Network Properties of Genes Harboring Inherited Disease Mutations
Feldman, Igor, Rzhetsky, Andrey, Vitkup, Dennis
Published in Proceedings of the National Academy of Sciences - PNAS (18.03.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (18.03.2008)
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An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies
O'Neil, Jennifer, Benita, Yair, Feldman, Igor, Chenard, Melissa, Roberts, Brian, Liu, Yaping, Li, Jing, Kral, Astrid, Lejnine, Serguei, Loboda, Andrey, Arthur, William, Cristescu, Razvan, Haines, Brian B, Winter, Christopher, Zhang, Theresa, Bloecher, Andrew, Shumway, Stuart D
Published in Molecular cancer therapeutics (01.06.2016)
Published in Molecular cancer therapeutics (01.06.2016)
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Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: In Vitro and In Vivo Preclinical Models
Chan-Penebre, Elayne, Armstrong, Kelli, Drew, Allison, Grassian, Alexandra R, Feldman, Igor, Knutson, Sarah K, Kuplast-Barr, Kristy, Roche, Maria, Campbell, John, Ho, Peter, Copeland, Robert A, Chesworth, Richard, Smith, Jesse J, Keilhack, Heike, Ribich, Scott A
Published in Molecular cancer therapeutics (01.05.2017)
Published in Molecular cancer therapeutics (01.05.2017)
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Preclinical evaluation of the WEE1 inhibitor MK-1775 as single-agent anticancer therapy
Guertin, Amy D, Li, Jing, Liu, Yaping, Hurd, Melissa S, Schuller, Alwin G, Long, Brian, Hirsch, Heather A, Feldman, Igor, Benita, Yair, Toniatti, Carlo, Zawel, Leigh, Fawell, Stephen E, Gilliland, D Gary, Shumway, Stuart D
Published in Molecular cancer therapeutics (01.08.2013)
Published in Molecular cancer therapeutics (01.08.2013)
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EZH2 Inhibition by Tazemetostat Results in Altered Dependency on B-cell Activation Signaling in DLBCL
Brach, Dorothy, Johnston-Blackwell, Danielle, Drew, Allison, Lingaraj, Trupti, Motwani, Vinny, Warholic, Natalie M, Feldman, Igor, Plescia, Christopher, Smith, Jesse J, Copeland, Robert A, Keilhack, Heike, Chan-Penebre, Elayne, Knutson, Sarah K, Ribich, Scott A, Raimondi, Alejandra, Thomenius, Michael J
Published in Molecular cancer therapeutics (01.11.2017)
Published in Molecular cancer therapeutics (01.11.2017)
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Antibodies Targeting Human or Mouse VSIG4 Repolarize Tumor-Associated Macrophages Providing the Potential of Potent and Specific Clinical Anti-Tumor Response Induced across Multiple Cancer Types
Sazinsky, Stephen, Zafari, Mohammad, Klebanov, Boris, Ritter, Jessica, Nguyen, Phuong A, Phennicie, Ryan T, Wahle, Joe, Kauffman, Kevin J, Razlog, Maja, Manfra, Denise, Feldman, Igor, Novobrantseva, Tatiana
Published in International journal of molecular sciences (01.06.2024)
Published in International journal of molecular sciences (01.06.2024)
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A gene expression signature of RAS pathway dependence predicts response to PI3K and RAS pathway inhibitors and expands the population of RAS pathway activated tumors
Loboda, Andrey, Nebozhyn, Michael, Klinghoffer, Rich, Frazier, Jason, Chastain, Michael, Arthur, William, Roberts, Brian, Zhang, Theresa, Chenard, Melissa, Haines, Brian, Andersen, Jannik, Nagashima, Kumiko, Paweletz, Cloud, Lynch, Bethany, Feldman, Igor, Dai, Hongyue, Huang, Pearl, Watters, James
Published in BMC genomics (30.06.2010)
Published in BMC genomics (30.06.2010)
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Preclinical Efficacy of VTX-0811: A Humanized First-in-Class PSGL-1 mAb Targeting TAMs to Suppress Tumor Growth
Novobrantseva, Tatiana, Manfra, Denise, Ritter, Jessica, Razlog, Maja, O'Nuallain, Brian, Zafari, Mohammad, Nowakowska, Dominika, Basinski, Sara, Phennicie, Ryan T, Nguyen, Phuong A, Brehm, Michael A, Sazinsky, Stephen, Feldman, Igor
Published in Cancers (06.08.2024)
Published in Cancers (06.08.2024)
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Journal Article
Unique functions of CHK1 and WEE1 underlie synergistic anti-tumor activity upon pharmacologic inhibition
Guertin, Amy D, Martin, Melissa M, Roberts, Brian, Hurd, Melissa, Qu, Xianlu, Miselis, Nathan R, Liu, Yaping, Li, Jing, Feldman, Igor, Benita, Yair, Bloecher, Andrew, Toniatti, Carlo, Shumway, Stuart D
Published in Cancer cell international (13.11.2012)
Published in Cancer cell international (13.11.2012)
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1043 Intratumoral mRNA IL-12 can induce a dose dependent immunostimulatory effect within tumor microenvironment in patients with advanced solid tumors
