Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2
Clark, Michael P, Ledeboer, Mark W, Davies, Ioana, Byrn, Randal A, Jones, Steven M, Perola, Emanuele, Tsai, Alice, Jacobs, Marc, Nti-Addae, Kwame, Bandarage, Upul K, Boyd, Michael J, Bethiel, Randy S, Court, John J, Deng, Hongbo, Duffy, John P, Dorsch, Warren A, Farmer, Luc J, Gao, Huai, Gu, Wenxin, Jackson, Katrina, Jacobs, Dylan H, Kennedy, Joseph M, Ledford, Brian, Liang, Jianglin, Maltais, François, Murcko, Mark, Wang, Tiansheng, Wannamaker, M. Woods, Bennett, Hamilton B, Leeman, Joshua R, McNeil, Colleen, Taylor, William P, Memmott, Christine, Jiang, Min, Rijnbrand, Rene, Bral, Christopher, Germann, Ursula, Nezami, Azin, Zhang, Yuegang, Salituro, Francesco G, Bennani, Youssef L, Charifson, Paul S
Published in Journal of medicinal chemistry (14.08.2014)
Published in Journal of medicinal chemistry (14.08.2014)
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Robust Strategy for Hit-to-Lead Discovery: NMR for SAR
Larda, Sacha T., Ayotte, Yann, Denk, Maria M., Coote, Paul, Heffron, Gregory, Bendahan, David, Shahout, Fatma, Girard, Nicolas, Iddir, Mustapha, Bouchard, Patricia, Bilodeau, Francois, Woo, Simon, Farmer, Luc J., LaPlante, Steven R.
Published in Journal of medicinal chemistry (12.10.2023)
Published in Journal of medicinal chemistry (12.10.2023)
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Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases
Farmer, Luc J, Ledeboer, Mark W, Hoock, Thomas, Arnost, Michael J, Bethiel, Randy S, Bennani, Youssef L, Black, James J, Brummel, Christopher L, Chakilam, Ananthsrinivas, Dorsch, Warren A, Fan, Bin, Cochran, John E, Halas, Summer, Harrington, Edmund M, Hogan, James K, Howe, David, Huang, Hui, Jacobs, Dylan H, Laitinen, Leena M, Liao, Shengkai, Mahajan, Sudipta, Marone, Valerie, Martinez-Botella, Gabriel, McCarthy, Pamela, Messersmith, David, Namchuk, Mark, Oh, Luke, Penney, Marina S, Pierce, Albert C, Raybuck, Scott A, Rugg, Arthur, Salituro, Francesco G, Saxena, Kumkum, Shannon, Dean, Shlyakter, Dina, Swenson, Lora, Tian, Shi-Kai, Town, Christopher, Wang, Jian, Wang, Tiansheng, Wannamaker, M. Woods, Winquist, Raymond J, Zuccola, Harmon J
Published in Journal of medicinal chemistry (24.09.2015)
Published in Journal of medicinal chemistry (24.09.2015)
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Synthesis and Biological Activity of a Novel Series of Nonsteroidal, Peripherally Selective Androgen Receptor Antagonists Derived from 1,2-Dihydropyridono[5,6-g]quinolines
Hamann, Lawrence G, Higuchi, Robert I, Zhi, Lin, Edwards, James P, Wang, Xiao-Ning, Marschke, Keith B, Kong, James W, Farmer, Luc J, Jones, Todd K
Published in Journal of medicinal chemistry (12.02.1998)
Published in Journal of medicinal chemistry (12.02.1998)
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Journal Article
Discovery of Novel, Orally Bioavailable β‑Amino Acid Azaindole Inhibitors of Influenza PB2
Farmer, Luc J., Clark, Michael P., Boyd, Michael J., Perola, Emanuele, Jones, Steven M., Tsai, Alice, Jacobs, Marc D., Bandarage, Upul K., Ledeboer, Mark W., Wang, Tiansheng, Deng, Hongbo, Ledford, Brian, Gu, Wenxin, Duffy, John P., Bethiel, Randy S., Shannon, Dean, Byrn, Randal A., Leeman, Joshua R., Rijnbrand, Rene, Bennett, Hamilton B., O’Brien, Colleen, Memmott, Christine, Nti-Addae, Kwame, Bennani, Youssef L., Charifson, Paul S.
