Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility
Valdearcos, Martin, Douglass, John D., Robblee, Megan M., Dorfman, Mauricio D., Stifler, Daniel R., Bennett, Mariko L., Gerritse, Irene, Fasnacht, Rachael, Barres, Ben A., Thaler, Joshua P., Koliwad, Suneil K.
Published in Cell metabolism (05.07.2017)
Published in Cell metabolism (05.07.2017)
Get full text
Journal Article
Prostaglandin PGE2 Receptor EP4 Regulates Microglial Phagocytosis and Increases Susceptibility to Diet-Induced Obesity
Niraula, Anzela, Fasnacht, Rachael D, Ness, Kelly M, Frey, Jeremy M, Cuschieri, Sophia A, Dorfman, Mauricio D, Thaler, Joshua P
Published in Diabetes (New York, N.Y.) (01.02.2023)
Published in Diabetes (New York, N.Y.) (01.02.2023)
Get full text
Journal Article
Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice
Dorfman, Mauricio D., Krull, Jordan E., Douglass, John D., Fasnacht, Rachael, Lara-Lince, Fernando, Meek, Thomas H., Shi, Xiaogang, Damian, Vincent, Nguyen, Hong T., Matsen, Miles E., Morton, Gregory J., Thaler, Joshua P.
Published in Nature communications (22.02.2017)
Published in Nature communications (22.02.2017)
Get full text
Journal Article
Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance
Douglass, John D, Ness, Kelly M, Valdearcos, Martin, Wyse-Jackson, Alice, Dorfman, Mauricio D, Frey, Jeremy M, Fasnacht, Rachael D, Santiago, Olivia D, Niraula, Anzela, Banerjee, Jineta, Robblee, Megan, Koliwad, Suneil K, Thaler, Joshua P
Published in Cell metabolism (05.09.2023)
Published in Cell metabolism (05.09.2023)
Get full text
Journal Article
Central androgen action reverses hypothalamic astrogliosis and atherogenic risk factors induced by orchiectomy and high-fat diet feeding in male mice
Dorfman, Mauricio D, Monfeuga, Thomas, Melhorn, Susan J, Kanter, Jenny E, Frey, Jeremy M, Fasnacht, Rachael D, Chandran, Anandhakumar, Lala, Emaad, Velasco, Inmaculada, Rubinow, Katya B, Meek, Thomas H, Schur, Ellen A, Bornfeldt, Karin E, Thaler, Joshua P
Published in American journal of physiology: endocrinology and metabolism (01.05.2023)
Published in American journal of physiology: endocrinology and metabolism (01.05.2023)
Get full text
Journal Article
CX3CL1 Action on Microglia Protects from Diet-Induced Obesity by Restoring POMC Neuronal Excitability and Melanocortin System Activity Impaired by High-Fat Diet Feeding
Banerjee, Jineta, Dorfman, Mauricio D, Fasnacht, Rachael, Douglass, John D, Wyse-Jackson, Alice C, Barria, Andres, Thaler, Joshua P
Published in International journal of molecular sciences (07.06.2022)
Published in International journal of molecular sciences (07.06.2022)
Get full text
Journal Article
Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility
Valdearcos, Martin, Douglass, John D., Robblee, Megan M., Dorfman, Mauricio D., Stifler, Daniel R., Bennett, Mariko L., Gerritse, Irene, Fasnacht, Rachael, Barres, Ben A., Thaler, Joshua P., Koliwad, Suneil K.