Abadier, Michael, Chow, Jacky, Van, Linh, Sehgal, Vasudha, Feldman, Igor, Do, Khanh, Aanur, Praveen, Durham, Nicholas, Chen, Xiaoru, Wu, Yuling, Fraenkel, Paula G, Azaro, Analia, Alvarez, Eduardo Castanon, Zamarin, Dmitriy, Carneiro, Benedito, Marron, Thomas, Patel, Sandip P, Subbiah, Vivek, Mehmi, Inderjit, Oberoi, Arjun, El-Khoueiry, Anthony, Hamid, Omid
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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1530 T-cell responses to individualized neoantigen therapy (INT) mRNA-4157 (V940) as monotherapy or in combination with pembrolizumab
Gainor, Justin F, Patel, Manish R, Weber, Jeffrey, Gutierrez, Martin, Bauman, Julie E, Clarke, Jeffrey M, Julian, Ricklie A, Scott, Aaron J, Geiger, Jessica L, Kirtane, Kedar, Robert-Tissot, Celine, Coder, Brandon, Tasneem, Moomal, Sun, Jing, Zheng, Wei, Gerbereux, Lauren, Laino, Andressa, Pollard, Jack, Hou, Peijie, Sehgal, Vasudha, Daghestani, Hikmat N, Feldman, Igor, Srinivasan, Lakshmi, Frederick, Joshua, Brown, Michelle, Aanur, Praveen, Meehan, Robert, Burris, Howard A
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
886 Targeting VSIG4, a novel macrophage checkpoint, repolarizes suppressive macrophages which induces an inflammatory response in primary cell in vitro assays and fresh human tumor cultures
Sazinsky, Steve, Nguyen, Phuong, Zafari, Mohammad, Phennicie, Ryan, Wahle, Joe, Komoroski, Veronica, Rooney, Kathryn, Mizzoni, Craig, Klebanov, Boris, Manfra, Denise, Ritter, Jessica, Feldman, Igor, Novobrantseva, Tatiana
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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Journal Article
862 Targeting PSGL-1, a novel macrophage checkpoint, repolarizes suppressive macrophages, induces an inflammatory tumor microenvironment, and suppresses tumor growth
Nguyen, Phuong, Phennicie, Ryan, Kauffman, Kevin, Nowakowska, Dominika, Zafari, Mohammad, Komoroski, Veronica, Sazinsky, Steve, Wahle, Joe, Manfra, Denise, Vaidya, Shantashri, Brehm, Michael, Feldman, Igor, Novobrantseva, Tatiana
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Journal Article
Individualised neoantigen therapy mRNA-4157 (V940) plus pembrolizumab versus pembrolizumab monotherapy in resected melanoma (KEYNOTE-942): a randomised, phase 2b study
Weber, Jeffrey S, Carlino, Matteo S, Khattak, Adnan, Meniawy, Tarek, Ansstas, George, Taylor, Matthew H, Kim, Kevin B, McKean, Meredith, Long, Georgina V, Sullivan, Ryan J, Faries, Mark, Tran, Thuy T, Cowey, C Lance, Pecora, Andrew, Shaheen, Montaser, Segar, Jennifer, Medina, Theresa, Atkinson, Victoria, Gibney, Geoffrey T, Luke, Jason J, Thomas, Sajeve, Buchbinder, Elizabeth I, Healy, Jane A, Huang, Mo, Morrissey, Manju, Feldman, Igor, Sehgal, Vasudha, Robert-Tissot, Celine, Hou, Peijie, Zhu, Lili, Brown, Michelle, Aanur, Praveen, Meehan, Robert S, Zaks, Tal
Published in The Lancet (British edition) (17.02.2024)
Published in The Lancet (British edition) (17.02.2024)
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Journal Article
Macrophages - Controlling the Bifurcation Between Tumor Existence or Regression
Novobrantseva, Tatiana, Manfra, Denise, Nguyen, Ani, Feldman, Igor
Published in Advanced biology (01.10.2023)
Published in Advanced biology (01.10.2023)
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Journal Article
PSGL-1 is a novel macrophage checkpoint in immuno-oncology
Nowakowska, Dominika, Phennicie, Ryan, Kauffman, Kevin, Zafari, Mohammad, Rooney, Kathryn, O’Nuallain, Brian, Sazinsky, Steve, Wahle, Joe, Feldman, Igor, Novobrantseva, Tatiana
Published in Journal of clinical oncology (20.05.2020)
Published in Journal of clinical oncology (20.05.2020)
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Journal Article
Abstract P105: Targeting VSIG4, a novel macrophage checkpoint, repolarizes suppressive macrophages which induces an inflammatory response in primary cell in vitro assays and fresh human tumor cultures
Sazinsky, Steve, Nguyen, Ani, Zafari, Mohammad, Phennicie, Ryan, Wahle, Joe, Komoroski, Veronica, Rooney, Kathryn, Mizzoni, Craig, Klebanov, Boris, Ritter, Jessica, Manfra, Denise, Feldman, Igor, Novobrantseva, Tatiana
Published in Molecular cancer therapeutics (01.12.2021)
Published in Molecular cancer therapeutics (01.12.2021)
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Journal Article
Abstract P107: PSGL-1 blocking antibodies repolarize tumor associated macrophages, reduce suppressive myeloid populations and induce inflammation in the tumor microenvironment, leading to suppression of tumor growth
Nguyen, Ani, Ritter, Jessica, Zafari, Mohammad, Manfra, Denise, Komoroski, Veronica, O'Nuallain, Brian, Phennicie, Ryan, Kauffman, Kevin, Nowakowska, Dominika, Wahle, Joe, Sazinsky, Steve, Brehm, Michael, Feldman, Igor, Novobrantseva, Tatiana
Published in Molecular cancer therapeutics (01.12.2021)
Published in Molecular cancer therapeutics (01.12.2021)
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