A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy
Ronan, Baptiste, Flamand, Odile, Vescovi, Lionel, Dureuil, Christine, Durand, Laurence, Fassy, Florence, Bachelot, Marie-France, Lamberton, Annabelle, Mathieu, Magali, Bertrand, Thomas, Marquette, Jean-Pierre, El-Ahmad, Youssef, Filoche-Romme, Bruno, Schio, Laurent, Garcia-Echeverria, Carlos, Goulaouic, Hélène, Pasquier, Benoit
Published in Nature chemical biology (01.12.2014)
Published in Nature chemical biology (01.12.2014)
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SAR439859, a Novel Selective Estrogen Receptor Degrader (SERD), Demonstrates Effective and Broad Antitumor Activity in Wild-Type and Mutant ER-Positive Breast Cancer Models
Shomali, Maysoun, Cheng, Jane, Sun, Fangxian, Koundinya, Malvika, Guo, Zhuyan, Hebert, Andrew T, McManus, Jessica, Levit, Mikhail N, Hoffmann, Dietmar, Courjaud, Albane, Arrebola, Rosalia, Cao, Hui, Pollard, Jack, Lee, Joon Sang, Besret, Laurent, Caron, Anne, Bangari, Dinesh S, Abecassis, Pierre-Yves, Schio, Laurent, El-Ahmad, Youssef, Halley, Frank, Tabart, Michel, Certal, Victor, Thompson, Fabienne, McCort, Gary, Filoche-Rommé, Bruno, Cheng, Hong, Garcia-Echeverria, Carlos, Debussche, Laurent, Bouaboula, Monsif
Published in Molecular cancer therapeutics (01.02.2021)
Published in Molecular cancer therapeutics (01.02.2021)
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Discovery of 6‑(2,4-Dichlorophenyl)-5-[4-[(3S)‑1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro‑7H‑benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer
El-Ahmad, Youssef, Tabart, Michel, Halley, Frank, Certal, Victor, Thompson, Fabienne, Filoche-Rommé, Bruno, Gruss-Leleu, Florence, Muller, Claire, Brollo, Maurice, Fabien, Laurence, Loyau, Véronique, Bertin, Luc, Richepin, Patrick, Pilorge, Fabienne, Desmazeau, Pascal, Girardet, Chrystelle, Beccari, Sylvie, Louboutin, Audrey, Lebourg, Gilles, Le-Roux, Jacques, Terrier, Corinne, Vallée, François, Steier, Valérie, Mathieu, Magali, Rak, Alexey, Abecassis, Pierre-Yves, Vicat, Pascale, Benard, Tsiala, Bouaboula, Monsif, Sun, Fangxian, Shomali, Maysoun, Hebert, Andrew, Levit, Mikhail, Cheng, Hong, Courjaud, Albane, Ginesty, Celine, Perrault, Christelle, Garcia-Echeverria, Carlos, McCort, Gary, Schio, Laurent
Published in Journal of medicinal chemistry (23.01.2020)
Published in Journal of medicinal chemistry (23.01.2020)
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Discovery of (2S)‑8-[(3R)‑3-Methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro‑2H‑pyrimido[1,2‑a]pyrimidin-6-one: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors
Pasquier, Benoit, El-Ahmad, Youssef, Filoche-Rommé, Bruno, Dureuil, Christine, Fassy, Florence, Abecassis, Pierre-Yves, Mathieu, Magali, Bertrand, Thomas, Benard, Tsiala, Barrière, Cédric, El Batti, Samira, Letallec, Jean-Philippe, Sonnefraud, Véronique, Brollo, Maurice, Delbarre, Laurence, Loyau, Véronique, Pilorge, Fabienne, Bertin, Luc, Richepin, Patrick, Arigon, Jérôme, Labrosse, Jean-Robert, Clément, Jacques, Durand, Florence, Combet, Romain, Perraut, Pierre, Leroy, Vincent, Gay, Frédéric, Lefrançois, Dominique, Bretin, François, Marquette, Jean-Pierre, Michot, Nadine, Caron, Anne, Castell, Christelle, Schio, Laurent, McCort, Gary, Goulaouic, Hélène, Garcia-Echeverria, Carlos, Ronan, Baptiste
Published in Journal of medicinal chemistry (08.01.2015)
Published in Journal of medicinal chemistry (08.01.2015)
