Small Amounts of Sub-Visible Aggregates Enhance the Immunogenic Potential of Monoclonal Antibody Therapeutics
Ahmadi, Maryam, Bryson, Christine J., Cloake, Edward A., Welch, Katie, Filipe, Vasco, Romeijn, Stefan, Hawe, Andrea, Jiskoot, Wim, Baker, Matthew P., Fogg, Mark H.
Published in Pharmaceutical research (01.04.2015)
Published in Pharmaceutical research (01.04.2015)
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Journal Article
Immunogenicity of different stressed IgG monoclonal antibody formulations in immune tolerant transgenic mice
Filipe, Vasco, Jiskoot, Wim, Basmeleh, Abdul Hafid, Halim, Andhyk, Schellekens, Huub, Brinks, Vera
Published in mAbs (01.11.2012)
Published in mAbs (01.11.2012)
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Journal Article
Surfactant Protection Efficacy at Surfaces Varies with the Nature of Hydrophobic Materials
Lefebvre, Guillaume, Maze, Antoine, Alvarez-Palencia Jimenez, Rosa, Bruckert, Franz, Filipe, Vasco, Huille, Sylvain, Weidenhaupt, Marianne
Published in Pharmaceutical research (01.12.2021)
Published in Pharmaceutical research (01.12.2021)
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Journal Article
Analytical approaches to assess the degradation of therapeutic proteins
Filipe, Vasco, Hawe, Andrea, Carpenter, John F., Jiskoot, Wim
Published in TrAC, Trends in analytical chemistry (Regular ed.) (01.09.2013)
Published in TrAC, Trends in analytical chemistry (Regular ed.) (01.09.2013)
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Journal Article
Mass Spectrometric Analysis of Intact Human Monoclonal Antibody Aggregates Fractionated by Size-Exclusion Chromatography
Kükrer, Başak, Filipe, Vasco, van Duijn, Esther, Kasper, Piotr T, Vreeken, Rob J, Heck, Albert J. R, Jiskoot, Wim
Published in Pharmaceutical research (01.10.2010)
Published in Pharmaceutical research (01.10.2010)
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Journal Article
Clogging of microfluidic constrictions by monoclonal antibody aggregates: role of aggregate shape and deformability
Duchêne, Charles, Filipe, Vasco, Huille, Sylvain, Lindner, Anke
Published in Soft matter (28.01.2020)
Published in Soft matter (28.01.2020)
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Journal Article
Stress Factors in mAb Drug Substance Production Processes: Critical Assessment of Impact on Product Quality and Control Strategy
Das, Tapan K., Narhi, Linda O., Sreedhara, Alavattam, Menzen, Tim, Grapentin, Christoph, Chou, Danny K., Antochshuk, Valentyn, Filipe, Vasco
Published in Journal of pharmaceutical sciences (01.01.2020)
Published in Journal of pharmaceutical sciences (01.01.2020)
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Journal Article
Detection and Characterization of Subvisible Aggregates of Monoclonal IgG in Serum
Filipe, Vasco, Poole, Robert, Oladunjoye, Olubukayo, Braeckmans, Kevin, Jiskoot, Wim
Published in Pharmaceutical research (01.08.2012)
Published in Pharmaceutical research (01.08.2012)
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Journal Article
How spray drying processing and solution composition can affect the mAbs stability in reconstituted solutions for subcutaneous injections. Part II: Exploring each protein stabilizer effect
Barcelo-Chong, Carla M., Filipe, Vasco, Nakach, Mostafa, Inês Ré, Maria
Published in International journal of pharmaceutics (25.04.2024)
Published in International journal of pharmaceutics (25.04.2024)
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Journal Article
A Systematic Approach to Evaluating Closed System Drug-Transfer Devices During Drug Product Development
Patke, Sanket, Gaillat, Erika Naumann, Calero-Rubio, Cesar, Gooding, Tamera B., Audat, Heloise, Leman, Marie, Filipe, Vasco, Saluja, Atul
Published in Journal of pharmaceutical sciences (01.05.2022)
Published in Journal of pharmaceutical sciences (01.05.2022)
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Journal Article
Mechanistic understanding of metal-catalyzed oxidation of polysorbate 80 and monoclonal antibody in biotherapeutic formulations
Bensaid, Fethi, Dagallier, Camille, Authelin, Jean-René, Audat, Héloïse, Filipe, Vasco, Narradon, Christine, Guibal, Pierre, Clavier, Séverine, Wils, Pierre
Published in International journal of pharmaceutics (05.03.2022)
Published in International journal of pharmaceutics (05.03.2022)
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Journal Article
Asymmetrical Flow Field-Flow Fractionation Method for the Analysis of Submicron Protein Aggregates
Hawe, Andrea, Romeijn, Stefan, Filipe, Vasco, Jiskoot, Wim
Published in Journal of pharmaceutical sciences (01.11.2012)
Published in Journal of pharmaceutical sciences (01.11.2012)
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Journal Article
Stress Factors in Protein Drug Product Manufacturing and Their Impact on Product Quality
Das, Tapan K., Sreedhara, Alavattam, Colandene, James D., Chou, Danny K., Filipe, Vasco, Grapentin, Christoph, Searles, Jim, Christian, Twinkle R., Narhi, Linda O., Jiskoot, Wim
Published in Journal of pharmaceutical sciences (01.04.2022)
Published in Journal of pharmaceutical sciences (01.04.2022)
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Journal Article
How spray drying processing and solution composition can affect the mAbs stability in reconstituted solutions for subcutaneous injections. Part I: Contribution of processing stresses against composition
Barceló-Chong, Carla M., Filipe, Vasco, Nakach, Mostafa, Ré, Maria Inês
Published in International journal of pharmaceutics (25.04.2024)
Published in International journal of pharmaceutics (25.04.2024)
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Journal Article
Native and Non-Native aggregation pathways of antibodies anticipated by cold-accelerated studies
Rodrigues, Miguel A., Duarte, Andreia, Geraldes, Vitor, Kingsbury, Jonathan S., Sanket, Patke, Filipe, Vasco, Nakach, Mostafa, Authelin, Jean-Rene
Published in European journal of pharmaceutics and biopharmaceutics (01.11.2023)
Published in European journal of pharmaceutics and biopharmaceutics (01.11.2023)
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Journal Article
Nanoparticulate Impurities in Pharmaceutical-Grade Sugars and their Interference with Light Scattering-Based Analysis of Protein Formulations
Weinbuch, Daniel, Cheung, Jason K., Ketelaars, Jurgen, Filipe, Vasco, Hawe, Andrea, den Engelsman, John, Jiskoot, Wim
Published in Pharmaceutical research (01.07.2015)
Published in Pharmaceutical research (01.07.2015)
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Journal Article