MCOLN1 is a ROS sensor in lysosomes that regulates autophagy
Zhang, Xiaoli, Cheng, Xiping, Yu, Lu, Yang, Junsheng, Calvo, Raul, Patnaik, Samarjit, Hu, Xin, Gao, Qiong, Yang, Meimei, Lawas, Maria, Delling, Markus, Marugan, Juan, Ferrer, Marc, Xu, Haoxing
Published in Nature communications (30.06.2016)
Published in Nature communications (30.06.2016)
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High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer
Datta, Amrita, Kim, Hogyoung, McGee, Lauren, Johnson, Adedoyin E., Talwar, Sudha, Marugan, Juan, Southall, Noel, Hu, Xin, Lal, Madhu, Mondal, Debasis, Ferrer, Marc, Abdel-Mageed, Asim B.
Published in Scientific reports (25.05.2018)
Published in Scientific reports (25.05.2018)
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Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation
Wang, Wuyang, Gao, Qiong, Yang, Meimei, Zhang, Xiaoli, Yu, Lu, Lawas, Maria, Li, Xinran, Bryant-Genevier, Marthe, Southall, Noel T., Marugan, Juan, Ferrer, Marc, Xu, Haoxing
Published in Proceedings of the National Academy of Sciences - PNAS (17.03.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (17.03.2015)
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Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors
Singh, Anju, Venkannagari, Sreedhar, Oh, Kyu H, Zhang, Ya-Qin, Rohde, Jason M, Liu, Li, Nimmagadda, Sridhar, Sudini, Kuladeep, Brimacombe, Kyle R, Gajghate, Sachin, Ma, Jinfang, Wang, Amy, Xu, Xin, Shahane, Sampada A, Xia, Menghang, Woo, Juhyung, Mensah, George A, Wang, Zhibin, Ferrer, Marc, Gabrielson, Edward, Li, Zhuyin, Rastinejad, Fraydoon, Shen, Min, Boxer, Matthew B, Biswal, Shyam
Published in ACS chemical biology (18.11.2016)
Published in ACS chemical biology (18.11.2016)
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PAX3-FOXO1 Establishes Myogenic Super Enhancers and Confers BET Bromodomain Vulnerability
Gryder, Berkley E, Yohe, Marielle E, Chou, Hsien-Chao, Zhang, Xiaohu, Marques, Joana, Wachtel, Marco, Schaefer, Beat, Sen, Nirmalya, Song, Young, Gualtieri, Alberto, Pomella, Silvia, Rota, Rossella, Cleveland, Abigail, Wen, Xinyu, Sindiri, Sivasish, Wei, Jun S, Barr, Frederic G, Das, Sudipto, Andresson, Thorkell, Guha, Rajarshi, Lal-Nag, Madhu, Ferrer, Marc, Shern, Jack F, Zhao, Keji, Thomas, Craig J, Khan, Javed
Published in Cancer discovery (01.08.2017)
Published in Cancer discovery (01.08.2017)
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Exploiting Synthetic Lethality for the Therapy of ABC Diffuse Large B Cell Lymphoma
Yang, Yibin, Shaffer, Arthur L., Emre, N.C. Tolga, Ceribelli, Michele, Zhang, Meili, Wright, George, Xiao, Wenming, Powell, John, Platig, John, Kohlhammer, Holger, Young, Ryan M., Zhao, Hong, Yang, Yandan, Xu, Weihong, Buggy, Joseph J., Balasubramanian, Sriram, Mathews, Lesley A., Shinn, Paul, Guha, Rajarshi, Ferrer, Marc, Thomas, Craig, Waldmann, Thomas A., Staudt, Louis M.
