Selective inhibition of TGFβ1 activation overcomes primary resistance to checkpoint blockade therapy by altering tumor immune landscape
Martin, Constance J, Datta, Abhishek, Littlefield, Christopher, Kalra, Ashish, Chapron, Christopher, Wawersik, Stefan, Dagbay, Kevin B, Brueckner, Christopher T, Nikiforov, Anastasia, Danehy, Jr, Francis T, Streich, Jr, Frederick C, Boston, Christopher, Simpson, Allison, Jackson, Justin W, Lin, Susan, Danek, Nicole, Faucette, Ryan R, Raman, Pichai, Capili, Allan D, Buckler, Alan, Carven, Gregory J, Schürpf, Thomas
Published in Science translational medicine (25.03.2020)
Published in Science translational medicine (25.03.2020)
Get more information
Journal Article
Intergenerational Transmission of Glucose Intolerance and Obesity by In Utero Undernutrition in Mice
JIMENEZ-CHILLARON, Josep C, ISGANAITIS, Elvira, PATTI, Mary-Elizabeth, CHARALAMBOUS, Marika, GESTA, Stephane, PENTINAT-PELEGRIN, Thais, FAUCETTE, Ryan R, OTIS, Jessica P, CHOW, Alice, DIAZ, Ruben, FERGUSON-SMITH, Anne
Published in Diabetes (New York, N.Y.) (01.02.2009)
Published in Diabetes (New York, N.Y.) (01.02.2009)
Get full text
Journal Article
Inhibition of Plasma Kallikrein by a Highly Specific Active Site Blocking Antibody
Kenniston, Jon A., Faucette, Ryan R., Martik, Diana, Comeau, Stephen R., Lindberg, Allison P., Kopacz, Kris J., Conley, Gregory P., Chen, Jie, Viswanathan, Malini, Kastrapeli, Niksa, Cosic, Janja, Mason, Shauna, DiLeo, Mike, Abendroth, Jan, Kuzmic, Petr, Ladner, Robert C., Edwards, Thomas E., TenHoor, Christopher, Adelman, Burt A., Nixon, Andrew E., Sexton, Daniel J.
Published in The Journal of biological chemistry (22.08.2014)
Published in The Journal of biological chemistry (22.08.2014)
Get full text
Journal Article
Structural basis of specific inhibition of extracellular activation of pro- or latent myostatin by the monoclonal antibody SRK-015
Dagbay, Kevin B., Treece, Erin, Streich, Frederick C., Jackson, Justin W., Faucette, Ryan R., Nikiforov, Anastasia, Lin, Susan C., Boston, Chris J., Nicholls, Samantha B., Capili, Allan D., Carven, Gregory J.
Published in The Journal of biological chemistry (17.04.2020)
Published in The Journal of biological chemistry (17.04.2020)
Get full text
Journal Article
2D-LC-MS/MS to measure cleaved high-molecular-weight kininogen in human plasma as a biomarker for C1-INH-HAE
Zhang, Guodong, Sexton, Daniel J, Faucette, Ryan R, Qiu, Yongchang, Wu, Jiang
Published in Bioanalysis (01.10.2017)
Published in Bioanalysis (01.10.2017)
Get full text
Journal Article
A phase 1 study investigating DX-2930 in healthy subjects
Chyung, Yung, MD, Vince, Bradley, DO, Iarrobino, Ryan, BA, Sexton, Dan, PhD, Kenniston, Jon, PhD, Faucette, Ryan, BS, TenHoor, Chris, PharmD, PhD, Stolz, Leslie E., PhD, Stevens, Chris, MD, Biedenkapp, Joseph, PhD, Adelman, Burt, MD
Published in Annals of allergy, asthma, & immunology (01.10.2014)
Published in Annals of allergy, asthma, & immunology (01.10.2014)
Get full text
Journal Article
