Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy
Chuang, Chihyuan, Collibee, Scott, Ashcraft, Luke, Wang, Wenyue, Vander Wal, Mark, Wang, Xiaolin, Hwee, Darren T, Wu, Yangsong, Wang, Jingying, Chin, Eva R, Cremin, Peadar, Zamora, Jeanelle, Hartman, James, Schaletzky, Julia, Wehri, Eddie, Robertson, Laura A, Malik, Fady I, Morgan, Bradley P
Published in Journal of medicinal chemistry (14.10.2021)
Published in Journal of medicinal chemistry (14.10.2021)
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Effect of Ejection Fraction on Clinical Outcomes in Patients Treated With Omecamtiv Mecarbil in GALACTIC-HF
Teerlink, John R., Diaz, Rafael, Felker, G. Michael, McMurray, John J.V., Metra, Marco, Solomon, Scott D., Biering-Sørensen, Tor, Böhm, Michael, Bonderman, Diana, Fang, James C., Lanfear, David E., Lund, Mayanna, Momomura, Shin-ichi, O'Meara, Eileen, Ponikowski, Piotr, Spinar, Jindrich, Flores-Arredondo, Jose H., Claggett, Brian L., Heitner, Stephen B., Kupfer, Stuart, Abbasi, Siddique A., Malik, Fady I.
Published in Journal of the American College of Cardiology (13.07.2021)
Published in Journal of the American College of Cardiology (13.07.2021)
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Omecamtiv Mecarbil in Chronic Heart Failure With Reduced Ejection Fraction: Rationale and Design of GALACTIC-HF
Teerlink, John R, Diaz, Rafael, Felker, G Michael, McMurray, John J V, Metra, Marco, Solomon, Scott D, Legg, Jason C, Büchele, Gustavo, Varin, Claire, Kurtz, Christopher E, Malik, Fady I, Honarpour, Narimon
Published in JACC. Heart failure (01.04.2020)
Published in JACC. Heart failure (01.04.2020)
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Journal Article
Effect of Omecamtiv Mecarbil on Exercise Capacity in Chronic Heart Failure With Reduced Ejection Fraction: The METEORIC-HF Randomized Clinical Trial
Lewis, Gregory D, Voors, Adriaan A, Cohen-Solal, Alain, Metra, Marco, Whellan, David J, Ezekowitz, Justin A, Böhm, Michael, Teerlink, John R, Docherty, Kieran F, Lopes, Renato D, Divanji, Punag H, Heitner, Stephen B, Kupfer, Stuart, Malik, Fady I, Meng, Lisa, Wohltman, Amy, Felker, G Michael
Published in JAMA : the journal of the American Medical Association (19.07.2022)
Published in JAMA : the journal of the American Medical Association (19.07.2022)
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Journal Article
Phase 2 Study of Aficamten in Patients With Obstructive Hypertrophic Cardiomyopathy
Maron, Martin S., Masri, Ahmad, Choudhury, Lubna, Olivotto, Iacopo, Saberi, Sara, Wang, Andrew, Garcia-Pavia, Pablo, Lakdawala, Neal K., Nagueh, Sherif F., Rader, Florian, Tower-Rader, Albree, Turer, Aslan T., Coats, Caroline, Fifer, Michael A., Owens, Anjali, Solomon, Scott D., Watkins, Hugh, Barriales-Villa, Roberto, Kramer, Christopher M., Wong, Timothy C., Paige, Sharon L., Heitner, Stephen B., Kupfer, Stuart, Malik, Fady I., Meng, Lisa, Wohltman, Amy, Abraham, Theodore
Published in Journal of the American College of Cardiology (03.01.2023)
Published in Journal of the American College of Cardiology (03.01.2023)
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Journal Article
Influence of atrial fibrillation on efficacy and safety of omecamtiv mecarbil in heart failure: the GALACTIC-HF trial
Solomon, Scott D, Claggett, Brian L, Miao, Zi Michael, Diaz, Rafael, Felker, G Michael, McMurray, John J V, Metra, Marco, Corbalan, Ramon, Filippatos, Gerasimos, Goudev, Assen R, Mareev, Viatcheslav, Serpytis, Pranas, Suter, Thomas, Yilmaz, Mehmet B, Zannad, Faiez, Kupfer, Stuart, Heitner, Stephen B, Malik, Fady I, Teerlink, John R