Published in Cell metabolism (05.06.2018)
Published in Cell metabolism (05.06.2018)
Get full text
Journal Article
Correlations between Synaptic Initiation and Meiotic Recombination: A Study of Humans and Mice
Gruhn, Jennifer R., Al-Asmar, Nasser, Fasnacht, Rachael, Maylor-Hagen, Heather, Peinado, Vanessa, Rubio, Carmen, Broman, Karl W., Hunt, Patricia A., Hassold, Terry
Published in American journal of human genetics (07.01.2016)
Published in American journal of human genetics (07.01.2016)
Get full text
Journal Article
Sa1117: A NEWLY DISCOVERED REGULATORY CD8 T CELL NETWORK HAS THE POTENTIAL TO REGULATE AND ELIMINATE PATHOGENIC CD4 T CELLS IN AUTOIMMUNE MEDIATED DIGESTIVE DISEASE
Crane, Courtney, Bowser, Justin, Fasnacht, Rachael, Gardell, Jennifer, Julien, Susan, Maurer, Meghan, Templeton, Megan L., Therriault, Jon, Swiderek, Kristine M.
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2022)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2022)
Get full text
Journal Article
A NEWLY DISCOVERED REGULATORY CD8 T CELL NETWORK HAS THE POTENTIAL TO REGULATE AND ELIMINATE PATHOGENIC CD4 T CELLS IN AUTOIMMUNE MEDIATED DISEASE OF THE GUT
Crane, Courtney, Bowser, Justin, Fasnacht, Rachael, Gardell, Jennifer, Maurer, Meghan, Julien, Susan, Templeton, Megan, Therriault, Jon Henry, Swiderek, Kristine
Published in Gastroenterology (New York, N.Y. 1943) (01.02.2022)
Published in Gastroenterology (New York, N.Y. 1943) (01.02.2022)
Get full text
Journal Article
Abstract PO-076: Murine adapted FOLFIRINOX for standard-of-care in KPC mice
Whittle, Martin C., Palkar, Aditi, Fasnacht, Rachael, Yan, James, Kheng, Borith, Sinfuego, Kianna, Thorsen, Shelley, Hingorani, Sunil R.
Published in Cancer research (Chicago, Ill.) (15.11.2021)
Published in Cancer research (Chicago, Ill.) (15.11.2021)
Get full text
Journal Article
A NOVEL BISPECIFIC CD8 TREG MODULATOR TARGETING CYTOLYTIC CD8 REGULATORY T CELLS REDUCES PATHOGENIC CD4 T CELLS AND INFLAMMATION IN TRANSLATIONAL MODELS OF INTESTINAL AUTOIMMUNE AND INFLAMMATORY DISEASE
Gardell, Jennifer, Boster, Daniel, Bowser, Justin, Crane, Courtney, Fasnacht, Rachael, Fitzpatrick, Kristin, Hermansky, Gleda, Julien, Susan, Maurer, Meghan, McMahan, Cathy, Meengs, Brent, Patton, Dan, Pham, Minh, Swiderek, Kristine
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2023)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2023)
Get full text
Journal Article
A NEWLY DISCOVERED REGULATORY CD8 T CELL NETWORK HAS THE POTENTIAL TO REGULATE AND ELIMINATE PATHOGENIC CD4 T CELLS IN AUTOIMMUNE MEDIATED DISEASE OF THE GUT
Crane, Courtney, Bowser, Justin, Fasnacht, Rachael, Gardell, Jennifer, Maurer, Meghan, Julien, Susan, Templeton, Megan, Therriault, Jon Henry, Swiderek, Kristine
Published in Inflammatory bowel diseases (22.01.2022)
Published in Inflammatory bowel diseases (22.01.2022)
Get full text
Journal Article
Bispecific CD8 Treg modulators regulate a novel regulatory CD8 T cell network and eliminate pathogenic CD4 T cells in live cell co-culture system
Gardell, Jennifer L, Crane, Courtney, Bowser, Justin, Fasnacht, Rachael, Julien, Susan, Maurer, Meghan E, Templeton, Megan, Therriault, Jon, Yang, Su Jung, Swiderek, Kristine M
Published in The Journal of immunology (1950) (01.05.2022)
