RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4
Najjar, Malek, Saleh, Danish, Zelic, Matija, Nogusa, Shoko, Shah, Saumil, Tai, Albert, Finger, Joshua N., Polykratis, Apostolos, Gough, Peter J., Bertin, John, Whalen, Michael J., Pasparakis, Manolis, Balachandran, Siddharth, Kelliher, Michelle, Poltorak, Alexander, Degterev, Alexei
Published in Immunity (Cambridge, Mass.) (19.07.2016)
Published in Immunity (Cambridge, Mass.) (19.07.2016)
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Herpes Simplex Virus Suppresses Necroptosis in Human Cells
Guo, Hongyan, Omoto, Shinya, Harris, Philip A., Finger, Joshua N., Bertin, John, Gough, Peter J., Kaiser, William J., Mocarski, Edward S.
Published in Cell host & microbe (11.02.2015)
Published in Cell host & microbe (11.02.2015)
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Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis
Zille, Marietta, Karuppagounder, Saravanan S, Chen, Yingxin, Gough, Peter J, Bertin, John, Finger, Joshua, Milner, Teresa A, Jonas, Elizabeth A, Ratan, Rajiv R
Published in Stroke (1970) (01.04.2017)
Published in Stroke (1970) (01.04.2017)
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Autolytic Proteolysis within the Function to Find Domain (FIIND) Is Required for NLRP1 Inflammasome Activity
Finger, Joshua N., Lich, John D., Dare, Lauren C., Cook, Michael N., Brown, Kristin K., Duraiswami, Chaya, Bertin, John J., Gough, Peter J.
Published in The Journal of biological chemistry (20.07.2012)
Published in The Journal of biological chemistry (20.07.2012)
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Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice
Berger, Scott B, Kasparcova, Viera, Hoffman, Sandy, Swift, Barb, Dare, Lauren, Schaeffer, Michelle, Capriotti, Carol, Cook, Michael, Finger, Joshua, Hughes-Earle, Angela, Harris, Philip A, Kaiser, William J, Mocarski, Edward S, Bertin, John, Gough, Peter J
Published in The Journal of immunology (1950) (15.06.2014)
Published in The Journal of immunology (1950) (15.06.2014)
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RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity
Mandal, Pratyusha, Berger, Scott B., Pillay, Sirika, Moriwaki, Kenta, Huang, Chunzi, Guo, Hongyan, Lich, John D., Finger, Joshua, Kasparcova, Viera, Votta, Bart, Ouellette, Michael, King, Bryan W., Wisnoski, David, Lakdawala, Ami S., DeMartino, Michael P., Casillas, Linda N., Haile, Pamela A., Sehon, Clark A., Marquis, Robert W., Upton, Jason, Daley-Bauer, Lisa P., Roback, Linda, Ramia, Nancy, Dovey, Cole M., Carette, Jan E., Chan, Francis Ka-Ming, Bertin, John, Gough, Peter J., Mocarski, Edward S., Kaiser, William J.
