Discovery of Selective RNA-Binding Small Molecules by Affinity-Selection Mass Spectrometry
Rizvi, Noreen F, Howe, John A, Nahvi, Ali, Klein, Daniel J, Fischmann, Thierry O, Kim, Hai-Young, McCoy, Mark A, Walker, Scott S, Hruza, Alan, Richards, Matthew P, Chamberlin, Chad, Saradjian, Peter, Butko, Margaret T, Mercado, Gabriel, Burchard, Julja, Strickland, Corey, Dandliker, Peter J, Smith, Graham F, Nickbarg, Elliott B
Published in ACS chemical biology (16.03.2018)
Published in ACS chemical biology (16.03.2018)
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Journal Article
Atomic resolution mechanistic studies of ribocil: A highly selective unnatural ligand mimic of the E. coli FMN riboswitch
Howe, John A., Xiao, Li, Fischmann, Thierry O., Wang, Hao, Tang, Haifeng, Villafania, Artjohn, Zhang, Rumin, Barbieri, Christopher M., Roemer, Terry
Published in RNA biology (02.10.2016)
Published in RNA biology (02.10.2016)
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Journal Article
Structural basis of CX-4945 binding to human protein kinase CK2
Ferguson, Andrew D., Sheth, Payal R., Basso, Andrea D., Paliwal, Sunil, Gray, Kimberly, Fischmann, Thierry O., Le, Hung V.
Published in FEBS letters (03.01.2011)
Published in FEBS letters (03.01.2011)
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Journal Article
Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases
Kleiner, Victoria A, O Fischmann, Thierry, Howe, John A, Beshore, Douglas C, Eddins, Michael J, Hou, Yan, Mayhood, Todd, Klein, Daniel, Nahas, Debbie D, Lucas, Bob J, Xi, He, Murray, Edward, Ma, Daphne Y, Getty, Krista, Fearns, Rachel
Published in Communications biology (19.06.2023)
Published in Communications biology (19.06.2023)
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Journal Article
Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach—Part 1
Dwyer, Michael P., Paruch, Kamil, Labroli, Marc, Alvarez, Carmen, Keertikar, Kerry M., Poker, Cory, Rossman, Randall, Fischmann, Thierry O., Duca, Jose S., Madison, Vincent, Parry, David, Davis, Nicole, Seghezzi, Wolfgang, Wiswell, Derek, Guzi, Timothy J.
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Journal Article
Structural insights into selective small molecule activation of PKG1α
Metwally, Essam, Mak, Victor, Soriano, Aileen, Zebisch, Matthias, Silvestre, H Leonardo, McEwan, Paul A, Ermakov, Grigori, Beaumont, Maribel, Tawa, Paul, Barker, John J, Yen, Rose, Patel, Akash, Lim, Yeon-Hee, Healy, David, Hanisak, Jennifer, Cheng, Alan C, Greshock, Tom, Fischmann, Thierry O
Published in Communications biology (31.07.2023)
Published in Communications biology (31.07.2023)
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Journal Article
Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach—Part 2
Labroli, Marc, Paruch, Kamil, Dwyer, Michael P., Alvarez, Carmen, Keertikar, Kartik, Poker, Cory, Rossman, Randall, Duca, Jose S., Fischmann, Thierry O., Madison, Vincent, Parry, David, Davis, Nicole, Seghezzi, Wolfgang, Wiswell, Derek, Guzi, Timothy J.