Published in The Journal of immunology (1950) (01.05.2022)
Get full text
Journal Article
Demonstration of regulatory CD8 T cell prevalence, phenotype, and functions in autoimmune patients treated with a tolerizing peptide vaccine
Maurer, Meghan, Bowser, Justin, Fasnacht, Rachael, Gardell, Jennifer L, Julien, Susan, Templeton, Megan, Therriault, Jon, Yang, Su J, Swiderek, Kristine, Crane, Courtney
Published in The Journal of immunology (1950) (01.05.2022)
Published in The Journal of immunology (1950) (01.05.2022)
Get full text
Journal Article
A NOVEL BISPECIFIC CD8 TREG MODULATOR TARGETING CYTOLYTIC CD8 REGULATORY T CELLS REDUCES PATHOGENIC CD4 T CELLS AND INFLAMMATION IN TRANSLATIONAL MODELS OF INTESTINAL AUTOIMMUNE AND INFLAMMATORY DISEASE
Gardell, Jennifer, Boster, Daniel, Bowser, Justin, Crane, Courtney, Fasnacht, Rachael, Fitzpatrick, Kristin, Hermansky, Gleda, Julien, Susan, Maurer, Meghan, McMahan, Cathy, Meengs, Brent, Patton, Dan, Pham, Minh, Swiderek, Kristine
Published in Inflammatory bowel diseases (26.01.2023)
Published in Inflammatory bowel diseases (26.01.2023)
Get full text
Journal Article
Su1210 A NOVEL BISPECIFIC CD8 TREG MODULATOR TARGETING CYTOLYTIC CD8 REGULATORY T CELLS REDUCES PATHOGENIC CD4 T CELLS AND INFLAMMATION IN TRANSLATIONAL MODELS OF INTESTINAL AUTOIMMUNE AND INFLAMMATORY DISEASE
Gardell, Jennifer L., Boster, Daniel, Bowser, Justin, Crane, Courtney, Fasnacht, Rachael, Fitzpatrick, Kristin, Hermansky, Gleda, Julien, Susan, Maurer, Meghan, McMahan, Catherine J., Meengs, Brent, Patton, Daniel, Pham, Minh, Therriault, Jon, Swiderek, Kristine M.
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2023)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2023)
Get full text
Journal Article
A KIR x CD8 targeting bispecific modulator enhances regulatory CD8 T cell functions, and reduces inflammation in models of autoimmune disease
Gardell, Jennifer L, Boster, Daniel, Bowser, Justin, Fasnacht, Rachael, Fitzpatrick, Kristin, Hermansky, Gleda, Julien, Susan, Maurer, Meghan, McMahan, Catherine, Meengs, Brent, Patton, Daniel, Pham, Minh, Therriault, Jon, Swiderek, Kristine M, Crane, Courtney
Published in The Journal of immunology (1950) (01.05.2023)
Published in The Journal of immunology (1950) (01.05.2023)
Get full text
Journal Article
1759-P: Prostaglandin PGE2 Receptor EP4 Signaling Deficiency in Microglia Reduces Weight Gain with Transient Glucose Improvements in Diet-Induced Obesity
NIRAULA, ANZELA, FASNACHT, RACHAEL, NESS, KELLY M., FREY, JEREMY, DORFMAN, MAURICIO D., THALER, JOSHUA
Published in Diabetes (New York, N.Y.) (01.06.2020)
Published in Diabetes (New York, N.Y.) (01.06.2020)
Get full text
Journal Article
Pre-clinical pharmacologic and tolerability characterization of a novel KIRxCD8 targeting bispecific CD8 Treg modulator
McMahan, Catherine J, Pham, Minh, Boster, Daniel, Hermansky, Gleda, Gardell, Jennifer, Bowser, Justin, Rachael, Fasnacht, Chen, Alex, Gilbertson, Emily, Morgan, Nadine, Childs, Monica, Fitzpatrick, Kristin, Tan, Cong, Mauer, Meghan, Meengs, Brent, Therriault, Jon, Patton, Dan, Julien, Susan, Crane, Courtney, Swiderek, Kristine M
Published in The Journal of immunology (1950) (01.05.2023)
Published in The Journal of immunology (1950) (01.05.2023)
Get full text
Journal Article