New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource
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Potent antimalarial 4-pyridones with improved physico-chemical properties
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Published in Bioorganic & medicinal chemistry letters (15.09.2011)
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Published in Nature (London) (01.08.2018)
Published in Nature (London) (01.08.2018)
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Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition
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Published in Proceedings of the National Academy of Sciences - PNAS (07.05.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (07.05.2019)
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Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis
Thomas, Michael, Brand, Stephen, De Rycker, Manu, Zuccotto, Fabio, Lukac, Iva, Dodd, Peter G, Ko, Eun-Jung, Manthri, Sujatha, McGonagle, Kate, Osuna-Cabello, Maria, Riley, Jennifer, Pont, Caterina, Simeons, Frederick, Stojanovski, Laste, Thomas, John, Thompson, Stephen, Viayna, Elisabet, Fiandor, Jose M, Martin, Julio, Wyatt, Paul G, Miles, Timothy J, Read, Kevin D, Marco, Maria, Gilbert, Ian H
Published in Journal of medicinal chemistry (13.05.2021)
Published in Journal of medicinal chemistry (13.05.2021)
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Short-course combination treatment for experimental chronic Chagas disease
González, Silvia, Wall, Richard J, Thomas, John, Braillard, Stephanie, Brunori, Gino, Camino Díaz, Isabel, Cantizani, Juan, Carvalho, Sandra, Castañeda Casado, Pablo, Chatelain, Eric, Cotillo, Ignacio, Fiandor, Jose M, Francisco, Amanda Fortes, Grimsditch, David, Keenan, Martine, Kelly, John M, Kessler, Albane, Luise, Chiara, Lyon, Jon J, MacLean, Lorna, Marco, Maria, Martin, J Julio, Martinez Martinez, Maria S, Paterson, Christy, Read, Kevin D, Santos-Villarejo, Angel, Zuccotto, Fabio, Wyllie, Susan, Miles, Tim J, De Rycker, Manu
Published in Science translational medicine (13.12.2023)
Published in Science translational medicine (13.12.2023)
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Author Correction: Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis
Wyllie, Susan, Thomas, Michael, Patterson, Stephen, Crouch, Sabrinia, De Rycker, Manu, Lowe, Rhiannon, Gresham, Stephanie, Urbaniak, Michael D, Otto, Thomas D, Stojanovski, Laste, Simeons, Frederick R C, Manthri, Sujatha, MacLean, Lorna M, Zuccotto, Fabio, Homeyer, Nadine, Pflaumer, Hannah, Boesche, Markus, Sastry, Lalitha, Connolly, Paul, Albrecht, Sebastian, Berriman, Matt, Drewes, Gerard, Gray, David W, Ghidelli-Disse, Sonja, Dixon, Susan, Fiandor, Jose M, Wyatt, Paul G, Ferguson, Michael A J, Fairlamb, Alan H, Miles, Timothy J, Read, Kevin D, Gilbert, Ian H
Published in Nature (London) (20.07.2023)
Published in Nature (London) (20.07.2023)
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Discovery and Optimization of 5‑Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi
Brand, Stephen, Ko, Eun Jung, Viayna, Elisabet, Thompson, Stephen, Spinks, Daniel, Thomas, Michael, Sandberg, Lars, Francisco, Amanda F, Jayawardhana, Shiromani, Smith, Victoria C, Jansen, Chimed, De Rycker, Manu, Thomas, John, MacLean, Lorna, Osuna-Cabello, Maria, Riley, Jennifer, Scullion, Paul, Stojanovski, Laste, Simeons, Frederick R. C, Epemolu, Ola, Shishikura, Yoko, Crouch, Sabrinia D, Bakshi, Tania S, Nixon, Christopher J, Reid, Iain H, Hill, Alan P, Underwood, Tim Z, Hindley, Sean J, Robinson, Sharon A, Kelly, John M, Fiandor, Jose M, Wyatt, Paul G, Marco, Maria, Miles, Timothy J, Read, Kevin D, Gilbert, Ian H
Published in Journal of medicinal chemistry (14.09.2017)
Published in Journal of medicinal chemistry (14.09.2017)
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Identification and Optimization of a Series of 8‑Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity: Initial SAR and Assessment of In Vivo Activity
Thomas, Michael G, De Rycker, Manu, Wall, Richard J, Spinks, Daniel, Epemolu, Ola, Manthri, Sujatha, Norval, Suzanne, Osuna-Cabello, Maria, Patterson, Stephen, Riley, Jennifer, Simeons, Frederick R. C, Stojanovski, Laste, Thomas, John, Thompson, Stephen, Naylor, Claire, Fiandor, Jose M, Wyatt, Paul G, Marco, Maria, Wyllie, Susan, Read, Kevin D, Miles, Timothy J, Gilbert, Ian H
Published in Journal of medicinal chemistry (10.09.2020)
Published in Journal of medicinal chemistry (10.09.2020)
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Synthesis and Structure–Activity Relationships of the Novel Antimalarials 5‑Pyridinyl-4(1H)‑Pyridones
Bueno, José M, Calderon, Félix, Chicharro, Jesús, De la Rosa, Juan C, Díaz, Beatriz, Fernández, Jorge, Fiandor, José M, Fraile, María T, García, Mercedes, Herreros, Esperanza, García-Pérez, Adolfo, Lorenzo, Milagros, Mallo, Araceli, Puente, Margarita, Saadeddin, Anas, Ferrer, Santiago, Angulo-Barturen, Iñigo, Burrows, Jeremy N, León, María L