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Journal Article
Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors
Seganish, W. Michael, Fischmann, Thierry O, Sherborne, Brad, Matasi, Julius, Lavey, Brian, McElroy, William T, Tulshian, Deen, Tata, James, Sondey, Christopher, Garlisi, Charles G, Devito, Kristine, Fossetta, James, Lundell, Daniel, Niu, Xiaoda
Published in ACS medicinal chemistry letters (13.08.2015)
Published in ACS medicinal chemistry letters (13.08.2015)
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Journal Article
Structure-guided discovery of cyclin-dependent kinase inhibitors
Fischmann, Thierry O., Hruza, Alan, Duca, José S., Ramanathan, Lata, Mayhood, Todd, Windsor, William T., Le, Hung V., Guzi, Timothy J., Dwyer, Michael P., Paruch, Kamil, Doll, Ronald J., Lees, Emma, Parry, David, Seghezzi, Wolfgang, Madison, Vincent
Published in Biopolymers (01.05.2008)
Published in Biopolymers (01.05.2008)
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Journal Article
Selective small-molecule inhibition of an RNA structural element
Howe, John A, Wang, Hao, Fischmann, Thierry O, Balibar, Carl J, Xiao, Li, Galgoci, Andrew M, Malinverni, Juliana C, Mayhood, Todd, Villafania, Artjohn, Nahvi, Ali, Murgolo, Nicholas, Barbieri, Christopher M, Mann, Paul A, Carr, Donna, Xia, Ellen, Zuck, Paul, Riley, Dan, Painter, Ronald E, Walker, Scott S, Sherborne, Brad, de Jesus, Reynalda, Pan, Weidong, Plotkin, Michael A, Wu, Jin, Rindgen, Diane, Cummings, John, Garlisi, Charles G, Zhang, Rumin, Sheth, Payal R, Gill, Charles J, Tang, Haifeng, Roemer, Terry
Published in Nature (London) (29.10.2015)
Published in Nature (London) (29.10.2015)
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Journal Article
Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors
Fischmann, Thierry O, Smith, Catherine K, Mayhood, Todd W, Myers, Joseph E, Reichert, Paul, Mannarino, Anthony, Carr, Donna, Zhu, Hugh, Wong, Jesse, Yang, Rong-Sheng, Le, Hung V, Madison, Vincent S
Published in Biochemistry (Easton) (31.03.2009)
Published in Biochemistry (Easton) (31.03.2009)
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Journal Article
Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation
Fischmann, Thierry O, Hruza, Alan, Niu, Xiao Da, Fossetta, James D, Lunn, Charles A, Dolphin, Edward, Prongay, Andrew J, Reichert, Paul, Lundell, Daniel J, Narula, Satwant K, Weber, Patricia C
Published in Nature structural biology (01.03.1999)
Published in Nature structural biology (01.03.1999)
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Journal Article
Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation
Smith, Graham F., Altman, Michael D., Andresen, Brian, Baker, James, Brubaker, Jason D., Chen, Hongmin, Chen, Yiping, Childers, Matthew, Donofrio, Anthony, Ferguson, Heidi, Fischer, Christian, Fischmann, Thierry O., Gibeau, Craig, Hicks, Alexander, Jin, Sue, Kattar, Sam, Kleinschek, Melanie A., Leccese, Erica, Lesburg, Charles, Li, Chaomin, Lim, Jongwon, Liu, Duan, Maclean, John K.F., Mansoor, Faruk, Moy, Lilly Y., Mulrooney, Erin F., Necheva, Antoaneta S., Presland, Jeremy, Rakhilina, Larissa, Yang, Ruojing, Torres, Luis, Zhang-Hoover, Jie, Northrup, Alan
Published in Bioorganic & medicinal chemistry letters (15.06.2017)
Published in Bioorganic & medicinal chemistry letters (15.06.2017)
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Journal Article
Discovery of novel BTK inhibitors with carboxylic acids
Gao, Xiaolei, Wang, James, Liu, Jian, Guiadeen, Deodial, Krikorian, Arto, Boga, Sobhana Babu, Alhassan, Abdul-Basit, Selyutin, Oleg, Yu, Wensheng, Yu, Younong, Anand, Rajan, Liu, Shilan, Yang, Chundao, Wu, Hao, Cai, Jiaqiang, Cooper, Alan, Zhu, Hugh, Maloney, Kevin, Gao, Ying-Duo, Fischmann, Thierry O., Presland, Jeremy, Mansueto, My, Xu, Zangwei, Leccese, Erica, Zhang-Hoover, Jie, Knemeyer, Ian, Garlisi, Charles G., Bays, Nathan, Stivers, Peter, Brandish, Philip E., Hicks, Alexandra, Kim, Ronald, Kozlowski, Joeseph A.
