moiety
Hutchinson, Douglas K., Flentge, Charles A., Donner, Pamela L., Wagner, Rolf, Maring, Clarence J., Kati, Warren M., Liu, Yaya, Masse, Sherie V., Middleton, Tim, Mo, Hongmei, Montgomery, Debra, Jiang, Wen W., Koev, Gennadiy, Beno, David W.A., Stewart, Kent D., Stoll, Vincent S., Molla, Akhteruzzaman, Kempf, Dale J.
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
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Synthesis and evaluation of inhibitors of cytochrome P450 3A (CYP3A) for pharmacokinetic enhancement of drugs
Flentge, Charles A., Randolph, John T., Huang, Peggy P., Klein, Larry L., Marsh, Kennan C., Harlan, John E., Kempf, Dale J.
Published in Bioorganic & medicinal chemistry letters (15.09.2009)
Published in Bioorganic & medicinal chemistry letters (15.09.2009)
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Discovery of Ritonavir, a Potent Inhibitor of HIV Protease with High Oral Bioavailability and Clinical Efficacy
Kempf, Dale J, Sham, Hing L, Marsh, Kennan C, Flentge, Charles A, Betebenner, David, Green, Brian E, McDonald, Edith, Vasavanonda, Sudthida, Saldivar, Ayda, Wideburg, Norman E, Kati, Warren M, Ruiz, Lisa, Zhao, Chen, Fino, LynnMarie, Patterson, Jean, Molla, Akhteruzzaman, Plattner, Jacob J, Norbeck, Daniel W
Published in Journal of medicinal chemistry (12.02.1998)
Published in Journal of medicinal chemistry (12.02.1998)
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Oximinoarylsulfonamides as potent HIV protease inhibitors
Yeung, Clinton M., Klein, Larry L., Flentge, Charles A., Randolph, John T., Zhao, Chen, Sun, MingHua, Dekhtyar, Tatyana, Stoll, Vincent S., Kempf, Dale J.
Published in Bioorganic & medicinal chemistry letters (02.05.2005)
Published in Bioorganic & medicinal chemistry letters (02.05.2005)
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KV7 채널 활성화제 조성물 및 이의 사용 방법
MARESKA DAVID A, HALE JAMES S, HARRIED SCOTT S, RESNICK LYNN, BOZIK MICHAEL E, BELARDI JUSTIN K, FLENTGE CHARLES A, TOPALOV GEORGE T
Year of Publication 26.11.2020
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Year of Publication 26.11.2020
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ANTI-VIRAL COMPOUNDS
ALLAN C KRUEGER, BETEBENNER DAVID A, HUTCHINSON DOUGLAS K, ROCKWAY TODD W, JEAN C CALIFANO, FLENTGE CHARLES A, CHARLES W HUTCHINS, SARRIS KATHY, GAO YI, DEGOEY DAVID A, KATI WARREN M, KEDDY RYAN G, MATULENKO MARK A, TAMMIE K JINKERSON, MARING CLARENCE J, DONNER PAMELA L, PRATT JOHN K, NELSON LISSA T, WAGNER ROLF, SACHIN V PATEL, WAGAW SABLE H, RANDOLPH JOHN T, TUFANO MICHAEL D, WILLIAM A CARROLL, MOTTER CHRISTOPHER E, LIU DACHUN, DANIEL D CASPI, LI WENKE, BELLIZZI MARY E, KEVIN R WOLLER
Year of Publication 04.03.2021
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Year of Publication 04.03.2021
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ALLAN C KRUEGER, BETEBENNER DAVID A, HUTCHINSON DOUGLAS K, ROCKWAY TODD W, JEAN C CALIFANO, FLENTGE CHARLES A, CHARLES W HUTCHINS, SARRIS KATHY, GAO YI, DEGOEY DAVID A, KATI WARREN M, KEDDY RYAN G, MATULENKO MARK A, TAMMIE K JINKERSON, MARING CLARENCE J, DONNER PAMELA L, PRATT JOHN K, NELSON LISSA T, WAGNER ROLF, SACHIN V PATEL, WAGAW SABLE H, RANDOLPH JOHN T, TUFANO MICHAEL D, WILLIAM A CARROLL, MOTTER CHRISTOPHER E, LIU DACHUN, DANIEL D CASPI, LI WENKE, BELLIZZI MARY E, KEVIN R WOLLER
Year of Publication 16.04.2020
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Year of Publication 16.04.2020
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ANTI-VIRAL COMPOUNDS FOR TREATING HCV INFECTION
ALLAN C KRUEGER, BETEBENNER DAVID A, HUTCHINSON DOUGLAS K, ROCKWAY TODD W, JEAN C CALIFANO, FLENTGE CHARLES A, CHARLES W HUTCHINS, SARRIS KATHY, GAO YI, DEGOEY DAVID A, KATI WARREN M, KEDDY RYAN G, MATULENKO MARK A, TAMMIE K JINKERSON, MARING CLARENCE J, DONNER PAMELA L, PRATT JOHN K, NELSON LISSA T, WAGNER ROLF, SACHIN V PATEL, WAGAW SABLE H, RANDOLPH JOHN T, TUFANO MICHAEL D, MOTTER CHRISTOPHER E, LIU DACHUN, DANIEL D CASPI, LI WENKE, BELLIZZI MARY E, KEVIN R WOLLER
Year of Publication 07.11.2019
