Search Results - "FAESSEL, Hélène M" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Phase I Study of the Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (TAK-924/MLN4924) in Patients with Advanced Solid Tumors

Phase I Study of the Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (TAK-924/MLN4924) in Patients with Advanced Solid Tumors

by Sarantopoulos, John, Shapiro, Geoffrey I, Cohen, Roger B, Clark, Jeffrey W, Kauh, John S, Weiss, Glen J, Cleary, James M, Mahalingam, Devalingam, Pickard, Michael D, Faessel, Hélène M, Berger, Allison J, Burke, Kristine, Mulligan, George, Dezube, Bruce J, Harvey, R Donald
Published in Clinical cancer research (15.02.2016)

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Pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, combined with azacitidine in patients with AML

Pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, combined with azacitidine in patients with AML

by Swords, Ronan T., Coutre, Steven, Maris, Michael B., Zeidner, Joshua F., Foran, James M., Cruz, Jose, Erba, Harry P., Berdeja, Jesus G., Tam, Wayne, Vardhanabhuti, Saran, Pawlikowska-Dobler, Iwona, Faessel, Hélène M., Dash, Ajeeta B., Sedarati, Farhad, Dezube, Bruce J., Faller, Douglas V., Savona, Michael R.
Published in Blood (29.03.2018)

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Medical Castration Using the Investigational Oral GnRH Antagonist TAK-385 (Relugolix): Phase 1 Study in Healthy Males

Medical Castration Using the Investigational Oral GnRH Antagonist TAK-385 (Relugolix): Phase 1 Study in Healthy Males

by MacLean, David B, Shi, Hongliang, Faessel, Hélène M, Saad, Fred
Published in The journal of clinical endocrinology and metabolism (01.12.2015)

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$Phase I Study of the Novel Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (MLN4924) in Patients with Relapsed/Refractory Multiple Myeloma or Lymphoma$

Phase I Study of the Novel Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (MLN4924) in Patients with Relapsed/Refractory Multiple Myeloma or Lymphoma

by Shah, Jatin J, Jakubowiak, Andrzej J, O'Connor, Owen A, Orlowski, Robert Z, Harvey, R Donald, Smith, Mitchell R, Lebovic, Daniel, Diefenbach, Catherine, Kelly, Kevin, Hua, Zhaowei, Berger, Allison J, Mulligan, George, Faessel, Hélène M, Tirrell, Stephen, Dezube, Bruce J, Lonial, Sagar
Published in Clinical cancer research (01.01.2016)

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Pharmacokinetics, pharmacodynamics and safety assessment of multiple doses of soticlestat in healthy volunteers

Pharmacokinetics, pharmacodynamics and safety assessment of multiple doses of soticlestat in healthy volunteers

by Wang, Shining, Chen, Grace, Merlo Pich, Emilio, Affinito, John, Cwik, Michael, Faessel, Hélène M.
Published in British journal of clinical pharmacology (01.06.2022)

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The Oral Gonadotropin-releasing Hormone Receptor Antagonist Relugolix as Neoadjuvant/Adjuvant Androgen Deprivation Therapy to External Beam Radiotherapy in Patients with Localised Intermediate-risk Prostate Cancer: A Randomised, Open-label, Parallel-group Phase 2 Trial

The Oral Gonadotropin-releasing Hormone Receptor Antagonist Relugolix as Neoadjuvant/Adjuvant Androgen Deprivation Therapy to External Beam Radiotherapy in Patients with Localised Intermediate-risk Prostate Cancer: A Randomised, Open-label, Parallel-group Phase 2 Trial

by Dearnaley, David P., Saltzstein, Daniel R., Sylvester, John E., Karsh, Lawrence, Mehlhaff, Bryan A., Pieczonka, Christopher, Bailen, James L., Shi, Hongliang, Ye, Zhan, Faessel, Hélène M., Lin, Huamao, Zhu, Yanyan, Saad, Fred, MacLean, David B., Shore, Neal D.
Published in European urology (01.08.2020)

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Population pharmacokinetics of pevonedistat alone or in combination with standard of care in patients with solid tumours or haematological malignancies

Population pharmacokinetics of pevonedistat alone or in combination with standard of care in patients with solid tumours or haematological malignancies

by Faessel, Hélène M., Mould, Diane R., Zhou, Xiaofei, Faller, Douglas V., Sedarati, Farhad, Venkatakrishnan, Karthik
Published in British journal of clinical pharmacology (01.11.2019)

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A Review of the Clinical Pharmacokinetics and Pharmacodynamics of Varenicline for Smoking Cessation

A Review of the Clinical Pharmacokinetics and Pharmacodynamics of Varenicline for Smoking Cessation

by Faessel, Hélène M., Obach, R. Scott, Rollema, Hans, Ravva, Patanjali, Williams, Kathryn E., Burstein, Aaron H.
Published in Clinical pharmacokinetics (01.12.2010)

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Phase I study assessing the mass balance, pharmacokinetics, and excretion of [14C]-pevonedistat, a NEDD8-activating enzyme inhibitor in patients with advanced solid tumors

Phase I study assessing the mass balance, pharmacokinetics, and excretion of [14C]-pevonedistat, a NEDD8-activating enzyme inhibitor in patients with advanced solid tumors

by Zhou, Xiaofei, Sedarati, Farhad, Faller, Douglas V., Zhao, Dan, Faessel, Hélène M., Chowdhury, Swapan, Bolleddula, Jayaprakasam, Li, Yuexian, Venkatakrishnan, Karthik, Papai, Zsuzsanna
Published in Investigational new drugs (01.04.2021)

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Population pharmacokinetic analysis of varenicline in adult smokers