Published in European heart journal (14.06.2022)
Published in European heart journal (14.06.2022)
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Journal Article
Discovery of Reldesemtiv, a Fast Skeletal Muscle Troponin Activator for the Treatment of Impaired Muscle Function
Collibee, Scott E, Bergnes, Gustave, Chuang, Chihyuan, Ashcraft, Luke, Gardina, Jeffrey, Garard, Marc, Jamison, Chris R, Lu, Kevin, Lu, Pu-Ping, Muci, Alexander, Romero, Antonio, Valkevich, Ellen, Wang, Wenyue, Warrington, Jeffrey, Yao, Bing, Durham, Nickie, Hartman, James, Marquez, Anna, Hinken, Aaron, Schaletzky, Julia, Xu, Donghong, Hwee, Darren T, Morgans, David, Malik, Fady I, Morgan, Bradley P
Published in Journal of medicinal chemistry (28.10.2021)
Published in Journal of medicinal chemistry (28.10.2021)
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Journal Article
Novel Small-Molecule Troponin Activator Increases Cardiac Contractile Function Without Negative Impact on Energetics
He, Huamei, Baka, Tomas, Balschi, James, Motani, Alykhan S, Nguyen, Kathy K, Liu, Qingxiang, Slater, Rebecca, Rock, Brooke, Wang, Chen, Hale, Christopher, Karamanlidis, Georgios, Hartman, James J, Malik, Fady I, Reagan, Jeff D, Luptak, Ivan
Published in Circulation. Heart failure (01.03.2022)
Published in Circulation. Heart failure (01.03.2022)
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Journal Article
Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure
Malik, Fady I., Hartman, James J., Elias, Kathleen A., Morgan, Bradley P., Rodriguez, Hector, Brejc, Katjuša, Anderson, Robert L., Sueoka, Sandra H., Lee, Kenneth H., Finer, Jeffrey T., Sakowicz, Roman, Baliga, Ramesh, Cox, David R., Garard, Marc, Godinez, Guillermo, Kawas, Raja, Kraynack, Erica, Lenzi, David, Lu, Pu Ping, Muci, Alexander, Niu, Congrong, Qian, Xiangping, Pierce, Daniel W., Pokrovskii, Maria, Suehiro, Ion, Sylvester, Sheila, Tochimoto, Todd, Valdez, Corey, Wang, Wenyue, Katori, Tatsuo, Kass, David A., Shen, You-Tang, Vatner, Stephen F., Morgans, David J.
Published in Science (American Association for the Advancement of Science) (18.03.2011)
Published in Science (American Association for the Advancement of Science) (18.03.2011)
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Acute and chronic tirasemtiv treatment improves in vivo and in vitro muscle performance in actin-based nemaline myopathy mice
de Winter, Josine M, Gineste, Charlotte, Minardi, Elisa, Brocca, Lorenza, Rossi, Maira, Borsboom, Tamara, Beggs, Alan H, Bernard, Monique, Bendahan, David, Hwee, Darren T, Malik, Fady I, Pellegrino, Maria Antonietta, Bottinelli, Roberto, Gondin, Julien, Ottenheijm, Coen A C
Published in Human molecular genetics (26.06.2021)
Published in Human molecular genetics (26.06.2021)
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Journal Article
Acute Treatment With Omecamtiv Mecarbil to Increase Contractility in Acute Heart Failure: The ATOMIC-AHF Study
Teerlink, John R, Felker, G Michael, McMurray, John J V, Ponikowski, Piotr, Metra, Marco, Filippatos, Gerasimos S, Ezekowitz, Justin A, Dickstein, Kenneth, Cleland, John G F, Kim, Jae B, Lei, Lei, Knusel, Beat, Wolff, Andrew A, Malik, Fady I, Wasserman, Scott M
Published in Journal of the American College of Cardiology (29.03.2016)
Published in Journal of the American College of Cardiology (29.03.2016)
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CK‐2127107 amplifies skeletal muscle response to nerve activation in humans
Andrews, Jinsy A., Miller, Timothy M., Vijayakumar, Vipin, Stoltz, Randall, James, Joyce K., Meng, Lisa, Wolff, Andrew A., Malik, Fady I.
