Identification of a Nonsteroidal Liver X Receptor Agonist through Parallel Array Synthesis of Tertiary Amines
Collins, Jon L, Fivush, Adam M, Watson, Michael A, Galardi, Cristin M, Lewis, Michael C, Moore, Linda B, Parks, Derek J, Wilson, Joan G, Tippin, Tim K, Binz, Jane G, Plunket, Kelli D, Morgan, Daniel G, Beaudet, Elizabeth J, Whitney, Karl D, Kliewer, Steven A, Willson, Timothy M
Published in Journal of medicinal chemistry (09.05.2002)
Published in Journal of medicinal chemistry (09.05.2002)
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Journal Article
Identification of a Chemical Tool for the Orphan Nuclear Receptor FXR
Maloney, Patrick R, Parks, Derek J, Haffner, Curt D, Fivush, Adam M, Chandra, Gyan, Plunket, Kelli D, Creech, Katrina L, Moore, Linda B, Wilson, Joan G, Lewis, Michael C, Jones, Stacey A, Willson, Timothy M
Published in Journal of medicinal chemistry (10.08.2000)
Published in Journal of medicinal chemistry (10.08.2000)
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Journal Article
Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression
Dressman, Bruce A., Tromiczak, Eric G., Chappell, Mark D., Tripp, Allie E., Quimby, Steven J., Vetman, Tatiana, Fivush, Adam M., Matt, James, Jaramillo, Carlos, Li, Renhua, Khilevich, Albert, Blanco, Maria-Jesus, Smith, Stephon C., Carpintero, Mercedes, de Diego, José Eugenio, Barberis, Mario, García-Cerrada, Susana, Soriano, José F., Schkeryantz, Jeffrey M., Witkin, Jeffrey M., Wafford, Keith A., Seidel, Wesley, Britton, Thomas, Overshiner, Carl D., Li, Xia, Wang, Xu-Shan, Heinz, Beverly A., Catlow, John T., Swanson, Steven, Bedwell, David, Ornstein, Paul L., Mitch, Charles H.
Published in Bioorganic & medicinal chemistry letters (01.12.2016)
Published in Bioorganic & medicinal chemistry letters (01.12.2016)
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Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator
Hao, Junliang, Dehlinger, Veronique, Fivush, Adam M., Rudyk, Helene C.E., Britton, Thomas C., Hollinshead, Sean P., Vokits, Benjamin P., Clark, Barry P., Henry, Steven S., Massey, Steven M., Peng, Langu, Dressman, Bruce A., Heinz, Beverly A., Roberts, Edda F., Bracey-Walker, Mallorie R., Swanson, Steven, Catlow, John T., Love, Patrick L., Tepool, Anita D., Peters, Steven C., Simmons, Rosa Maria A., Iyengar, Smriti, McKinzie, David L., Monn, James A.
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
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Journal Article
In vitro characterisation of the novel positive allosteric modulators of the mGlu5 receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat
Gilmour, Gary, Broad, Lisa M., Wafford, Keith A., Britton, Thomas, Colvin, Ellen M., Fivush, Adam, Gastambide, Francois, Getman, Brian, Heinz, Beverly A., McCarthy, Andrew P., Prieto, Lourdes, Shanks, Elaine, Smith, Janice W., Taboada, Lorena, Edgar, Dale M., Tricklebank, Mark D.
Published in Neuropharmacology (01.01.2013)
Published in Neuropharmacology (01.01.2013)
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Journal Article
Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ)—synthesis and biological activity
Sznaidman, Marcos L., Haffner, Curt D., Maloney, Patrick R., Fivush, Adam, Chao, Esther, Goreham, Donna, Sierra, Michael L., LeGrumelec, Christelle, Xu, H.Eric, Montana, Valerie G., Lambert, Millard H., Willson, Timothy M., Oliver, William R., Sternbach, Daniel D.
Published in Bioorganic & medicinal chemistry letters (05.05.2003)
Published in Bioorganic & medicinal chemistry letters (05.05.2003)
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Journal Article
3-INDAZOLYL-4-PYRIDYLISOTHIAZOLES
HOLLINSHEAD SEAN PATRICK, BRITTON THOMAS CHARLES, DEHLINGER VERONIQUE, VOKITS BENJAMIN PAUL, FIVUSH ADAM MICHAEL
Year of Publication 08.11.2010
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Year of Publication 08.11.2010
Patent
3-INDAZOLYL-4-PYRIDYLISOTHIAZOLE
FIVUSH, ADAM, HOLLINSHEAD, SEAN, VOKITS, BENJAMIN, DEHLINGER, VERONIQUE, BRITTON, THOMAS
Year of Publication 15.11.2011
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Year of Publication 15.11.2011
Patent
3-indazolyl-4-pyridylisothiazoles
BRITTON, THOMAS CHARLES, HOLLINSHEAD, SEAN PATRICK, DEHLINGER, VERONIQUE, FIVUSH, ADAM MICHAEL, VOKITS, BENJAMIN PAUL
Year of Publication 04.07.2013
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Year of Publication 04.07.2013
Patent
3-INDAZOLYL-4-PYRIDYLISOTHIAZOLES
BRITTON, THOMAS CHARLES, HOLLINSHEAD, SEAN PATRICK, DEHLINGER, VERONIQUE, FIVUSH, ADAM MICHAEL, VOKITS, BENJAMIN PAUL
Year of Publication 28.08.2012
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Year of Publication 28.08.2012
Patent
3-INDAZOLYL-4-PYRIDYLISOTHIAZOLES
BRITTON, THOMAS CHARLES, HOLLINSHEAD, SEAN PATRICK, DEHLINGER, VERONIQUE, FIVUSH, ADAM MICHAEL, VOKITS, BENJAMIN PAUL
Year of Publication 30.03.2012
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Year of Publication 30.03.2012
Patent
3-INDAZOLYL-4-PYRIDYLISOTHIAZOLES
HOLLINSHEAD SEAN PATRICK, BRITTON THOMAS CHARLES, DEHLINGER VERONIQUE, VOKITS BENJAMIN PAUL, FIVUSH ADAM MICHAEL
Year of Publication 29.02.2012
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Year of Publication 29.02.2012
Patent