Effect of the Selective Cardiac Myosin Activator, Omecamtiv Mecarbil, on Left Atrial Performance in Healthy Men
Habibzadeh, M. Reza, Schiller, Nelson B, Malik, Fady I, Chen, Michael M, Saikali, Khalil G, Wolff, Andrew A, Goldman, Jonathan H, Teerlink, John R
Published in Journal of cardiac failure (2010)
Published in Journal of cardiac failure (2010)
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Journal Article
An Analysis of the Response to CK-1827452, a Selective Cardiac Myosin Activator, in Stable Heart Failure Patients Stratified by Baseline Cardiac Function
Malik, Fady I, Saikali, Khalil G, Chen, Michael M, Lee, Jacqueline H, Goldman, Jonathan H, Wolff, Andrew A, Teerlink, John R
Published in Journal of cardiac failure (2009)
Published in Journal of cardiac failure (2009)
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Journal Article
Systolic Ejection Time Is a Sensitive Indicator of Left Ventricular Systolic Function during Treatment with the Selective Cardiac Myosin Activator, CK-1827452
Malik, Fady I, Saikali, Khalil G, Clarke, Cyril P, Teerlink, John R, Wolff, Andrew A
Published in Journal of cardiac failure (2007)
Published in Journal of cardiac failure (2007)
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Journal Article
Oral Bioavailability of the Selective Cardiac Myosin Activator CK-1827452: Chronic Oral Inotropic Therapy for Heart Failure?
Jerling, Markus, Chew, Terence, Escandon, Rafael D, Lee, Jacqueline, Venables, Ester, Clarke, Cyril P, Malik, Fady I, Wolff, Andrew A
Published in Journal of cardiac failure (2007)
Published in Journal of cardiac failure (2007)
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Journal Article
CK-271 Myosin Inhibition Enhances Myocardial Energetics, Reduces Hypertrophy, and Improves Diastolic Function and Exercise Tolerance in Troponin R92L-Mutant Hypertrophic Cardiomyopathy Mouse Model
Baka, Tomas, Qin, Fuzhong, Yurista, Salva, Pimentel, David, Hwee, Darren, Malik, Fady, Tardiff, Jil, Colucci, Wilson, Luptak, Ivan
Published in Journal of cardiac failure (01.09.2024)
Published in Journal of cardiac failure (01.09.2024)
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Journal Article
Abstract EC.04: The Effects Of Cardiac Troponin Activator CK-358 On Cardiac Contractility In A Mouse Model Of Genetic Dilated Cardiomyopathy
Neys, Stephanie, Kooiker, Kristina, Martinson, Amy, Hwee, Darren, Hartman, James, Murphy, Anne N, Morgan, Bradley, Davis, Jennifer, Malik, Fady, Moussavi-Harami, Farid
Published in Circulation research (04.08.2023)
Published in Circulation research (04.08.2023)
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Journal Article
Novel Potential Targets for Function-Promoting Therapies: Orphan Nuclear Receptors, Anti-inflammatory Drugs, Troponin Activators, Mas Receptor Agonists, and Urolithin A
Dioh, Waly, Narkar, Vihang, Singh, Anurag, Malik, Fady, Ferrucci, Luigi, Tourette, Cendrine, Mariani, Jean, van Maanen, Rob, Fielding, Roger A
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (16.06.2023)
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (16.06.2023)
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Journal Article
Abstract 615: The Cardiac Myosin Inhibitor, CK-3773274, Reduces Contractility in the R403q Mouse Model of Hypertrophic Cardiomyopathy
Hwee, Darren T, Wu, Yangsong, Cremin, Peadar, Morgan, Bradley P, Malik, Fady I, Chin, Eva R
Published in Circulation research (02.08.2019)
Published in Circulation research (02.08.2019)
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Journal Article
Effect of Aficamten on Cardiac Structure and Function in Obstructive Hypertrophic Cardiomyopathy
Masri, Ahmad, Cardoso, Rhanderson N., Abraham, Theodore P., Claggett, Brian L., Coats, Caroline J., Hegde, Sheila M., Kulac, Ian J., Lee, Matthew M.Y., Maron, Martin S., Merkely, Bela, Michels, Michelle, Olivotto, Iacopo, Oreziak, Artur, Jacoby, Daniel L., Heitner, Stephen B., Kupfer, Stuart, Malik, Fady I., Meng, Lisa, Solomon, Scott D., Wohltman, Amy, Kwong, Raymond Y., Kramer, Christopher M.
Published in Journal of the American College of Cardiology (05.11.2024)
Published in Journal of the American College of Cardiology (05.11.2024)
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Journal Article
Effect of Aficamten on Health Status Outcomes in Obstructive Hypertrophic Cardiomyopathy
Sherrod, Charles F., Saberi, Sara, Nassif, Michael E., Claggett, Brian L., Coats, Caroline J., Garcia-Pavia, Pablo, Januzzi, James L., Lewis, Gregory D., Ma, Changsheng, Maron, Martin S., Miao, Zi Michael, Olivotto, Iacopo, Veselka, Josef, Butzner, Michael, Jacoby, Daniel L., Heitner, Stephen B., Kupfer, Stuart, Malik, Fady I., Meng, Lisa, Wohltman, Amy, Spertus, John A.