Published in Muscle & nerve (01.05.2018)
Published in Muscle & nerve (01.05.2018)
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Assessment of Omecamtiv Mecarbil for the Treatment of Patients With Severe Heart Failure: A Post Hoc Analysis of Data From the GALACTIC-HF Randomized Clinical Trial
Felker, G Michael, Solomon, Scott D, Claggett, Brian, Diaz, Rafael, McMurray, John J V, Metra, Marco, Anand, Inder, Crespo-Leiro, Marisa G, Dahlström, Ulf, Goncalvesova, Eva, Howlett, Jonathan G, MacDonald, Peter, Parkhomenko, Alexander, Tomcsányi, János, Abbasi, Siddique A, Heitner, Stephen B, Hucko, Thomas, Kupfer, Stuart, Malik, Fady I, Teerlink, John R
Published in JAMA cardiology (01.01.2022)
Published in JAMA cardiology (01.01.2022)
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Dose-dependent augmentation of cardiac systolic function with the selective cardiac myosin activator, omecamtiv mecarbil: a first-in-man study
Teerlink, John R, Prof, Clarke, Cyril P, MBBS, Saikali, Khalil G, PhD, Lee, Jacqueline H, Chen, Michael M, MS, Escandon, Rafael D, PhD, Elliott, Lyndsey, Bee, Rachel, Habibzadeh, Mohammad Reza, MD, Goldman, Jonathan H, MD, Schiller, Nelson B, Prof, Malik, Fady I, MD, Wolff, Andrew A, MD
Published in The Lancet (British edition) (20.08.2011)
Published in The Lancet (British edition) (20.08.2011)
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Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure (COSMIC-HF): a phase 2, pharmacokinetic, randomised, placebo-controlled trial
Teerlink, John R, Prof, Felker, G Michael, Prof, McMurray, John J V, Prof, Solomon, Scott D, Prof, Adams, Kirkwood F, MD, Cleland, John G F, Prof, Ezekowitz, Justin A, MBBCh, Goudev, Assen, Prof, Macdonald, Peter, Prof, Metra, Marco, Prof, Mitrovic, Veselin, Prof, Ponikowski, Piotr, Prof, Serpytis, Pranas, Prof, Spinar, Jindrich, Prof, Tomcsányi, János, Prof, Vandekerckhove, Hans J, MD, Voors, Adriaan A, Prof, Monsalvo, Maria Laura, MD, Johnston, James, PhD, Malik, Fady I, MD, Honarpour, Narimon, MD
Published in The Lancet (British edition) (10.12.2016)
Published in The Lancet (British edition) (10.12.2016)
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Journal Article
Fast skeletal muscle troponin activator tirasemtiv increases muscle function and performance in the B6SJL-SOD1G93A ALS mouse model
Hwee, Darren T, Kennedy, Adam, Ryans, Julie, Russell, Alan J, Jia, Zhiheng, Hinken, Aaron C, Morgans, David J, Malik, Fady I, Jasper, Jeffrey R
Published in PloS one (07.05.2014)
Published in PloS one (07.05.2014)
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Journal Article
Fast skeletal muscle troponin activator CK‐2066260 increases fatigue resistance by reducing the energetic cost of muscle contraction
Cheng, Arthur J., Hwee, Darren T., Kim, Leo H., Durham, Nickie, Yang, Hsiao T., Hinken, Aaron C., Kennedy, Adam R., Terjung, Ronald L., Jasper, Jeffrey R., Malik, Fady I., Westerblad, Håkan
Published in The Journal of physiology (01.09.2019)
Published in The Journal of physiology (01.09.2019)
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Journal Article
The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial
Cleland, John GF, Prof, Teerlink, John R, Prof, Senior, Roxy, Prof, Nifontov, Evgeny M, Prof, Mc Murray, John JV, Prof, Lang, Chim C, Prof, Tsyrlin, Vitaly A, Prof, Greenberg, Barry H, Prof, Mayet, Jamil, MD, Francis, Darrel P, MD, Shaburishvili, Tamaz, MD, Monaghan, Mark, PhD, Saltzberg, Mitchell, MD, Neyses, Ludwig, Prof, Wasserman, Scott M, MD, Lee, Jacqueline H, Saikali, Khalil G, PhD, Clarke, Cyril P, MBBS, Goldman, Jonathan H, MD, Wolff, Andrew A, MD, Malik, Fady I, MD
Published in The Lancet (British edition) (20.08.2011)
Published in The Lancet (British edition) (20.08.2011)
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Journal Article
Association Between Decline in Slow Vital Capacity and Respiratory Insufficiency, Use of Assisted Ventilation, Tracheostomy, or Death in Patients With Amyotrophic Lateral Sclerosis
Andrews, Jinsy A, Meng, Lisa, Kulke, Sarah F, Rudnicki, Stacy A, Wolff, Andrew A, Bozik, Michael E, Malik, Fady I, Shefner, Jeremy M
Published in JAMA neurology (01.01.2018)
Published in JAMA neurology (01.01.2018)
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