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Long‐term safety and sustained efficacy for up to 5 years of treatment with recombinant factor IX Fc fusion protein in subjects with haemophilia B: Results from the B‐YOND extension study
Pasi, K. John, Fischer, Kathelijn, Ragni, Margaret, Kulkarni, Roshni, Ozelo, Margareth C., Mahlangu, Johnny, Shapiro, Amy, P’Ng, Stephanie, Chambost, Hervé, Nolan, Beatrice, Bennett, Carolyn, Matsushita, Tadashi, Winding, Bent, Fruebis, Joachim, Yuan, Huixing, Rudin, Dan, Oldenburg, Johannes
Published in Haemophilia : the official journal of the World Federation of Hemophilia (01.11.2020)
Published in Haemophilia : the official journal of the World Federation of Hemophilia (01.11.2020)
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Safety and immunogenicity of Fc‐EDA, a recombinant ectodysplasin A1 replacement protein, in human subjects
Körber, Iris, Klein, Ophir D., Morhart, Patrick, Faschingbauer, Florian, Grange, Dorothy K., Clarke, Angus, Bodemer, Christine, Maitz, Silvia, Huttner, Kenneth, Kirby, Neil, Durand, Caroline, Schneider, Holm
Published in British journal of clinical pharmacology (01.10.2020)
Published in British journal of clinical pharmacology (01.10.2020)
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1859-LB: PG-102, a Novel Bispecific GLP-1R/GLP-2R Fc-Fused Agonist—Data on Safety, Tolerability, and Pharmacokinetics (PK) in Single Ascending Dose Trial in Healthy Subjects and Preliminary Population PK Modeling
HAN, SEUNGHOON, HAN, SUNGPIL, SON, KYOUNG-HWA, SUNG, YOUNGCHUL
Published in Diabetes (New York, N.Y.) (14.06.2024)
Published in Diabetes (New York, N.Y.) (14.06.2024)
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Long‐acting recombinant factor IX Fc fusion protein (rFIXFc) for perioperative management of subjects with haemophilia B in the phase 3 B‐LONG study
Powell, Jerry S., Apte, Shashikant, Chambost, Hervé, Hermans, Cedric, Jackson, Shannon, Josephson, Neil C., Mahlangu, Johnny N., Ozelo, Margareth C., Peerlinck, Kathelijne, Pasi, John, Perry, David, Ragni, Margaret V., Wang, Xuefeng, Jiang, Haiyan, Li, Shuanglian, Cristiano, Lynda M., Innes, Alison, Nugent, Karen, Brennan, Aoife, Luk, Alvin, Allen, Geoffrey, Pierce, Glenn F., Robinson, Brian
Published in British journal of haematology (01.01.2015)
Published in British journal of haematology (01.01.2015)
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Long-term safety and efficacy of recombinant factor VIII Fc fusion protein (rFVIIIFc) in subjects with haemophilia A
Nolan, B., Mahlangu, J., Perry, D., Young, G., Liesner, R., Konkle, B., Rangarajan, S., Brown, S., Hanabusa, H., Pasi, K. J., Pabinger, I., Jackson, S., Cristiano, L. M., Li, X., Pierce, G. F., Allen, G.
Published in Haemophilia : the official journal of the World Federation of Hemophilia (01.01.2016)
Published in Haemophilia : the official journal of the World Federation of Hemophilia (01.01.2016)
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Antibody Responses with Fc-Mediated Functions after Vaccination of HIV-Infected Subjects with Trivalent Influenza Vaccine
Kristensen, Anne B., Lay, William N., Ana-Sosa-Batiz, Fernanda, Vanderven, Hillary A., Madhavi, Vijaya, Laurie, Karen L., Carolan, Louise, Wines, Bruce D., Hogarth, Mark, Wheatley, Adam K., Kent, Stephen J.
Published in Journal of virology (15.06.2016)
Published in Journal of virology (15.06.2016)
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Phase 1 trial of HCB101, a novel Fc-based anti-SIRPα-CD47 fusion protein, in subjects with advanced cancers
Sun, David, Zhang, Vivien, Edenfield, William Jeffery, Iannotti, Nicholas, Zhang, Tian, Chang, Peter, Cheng, Wei-Hong, Zhang, Jian, Tong, Xiangmin, Zhang, Yan, Hsieh, Chihyi, Luk, Alvin, Lin, Chia-Chi
Published in Journal of clinical oncology (01.06.2025)
Published in Journal of clinical oncology (01.06.2025)
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Differentiation between control subjects and patients with chronic spontaneous urticaria based on the ability of anti-IgE autoantibodies (AAbs) to induce FcεRI crosslinking, as compared to anti-FcεRIα AAbs
Izaki, Satoshi, Toyoshima, Shota, Endo, Takahiro, Kanegae, Kazuko, Nunomura, Satoshi, Kashiwakura, Jun-ichi, Sasaki-Sakamoto, Tomomi, Nakamura, Ryosuke, Akiyama, Haruyo, Ra, Chisei, Hayama, Koremasa, Terui, Tadashi, Okayama, Yoshimichi
Published in Allergology international (01.07.2019)
Published in Allergology international (01.07.2019)
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Pharmacokinetic parameters of recombinant factor IX Fc fusion protein are not influenced by factor IX antigen levels in subjects from the Phase 3 B‐LONG trial
Sidonio, Robert F., Casiano, Sandra, Falk, Aletta, Altincatal, Arman, Katragadda, Suresh, Santagostino, Elena, Windyga, Jerzy
Published in Haemophilia : the official journal of the World Federation of Hemophilia (01.01.2023)
Published in Haemophilia : the official journal of the World Federation of Hemophilia (01.01.2023)
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Treatment of bleeding episodes with recombinant factor VIII Fc fusion protein in A‐LONG study subjects with severe haemophilia A
Shapiro, A. D., Mahlangu, J. N., Perry, D., Pasi, J., Quon, D. V., Chowdary, P., Tsao, E., Li, S., Innes, A., Pierce, G. F., Allen, G. A.