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Discovery and Optimization of New Benzimidazole- and Benzoxazole-Pyrimidone Selective PI3Kβ Inhibitors for the Treatment of Phosphatase and TENsin homologue (PTEN)-Deficient Cancers
Certal, Victor, Halley, Frank, Virone-Oddos, Angela, Delorme, Cécile, Karlsson, Andreas, Rak, Alexey, Thompson, Fabienne, Filoche-Rommé, Bruno, El-Ahmad, Youssef, Carry, Jean-Christophe, Abecassis, Pierre-Yves, Lejeune, Pascale, Vincent, Loic, Bonnevaux, Hélène, Nicolas, Jean-Paul, Bertrand, Thomas, Marquette, Jean-Pierre, Michot, Nadine, Benard, Tsiala, Below, Peter, Vade, Isabelle, Chatreaux, Fabienne, Lebourg, Gilles, Pilorge, Fabienne, Angouillant-Boniface, Odile, Louboutin, Audrey, Lengauer, Christoph, Schio, Laurent
Published in Journal of medicinal chemistry (24.05.2012)
Published in Journal of medicinal chemistry (24.05.2012)
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Identification of β‑Lactams Active against Mycobacterium tuberculosis by a Consortium of Pharmaceutical Companies and Academic Institutions
Gold, Ben, Zhang, Jun, Quezada, Landys Lopez, Roberts, Julia, Ling, Yan, Wood, Madeleine, Shinwari, Wasima, Goullieux, Laurent, Roubert, Christine, Fraisse, Laurent, Bacqué, Eric, Lagrange, Sophie, Filoche-Rommé, Bruno, Vieth, Michal, Hipskind, Philip A, Jungheim, Louis N, Aubé, Jeffrey, Scarry, Sarah M, McDonald, Stacey L, Li, Kelin, Perkowski, Andrew, Nguyen, Quyen, Dartois, Véronique, Zimmerman, Matthew, Olsen, David B, Young, Katherine, Bonnett, Shilah, Joerss, Douglas, Parish, Tanya, Boshoff, Helena I, Arora, Kriti, Barry, Clifton E, Guijarro, Laura, Anca, Sara, Rullas, Joaquín, Rodríguez-Salguero, Beatriz, Martínez-Martínez, Maria S, Porras-De Francisco, Esther, Cacho, Monica, Barros-Aguirre, David, Smith, Paul, Berthel, Steven J, Nathan, Carl, Bates, Robert H
Published in ACS infectious diseases (11.03.2022)
Published in ACS infectious diseases (11.03.2022)
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SAR156497, an Exquisitely Selective Inhibitor of Aurora Kinases
Carry, Jean-Christophe, Clerc, François, Minoux, Hervé, Schio, Laurent, Mauger, Jacques, Nair, Anil, Parmantier, Eric, Le Moigne, Ronan, Delorme, Cécile, Nicolas, Jean-Paul, Krick, Alain, Abécassis, Pierre-Yves, Crocq-Stuerga, Véronique, Pouzieux, Stéphanie, Delarbre, Laure, Maignan, Sébastien, Bertrand, Thomas, Bjergarde, Kirsten, Ma, Nina, Lachaud, Sylvette, Guizani, Houlfa, Lebel, Rémi, Doerflinger, Gilles, Monget, Sylvie, Perron, Sébastien, Gasse, Francis, Angouillant-Boniface, Odile, Filoche-Rommé, Bruno, Murer, Michel, Gontier, Sylvie, Prévost, Céline, Monteiro, Marie-Line, Combeau, Cécile
Published in Journal of medicinal chemistry (08.01.2015)
Published in Journal of medicinal chemistry (08.01.2015)
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Preparation and optimization of new 4-(morpholin-4-yl)-(6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives as PI3Kβ inhibitors
Certal, Victor, Halley, Frank, Virone-Oddos, Angela, Thompson, Fabienne, Filoche-Rommé, Bruno, El-Ahmad, Youssef, Carry, Jean-Christophe, Delorme, Cécile, Karlsson, Andreas, Abecassis, Pierre-Yves, Vincent, Loic, Bonnevaux, Hélène, Nicolas, Jean-Paul, Morales, Renaud, Michot, Nadine, Vade, Isabelle, Louboutin, Audrey, Perron, Sébastien, Doerflinger, Gilles, Tric, Bernadette, Monget, Sylvie, Lengauer, Christoph, Schio, Laurent
Published in Bioorganic & medicinal chemistry letters (15.10.2012)
Published in Bioorganic & medicinal chemistry letters (15.10.2012)