Published in ACS medicinal chemistry letters (09.02.2017)
Published in ACS medicinal chemistry letters (09.02.2017)
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Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK)
FARMER, Luc J, BEMIS, Guy, TER HAAR, Ernst, JIAN WANG, ZHAVERI, Darshana, SALITURO, Francesco G, BRITT, Shawn D, COCHRAN, John, CONNORS, Martin, HARRINGTON, Edmund M, HOOCK, Thomas, MARKLAND, William, NANTHAKUMAR, Suganthini, TASLIMI, Paul
Published in Bioorganic & medicinal chemistry (01.12.2008)
Published in Bioorganic & medicinal chemistry (01.12.2008)
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Journal Article
Synthesis and Biological Activity of Novel Nonsteroidal Progesterone Receptor Antagonists Based on Cyclocymopol Monomethyl Ether
Hamann, Lawrence G, Farmer, Luc J, Johnson, Michael G, Bender, Steven L, Mais, Dale E, Wang, Ming-Wei, Crombie, Diane, Goldman, Mark E, Jones, Todd K
Published in Journal of medicinal chemistry (26.04.1996)
Published in Journal of medicinal chemistry (26.04.1996)
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Inhibitors of hepatitis C virus NS3·4A protease. Part 3: P 2 proline variants
Perni, Robert B, Farmer, Luc J, Cottrell, Kevin M, Court, John J, Courtney, Lawrence F, Deininger, David D, Gates, Cynthia A, Harbeson, Scott L, Kim, Joseph L, Lin, Chao, Lin, Kai, Luong, Yu-Ping, Maxwell, John P, Murcko, Mark A, Pitlik, Janos, Rao, B.Govinda, Schairer, Wayne C, Tung, Roger D, Van Drie, John H, Wilson, Keith, Thomson, John A
Published in Bioorganic & medicinal chemistry letters (19.04.2004)
Published in Bioorganic & medicinal chemistry letters (19.04.2004)
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Aza-retinoids as novel retinoid X receptor-specific agonists
Farmer, Luc J., Marron, Kristen S., Canan Koch, Stacie S., Hwang, C.K., Kallel, E Adam, Zhi, Lin, Nadzan, Alex M., Robertson, Dave W., Bennani, Youssef L.
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
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Journal Article
Retinoic acid receptor ligands based on the 6-cyclopropyl-2,4-hexadienoic acid
Farmer, Luc J., Zhi, Lin, Jeong, Susan, Lamph, William W., Osburn, Deborah L., Croston, Glenn, Flatten, Karen S., Heyman, Rich A., Nadzan, Alex M.
Published in Bioorganic & medicinal chemistry letters (20.01.2003)
Published in Bioorganic & medicinal chemistry letters (20.01.2003)
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INHIBITORS OF INFLUENZA VIRUSES REPLICATION
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Year of Publication 23.01.2020
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Year of Publication 23.01.2020
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INHIBITORS OF INFLUENZA VIRUS REPLICATION
BETHIEL RANDY S, GU WENXIN, FARMER LUC J, LEDFORD BRIAN, MALTAIS FRANCOIS, JOSEPH M KENNEDY, DENG HONGBO, EMANUELE PEROLA, UPUL K BANDARAGE, MICHEAL J BOYD, CLARK MICHAEL P, GAO HUAI, LEDEBOER MARK W, IOANA DAVIES, DUFFY JOHN P, CHARIFSON PAUL S, WANG TIANSHENG
Year of Publication 19.04.2018
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Year of Publication 19.04.2018
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INHIBITORS OF INFLUENZA VIRUS REPLICATION
GU WENXIN, FARMER LUC J, SALITURO FRANCESCO G, LEDFORD BRIAN, KWONG ANN DAK-YEE, JIANG MIN, II CHOU, M WOODS WANNAMAKER, CLARK MICHAEL P, GAO HUAI, LEDEBOER MARK W, CHARIFSON PAUL S, JONES STEVEN, BETHIEL RANDY S, MALTAIS FRANCOIS, JOSEPH M KENNEDY, DYLAN H JACOBS, URSULA A GERMANN, DENG HONGBO, EMANUELE PEROLA, UPUL K BANDARAGE, BYRN RANDAL, LIN CHAO, COURT JOHN J, IOANA DAVIES, DUFFY JOHN P, WANG TIANSHENG
Year of Publication 11.01.2018
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Year of Publication 11.01.2018
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2 IMIDAZOPYRIDAZINES USEFUL AS INHIBITORS OF THE PAR-2 SIGNALING PATHWAY