Published in Bioorganic & medicinal chemistry letters (15.03.2017)
Published in Bioorganic & medicinal chemistry letters (15.03.2017)
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Journal Article
Pembrolizumab microgravity crystallization experimentation
Reichert, Paul, Prosise, Winifred, Fischmann, Thierry O, Scapin, Giovanna, Narasimhan, Chakravarthy, Spinale, April, Polniak, Ray, Yang, Xiaoyu, Walsh, Erika, Patel, Daya, Benjamin, Wendy, Welch, Johnathan, Simmons, Denarra, Strickland, Corey
Published in NPJ microgravity (02.12.2019)
Published in NPJ microgravity (02.12.2019)
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Journal Article
Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: A template-based approach
Dwyer, Michael P., Keertikar, Kartik, Paruch, Kamil, Alvarez, Carmen, Labroli, Marc, Poker, Cory, Fischmann, Thierry O., Mayer-Ezell, Rosemary, Bond, Richard, Wang, Yan, Azevedo, Rita, Guzi, Timothy J.
Published in Bioorganic & medicinal chemistry letters (15.11.2013)
Published in Bioorganic & medicinal chemistry letters (15.11.2013)
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Journal Article
Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation
McElroy, William T., Tan, Zheng, Ho, Ginny, Paliwal, Sunil, Li, Guoqing, Seganish, W. Michael, Tulshian, Deen, Tata, James, Fischmann, Thierry O., Sondey, Christopher, Bian, Hong, Bober, Loretta, Jackson, James, Garlisi, Charles G., Devito, Kristine, Fossetta, James, Lundell, Daniel, Niu, Xiaoda
Published in ACS medicinal chemistry letters (11.06.2015)
Published in ACS medicinal chemistry letters (11.06.2015)
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Journal Article
Discovery of 3-morpholino-imidazole[1,5-a]pyrazine BTK inhibitors for rheumatoid arthritis
Boga, Sobhana Babu, Alhassan, Abdul-Basit, Liu, Jian, Guiadeen, Deodial, Krikorian, Arto, Gao, Xiaolei, Wang, James, Yu, Younong, Anand, Rajan, Liu, Shilan, Yang, Chundao, Wu, Hao, Cai, Jiaqiang, Zhu, Hugh, Desai, Jagdish, Maloney, Kevin, Gao, Ying-Duo, Fischmann, Thierry O., Presland, Jeremy, Mansueto, My, Xu, Zangwei, Leccese, Erica, Knemeyer, Ian, Garlisi, Charles G., Bays, Nathan, Stivers, Peter, Brandish, Philip E., Hicks, Alexandra, Cooper, Alan, Kim, Ronald M., Kozlowski, Joseph A.
Published in Bioorganic & medicinal chemistry letters (15.08.2017)
Published in Bioorganic & medicinal chemistry letters (15.08.2017)
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Journal Article
Discovery and hit-to-lead optimization of 2,6-diaminopyrimidine inhibitors of interleukin-1 receptor-associated kinase 4
McElroy, William T., Seganish, W. Michael, Herr, R. Jason, Harding, James, Yang, Jinhai, Yet, Larry, Komanduri, Venukrishnan, Prakash, Koraboina Chandra, Lavey, Brian, Tulshian, Deen, Greenlee, William J., Sondey, Christopher, Fischmann, Thierry O., Niu, Xiaoda
Published in Bioorganic & medicinal chemistry letters (01.05.2015)
Published in Bioorganic & medicinal chemistry letters (01.05.2015)
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Journal Article
Structure-based design and optimization of 2-aminothiazole-4-carboxamide as a new class of CHK1 inhibitors
Huang, Xiaohua, Cheng, Cliff C., Fischmann, Thierry O., Duca, José S., Richards, Matthew, Tadikonda, Praveen K., Reddy, Panduranga Adulla, Zhao, Lianyun, Arshad Siddiqui, M., Parry, David, Davis, Nicole, Seghezzi, Wolfgang, Wiswell, Derek, Shipps, Gerald W.
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
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