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FILOCHE ROMME BRUNO, CERTAL VICTOR, EL AHMAD YOUSSEF, TABART MICHEL, TERRIER CORINNE, THOMPSON FABIENNE, MCCORT GARY, HALLEY FRANK, BOUABOULA MONSIF, BROLLO MAURICE, SCHIO LAURENT
Year of Publication 08.07.2022
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Year of Publication 08.07.2022
Patent
Discovery and Optimization of Pyrimidone Indoline Amide PI3Kβ Inhibitors for the Treatment of Phosphatase and Tensin Homologue (PTEN)-Deficient Cancers
Certal, Victor, Carry, Jean-Christophe, Halley, Frank, Virone-Oddos, Angela, Thompson, Fabienne, Filoche-Rommé, Bruno, El-Ahmad, Youssef, Karlsson, Andreas, Charrier, Véronique, Delorme, Cécile, Rak, Alexey, Abecassis, Pierre-Yves, Amara, Céline, Vincent, Loïc, Bonnevaux, Hélène, Nicolas, Jean-Paul, Mathieu, Magali, Bertrand, Thomas, Marquette, Jean-Pierre, Michot, Nadine, Benard, Tsiala, Perrin, Marc-Antoine, Lemaitre, Olivier, Guerif, Stephane, Perron, Sébastien, Monget, Sylvie, Gruss-Leleu, Florence, Doerflinger, Gilles, Guizani, Houlfa, Brollo, Maurice, Delbarre, Laurence, Bertin, Luc, Richepin, Patrick, Loyau, Véronique, Garcia-Echeverria, Carlos, Lengauer, Christoph, Schio, Laurent
Published in Journal of medicinal chemistry (13.02.2014)
Published in Journal of medicinal chemistry (13.02.2014)
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신규 치환된 N--피롤리딘 화합물, 그의 제조 방법 및 그의 치료 용도
FILOCHE ROMME BRUNO, CERTAL VICTOR, EL AHMAD YOUSSEF, TABART MICHEL, TERRIER CORINNE, THOMPSON FABIENNE, MCCORT GARY, HALLEY FRANK, BOUABOULA MONSIF, BROLLO MAURICE, SCHIO LAURENT
Year of Publication 03.07.2019
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Year of Publication 03.07.2019
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에스트로겐 수용체 조절자로서의 6,7-디하이드로-5H-벤조[7]아눌렌 유도체
FILOCHE ROMME BRUNO, CERTAL VICTOR, EL AHMAD YOUSSEF, TABART MICHEL, TERRIER CORINNE, THOMPSON FABIENNE, MCCORT GARY, HALLEY FRANK, BOUABOULA MONSIF, BROLLO MAURICE, SCHIO LAURENT
Year of Publication 28.09.2018
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Year of Publication 28.09.2018
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PYRIMIDINONE DERIVATIVES AS ANTIMALARIAL AGENTS
FILOCHE ROMME BRUNO, EL AHMAD YOUSSEF, VIVET BERTRAND, ZERR VERONIQUE, GANZHORM AXEL, MARCINIAK GILBERT, MUZET NICOLAS, RONAN BAPTISTE
Year of Publication 05.03.2015
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Year of Publication 05.03.2015
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NOVEL 2,3-DIHYDRO-1H-IMIDAZO[1,2-A]PYRIMIDIN-5-ONE AND THIS 1,2,3,4-TETRAHYDROPYRIMIDO[1,2-A]PYRIMIDIN-6-ONE DERIVATIVES COMPRISING A SUBSTITUTED MORPHOLINE, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF
FILOCHE ROMME BRUNO, EL AHMAD YOUSSEF, VIVET BERTRAND, MARCINIAK GILBERT, LETALLEC JEAN PHILIPPE, RONAN BAPTISTE, BROLLO MAURICE
Year of Publication 05.03.2015
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Year of Publication 05.03.2015
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Preparation and optimization of new 4-(2-(indolin-1-yl)-2-oxoethyl)-2-morpholinothiazole-5-carboxylic acid and amide derivatives as potent and selective PI3Kβ inhibitors
Certal, Victor, Halley, Frank, Virone-Oddos, Angela, Filoche-Rommé, Bruno, Carry, Jean-Christophe, Gruss-Leleu, Florence, Bertin, Luc, Guizani, Houlfa, Pilorge, Fabienne, Richepin, Patrick, Karlsson, Andreas, Charrier, Véronique, Abecassis, Pierre-Yves, Vincent, Loic, Nicolas, Jean-Paul, Lengauer, Christoph, Garcia-Echeverria, Carlos, Schio, Laurent