FOURNIER PIERRE ANDRE, FARMER LUC J, LACOSTE JEAN ERIC, LESSARD STEPHANIE, BUBENIK MONICA, STURINO CLAUDIO, LIU BINGCAN, VALLEE FREDERIC, RAMTOHUL YEEMAN, SZYCHOWSKI JANEK, YANNOPOULOS CONSTANTIN, ST ONGE MIGUEL, MARTEL JULIEN, SAYEGH CAMIL ELIE
Year of Publication 27.05.2016
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Year of Publication 27.05.2016
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Inhibitors of hepatitis C virus NS3·4A protease. Part 3: P2 proline variants
Perni, Robert B, Farmer, Luc J, Cottrell, Kevin M, Court, John J, Courtney, Lawrence F, Deininger, David D, Gates, Cynthia A, Harbeson, Scott L, Kim, Joseph L, Lin, Chao, Lin, Kai, Luong, Yu-Ping, Maxwell, John P, Murcko, Mark A, Pitlik, Janos, Rao, B.Govinda, Schairer, Wayne C, Tung, Roger D, Van Drie, John H, Wilson, Keith, Thomson, John A
Published in Bioorganic & medicinal chemistry letters (01.04.2004)
Published in Bioorganic & medicinal chemistry letters (01.04.2004)
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INHIBITORS OF INFLUENZA VIRUS REPLICATION
BETHIEL RANDY S, GU WENXIN, FARMER LUC J, LEDFORD BRIAN, MALTAIS FRANCOIS, JOSEPH M KENNEDY, DENG HONGBO, EMANUELE PEROLA, UPUL K BANDARAGE, MICHEAL J BOYD, CLARK MICHAEL P, GAO HUAI, LEDEBOER MARK W, IOANA DAVIES, DUFFY JOHN P, CHARIFSON PAUL S, WANG TIANSHENG
Year of Publication 07.07.2016
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Year of Publication 07.07.2016
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INHIBITORS OF INFLUENZA VIRUS REPLICATION
GU WENXIN, FARMER LUC J, SALITURO FRANCESCO G, LEDFORD BRIAN, KWONG ANN DAK-YEE, JIANG MIN, II CHOU, M WOODS WANNAMAKER, CLARK MICHAEL P, GAO HUAI, LEDEBOER MARK W, CHARIFSON PAUL S, JONES STEVEN, BETHIEL RANDY S, MALTAIS FRANCOIS, JOSEPH M KENNEDY, DYLAN H JACOBS, URSULA A GERMANN, DENG HONGBO, EMANUELE PEROLA, UPUL K BANDARAGE, BYRN RANDAL, LIN CHAO, COURT JOHN J, IOANA DAVIES, DUFFY JOHN P, WANG TIANSHENG
Year of Publication 08.12.2016
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Year of Publication 08.12.2016
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INHIBITORS OF INFLUENZA VIRUSES REPLICATION
GU WENXIN, FARMER LUC J, SALITURO FRANCESCO G, LEDFORD BRIAN, KWONG ANN DAK-YEE, JIANG MIN, II CHOU, M WOODS WANNAMAKER, CLARK MICHAEL P, GAO HUAI, LEDEBOER MARK W, CHARIFSON PAUL S, JONES STEVEN, BETHIEL RANDY S, MALTAIS FRANCOIS, JOSEPH M KENNEDY, DYLAN H JACOBS, URSULA A GERMANN, DENG HONGBO, EMANUELE PEROLA, UPUL K BANDARAGE, BYRN RANDAL, LIN CHAO, COURT JOHN J, IOANA DAVIES, DUFFY JOHN P, WANG TIANSHENG
Year of Publication 26.02.2015
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Year of Publication 26.02.2015
Patent
INHIBITORS OF INFLUENZA VIRUSES REPLICATION
GU WENXIN, FARMER LUC J, SALITURO FRANCESCO G, LEDFORD BRIAN, KWONG ANN DAK-YEE, JIANG MIN, II CHOU, M WOODS WANNAMAKER, CLARK MICHAEL P, GAO HUAI, LEDEBOER MARK W, CHARIFSON PAUL S, JONES STEVEN, BETHIEL RANDY S, MALTAIS FRANCOIS, JOSEPH M KENNEDY, DYLAN H JACOBS, URSULA A GERMANN, DENG HONGBO, EMANUELE PEROLA, UPUL K BANDARAGE, BYRN RANDAL, LIN CHAO, COURT JOHN J, IOANA DAVIES, DUFFY JOHN P, WANG TIANSHENG
Year of Publication 19.02.2015
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Year of Publication 19.02.2015
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INHIBITORS OF INFLUENZA VIRUSES REPLICATION
BETHIEL RANDY S, GU WENXIN, BANDARAGE UPUL K, KENNEDY JOSEPH M, FARMER LUC J, PEROLA EMANUELE, LEDFORD BRIAN, MALTAIS FRANCOIS, DENG HONGBO, BOYD MICHAEL J, CLARK MICHAEL P, GAO HUAI, LEDEBOER MARK W, DUFFY JOHN P, CHARIFSON PAUL S, WANG TIANSHENG, DAVIES IOANA
Year of Publication 28.05.2014
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Year of Publication 28.05.2014
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