Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling
Eyre, Rachel, Alférez, Denis G, Santiago-Gómez, Angélica, Spence, Kath, McConnell, James C, Hart, Claire, Simões, Bruno M, Lefley, Diane, Tulotta, Claudia, Storer, Joanna, Gurney, Austin, Clarke, Noel, Brown, Mick, Howell, Sacha J, Sims, Andrew H, Farnie, Gillian, Ottewell, Penelope D, Clarke, Robert B
Published in Nature communications (01.11.2019)
Published in Nature communications (01.11.2019)
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Regulation of Breast Cancer Stem Cell Activity by Signaling through the Notch4 Receptor
HARRISON, Hannah, FARNIE, Gillian, HOWELL, Sacha J, ROCK, Rebecca E, STYLIANOU, Spyros, BRENNAN, Keith R, BUNDRED, Nigel J, CLARKE, Robert B
Published in Cancer research (Chicago, Ill.) (15.01.2010)
Published in Cancer research (Chicago, Ill.) (15.01.2010)
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A Detailed Mammosphere Assay Protocol for the Quantification of Breast Stem Cell Activity
Shaw, Frances L., Harrison, Hannah, Spence, Katherine, Ablett, Matthew P., Simões, Bruno M., Farnie, Gillian, Clarke, Robert B.
Published in Journal of mammary gland biology and neoplasia (01.06.2012)
Published in Journal of mammary gland biology and neoplasia (01.06.2012)
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PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression
Chiang, Kelly, Zielinska, Agnieszka E., Shaaban, Abeer M., Sanchez-Bailon, Maria Pilar, Jarrold, James, Clarke, Thomas L., Zhang, Jingxian, Francis, Adele, Jones, Louise J., Smith, Sally, Barbash, Olena, Guccione, Ernesto, Farnie, Gillian, Smalley, Matthew J., Davies, Clare C.
Published in Cell reports (Cambridge) (19.12.2017)
Published in Cell reports (Cambridge) (19.12.2017)
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Targeting CXCR1/2 Significantly Reduces Breast Cancer Stem Cell Activity and Increases the Efficacy of Inhibiting HER2 via HER2-Dependent and -Independent Mechanisms
SINGH, Jagdeep K, FARNIE, Gillian, BUNDRED, Nigel J, SIMOES, Bruno M, SHERGILL, Amrita, LANDBERG, Goran, HOWELL, Sacha J, CLARKE, Robert B
Published in Clinical cancer research (01.02.2013)
Published in Clinical cancer research (01.02.2013)
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Discovery of an MLLT1/3 YEATS Domain Chemical Probe
Moustakim, Moses, Christott, Thomas, Monteiro, Octovia P., Bennett, James, Giroud, Charline, Ward, Jennifer, Rogers, Catherine M., Smith, Paul, Panagakou, Ioanna, Díaz‐Sáez, Laura, Felce, Suet Ling, Gamble, Vicki, Gileadi, Carina, Halidi, Nadia, Heidenreich, David, Chaikuad, Apirat, Knapp, Stefan, Huber, Kilian V. M., Farnie, Gillian, Heer, Jag, Manevski, Nenad, Poda, Gennady, Al‐awar, Rima, Dixon, Darren J., Brennan, Paul E., Fedorov, Oleg
Published in Angewandte Chemie International Edition (10.12.2018)
Published in Angewandte Chemie International Edition (10.12.2018)
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PRMT5 inhibition shows in vitro efficacy against H3K27M-altered diffuse midline glioma, but does not extend survival in vivo
Brown, Elizabeth J, Balaguer-Lluna, Leire, Cribbs, Adam P, Philpott, Martin, Campo, Leticia, Browne, Molly, Wong, Jong Fu, Oppermann, Udo, Carcaboso, Ángel M, Bullock, Alex N, Farnie, Gillian
Published in Scientific reports (03.01.2024)
Published in Scientific reports (03.01.2024)
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Focal Adhesion Kinase and Wnt Signaling Regulate Human Ductal Carcinoma In Situ Stem Cell Activity and Response to Radiotherapy
Williams, Kathryn E., Bundred, Nigel J., Landberg, Göran, Clarke, Robert B., Farnie, Gillian
Published in Stem cells (Dayton, Ohio) (01.02.2015)
Published in Stem cells (Dayton, Ohio) (01.02.2015)
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FAK inhibition alone or in combination with adjuvant therapies reduces cancer stem cell activity
Timbrell, Simon, Aglan, Hosam, Cramer, Angela, Foden, Phil, Weaver, David, Pachter, Jonathan, Kilgallon, Aoife, Clarke, Robert B., Farnie, Gillian, Bundred, Nigel J.
