Preclinical Profile of BI 224436, a Novel HIV-1 Non-Catalytic-Site Integrase Inhibitor
FENWICK, Craig, AMAD, Ma'an, FADER, Lee D, FAUCHER, Anne-Marie, GARNEAU, Michel, JAKALIAN, Araz, KAWAI, Stephen, LAMORTE, Louie, LAPLANTE, Steven, LAIBIN LUO, MASON, Steve, POUPART, Marc-André, BAILEY, Murray D, RIOUX, Nathalie, SCHROEDER, Patricia, SIMONEAU, Bruno, TREMBLAY, Sonia, TSANTRIZOS, Youla, WITVROUW, Myriam, YOAKIM, Christiane, BETHELL, Richard, BÖS, Michael, BONNEAU, Pierre, CORDINGLEY, Michael, COULOMBE, René, DUAN, Jianmin, EDWARDS, Paul
Published in Antimicrobial agents and chemotherapy (01.06.2014)
Published in Antimicrobial agents and chemotherapy (01.06.2014)
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Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein
LEMKE, Christopher T, TITOLO, Steve, GAGNON, Alexandre, KAWAI, Stephen H, RANCOURT, Jean, TREMBLAY, Martin, YOAKIM, Christiane, SIMONEAU, Bruno, ARCHAMBAULT, Jacques, SUNDQUIST, Wesley I, MASON, Stephen W, VON SCHWEDLER, Uta, GOUDREAU, Nathalie, MERCIER, Jean-François, WARDROP, Elizabeth, FAUCHER, Anne-Marie, COULOMBE, Rene, BANIK, Soma S. R, FADER, Lee
Published in Journal of Virology (01.06.2012)
Published in Journal of Virology (01.06.2012)
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Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV‑1
Fader, Lee D, Malenfant, Eric, Parisien, Mathieu, Carson, Rebekah, Bilodeau, François, Landry, Serge, Pesant, Marc, Brochu, Christian, Morin, Sébastien, Chabot, Catherine, Halmos, Ted, Bousquet, Yves, Bailey, Murray D, Kawai, Stephen H, Coulombe, René, LaPlante, Steven, Jakalian, Araz, Bhardwaj, Punit K, Wernic, Dominik, Schroeder, Patricia, Amad, Ma’an, Edwards, Paul, Garneau, Michel, Duan, Jianmin, Cordingley, Michael, Bethell, Richard, Mason, Stephen W, Bös, Michael, Bonneau, Pierre, Poupart, Marc-André, Faucher, Anne-Marie, Simoneau, Bruno, Fenwick, Craig, Yoakim, Christiane, Tsantrizos, Youla
Published in ACS medicinal chemistry letters (10.04.2014)
Published in ACS medicinal chemistry letters (10.04.2014)
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A novel inhibitor-binding site on the HIV-1 capsid N-terminal domain leads to improved crystallization via compound-mediated dimerization
Lemke, Christopher T., Titolo, Steve, Goudreau, Nathalie, Faucher, Anne-Marie, Mason, Stephen W., Bonneau, Pierre
Published in Acta crystallographica. Section D, Biological crystallography. (01.06.2013)
Published in Acta crystallographica. Section D, Biological crystallography. (01.06.2013)
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Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly
Fader, Lee D., Bethell, Richard, Bonneau, Pierre, Bös, Michael, Bousquet, Yves, Cordingley, Michael G., Coulombe, René, Deroy, Patrick, Faucher, Anne-Marie, Gagnon, Alexandre, Goudreau, Nathalie, Grand-Maître, Chantal, Guse, Ingrid, Hucke, Oliver, Kawai, Stephen H., Lacoste, Jean-Eric, Landry, Serge, Lemke, Christopher T., Malenfant, Eric, Mason, Stephen, Morin, Sébastien, O’Meara, Jeff, Simoneau, Bruno, Titolo, Steve, Yoakim, Christiane
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Evaluation of Phosphatidylinositol-4-Kinase IIIα as a Hepatitis C Virus Drug Target
VAILLANCOURT, Frederic H, BRAULT, Martine, CHIU, Tim T, MAHROUCHE, Louiza, FAUCHER, Anne-Marie, CARTIER, Mireille, CORDINGLEY, Michael G, BETHELL, Richard C, HUIPING JIANG, WHITE, Peter W, KUKOLJ, George, PILOTE, Louise, UYTTERSPROT, Nathalie, GAILLARD, Elias T, STOTTZ, James H, KNIGHT, Brian L, PANTAGES, Lynn, MCFARIAND, Mary, BREITFELDER, Steffen
Published in Journal of Virology (01.11.2012)
Published in Journal of Virology (01.11.2012)
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Landscape Transformation During Ceramic Age and Colonial Occupations of Barbuda, West Indies
Bain, Allison, Faucher, Anne-Marie, Kennedy, Lisa M., LeBlanc, Allison R., Burn, Michael J., Boger, Rebecca, Perdikaris, Sophia
Published in Environmental archaeology : the journal of human palaeoecology (02.01.2018)
Published in Environmental archaeology : the journal of human palaeoecology (02.01.2018)
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Biphenylsulfonacetic Acid Inhibitors of the Human Papillomavirus Type 6 E1 Helicase Inhibit ATP Hydrolysis by an Allosteric Mechanism Involving Tyrosine 486
WHITE, Peter W, FAUCHER, Anne-Marie, MASSARIOL, Marie-Josée, WELCHNER, Ewald, RANCOURT, Jean, CARTIER, Mireille, ARCHAMBAULT, Jacques
Published in Antimicrobial Agents and Chemotherapy (01.12.2005)
Published in Antimicrobial Agents and Chemotherapy (01.12.2005)
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Discovery and Structural Characterization of a New Inhibitor Series of HIV-1 Nucleocapsid Function: NMR Solution Structure Determination of a Ternary Complex Involving a 2:1 Inhibitor/NC Stoichiometry