Published in Molecular cell (20.11.2014)
Published in Molecular cell (20.11.2014)
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DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors
Harris, Philip A, King, Bryan W, Bandyopadhyay, Deepak, Berger, Scott B, Campobasso, Nino, Capriotti, Carol A, Cox, Julie A, Dare, Lauren, Dong, Xiaoyang, Finger, Joshua N, Grady, LaShadric C, Hoffman, Sandra J, Jeong, Jae U, Kang, James, Kasparcova, Viera, Lakdawala, Ami S, Lehr, Ruth, McNulty, Dean E, Nagilla, Rakesh, Ouellette, Michael T, Pao, Christina S, Rendina, Alan R, Schaeffer, Michelle C, Summerfield, Jennifer D, Swift, Barbara A, Totoritis, Rachel D, Ward, Paris, Zhang, Aming, Zhang, Daohua, Marquis, Robert W, Bertin, John, Gough, Peter J
Published in Journal of medicinal chemistry (10.03.2016)
Published in Journal of medicinal chemistry (10.03.2016)
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Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer
Harris, Philip A, Marinis, Jill M, Lich, John D, Berger, Scott B, Chirala, Anirudh, Cox, Julie A, Eidam, Patrick M, Finger, Joshua N, Gough, Peter J, Jeong, Jae U, Kang, James, Kasparcova, Viera, Leister, Lara K, Mahajan, Mukesh K, Miller, George, Nagilla, Rakesh, Ouellette, Michael T, Reilly, Michael A, Rendina, Alan R, Rivera, Elizabeth J, Sun, Helen H, Thorpe, James H, Totoritis, Rachel D, Wang, Wei, Wu, Dongling, Zhang, Daohua, Bertin, John, Marquis, Robert W
Published in ACS medicinal chemistry letters (13.06.2019)
Published in ACS medicinal chemistry letters (13.06.2019)
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Journal Article
MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses
Yu, Jong W, Hoffman, Sandy, Beal, Allison M, Dykon, Angela, Ringenberg, Michael A, Hughes, Anna C, Dare, Lauren, Anderson, Amber D, Finger, Joshua, Kasparcova, Viera, Rickard, David, Berger, Scott B, Ramanjulu, Joshi, Emery, John G, Gough, Peter J, Bertin, John, Foley, Kevin P
Published in PloS one (12.05.2015)
Published in PloS one (12.05.2015)
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Journal Article
The Rat Epididymal Transcriptome: Comparison of Segmental Gene Expression in the Rat and Mouse Epididymides
JELINSKY, Scott A, TURNER, Terry T, BANG, Hyun J, FINGER, Joshua N, SOLARZ, Mark K, WILSON, Ewa, BROWN, Eugene L, KOPF, Gregory S, JOHNSTON, Daniel S
Published in Biology of reproduction (01.04.2007)
Published in Biology of reproduction (01.04.2007)
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Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis
Harris, Philip A, Bandyopadhyay, Deepak, Berger, Scott B, Campobasso, Nino, Capriotti, Carol A, Cox, Julie A, Dare, Lauren, Finger, Joshua N, Hoffman, Sandra J, Kahler, Kirsten M, Lehr, Ruth, Lich, John D, Nagilla, Rakesh, Nolte, Robert T, Ouellette, Michael T, Pao, Christina S, Schaeffer, Michelle C, Smallwood, Angela, Sun, Helen H, Swift, Barbara A, Totoritis, Rachel D, Ward, Paris, Marquis, Robert W, Bertin, John, Gough, Peter J
Published in ACS medicinal chemistry letters (12.12.2013)
Published in ACS medicinal chemistry letters (12.12.2013)
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Journal Article
Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases
Harris, Philip A, Berger, Scott B, Jeong, Jae U, Nagilla, Rakesh, Bandyopadhyay, Deepak, Campobasso, Nino, Capriotti, Carol A, Cox, Julie A, Dare, Lauren, Dong, Xiaoyang, Eidam, Patrick M, Finger, Joshua N, Hoffman, Sandra J, Kang, James, Kasparcova, Viera, King, Bryan W, Lehr, Ruth, Lan, Yunfeng, Leister, Lara K, Lich, John D, MacDonald, Thomas T, Miller, Nathan A, Ouellette, Michael T, Pao, Christina S, Rahman, Attiq, Reilly, Michael A, Rendina, Alan R, Rivera, Elizabeth J, Schaeffer, Michelle C, Sehon, Clark A, Singhaus, Robert R, Sun, Helen H, Swift, Barbara A, Totoritis, Rachel D, Vossenkämper, Anna, Ward, Paris, Wisnoski, David D, Zhang, Daohua, Marquis, Robert W, Gough, Peter J, Bertin, John