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Falcipain Inhibitors: Optimization Studies of the 2-Pyrimidinecarbonitrile Lead Series
Coterón, Jose M, Catterick, David, Castro, Julia, Chaparro, María J, Díaz, Beatriz, Fernández, Esther, Ferrer, Santiago, Gamo, Francisco J, Gordo, Mariola, Gut, Jiri, de las Heras, Laura, Legac, Jennifer, Marco, Maria, Miguel, Juan, Muñoz, Vicente, Porras, Esther, de la Rosa, Juan C, Ruiz, Jose R, Sandoval, Elena, Ventosa, Pilar, Rosenthal, Philip J, Fiandor, Jose M
Published in Journal of medicinal chemistry (26.08.2010)
Published in Journal of medicinal chemistry (26.08.2010)
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Metabolic Clustering Analysis as a Strategy for Compound Selection in the Drug Discovery Pipeline for Leishmaniasis
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Published in ACS chemical biology (18.05.2018)
Published in ACS chemical biology (18.05.2018)
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Discovery of pyrazolopyrrolidinones as potent, broad-spectrum inhibitors of Leishmania infection
Kavouris, John A, McCall, Laura-Isobel, Giardini, Miriam A, De Muylder, Geraldine, Thomas, Diane, Garcia-Pérez, Adolfo, Cantizani, Juan, Cotillo, Ignacio, Fiandor, Jose M, McKerrow, James H, De Oliveira, Camila I, Siqueira-Neto, Jair L, González, Silvia, Brown, Lauren E, Schaus, Scott E
Published in Frontiers in tropical diseases (2023)
Published in Frontiers in tropical diseases (2023)
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Synthesis and Structure–Activity Relationships of 4-Pyridones as Potential Antimalarials
Yeates, Clive L, Batchelor, John F, Capon, Edward C, Cheesman, Neil J, Fry, Mitch, Hudson, Alan T, Pudney, Mary, Trimming, Helen, Woolven, James, Bueno, José M, Chicharro, Jesús, Fernández, Esther, Fiandor, José M, Gargallo-Viola, Domingo, Gómez de las Heras, Federico, Herreros, Esperanza, León, María L
Published in Journal of medicinal chemistry (08.05.2008)
Published in Journal of medicinal chemistry (08.05.2008)
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Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis
Thomas, Michael G, De Rycker, Manu, Ajakane, Myriam, Crouch, Sabrinia D, Campbell, Lorna, Daugan, Alain, Fra, Gloria, Guerrero, César, Mackenzie, Claire J, MacLean, Lorna, Manthri, Sujatha, Martin, Franck, Norval, Suzanne, Osuna-Cabello, Maria, Riley, Jennifer, Shishikura, Yoko, Miguel-Siles, Juan, Simeons, Frederick R C, Stojanovski, Laste, Thomas, John, Thompson, Stephen, Velasco, Raul F, Fiandor, Jose M, Wyatt, Paul G, Read, Kevin D, Gilbert, Ian H, Miles, Timothy J
Published in MedChemComm (01.10.2020)
Published in MedChemComm (01.10.2020)
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Identification of 6-amino-1 H -pyrazolo[3,4- d ]pyrimidines with in vivo efficacy against visceral leishmaniasis
Thomas, Michael G, De Rycker, Manu, Ajakane, Myriam, Crouch, Sabrinia D, Campbell, Lorna, Daugan, Alain, Fra, Gloria, Guerrero, César, Mackenzie, Claire J, MacLean, Lorna, Manthri, Sujatha, Martin, Franck, Norval, Suzanne, Osuna-Cabello, Maria, Riley, Jennifer, Shishikura, Yoko, Miguel-Siles, Juan, Simeons, Frederick R C, Stojanovski, Laste, Thomas, John, Thompson, Stephen, Velasco, Raul F, Fiandor, Jose M, Wyatt, Paul G, Read, Kevin D, Gilbert, Ian H, Miles, Timothy J
Published in RSC medicinal chemistry (01.10.2020)
Published in RSC medicinal chemistry (01.10.2020)
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Corrections to Falcipain Inhibitors: Optimization Studies of the 2-Pyrimidinecarbonitrile Lead Series
Coterón, Jose M, Catterick, David, Castro, Julia, Chaparro, María J, Díaz, Beatriz, Fernández, Esther, Ferrer, Santiago, Gamo, Francisco J, Gordo, Mariola, Gut, Jiri, de las Heras, Laura, Legac, Jennifer, Marco, Maria, Miguel, Juan, Muñoz, Vicente, Porras, Esther, de la Rosa, Juan C, Ruiz, Jose R, Sandoval, Elena, Ventosa, Pilar, Rosenthal, Philip J, Fiandor, Jose M
Published in Journal of medicinal chemistry (11.11.2010)
Published in Journal of medicinal chemistry (11.11.2010)
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Exploration of 4(1H)-pyridones as a novel family of potent antimalarial inhibitors of the plasmodial cytochrome bc1
Bueno, José M, Herreros, Esperanza, Angulo-Barturen, Iñigo, Ferrer, Santiago, Fiandor, José M, Gamo, Francisco J, Gargallo-Viola, Domingo, Derimanov, Geo
Published in Future medicinal chemistry (01.12.2012)
Published in Future medicinal chemistry (01.12.2012)
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Stereoselective synthesis of the antifungal GM222712
Bueno, José M, Coterón, José M, Chiara, Jose Luis, Fernández-Mayoralas, Alfonso, Fiandor, José M, Valle, Nuria
Published in Tetrahedron letters (08.06.2000)
Published in Tetrahedron letters (08.06.2000)
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