Population pharmacokinetic analysis of varenicline in adult smokers

by Ravva, Patanjali, Gastonguay, Marc R., Tensfeldt, Thomas G., Faessel, Hélène M.
Published in British journal of clinical pharmacology (01.11.2009)

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Pharmacokinetic-pharmacodynamic modeling of the effect of varenicline on nicotine craving in adult smokers

Pharmacokinetic-pharmacodynamic modeling of the effect of varenicline on nicotine craving in adult smokers

by Ravva, Patanjali, Gastonguay, Marc R, Faessel, Hélène M, Lee, Theodore C, Niaura, Raymond
Published in Nicotine & tobacco research (01.01.2015)

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PD28-01 TESTOSTERONE LOWERING, PSA RESPONSE AND QUALITY OF LIFE IN PATIENTS WITH ADVANCED HORMONE SENSITIVE PROSTATE CANCER RECEIVING TAK-385, AN ORAL GNRH ANTAGONIST: PHASE 2 INTERIM ANALYSIS

PD28-01 TESTOSTERONE LOWERING, PSA RESPONSE AND QUALITY OF LIFE IN PATIENTS WITH ADVANCED HORMONE SENSITIVE PROSTATE CANCER RECEIVING TAK-385, AN ORAL GNRH ANTAGONIST: PHASE 2 INTERIM ANALYSIS

by Shore, Neal D, Bailen, James L, Pieczonka, Christopher, Saltzstein, Daniel R, Sieber, Paul R, MacLean, David B, Shi, Hongliang, Faessel, Hélène M, Lin, Huamao Mark, Zhu, Yanyan, Saad, Fred
Published in The Journal of urology (01.04.2016)

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Multiple-dose pharmacokinetics of the selective nicotinic receptor partial agonist, varenicline, in healthy smokers

Multiple-dose pharmacokinetics of the selective nicotinic receptor partial agonist, varenicline, in healthy smokers

by Faessel, Hélène M, Gibbs, Megan A, Clark, David J, Rohrbacher, Kevin, Stolar, Marilyn, Burstein, Aaron H
Published in Journal of clinical pharmacology (01.12.2006)

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Single-dose pharmacokinetics of varenicline, a selective nicotinic receptor partial agonist, in healthy smokers and nonsmokers

Single-dose pharmacokinetics of varenicline, a selective nicotinic receptor partial agonist, in healthy smokers and nonsmokers

by Faessel, Hélène M, Smith, Bill J, Gibbs, Megan A, Gobey, Jason S, Clark, David J, Burstein, Aaron H
Published in Journal of clinical pharmacology (01.09.2006)

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Pharmacokinetics, safety, and tolerability after single and multiple oral doses of varenicline in elderly smokers

Pharmacokinetics, safety, and tolerability after single and multiple oral doses of varenicline in elderly smokers

by Burstein, Aaron H, Fullerton, Terence, Clark, David J, Faessel, Hélène M
Published in Journal of clinical pharmacology (01.11.2006)

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Lack of pharmacokinetic and pharmacodynamic interactions between a smoking cessation therapy, varenicline, and warfarin: an in vivo and in vitro study

Lack of pharmacokinetic and pharmacodynamic interactions between a smoking cessation therapy, varenicline, and warfarin: an in vivo and in vitro study

by Burstein, Aaron H, Clark, David J, O'Gorman, Melissa, Willavize, Susan A, Brayman, Timothy G, Grover, G Scott, Walsky, Robert L, Obach, R Scott, Faessel, Hélène M
Published in Journal of clinical pharmacology (01.11.2007)

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Second interim analysis (IA2) results from a phase II trial of TAK-385, an oral GnRH antagonist, in prostate cancer patients (pts)

Second interim analysis (IA2) results from a phase II trial of TAK-385, an oral GnRH antagonist, in prostate cancer patients (pts)

by Saad, Fred, Bailen, James L., Pieczonka, Christopher Michael, Saltzstein, Daniel R., Sieber, Paul R., Maclean, David B., Shi, Hongliang, Faessel, Helene M., Shore, Neal D.
Published in Journal of clinical oncology (10.01.2016)

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Nonlinear Response Surface and Mixture Experiment Methodologies Applied to the Study of Synergism

Nonlinear Response Surface and Mixture Experiment Methodologies Applied to the Study of Synergism

by White, Donald B., Faessel, Hélène M., Slocum, Harry K., Khinkis, Leonid, Greco, William R.
Published in Biometrical journal (01.02.2004)

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Super in vitro synergy between inhibitors of dihydrofolate reductase and inhibitors of other folate-requiring enzymes: The critical role of polyglutamylation

Super in vitro synergy between inhibitors of dihydrofolate reductase and inhibitors of other folate-requiring enzymes: The critical role of polyglutamylation

by FAESSEL, H. M, SLOCUM, H. K, JACKSON, R. C, BORITZKI, T. J, RUSTUM, Y. M, NAIR, M. G, GRECO, W. R
Published in Cancer research (Chicago, Ill.) (15.07.1998)

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Thymidine and hypoxanthine protection patterns of the folic acid-enhanced synergies for combinations of trimetrexate plus a polyglutamylatable inhibitor of purine or thymidylate synthesis against human ileocecal HCT-8 cells

Thymidine and hypoxanthine protection patterns of the folic acid-enhanced synergies for combinations of trimetrexate plus a polyglutamylatable inhibitor of purine or thymidylate synthesis against human ileocecal HCT-8 cells

by Faessel, Hélène M, Slocum, Harry K, Rustum, Youcef M, Greco, William R
Published in International journal of oncology (01.08.2003)

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