Published in Journal of medicinal chemistry (23.02.2017)
Published in Journal of medicinal chemistry (23.02.2017)
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Randomized clinical study of safety, pharmacokinetics, and pharmacodynamics of RIPK1 inhibitor GSK2982772 in healthy volunteers
Weisel, Kathleen, Scott, Nicola E., Tompson, Debra J., Votta, Bartholomew J., Madhavan, Sujith, Povey, Kat, Wolstenholme, Allen, Simeoni, Monica, Rudo, Todd, Richards‐Peterson, Lauren, Sahota, Tarjinder, Wang, J. Gene, Lich, John, Finger, Joshua, Verticelli, Adeline, Reilly, Michael, Gough, Peter J., Harris, Philip A., Bertin, John, Wang, Mei‐Lun
Published in Pharmacology research & perspectives (01.12.2017)
Published in Pharmacology research & perspectives (01.12.2017)
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The Identification and Pharmacological Characterization of 6‑(tert-Butylsulfonyl)‑N‑(5-fluoro‑1H‑indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase
Haile, Pamela A, Votta, Bartholomew J, Marquis, Robert W, Bury, Michael J, Mehlmann, John F, Singhaus, Robert, Charnley, Adam K, Lakdawala, Ami S, Convery, Máire A, Lipshutz, David B, Desai, Biva M, Swift, Barbara, Capriotti, Carol A, Berger, Scott B, Mahajan, Mukesh K, Reilly, Michael A, Rivera, Elizabeth J, Sun, Helen H, Nagilla, Rakesh, Beal, Allison M, Finger, Joshua N, Cook, Michael N, King, Bryan W, Ouellette, Michael T, Totoritis, Rachel D, Pierdomenico, Maria, Negroni, Anna, Stronati, Laura, Cucchiara, Salvatore, Ziółkowski, Bartłomiej, Vossenkämper, Anna, MacDonald, Thomas T, Gough, Peter J, Bertin, John, Casillas, Linda N
Published in Journal of medicinal chemistry (26.05.2016)
Published in Journal of medicinal chemistry (26.05.2016)
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Journal Article
Gene Expression During Development of Fetal and Adult Leydig Cells
DONG, LEI, JELINSKY, SCOTT A., FINGER, JOSHUA N., JOHNSTON, DANIEL S., KOPF, GREGORY S., SOTTAS, CHANTAL M., HARDY, MATTHEW P., GE, REN-SHAN
Published in Annals of the New York Academy of Sciences (01.12.2007)
Published in Annals of the New York Academy of Sciences (01.12.2007)
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Journal Article
Identification of an antibody‐based immunoassay for measuring direct target binding of RIPK1 inhibitors in cells and tissues
Finger, Joshua N., Brusq, Jean‐Marie, Campobasso, Nino, Cook, Michael N., Deutsch, Jennifer, Haag, Heather, Harris, Philip A., Jenkins, Earl L., Joglekar, Devika, Lich, John D., Maguire, Sean, Nagilla, Rakesh, Rivera, Elizabeth J., Sun, Helen, Votta, Bartholomew J., Bertin, John, Gough, Peter J.
Published in Pharmacology research & perspectives (01.12.2017)
Published in Pharmacology research & perspectives (01.12.2017)
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Journal Article
Identification of testis-specific male contraceptive targets: insights from transcriptional profiling of the cycle of the rat seminiferous epithelium and purified testicular cells
Johnston, Daniel S, Jelinsky, Scott A, Zhi, Yu, Finger, Joshua N, Kopf, Gregory S, Wright, William W
Published in Annals of the New York Academy of Sciences (01.12.2007)
Published in Annals of the New York Academy of Sciences (01.12.2007)
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Journal Article
Segment boundaries of the adult rat epididymis limit interstitial signaling by potential paracrine factors and segments lose differential gene expression after efferent duct ligation
Turner, Terry T., Johnston, Daniel S., Jelinsky, Scott A., Tomsig, Jose L., Finger, Joshua N.
Published in Asian journal of andrology (01.07.2007)
Published in Asian journal of andrology (01.07.2007)
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