Published in Haemophilia : the official journal of the World Federation of Hemophilia (01.05.2017)
Published in Haemophilia : the official journal of the World Federation of Hemophilia (01.05.2017)
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Safety, pharmacokinetics, and pharmacodynamics of TG103, a novel long-acting GLP-1/Fc fusion protein after a single ascending dose in Chinese healthy subjects
Jin, Jiangli, Cui, Gang, Mi, Na, Wu, Wei, Zhang, Xin, Xiao, Chunyan, Wang, Jing, Qiu, Xueying, Han, Mai, Li, Ziyan, Wang, Lei, Lu, Tong, Niu, Huikun, Wu, Zhaoxi, Li, Jintong
Published in European journal of pharmaceutical sciences (01.06.2023)
Published in European journal of pharmaceutical sciences (01.06.2023)
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Safety, Tolerability, Pharmacokinetics, and pharmacodynamics of YH35324, a novel Long-Acting High-Affinity IgETrap-Fc protein in subjects with Atopy: Results from the First-in-Human study
Ye, Young-Min, Park, Jung-Won, Kim, Sae-Hoon, Cho, You Sook, Lee, Sook Young, Lee, Sae Young, Sim, Sujin, Song, Eunji, Kim, Bomin, Lee, Jieon, Kim, Su Kyung, Jang, Myoung Ho, Park, Hae-Sim
Published in International immunopharmacology (30.03.2024)
Published in International immunopharmacology (30.03.2024)
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Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of YH35324, a Novel Long-Acting High-Affinity IgETrap-Fc Fusion Protein, in Atopic Subjects with a Total IgE > 700 IU/mL
Ye, Young-Min, Park, Jung-Won, Kim, Sae-Hoon, Cho, Yoo Sook, Lee, Sook Young, Lee, Sae Young, Sim, Sujin, Song, Eunji, Kim, Bomin, Lee, Jieon, Kim, Su Kyung, Jang, Myoung Ho, Park, Hae-Sim
Published in Journal of allergy and clinical immunology (01.02.2024)
Published in Journal of allergy and clinical immunology (01.02.2024)
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Improved joint health in subjects with severe haemophilia A treated prophylactically with recombinant factor VIII Fc fusion protein
Oldenburg, J., Kulkarni, R., Srivastava, A., Mahlangu, J. N., Blanchette, V. S., Tsao, E., Winding, B., Dumont, J., Jain, N.
Published in Haemophilia : the official journal of the World Federation of Hemophilia (01.01.2018)
Published in Haemophilia : the official journal of the World Federation of Hemophilia (01.01.2018)
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Safety, tolerability and pharmacokinetics and pharmacodynamics of HL2351, a novel hybrid fc‐fused interleukin‐1 receptor antagonist, in healthy subjects: A first‐in‐human study
Oh, Jaeseong, Huh, Ki Young, Cho, Young‐Gyu, Cha, Ji‐Eun, Kim, Se‐Jin, Yoon, Seo Hyun, Park, Sung Sup, Yoon, Hyunyee, Lee, Jieon, Lee, Howard
Published in British journal of clinical pharmacology (01.02.2020)
Published in British journal of clinical pharmacology (01.02.2020)
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Population Pharmacokinetic Analysis of Recombinant Factor VIII Fc Fusion Protein in Subjects With Severe Hemophilia A: Expanded to Include Pediatric Subjects
Katragadda, Suresh, Neelakantan, Srividya, Diao, Lei, Wong, Nancy
Published in Journal of clinical pharmacology (01.07.2021)
Published in Journal of clinical pharmacology (01.07.2021)
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Phase 1/2a clinical trial of BI-1206, an anti-CD32b (FcγRIIB) antibody, in combination with pembrolizumab in subjects with advanced solid tumors previously treated with anti-PD-1/PD-L1
Carneiro, Ana, Yachnin, Jeffrey, Aljumaily, Raid, Abel, Edvard, Falchook, Gerald Steven, Ji, Yan, Borggren, Marie, Mårtensson, Linda, Gertsson, Susanne, Karlsson, Ingrid, Teige, Ingrid, Tehranchi, Ramin, Chisamore, Michael Jon, Frendeus, Björn, McAllister, Andres
Published in Journal of clinical oncology (01.06.2024)
Published in Journal of clinical oncology (01.06.2024)
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