Preclinical Antitumor Activity of BMS-599626, a pan-HER Kinase Inhibitor That Inhibits HER1/HER2 Homodimer and Heterodimer Signaling
WONG, Tai W, LEE, Francis Y, GAVAI, Ashvinikumar V, VITE, Gregory D, YU, Chiang, LUO, Feng R, OPPENHEIMER, Simone, HONGJIAN ZHANG, SMYKLA, Richard A, MASTALERZ, Harold, FINK, Brian E, HUNT, John T
Published in Clinical cancer research (15.10.2006)
Published in Clinical cancer research (15.10.2006)
Get full text
Journal Article
New dual inhibitors of EGFR and HER2 protein tyrosine kinases
Fink, Brian E., Vite, Gregory D., Mastalerz, Harold, Kadow, John F., Kim, Soong-Hoon, Leavitt, Kenneth J., Du, Karen, Crews, Donald, Mitt, Toomas, Wong, Tai W., Hunt, John T., Vyas, Dolatrai M., Tokarski, John S.
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
Get full text
Journal Article
Heterobicyclic inhibitors of transforming growth factor beta receptor I (TGFβRI)
Harikrishnan, Lalgudi S., Warrier, Jayakumar, Tebben, Andrew J., Tonukunuru, Gopikishan, Madduri, Sudhakara R., Baligar, Vishweshwaraiah, Mannoori, Raju, Seshadri, Balaji, Rahaman, Hasibur, Arunachalam, P.N., Dikundwar, Amol G., Fink, Brian E., Fargnoli, Joseph, Fereshteh, Mark, Fan, Yi, Lippy, Jonathan, Ho, Ching-Ping, Wautlet, Barri, Sheriff, Steven, Ruzanov, Max, Borzilleri, Robert M.
Published in Bioorganic & medicinal chemistry (01.03.2018)
Published in Bioorganic & medicinal chemistry (01.03.2018)
Get full text
Journal Article
Substituted benzyloxytricyclic compounds as retinoic acid-related orphan receptor gamma t (RORγt) agonists
Harikrishnan, Lalgudi S., Gill, Patrice, Kamau, Muthoni G., Qin, Lan-Ying, Ruan, Zheming, O'Malley, Daniel, Huynh, Tram, Stachura, Sylwia, Cavallaro, Cullen L., Lu, Zhonghui, J.-W. Duan, James, Weigelt, Carolyn A., Sack, John S., Ruzanov, Max, Khan, Javed, Gururajan, Murali, Wong, Jessica J., Huang, Yanling, Yarde, Melissa, Li, Zhuyin, Chen, Cliff, Sun, Huadong, Borowski, Virna, Murtaza, Anwar, Fink, Brian E.
Published in Bioorganic & medicinal chemistry letters (15.06.2020)
Published in Bioorganic & medicinal chemistry letters (15.06.2020)
Get full text
Journal Article
Substituted diaryl ether compounds as retinoic acid-related orphan Receptor-γt (RORγt) agonists
Ruan, Zheming, Park, Peter K., Wei, Donna, Purandare, Ashok, Wan, Honghe, O'Malley, Daniel, Stachura, Sylwia, Perez, Heidi, Cavallaro, Cullen L., Weigelt, Carolyn A., Sack, John S., Ruzanov, Max, Khan, Javed, Gururajan, Murali, Wong, Jessica J., Huang, Yanling, Yarde, Melissa, Li, Zhuyin, Chen, Cliff, Sun, Huadong, Borowski, Virna, Xie, Jenny H., Anthony, Monique, Agler, Michele, Fink, Brian E., Harikrishnan, Lalgudi S.
Published in Bioorganic & medicinal chemistry letters (01.03.2021)
Published in Bioorganic & medicinal chemistry letters (01.03.2021)
Get full text
Journal Article
Discovery of 4‑Azaindole Inhibitors of TGFβRI as Immuno-oncology Agents
Zhang, Yong, Zhao, Yufen, Tebben, Andrew J, Sheriff, Steven, Ruzanov, Max, Fereshteh, Mark P, Fan, Yi, Lippy, Jonathan, Swanson, Jesse, Ho, Ching-Ping, Wautlet, Barri S, Rose, Anne, Parrish, Karen, Yang, Zheng, Donnell, Andrew F, Zhang, Liping, Fink, Brian E, Vite, Gregory D, Augustine-Rauch, Karen, Fargnoli, Joseph, Borzilleri, Robert M
Published in ACS medicinal chemistry letters (08.11.2018)
Published in ACS medicinal chemistry letters (08.11.2018)
Get full text
Journal Article
Constitutively active receptor tyrosine kinases as oncogenes in preclinical models for cancer therapeutics
Kellar, Kristen A, Lorenzi, Matthew V, Ho, Ching Ping, You, Dan, Wen, Mei-Li, Ryseck, Rolf P, Oppenheimer, Simone, Fink, Brian E, Vite, Gregory D, Rowley, Bruce R, Yu, Chiang, Bol, David K, Lee, Francis Y, Wong, Tai W
Published in Molecular cancer therapeutics (01.06.2006)
Published in Molecular cancer therapeutics (01.06.2006)
Get full text
Journal Article
Total Synthesis of Distamycin A and 2640 Analogues: A Solution-Phase Combinatorial Approach to the Discovery of New, Bioactive DNA Binding Agents and Development of a Rapid, High-Throughput Screen for Determining Relative DNA Binding Affinity or DNA Binding Sequence Selectivity
Boger, Dale L, Fink, Brian E, Hedrick, Michael P
Published in Journal of the American Chemical Society (12.07.2000)
Published in Journal of the American Chemical Society (12.07.2000)
Get full text
Journal Article
Novel pyrrolo[2,1- f][1,2,4]triazin-4-amines: Dual inhibitors of EGFR and HER2 protein tyrosine kinases
Fink, Brian E., Norris, Derek, Mastalerz, Harold, Chen, Ping, Goyal, Bindu, Zhao, Yufen, Kim, Soong-Hoon, Vite, Gregory D., Lee, Francis Y., Zhang, Hongjian, Oppenheimer, Simone, Tokarski, John S., Wong, Tai W., Gavai, Ashvinikumar V.
