Studies directed toward the synthesis of nakadomarin A
Haimowitz, Thomas, Fitzgerald, Mark E., Winkler, Jeffrey D.
Published in Tetrahedron letters (27.04.2011)
Published in Tetrahedron letters (27.04.2011)
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Journal Article
MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells
Kryukov, Gregory V., Wilson, Frederick H., Ruth, Jason R., Paulk, Joshiawa, Tsherniak, Aviad, Marlow, Sara E., Vazquez, Francisca, Weir, Barbara A., Fitzgerald, Mark E., Tanaka, Minoru, Bielski, Craig M., Scott, Justin M., Dennis, Courtney, Cowley, Glenn S., Boehm, Jesse S., Root, David E., Golub, Todd R., Clish, Clary B., Bradner, James E., Hahn, William C., Garraway, Levi A.
Published in Science (American Association for the Advancement of Science) (11.03.2016)
Published in Science (American Association for the Advancement of Science) (11.03.2016)
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Structural Characterization of Degrader-Induced Ternary Complexes Using Hydrogen–Deuterium Exchange Mass Spectrometry and Computational Modeling: Implications for Structure-Based Design
Eron, Scott J, Huang, Hongwei, Agafonov, Roman V, Fitzgerald, Mark E, Patel, Joe, Michael, Ryan E, Lee, Tobie D, Hart, Ashley A, Shaulsky, Jodi, Nasveschuk, Christopher G, Phillips, Andrew J, Fisher, Stewart L, Good, Andrew
Published in ACS chemical biology (19.11.2021)
Published in ACS chemical biology (19.11.2021)
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Journal Article
Evaluation of the Small-molecule BRD4 Degrader CFT-2718 in Small-cell Lung Cancer and Pancreatic Cancer Models
Sun, Danlin, Nikonova, Anna S, Zhang, Peishan, Deneka, Alexander Y, Fitzgerald, Mark E, Michael, Ryan E, Lee, Linda, Lilly, Anna C, Fisher, Stewart L, Phillips, Andrew J, Nasveschuk, Christopher G, Proia, David A, Tu, Zhigang, Golemis, Erica A
Published in Molecular cancer therapeutics (01.08.2021)
Published in Molecular cancer therapeutics (01.08.2021)
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Diversity-Oriented Synthesis Probe Targets Plasmodium falciparum Cytochrome b Ubiquinone Reduction Site and Synergizes With Oxidation Site Inhibitors
Lukens, Amanda K., Heidebrecht, Richard W., Mulrooney, Carol, Beaudoin, Jennifer A., Comer, Eamon, Duvall, Jeremy R., Fitzgerald, Mark E., Masi, Daniela, Galinsky, Kevin, Scherer, Christina A., Palmer, Michelle, Munoz, Benito, Foley, Michael, Schreiber, Stuart L., Wiegand, Roger C., Wirth, Dyann F.
Published in The Journal of infectious diseases (01.04.2015)
Published in The Journal of infectious diseases (01.04.2015)
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Diversity-Oriented Synthesis-Facilitated Medicinal Chemistry: Toward the Development of Novel Antimalarial Agents
Comer, Eamon, Beaudoin, Jennifer A, Kato, Nobutaka, Fitzgerald, Mark E, Heidebrecht, Richard W, Lee, Maurice duPont, Masi, Daniela, Mercier, Marion, Mulrooney, Carol, Muncipinto, Giovanni, Rowley, Ann, Crespo-Llado, Keila, Serrano, Adelfa E, Lukens, Amanda K, Wiegand, Roger C, Wirth, Dyann F, Palmer, Michelle A, Foley, Michael A, Munoz, Benito, Scherer, Christina A, Duvall, Jeremy R, Schreiber, Stuart L
Published in Journal of medicinal chemistry (23.10.2014)
Published in Journal of medicinal chemistry (23.10.2014)
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Journal Article
Assessment of Bromodomain Target Engagement by a Series of BI2536 Analogues with Miniaturized BET-BRET
Koblan, Luke W., Buckley, Dennis L., Ott, Christopher J., Fitzgerald, Mark E., Ember, Stuart W. J., Zhu, Jin-Yi, Liu, Shuai, Roberts, Justin M., Remillard, David, Vittori, Sarah, Zhang, Wei, Schonbrunn, Ernst, Bradner, James E.
Published in ChemMedChem (06.12.2016)
Published in ChemMedChem (06.12.2016)
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Build/Couple/Pair Strategy for the Synthesis of Stereochemically Diverse Macrolactams via Head-to-Tail Cyclization
Fitzgerald, Mark E, Mulrooney, Carol A, Duvall, Jeremy R, Wei, Jingqiang, Suh, Byung-Chul, Akella, Lakshmi B, Vrcic, Anita, Marcaurelle, Lisa A
Published in ACS combinatorial science (13.02.2012)
Published in ACS combinatorial science (13.02.2012)
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Journal Article
Synthesis of Stereochemically and Skeletally Diverse Fused Ring Systems from Functionalized C‑Glycosides
Gerard, Baudouin, Lee, Maurice D, Dandapani, Sivaraman, Duvall, Jeremy R, Fitzgerald, Mark E, Kesavan, Sarathy, Lowe, Jason T, Marié, Jean-Charles, Pandya, Bhaumik A, Suh, Byung-Chul, O’Shea, Morgan Welzel, Dombrowski, Michael, Hamann, Diane, Lemercier, Berenice, Murillo, Tiffanie, Akella, Lakshmi B, Foley, Michael A, Marcaurelle, Lisa A
Published in Journal of organic chemistry (07.06.2013)
Published in Journal of organic chemistry (07.06.2013)
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Journal Article
Back Cover: Assessment of Bromodomain Target Engagement by a Series of BI2536 Analogues with Miniaturized BET-BRET (ChemMedChem 23/2016)
Koblan, Luke W., Buckley, Dennis L., Ott, Christopher J., Fitzgerald, Mark E., Ember, Stuart W. J., Zhu, Jin-Yi, Liu, Shuai, Roberts, Justin M., Remillard, David, Vittori, Sarah, Zhang, Wei, Schonbrunn, Ernst, Bradner, James E.