Published in Bioorganic & medicinal chemistry letters (15.03.2014)
Published in Bioorganic & medicinal chemistry letters (15.03.2014)
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FUSED PENTACYCLIC IMIDAZOLE DERIVATIVES
FILOCHE ROMME BRUNO, JADOT SOPHIE, BROOKINGS DANIEL CHRISTOPHER, FORICHER YANN, SELBY MATTHEW DUNCAN, DE HARO GARCIA TERESA, KEYAERTS JEAN, DELIGNY MICHAEL, ZHU ZHAONING, SWINNEN DOMINIQUE LOUIS LEON, XUAN MENGYANG, CALMIANO MARK DANIEL, SHAW MICHAEL ALAN, JOHNSON JAMES ANDREW, HUTCHINGS MARTIN CLIVE, HEER JAG PAUL, QUINCEY JOANNA RACHEL, EVRARD YVES, MAC COSS MALCOLM, SCHIO LAURENT
Year of Publication 19.06.2017
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Year of Publication 19.06.2017
Patent
Discovery and Optimization of Pyrimidone Indoline Amide P13K beta Inhibitors for the Treatment of Phosphatase and Tensin Homologue (PTEN)-Deficient Cancers
Certal, Victor, Carry, Jean-Christophe, Halley, Frank, Virone-Oddos, Angela, Thompson, Fabienne, Filoche-Romme, Bruno, El-Ahmad, Youssef, Karlsson, Andreas, Charrier, Veronique, Delorme, Cecile, Rak, Alexey, Abecassis, Pierre-Yves, Amara, Celine, Vincent, Loic, Bonnevaux, Helene, Nicolas, Jean-Paul, Mathieu, Magali, Bertrand, Thomas, Marquette, Jean-Pierre, Michot, Nadine, Benard, Tsiala, Perrin, Marc-Antoine, Lemaitre, Olivier, Guerif, Stephane, Perron, Sebastien, Monget, Sylvie, Gruss-Leleu, Florence, Doerflinger, Gilles, Guizani, Houlfa, Brollo, Maurice, Delbarre, Laurence, Benin, Luc, Richepin, Patrick, Loyau, Veronique, Garcia-Echeverria, Carlos, Lengauer, Christoph, Schio, Laurent
Published in Journal of medicinal chemistry (13.02.2014)
Published in Journal of medicinal chemistry (13.02.2014)
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Journal Article
SARI 56497, an Exquisitely Selective Inhibitor of Aurora Kinases
Carry, Jean-Christophe, Clerc, Francois, Minoux, Herve, Schio, Laurent, Mauger, Jacques, Nair, Anil, Parmantier, Eric, Le Moigne, Ronan, Delorme, Cecile, Nicolas, Jean-Paul, Krick, Alain, Abecassis, Pierre-Yves, Crocq-Stuerga, Veronique, Pouzieux, Stephanie, Delarbre, Laure, Maignan, Sebastien, Bertrand, Thomas, Bjergarde, Kirsten, Ma, Nina, Lachaud, Sylvette, Guizani, Houlfa, Lebel, Remi, Doerflinger, Gilles, Monget, Sylvie, Perron, Sebastien, Gasse, Francis, Angouillant-Boniface, Odile, Filoche-Romme, Bruno, Murer, Michel, Gontier, Sylvie, Prevost, Celine, Monteiro, Marie-Line, Combeau, Cecile
Published in Journal of medicinal chemistry (08.01.2015)
Published in Journal of medicinal chemistry (08.01.2015)
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Journal Article
NOVEL 2,3-DIHYDRO-1H-IMIDAZO(1,2-A)PYRIMIDIN-5-ONE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL USE THEREOF
FILOCHE ROMME BRUNO, EL AHMAD YOUSSEF, CLAUSS ANNIE, VIVIANI FABRICE, VIVET BERTRAND, ZIMMERMANN ANDRE, HALLEY FRANK, KARLSSON KARL ANDREAS, MARCINIAK GILBERT, BROLLO MAURICE, RONAN BAPTISTE, SCHIO LAURENT
Year of Publication 19.09.2012
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Year of Publication 19.09.2012
Patent
NOVEL 1,2,3,4-TETRAHYDRO-PYRIMIDO(1,2-A)PYRIMIDIN-6-ONE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL USE THEREOF
FILOCHE ROMME BRUNO, CLAUSS ANNIE, BROLLO MAURICE, EL AHMAD YOUSSEF, VIVIANI FABRICE, VIVET BERTRAND, BACQUE ERIC, ZIMMERMANN ANDRE, HALLEY FRANK, KARLSSON KARL ANDREAS, MARCINIAK GILBERT, RONAN BAPTISTE, SCHIO LAURENT
Year of Publication 19.09.2012
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Year of Publication 19.09.2012
Patent