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Year of Publication 07.11.2019
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ALLAN C KRUEGER, BETEBENNER DAVID A, HUTCHINSON DOUGLAS K, ROCKWAY TODD W, JEAN C CALIFANO, FLENTGE CHARLES A, CHARLES W HUTCHINS, SARRIS KATHY, GAO YI, DEGOEY DAVID A, KATI WARREN M, KEDDY RYAN G, MATULENKO MARK A, TAMMIE K JINKERSON, MARING CLARENCE J, DONNER PAMELA L, PRATT JOHN K, NELSON LISSA T, WAGNER ROLF, SACHIN V PATEL, WAGAW SABLE H, RANDOLPH JOHN T, TUFANO MICHAEL D, WILLIAM A CARROLL, MOTTER CHRISTOPHER E, LIU DACHUN, DANIEL D CASPI, LI WENKE, BELLIZZI MARY E, KEVIN R WOLLER
Year of Publication 26.04.2018
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Year of Publication 26.04.2018
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HUTCHINS CHARLES W, WOLLER KEVIN R, WAGAW SEBEL H, BETEBENNER DAVID A, HUTCHINSON DOUGLAS K, ROCKWAY TODD W, FLENTGE CHARLES A, JINKERSON TAMMIE K, SARRIS KATHY, GAO YI, DEGOEY DAVID A, KATI WARREN M, KEDDY RYAN G, MATULENKO MARK A, CALIFANO JEAN C, CASPI DANIEL D, MARING CLARENCE J, DONNER PAMELA L, PRATT JOHN K, NELSON LISSA T, WAGNER ROLF, RANDOLPH JOHN T, CARROLL WILLIAM A, TUFANO MICHAEL D, KRUEGER ALLAN C, MOTTER CHRISTOPHER E, LIU DACHUN, PATEL SACHEL V, LI WENKE, BELLIZZI MARY E
Year of Publication 13.03.2018
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Year of Publication 13.03.2018
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ANTI-VIRAL COMPOUNDS TO TREAT HCV INFECTION
ALLAN C KRUEGER, BETEBENNER DAVID A, HUTCHINSON DOUGLAS K, ROCKWAY TODD W, JEAN C CALIFANO, FLENTGE CHARLES A, CHARLES W HUTCHINS, SARRIS KATHY, GAO YI, DEGOEY DAVID A, KATI WARREN M, KEDDY RYAN G, MATULENKO MARK A, TAMMIE K JINKERSON, MARING CLARENCE J, DONNER PAMELA L, PRATT JOHN K, NELSON LISSA T, WAGNER ROLF, SACHIN V PATEL, WAGAW SABLE H, RANDOLPH JOHN T, TUFANO MICHAEL D, MOTTER CHRISTOPHER E, LIU DACHUN, DANIEL D CASPI, LI WENKE, BELLIZZI MARY E, KEVIN R WOLLER
Year of Publication 28.09.2017
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Year of Publication 28.09.2017
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ANTI-VIRAL COMPOUNDS FOR TREATING HCV INFECTION
ALLAN C KRUEGER, BETEBENNER DAVID A, HUTCHINSON DOUGLAS K, ROCKWAY TODD W, JEAN C CALIFANO, FLENTGE CHARLES A, CHARLES W HUTCHINS, SARRIS KATHY, GAO YI, DEGOEY DAVID A, KATI WARREN M, KEDDY RYAN G, MATULENKO MARK A, TAMMIE K JINKERSON, MARING CLARENCE J, DONNER PAMELA L, PRATT JOHN K, NELSON LISSA T, WAGNER ROLF, SACHIN V PATEL, WAGAW SABLE H, RANDOLPH JOHN T, TUFANO MICHAEL D, MOTTER CHRISTOPHER E, LIU DACHUN, DANIEL D CASPI, LI WENKE, BELLIZZI MARY E, KEVIN R WOLLER
Year of Publication 14.07.2016
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Year of Publication 14.07.2016
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ANTI-VIRUS COMPOUND
ALLAN C KRUEGER, BETEBENNER DAVID A, HUTCHINSON DOUGLAS K, ROCKWAY TODD W, JEAN C CALIFANO, FLENTGE CHARLES A, CHARLES W HUTCHINS, SARRIS KATHY, GAO YI, DEGOEY DAVID A, KATI WARREN M, KEDDY RYAN G, MATULENKO MARK A, TAMMIE K JINKERSON, MARING CLARENCE J, DONNER PAMELA L, PRATT JOHN K, NELSON LISSA T, WAGNER ROLF, SACHIN V PATEL, WAGAW SABLE H, RANDOLPH JOHN T, TUFANO MICHAEL D, WILLIAM A CARROLL, MOTTER CHRISTOPHER E, LIU DACHUN, DANIEL D CASPI, LI WENKE, BELLIZZI MARY E, KEVIN R WOLLER
Year of Publication 16.06.2016
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Year of Publication 16.06.2016
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LIU YAYA, ALLAN C KRUEGER, LOU XIAOCHUN, BETEBENNER DAVID A, HUTCHINSON DOUGLAS K, FRANCZYK II THADDEUS S, ROCKWAY TODD W, FLENTGE CHARLES A, GAO YI, DEGOEY DAVID A, KATI WARREN M, MARING CLARENCE J, BARNES DAVID M, DONNER PAMELA L, PRATT JOHN K, CHEN SHUANG, WAGNER ROLF, HENGEVELD JOHN E, ZHANG GEOFF G Z, RANDOLPH JOHN T, KENT D STEWART, LIU DACHUN, MOTTER CHRISTOPHER E, KOTECKI BRIAN J, KENTON L LONGENECKER, HAIGHT ANTHONY R
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Year of Publication 29.10.2015
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