Published in ChemMedChem (06.12.2016)
Published in ChemMedChem (06.12.2016)
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Journal Article
Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria
Heidebrecht, Richard W, Mulrooney, Carol, Austin, Christopher P, Barker, Robert H, Beaudoin, Jennifer A, Cheng, Ken Chih-Chien, Comer, Eamon, Dandapani, Sivaraman, Dick, Justin, Duvall, Jeremy R, Ekland, Eric H, Fidock, David A, Fitzgerald, Mark E, Foley, Michael, Guha, Rajarshi, Hinkson, Paul, Kramer, Martin, Lukens, Amanda K, Masi, Daniela, Marcaurelle, Lisa A, Su, Xin-Zhuan, Thomas, Craig J, Weïwer, Michel, Wiegand, Roger C, Wirth, Dyann, Xia, Menghang, Yuan, Jing, Zhao, Jinghua, Palmer, Michelle, Munoz, Benito, Schreiber, Stuart
Published in ACS medicinal chemistry letters (09.02.2012)
Published in ACS medicinal chemistry letters (09.02.2012)
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Journal Article
Identification of Highly Specific Diversity-Oriented Synthesis-Derived Inhibitors of Clostridium difficile
Duvall, Jeremy R, Bedard, Leanne, Naylor-Olsen, Adel M, Manson, Abigail L, Bittker, Joshua A, Sun, Wenye, Fitzgerald, Mark E, He, Zhenmin, Lee, Maurice D, Marie, Jean-Charles, Muncipinto, Giovanni, Rush, Diane, Xu, Deming, Xu, Huisheng, Zhang, Mingliang, Earl, Ashlee M, Palmer, Michelle A, Foley, Michael A, Vacca, Joseph P, Scherer, Christina A
Published in ACS infectious diseases (12.05.2017)
Published in ACS infectious diseases (12.05.2017)
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돌연변이 BRAF의 분해를 위한 요법
JACKSON KATRINA L, VEITS GESINE KERSTIN, PETTAZZONI PIERGIORGIO FRANCESO TOMMASO, FITZGERALD MARK E, HEWING DAVID STEPHEN, HUNZIKER DANIEL, DOLENTE COSIMO, GARZA VICTORIA, WICHMANN JUERGEN, YU ROBERT T, DUPLESSIS MARTIN, O'SHEA MORGAN WELZEL, NASVESCHUK CHRISTOPHER G, KRUMMENACHER DANIELA, LIANG YANKE, GOOD ANDREW CHARLES
Year of Publication 13.02.2024
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Year of Publication 13.02.2024
Patent
BRAF 분해제
JACKSON KATRINA L, PETTAZZONI PIERGIORGIO FRANCESCO TOMMASO, VEITS GESINE KERSTIN, MOUSTAKIM MOSES, FITZGERALD MARK E, KUHN BERND, HUNZIKER DANIEL, DOLENTE COSIMO, GARZA VICTORIA, HEWINGS DAVID STEPHEN, WICHMANN JUERGEN, DUPLESSIS MARTIN, O'SHEA MORGAN WELZEL, YU ROBERT T, NASVESCHUK CHRISTOPHER G, RIEMER CLAUS, YAP JEREMY L, RICKLIN FABIENNE, LIANG YANKE, GOOD ANDREW CHARLES
Year of Publication 23.03.2023
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Year of Publication 23.03.2023
Patent
Abstract 1949: In vivo profiling of BET degraders establishes optimal pharmacological properties that showcase distinct biological differences from BET inhibitors
Ladd, Brendon, Cocozziello, David, Fitzgerald, Mark E., Michael, Ryan E., Vieux, Ellen F., Lee, Linda, Issa, Marta, Feala, Jacob D., Agafonov, Roman V., Park, Eun Sun, Nasveschuk, Christopher G., Proia, David A.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
MTAP deletion confers enhanced dependency on the arginine methyltransferase PRMT5 in human cancer cells
Kryukov, Gregory V, Wilson, Frederick H, Ruth, Jason R, Paulk, Joshiawa, Tsherniak, Aviad, Marlow, Sara E, Vazquez, Francisca, Weir, Barbara A, Fitzgerald, Mark E, Tanaka, Minoru, Bielski, Craig M, Scott, Justin M, Dennis, Courtney, Cowley, Glenn S, Boehm, Jesse S, Root, David E, Golub, Todd R, Clish, Clary B, Bradner, James E, Hahn, William C, Garraway, Levi A
Published in Science (American Association for the Advancement of Science) (11.02.2016)
Published in Science (American Association for the Advancement of Science) (11.02.2016)
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Journal Article
DEGRADER COMPOUNDS AND USES THEREOF
FITZGERALD, Mark E, HIRD, Alexander W, KORT, Michael E, SWEIS, Ramzi F, VEITS, Gesine Kerstin
Year of Publication 01.05.2024
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Year of Publication 01.05.2024
Patent
DEGRADER COMPOUNDS AND USES THEREOF
FITZGERALD, Mark E, HIRD, Alexander W, KORT, Michael E, SWEIS, Ramzi F, VEITS, Gesine Kerstin
Year of Publication 01.02.2024
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Year of Publication 01.02.2024
Patent