Published in Cancer cell (12.06.2012)
Published in Cancer cell (12.06.2012)
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A TRP Channel in the Lysosome Regulates Large Particle Phagocytosis via Focal Exocytosis
Samie, Mohammad, Wang, Xiang, Zhang, Xiaoli, Goschka, Andrew, Li, Xinran, Cheng, Xiping, Gregg, Evan, Azar, Marlene, Zhuo, Yue, Garrity, Abigail G., Gao, Qiong, Slaugenhaupt, Susan, Pickel, Jim, Zolov, Sergey N., Weisman, Lois S., Lenk, Guy M., Titus, Steve, Bryant-Genevier, Marthe, Southall, Noel, Juan, Marugan, Ferrer, Marc, Xu, Haoxing
Published in Developmental cell (16.09.2013)
Published in Developmental cell (16.09.2013)
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Pharmacological activation of STING blocks SARS-CoV-2 infection
Li, Minghua, Ferretti, Max, Ying, Baoling, Descamps, Hélène, Lee, Emily, Dittmar, Mark, Lee, Jae Seung, Whig, Kanupriya, Kamalia, Brinda, Dohnalová, Lenka, Uhr, Giulia, Zarkoob, Hoda, Chen, Yu-Chi, Ramage, Holly, Ferrer, Marc, Lynch, Kristen, Schultz, David C., Thaiss, Christoph A., Diamond, Michael S., Cherry, Sara
Published in Science Immunology (18.05.2021)
Published in Science Immunology (18.05.2021)
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Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy
Kenny, Hilary A., Lal-Nag, Madhu, White, Erin A., Shen, Min, Chiang, Chun-Yi, Mitra, Anirban K., Zhang, Yilin, Curtis, Marion, Schryver, Elizabeth M., Bettis, Sam, Jadhav, Ajit, Boxer, Matthew B., Li, Zhuyin, Ferrer, Marc, Lengyel, Ernst
Published in Nature communications (05.02.2015)
Published in Nature communications (05.02.2015)
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Genome-scale RNAi screen for host factors required for HIV replication
Zhou, Honglin, Xu, Min, Huang, Qian, Gates, Adam T, Zhang, Xiaohua D, Castle, John C, Stec, Erica, Ferrer, Marc, Strulovici, Berta, Hazuda, Daria J, Espeseth, Amy S
Published in Cell host & microbe (13.11.2008)
Published in Cell host & microbe (13.11.2008)
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Blockade of oncogenic IκB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors
Ceribelli, Michele, Kelly, Priscilla N., Shaffer, Arthur L., Wright, George W., Xiao, Wenming, Yang, Yibin, Griner, Lesley A. Mathews, Guha, Rajarshi, Shinn, Paul, Keller, Jonathan M., Liu, Dongbo, Patel, Paresma R., Ferrer, Marc, Joshi, Shivangi, Nerle, Sujata, Sandy, Peter, Normant, Emmanuel, Thomas, Craig J., Staudt, Louis M.
Published in Proceedings of the National Academy of Sciences - PNAS (05.08.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (05.08.2014)
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Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model
Sharma, Ruchi, George, Aman, Nimmagadda, Malika, Ortolan, Davide, Karla, Barbosa-Sabanero, Qureshy, Zoya, Bose, Devika, Dejene, Roba, Liang, Genqing, Wan, Qin, Chang, Justin, Jha, Balendu Shekhar, Memon, Omar, Miyagishima, Kiyoharu Joshua, Rising, Aaron, Lal, Madhu, Hanson, Eric, King, Rebecca, Campos, Mercedes Maria, Ferrer, Marc, Amaral, Juan, McGaughey, David, Bharti, Kapil
Published in Nature communications (15.12.2021)
Published in Nature communications (15.12.2021)
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Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection
He, Shanshan, Lin, Billy, Chu, Virginia, Hu, Zongyi, Hu, Xin, Xiao, Jingbo, Wang, Amy Q, Schweitzer, Cameron J, Li, Qisheng, Imamura, Michio, Hiraga, Nobuhiko, Southall, Noel, Ferrer, Marc, Zheng, Wei, Chayama, Kazuaki, Marugan, Juan J, Liang, T Jake
Published in Science translational medicine (08.04.2015)
Published in Science translational medicine (08.04.2015)
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Targeting IRAK1 as a Therapeutic Approach for Myelodysplastic Syndrome
Rhyasen, Garrett W., Bolanos, Lyndsey, Fang, Jing, Jerez, Andres, Wunderlich, Mark, Rigolino, Carmela, Mathews, Lesley, Ferrer, Marc, Southall, Noel, Guha, Rajarshi, Keller, Jonathan, Thomas, Craig, Beverly, Levi J., Cortelezzi, Agostino, Oliva, Esther N., Cuzzola, Maria, Maciejewski, Jaroslaw P., Mulloy, James C., Starczynowski, Daniel T.
Published in Cancer cell (08.07.2013)
Published in Cancer cell (08.07.2013)
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Disease models for the development of therapies for lysosomal storage diseases
Xu, Miao, Motabar, Omid, Ferrer, Marc, Marugan, Juan J., Zheng, Wei, Ottinger, Elizabeth A.
Published in Annals of the New York Academy of Sciences (01.05.2016)
Published in Annals of the New York Academy of Sciences (01.05.2016)
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USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds
Madan, Babita, Walker, Matthew P., Young, Robert, Quick, Laura, Orgel, Kelly A., Ryan, Meagan, Gupta, Priti, Henrich, Ian C., Ferrer, Marc, Marine, Shane, Roberts, Brian S., Arthur, William T., Berndt, Jason D., Oliveira, Andre M., Moon, Randall T., Virshup, David M., Chou, Margaret M., Major, Michael B.
Published in Proceedings of the National Academy of Sciences - PNAS (24.05.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (24.05.2016)
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Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2–dependent adult T-cell leukemia
Zhang, Meili, Griner, Lesley A. Mathews, Ju, Wei, Duveau, Damien Y., Guha, Rajarshi, Petrus, Michael N., Wen, Bernard, Maeda, Michiyuki, Shinn, Paul, Ferrer, Marc, Conlon, Kevin D., Bamford, Richard N., O’Shea, John J., Thomas, Craig J., Waldmann, Thomas A.
Published in Proceedings of the National Academy of Sciences - PNAS (06.10.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (06.10.2015)
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