Goudreau, Nathalie, Hucke, Oliver, Faucher, Anne-Marie, Grand-Maître, Chantal, Lepage, Olivier, Bonneau, Pierre R., Mason, Stephen W., Titolo, Steve
Published in Journal of molecular biology (12.06.2013)
Published in Journal of molecular biology (12.06.2013)
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Oral Bioavailability and In Vivo Efficacy of the Helicase-Primase Inhibitor BILS 45 BS against Acyclovir-Resistant Herpes Simplex Virus Type 1
JIANMIN DUAN, LIUZZI, Michel, PARIS, William, LIARD, Francine, BROWNE, Abigail, DANSEREAU, Nathalie, SIMONEAU, Bruno, FAUCHER, Anne-Marie, CORDINGLEY, Michael G
Published in Antimicrobial Agents and Chemotherapy (01.06.2003)
Published in Antimicrobial Agents and Chemotherapy (01.06.2003)
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An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus
Lamarre, Daniel, Anderson, Paul C, Bailey, Murray, Beaulieu, Pierre, Bolger, Gordon, Bonneau, Pierre, Bös, Michael, Cameron, Dale R, Cartier, Mireille, Cordingley, Michael G, Faucher, Anne-Marie, Goudreau, Nathalie, Kawai, Stephen H, Kukolj, George, Lagacé, Lisette, LaPlante, Steven R, Narjes, Hans, Poupart, Marc-André, Rancourt, Jean, Sentjens, Roel E, St George, Roger, Simoneau, Bruno, Steinmann, Gerhard, Thibeault, Diane, Tsantrizos, Youla S, Weldon, Steven M, Yong, Chan-Loi, Llinàs-Brunet, Montse
Published in Nature (13.11.2003)
Published in Nature (13.11.2003)
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Novel Inhibitor Binding Site Discovery on HIV‑1 Capsid N‑Terminal Domain by NMR and X‑ray Crystallography
Goudreau, Nathalie, Lemke, Christopher T, Faucher, Anne-Marie, Grand-Maître, Chantal, Goulet, Sylvie, Lacoste, Jean-Eric, Rancourt, Jean, Malenfant, Eric, Mercier, Jean-François, Titolo, Steve, Mason, Stephen W
Published in ACS chemical biology (17.05.2013)
Published in ACS chemical biology (17.05.2013)
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Journal Article
Structure−Activity Study on a Novel Series of Macrocyclic Inhibitors of the Hepatitis C Virus NS3 Protease Leading to the Discovery of BILN 2061
Llinàs-Brunet, Montse, Bailey, Murray D, Bolger, Gordon, Brochu, Christian, Faucher, Anne-Marie, Ferland, Jean Marie, Garneau, Michel, Ghiro, Elise, Gorys, Vida, Grand-Maître, Chantal, Halmos, Ted, Lapeyre-Paquette, Nicole, Liard, Francine, Poirier, Martin, Rhéaume, Manon, Tsantrizos, Youla S, Lamarre, Daniel
Published in Journal of medicinal chemistry (25.03.2004)
Published in Journal of medicinal chemistry (25.03.2004)
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Herpes simplex virus helicase-primase inhibitors are active in animal models of human disease
Crute, James J, Grygon, Christine A, Hargrave, Karl D, Simoneau, Bruno, Faucher, Anne-Marie, Bolger, Gordon, Kibler, Philip, Liuzzi, Michel, Cordingley, Michael G
Published in Nature medicine (01.04.2002)
Published in Nature medicine (01.04.2002)
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Scaffold hopping in the rational design of novel HIV-1 non-nucleoside reverse transcriptase inhibitors
O’Meara, Jeff A., Jakalian, Araz, LaPlante, Steven, Bonneau, Pierre R., Coulombe, René, Faucher, Anne-Marie, Guse, Ingrid, Landry, Serge, Racine, Jennifer, Simoneau, Bruno, Thavonekham, Bounkham, Yoakim, Christiane
Published in Bioorganic & medicinal chemistry letters (15.06.2007)
Published in Bioorganic & medicinal chemistry letters (15.06.2007)
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Synthesis of BILN 2061, an HCV NS3 Protease Inhibitor with Proven Antiviral Effect in Humans
Faucher, Anne-Marie, Bailey, Murray D, Beaulieu, Pierre L, Brochu, Christian, Duceppe, Jean-Simon, Ferland, Jean-Marie, Ghiro, Elise, Gorys, Vida, Halmos, Ted, Kawai, Stephen H, Poirier, Martin, Simoneau, Bruno, Tsantrizos, Youla S, Llinàs-Brunet, Montse
Published in Organic letters (19.08.2004)
Published in Organic letters (19.08.2004)
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Identification of benzofurano[3,2-d]pyrimidin-2-ones, a new series of HIV-1 nucleotide-competing reverse transcriptase inhibitors
Tremblay, Martin, Bethell, Richard C., Cordingley, Michael G., DeRoy, Patrick, Duan, Jianmin, Duplessis, Martin, Edwards, Paul J., Faucher, Anne-Marie, Halmos, Ted, James, Clint A., Kuhn, Cyrille, Lacoste, Jean-Éric, Lamorte, Louie, LaPlante, Steven R., Malenfant, Éric, Minville, Joannie, Morency, Louis, Morin, Sébastien, Rajotte, Daniel, Salois, Patrick, Simoneau, Bruno, Tremblay, Sonia, Sturino, Claudio F.
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
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