Nonclinical Development of SRK-181: An Anti-Latent TGFβ1 Monoclonal Antibody for the Treatment of Locally Advanced or Metastatic Solid Tumors
Welsh, Brian T., Faucette, Ryan, Bilic, Sanela, Martin, Constance J., Schürpf, Thomas, Chen, David, Nicholls, Samantha, Lansita, Janice, Kalra, Ashish
Published in International journal of toxicology (01.05.2021)
Published in International journal of toxicology (01.05.2021)
Get full text
Journal Article
Abstract 1801: Development of a comprehensive biomarker strategy to support phase 1 clinical trial of SRK-181 the latent TGFβ1 inhibitor
Brueckner, Christopher, Faucette, Ryan, Caldwell, Charles, Reitsma, Sofia, Wawersik, Stefan, Kalra, Ashish, Gan, Lu, Lee-Hoeflich, Si Tuen
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Get full text
Journal Article
Inhibiting Plasma Kallikrein for Hereditary Angioedema Prophylaxis
Banerji, Aleena, Busse, Paula, Shennak, Mustafa, Lumry, William, Davis-Lorton, Mark, Wedner, Henry J, Jacobs, Joshua, Baker, James, Bernstein, Jonathan A, Lockey, Richard, Li, H. Henry, Craig, Timothy, Cicardi, Marco, Riedl, Marc, Al-Ghazawi, Ahmad, Soo, Carolyn, Iarrobino, Ryan, Sexton, Daniel J, TenHoor, Christopher, Kenniston, Jon A, Faucette, Ryan, Still, J. Gordon, Kushner, Harvey, Mensah, Robert, Stevens, Chris, Biedenkapp, Joseph C, Chyung, Yung, Adelman, Burt
Published in The New England journal of medicine (23.02.2017)
Published in The New England journal of medicine (23.02.2017)
Get full text
Journal Article
First-in-human phase 1 trial (DRAGON) of SRK-181, a potential first-in-class selective latent TGFβ1 inhibitor, alone or in combination with anti-PD-(L)1 treatment in patients with advanced solid tumors
Yap, Timothy A., Barve, Minal A., Gainor, Justin F., Weekes, Colin D., Bockorny, Bruno, Ju, Yawen, Faucette, Ryan, Bilic, Sanela, Lee-Hoeflich, Si Tuen, Song, Guochen, Chyung, Yung, Legler, Michelle, Gan, Lu, Bendell, Johanna C.
Published in Journal of clinical oncology (20.05.2021)
Published in Journal of clinical oncology (20.05.2021)
Get full text
Journal Article
Peroxisome Proliferator Activator Receptor γ Coactivator-1 Expression Is Reduced in Obesity: POTENTIAL PATHOGENIC ROLE OF SATURATED FATTY ACIDS AND p38 MITOGEN-ACTIVATED PROTEIN KINASE ACTIVATION
Crunkhorn, Sarah, Dearie, Farrell, Mantzoros, Christos, Gami, Hiral, da Silva, Wagner S, Espinoza, Daniel, Faucette, Ryan, Barry, Kristen, Bianco, Antonio C, Patti, Mary Elizabeth
Published in The Journal of biological chemistry (25.05.2007)
Published in The Journal of biological chemistry (25.05.2007)
Get full text
Journal Article
ASSAYS FOR DETERMINING PLASMA KALLIKREIN SYSTEM BIOMARKERS
NIXON ANDREW, KENNISTON JON A, TENHOOR CHRISTOPHER, ADELMAN BURT, FAUCETTE RYAN, SEXTON DANIEL J, CONLEY GREGORY P
Year of Publication 25.04.2023
Get full text
Year of Publication 25.04.2023
Patent
ASSAYS FOR DETERMINING PLASMA KALLIKREIN SYSTEM BIOMARKERS
NIXON ANDREW, KENNISTON JON A, TENHOOR CHRISTOPHER, ADELMAN BURT, FAUCETTE RYAN, SEXTON DANIEL J, CONLEY GREGORY P
Year of Publication 26.08.2022
Get full text
Year of Publication 26.08.2022
Patent