Published in NPJ breast cancer (28.05.2021)
Published in NPJ breast cancer (28.05.2021)
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Combined inhibition of ErbB1/2 and Notch receptors effectively targets breast ductal carcinoma in situ (DCIS) stem/progenitor cell activity regardless of ErbB2 status
Farnie, Gillian, Willan, Pamela M, Clarke, Robert B, Bundred, Nigel J
Published in PloS one (14.02.2013)
Published in PloS one (14.02.2013)
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Discovery of a Selective Inhibitor for the YEATS Domains of ENL/AF9
Christott, Thomas, Bennett, James, Coxon, Carmen, Monteiro, Octovia, Giroud, Charline, Beke, Viktor, Felce, Suet Ling, Gamble, Vicki, Gileadi, Carina, Poda, Gennady, Al-awar, Rima, Farnie, Gillian, Fedorov, Oleg
Published in SLAS discovery (01.02.2019)
Published in SLAS discovery (01.02.2019)
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A differential role for CXCR4 in the regulation of normal versus malignant breast stem cell activity
Ablett, Matthew P, O'Brien, Ciara S, Sims, Andrew H, Farnie, Gillian, Clarke, Robert B
Published in Oncotarget (15.02.2014)
Published in Oncotarget (15.02.2014)
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Small-Molecule Inhibitors of the MDM2-p53 Protein−Protein Interaction Based on an Isoindolinone Scaffold
Hardcastle, Ian R, Ahmed, Shafiq U, Atkins, Helen, Farnie, Gillian, Golding, Bernard T, Griffin, Roger J, Guyenne, Sabrina, Hutton, Claire, Källblad, Per, Kemp, Stuart J, Kitching, Martin S, Newell, David R, Norbedo, Stefano, Northen, Julian S, Reid, Rebecca J, Saravanan, K, Willems, Henriëtte M. G, Lunec, John
Published in Journal of medicinal chemistry (19.10.2006)
Published in Journal of medicinal chemistry (19.10.2006)
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The Mitogenic Action of Insulin-like Growth Factor I in Normal Human Mammary Epithelial Cells Requires the Epidermal Growth Factor Receptor Tyrosine Kinase
Ahmad, Tawhid, Farnie, Gillian, Bundred, Nigel J., Anderson, Neil G.
Published in The Journal of biological chemistry (16.01.2004)
Published in The Journal of biological chemistry (16.01.2004)
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Isoindolinone-based inhibitors of the MDM2–p53 protein–protein interaction
Hardcastle, Ian R., Ahmed, Shafiq U., Atkins, Helen, Calvert, A. Hilary, Curtin, Nicola J., Farnie, Gillian, Golding, Bernard T., Griffin, Roger J., Guyenne, Sabrina, Hutton, Claire, Källblad, Per, Kemp, Stuart J., Kitching, Martin S., Newell, David R., Norbedo, Stefano, Northen, Julian S., Reid, Rebecca J., Saravanan, K., Willems, Henriëtte M.G., Lunec, John
Published in Bioorganic & medicinal chemistry letters (01.03.2005)
Published in Bioorganic & medicinal chemistry letters (01.03.2005)
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A novel preclinical model of the normal human breast
Wilby, Anthony J., Cabral, Sara, Zoghi, Nastaran, Howell, Sacha J., Farnie, Gillian, Harrison, Hannah
Published in Journal of mammary gland biology and neoplasia (01.12.2024)
Published in Journal of mammary gland biology and neoplasia (01.12.2024)
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