SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration
Figley, Matthew D., Gu, Weixi, Nanson, Jeffrey D., Shi, Yun, Sasaki, Yo, Cunnea, Katie, Malde, Alpeshkumar K., Jia, Xinying, Luo, Zhenyao, Saikot, Forhad K., Mosaiab, Tamim, Masic, Veronika, Holt, Stephanie, Hartley-Tassell, Lauren, McGuinness, Helen Y., Manik, Mohammad K., Bosanac, Todd, Landsberg, Michael J., Kerry, Philip S., Mobli, Mehdi, Hughes, Robert O., Milbrandt, Jeffrey, Kobe, Bostjan, DiAntonio, Aaron, Ve, Thomas
Published in Neuron (Cambridge, Mass.) (07.04.2021)
Published in Neuron (Cambridge, Mass.) (07.04.2021)
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Journal Article
The SARM1 TIR NADase: Mechanistic Similarities to Bacterial Phage Defense and Toxin-Antitoxin Systems
DiAntonio, Aaron, Milbrandt, Jeffrey, Figley, Matthew D
Published in Frontiers in immunology (23.09.2021)
Published in Frontiers in immunology (23.09.2021)
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Journal Article
Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models
Armakola, Maria, Higgins, Matthew J, Figley, Matthew D, Barmada, Sami J, Scarborough, Emily A, Diaz, Zamia, Fang, Xiaodong, Shorter, James, Krogan, Nevan J, Finkbeiner, Steven, Farese, Robert V, Gitler, Aaron D
Published in Nature genetics (01.12.2012)
Published in Nature genetics (01.12.2012)
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Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss
Wu, Tong, Zhu, Jian, Strickland, Amy, Ko, Kwang Woo, Sasaki, Yo, Dingwall, Caitlin B., Yamada, Yurie, Figley, Matthew D., Mao, Xianrong, Neiner, Alicia, Bloom, A. Joseph, DiAntonio, Aaron, Milbrandt, Jeffrey
Published in Cell reports (Cambridge) (19.10.2021)
Published in Cell reports (Cambridge) (19.10.2021)
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Journal Article
cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons
Sasaki, Yo, Engber, Thomas M., Hughes, Robert O., Figley, Matthew D., Wu, Tong, Bosanac, Todd, Devraj, Rajesh, Milbrandt, Jeffrey, Krauss, Raul, DiAntonio, Aaron
Published in Experimental neurology (01.07.2020)
Published in Experimental neurology (01.07.2020)
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Journal Article
Multiple domain interfaces mediate SARM1 autoinhibition
Shen, Chen, Vohra, Mihir, Zhang, Pengfei, Mao, Xianrong, Figley, Matthew D., Zhu, Jian, Sasaki, Yo, Wu, Hao, DiAntonio, Aaron, Milbrandt, Jeffrey
Published in Proceedings of the National Academy of Sciences - PNAS (26.01.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (26.01.2021)
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