Published in Bioorganic & medicinal chemistry letters (15.01.2011)
Published in Bioorganic & medicinal chemistry letters (15.01.2011)
Get full text
Journal Article
Discovery and Preclinical Evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic Acid, (3S)-3-Morpholinylmethyl Ester (BMS-599626), a Selective and Orally Efficacious Inhibitor of Human Epidermal Growth Factor Receptor 1 and 2 Kinases
Gavai, Ashvinikumar V, Fink, Brian E, Fairfax, David J, Martin, Gregory S, Rossiter, Lana M, Holst, Christian L, Kim, Soong-Hoon, Leavitt, Kenneth J, Mastalerz, Harold, Han, Wen-Ching, Norris, Derek, Goyal, Bindu, Swaminathan, Shankar, Patel, Bharat, Mathur, Arvind, Vyas, Dolatrai M, Tokarski, John S, Yu, Chiang, Oppenheimer, Simone, Zhang, Hongjian, Marathe, Punit, Fargnoli, Joseph, Lee, Francis Y, Wong, Tai W, Vite, Gregory D
Published in Journal of medicinal chemistry (12.11.2009)
Published in Journal of medicinal chemistry (12.11.2009)
Get full text
Journal Article
New C-5 substituted pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases
Mastalerz, Harold, Chang, Ming, Chen, Ping, Dextraze, Pierre, Fink, Brian E., Gavai, Ashvinikumar, Goyal, Bindu, Han, Wen-Ching, Johnson, Walter, Langley, David, Lee, Francis Y., Marathe, Punit, Mathur, Arvind, Oppenheimer, Simone, Ruediger, Edward, Tarrant, James, Tokarski, John S., Vite, Gregory D., Vyas, Dolatrai M., Wong, Henry, Wong, Tai W., Zhang, Hongjian, Zhang, Guifen
Published in Bioorganic & medicinal chemistry letters (01.04.2007)
Published in Bioorganic & medicinal chemistry letters (01.04.2007)
Get full text
Journal Article
Design, Synthesis, and Conformational Analysis of a Proposed Type I β-Turn Mimic
Fink, Brian E, Kym, Phil R, Katzenellenbogen, John A
Published in Journal of the American Chemical Society (13.05.1998)
Published in Journal of the American Chemical Society (13.05.1998)
Get full text
Journal Article
5-((4-Aminopiperidin-1-yl)methyl)pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases
Mastalerz, Harold, Chang, Ming, Chen, Ping, Fink, Brian E., Gavai, Ashvinikumar, Han, Wen-Ching, Johnson, Walter, Langley, David, Lee, Francis Y., Leavitt, Kenneth, Marathe, Punit, Norris, Derek, Oppenheimer, Simone, Sleczka, Bogdan, Tarrant, James, Tokarski, John S., Vite, Gregory D., Vyas, Dolatrai M., Wong, Henry, Wong, Tai W., Zhang, Hongjian, Zhang, Guifen
Published in Bioorganic & medicinal chemistry letters (01.09.2007)
Published in Bioorganic & medicinal chemistry letters (01.09.2007)
Get full text
Journal Article
Identification of 2-amino-5-(thioaryl)thiazoles as inhibitors of nerve growth factor receptor TrkA
Kim, Soong-Hoon, Tokarski, John S., Leavitt, Kenneth J., Fink, Brian E., Salvati, Mark E., Moquin, Robert, Obermeier, Mary T., Trainor, George L., Vite, Gregory G., Stadnick, Linda K., Lippy, Jonathan S., You, Dan, Lorenzi, Matthew V., Chen, Ping
Published in Bioorganic & medicinal chemistry (15.01.2008)
Published in Bioorganic & medicinal chemistry (15.01.2008)
Get full text
Journal Article
Identification of a novel series of tetrahydrodibenzazocines as inhibitors of 17β-hydroxysteroid dehydrogenase type 3
Fink, Brian E., Gavai, Ashvinikumar V., Tokarski, John S., Goyal, Bindu, Misra, Raj, Xiao, Hai-Yun, Kimball, S. David, Han, Wen-Ching, Norris, Derek, Spires, Thomas E., You, Dan, Gottardis, Marco M., Lorenzi, Matthew V., Vite, Gregory D.
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
Get full text
Journal Article
항암제로서의 시클릭 디뉴클레오티드
RUAN ZHEMING, WATTERSON SCOTT HUNTER, QIN LAN YING, CHEN LIBING, FINK BRIAN E
Year of Publication 24.04.2020
Get full text
Year of Publication 24.04.2020
Patent