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Junutula, Jagath R, Mallet, William, Raab, Helga, Clark, Suzanna, Bhakta, Sunil, Leipold, Douglas D, Weir, Sylvia, Chen, Yvonne, Simpson, Michelle, Tsai, Siao Ping, Dennis, Mark S, Lu, Yanmei, Meng, Y Gloria, Ng, Carl, Yang, Jihong, Lee, Chien C, Duenas, Eileen, Gorrell, Jeffrey, Katta, Viswanatham, Kim, Amy, McDorman, Kevin, Flagella, Kelly, Venook, Rayna, Ross, Sarajane, Spencer, Susan D, Lee Wong, Wai, Lowman, Henry B, Vandlen, Richard, Sliwkowski, Mark X, Scheller, Richard H, Polakis, Paul
Published in Nature biotechnology (01.08.2008)
Published in Nature biotechnology (01.08.2008)
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Engineered Thio-Trastuzumab-DM1 Conjugate with an Improved Therapeutic Index to Target Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer
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Published in Clinical cancer research (01.10.2010)
Published in Clinical cancer research (01.10.2010)
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Humanization of a recombinant monoclonal antibody to produce a therapeutic HER dimerization inhibitor, pertuzumab
ADAMS, Camellia W, ALLISON, David E, FLAGELLA, Kelly, PRESTA, Leonard, CLARKE, Janet, DYBDAL, Noel, MCKEEVER, Kathleen, SLIWKOWSKI, Mark X
Published in Cancer Immunology, Immunotherapy (01.06.2006)
Published in Cancer Immunology, Immunotherapy (01.06.2006)
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Considerations for the nonclinical safety evaluation of antibody drug conjugates for oncology
Roberts, Stanley A., Andrews, Paul A., Blanset, Diann, Flagella, Kelly M., Gorovits, Boris, Lynch, Carmel M., Martin, Pauline L., Kramer-Stickland, Kimberly, Thibault, Stephane, Warner, Garvin
Published in Regulatory toxicology and pharmacology (01.12.2013)
Published in Regulatory toxicology and pharmacology (01.12.2013)
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Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates
Shen, Ben-Quan, Xu, Keyang, Liu, Luna, Raab, Helga, Bhakta, Sunil, Kenrick, Margaret, Parsons-Reponte, Kathryn L, Tien, Janet, Yu, Shang-Fan, Mai, Elaine, Li, Dongwei, Tibbitts, Jay, Baudys, Jakub, Saad, Ola M, Scales, Suzie J, McDonald, Paul J, Hass, Philip E, Eigenbrot, Charles, Nguyen, Trung, Solis, Willy A, Fuji, Reina N, Flagella, Kelly M, Patel, Darshana, Spencer, Susan D, Khawli, Leslie A, Ebens, Allen, Wong, Wai Lee, Vandlen, Richard, Kaur, Surinder, Sliwkowski, Mark X, Scheller, Richard H, Polakis, Paul, Junutula, Jagath R
Published in Nature biotechnology (01.02.2012)
Published in Nature biotechnology (01.02.2012)
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Toxicogenomics and cancer risk assessment: A framework for key event analysis and dose–response assessment for nongenotoxic carcinogens
Bercu, Joel P., Jolly, Robert A., Flagella, Kelly M., Baker, Thomas K., Romero, Pedro, Stevens, James L.
Published in Regulatory toxicology and pharmacology (01.12.2010)
Published in Regulatory toxicology and pharmacology (01.12.2010)
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Preclinical safety profile of trastuzumab emtansine (T-DM1): Mechanism of action of its cytotoxic component retained with improved tolerability
Poon, Kirsten Achilles, Flagella, Kelly, Beyer, Joseph, Tibbitts, Jay, Kaur, Surinder, Saad, Ola, Yi, Joo-Hee, Girish, Sandhya, Dybdal, Noel, Reynolds, Theresa
Published in Toxicology and applied pharmacology (01.12.2013)
Published in Toxicology and applied pharmacology (01.12.2013)
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Targeting LGR5+ cells with an antibody-drug conjugate for the treatment of colon cancer
Junttila, Melissa R, Mao, Weiguang, Wang, Xi, Wang, Bu-Er, Pham, Thinh, Flygare, John, Yu, Shang-Fan, Yee, Sharon, Goldenberg, David, Fields, Carter, Eastham-Anderson, Jeffrey, Singh, Mallika, Vij, Rajesh, Hongo, Jo-Anne, Firestein, Ron, Schutten, Melissa, Flagella, Kelly, Polakis, Paul, Polson, Andrew G
Published in Science translational medicine (18.11.2015)
Published in Science translational medicine (18.11.2015)
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New challenges and opportunities in nonclinical safety testing of biologics
Baumann, Andreas, Flagella, Kelly, Forster, Roy, de Haan, Lolke, Kronenberg, Sven, Locher, Mathias, Richter, Wolfgang F., Theil, Frank-Peter, Todd, Marque
Published in Regulatory toxicology and pharmacology (01.07.2014)
Published in Regulatory toxicology and pharmacology (01.07.2014)
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Abstract 4396: Conjugation site modulates the stability and biological activity of antibody drug conjugates
Shen, Ben-Quan, Xu, Keyang, Liu, Luna, Parsons, Kathryn, Bhakta, Sunil, Raab, Helga, Flagella, Kelly, Spencer, Susan D., Kaur, Surinder, Scheller, Richard H., Sliwkowski, Mark X., Polakis, Paul, Junutula, Jagath Reddy
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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