Published in Journal of the American College of Cardiology (05.11.2024)
Published in Journal of the American College of Cardiology (05.11.2024)
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Journal Article
Abstract 13640: Sex Differences in Heart Failure With Reduced Ejection Fraction in the GALACTIC-HF Trial
Pabon porras, Maria A, Cunningham, Jonathan, Claggett, Brian, Diaz, Rafael, Felker, Gary Michael, McMurray, John J, Metra, Marco, Heitner, Stephen, Kupfer, Stuart, Malik, Fady, Solomon, Scott, Teerlink, John R
Published in Circulation (New York, N.Y.) (08.11.2022)
Published in Circulation (New York, N.Y.) (08.11.2022)
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EFFICACY AND SAFETY OF AFICAMTEN IN THE FIRST COHORT OF PATIENTS WITH SYMPTOMATIC OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY COMPLETING 1-YEAR FOLLOW-UP: FINDINGS FROM THE FOREST-HCM STUDY
Saberi, Sara, Abraham, Theodore P., Choudhury, Lubna, Owens, Anjali Tiku, Tower-Rader, Albree, Rader, Florian, Pavia, Pablo Garcia, Olivotto, Iacopo, Coats, Caroline, Fifer, Michael A., Solomon, Scott D., Watkins, Hugh, Heitner, Steve, Jacoby, Dan, Kupfer, Stuart, Malik, Fady I., Melloni, Chiara, Meng, Lisa, Wei, Jenny, Maron, Martin S., Masri, Ahmad
Published in Journal of the American College of Cardiology (02.04.2024)
Published in Journal of the American College of Cardiology (02.04.2024)
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Journal Article
Abstract 14390: The Cardiac Myosin Inhibitor, Ck-3772271, Attenuates Cardiac Fibrosis and Diastolic Dysfunction in the Dahl/salt Sensitive Rat Model of Heart Failure With Preserved Ejection Fraction
Xu, Xihui, Hwee, Darren T, Hartman, James J, Wang, Jingying, Wu, Yangsong, McHugh, Claire, Chin, Eva R, Malik, Fady I, Morgan, Bradley P
Published in Circulation (New York, N.Y.) (17.11.2020)
Published in Circulation (New York, N.Y.) (17.11.2020)
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Journal Article
Abstract 14254: Pharmacodynamic Effects of a Single Dose of CK-3773274 in Cats With Hypertrophic Cardiomyopathy
Oldach, Maureen, Hwee, Darren T, Ontiveros, Eric S, Fousse, Samantha L, Gonzalez, Carina E, Morgan, Bradley P, Malik, Fady I, Harris, Samantha P, Stern, Joshua A
Published in Circulation (New York, N.Y.) (17.11.2020)
Published in Circulation (New York, N.Y.) (17.11.2020)
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Journal Article
THE EFFECT OF OMECAMTIV MECARBIL IN HOSPITALIZED PATIENTS AS COMPARED WITH OUTPATIENTS: A PRESPECIFIED ANALYSIS OF GALACTIC-HF
Docherty, Kieran F., Claggett, Brian, Diaz, Rafael, Felker, G. Michael, Metra, Marco, Solomon, Scott D., Divanji, Punag, Heitner, Stephen B., Kupfer, Stuart, Malik, Fady I., McMurray, John J.V., Teerlink, John R.
Published in Journal of the American College of Cardiology (01.03.2022)
Published in Journal of the American College of Cardiology (01.03.2022)
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Abstract 9199: A Novel Small Molecule Troponin Activator Increases Cardiac Contractile Function Without Negative Impact on Energetics or Diastolic Function
He, Huamei, Baka, Tomas, Balschi, James, Motani, Alykhan, Nguyen, Khanh K, Liu, Qingxiang, Slater, Rebecca, rock, brooke, Wang, Chen, Hale, Christopher, Karamanlidis, Georgios, Hartman, James J, Malik, Fady I, reagan, jeff D, Luptak, Ivan
Published in Circulation (New York, N.Y.) (16.11.2021)
Published in Circulation (New York, N.Y.) (16.11.2021)
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Journal Article
Kiosk 6R-TC-04 - Effect of Aficamten on Structure and Function in Patients with Obstructive Hypertrophic Cardiomyopathy: The FOREST-HCM CMR Sub-study
Masri, Ahmad, Cardoso, Rhanderson, Abraham, Theodore, Choudhury, Lubna, Rader, Florian, Saberi, Sara, Tower-Rader, Albree, Wang, Andrew, Heitner, Stephen, Kupfer, Stuart, Malik, Fady, Melloni, Chiara, Wei, Jenny, Wohltman, Amy, Kwong, Raymond
Published in Journal of cardiovascular magnetic resonance (2024)
Published in Journal of cardiovascular magnetic resonance (2024)
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Journal Article
AFICAMTEN IN PATIENTS WITH SYMPTOMATIC NON-OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY (REDWOOD-HCM COHORT 4)
Masri, Ahmad, Sherrid, Mark V., Choudhury, Lubna, Rader, Florian, Kramer, Christopher M., Saberi, Sara, Wong, Timothy C., Turer, Aslan Teyfik, Nagueh, Sherif F., Owens, Anjali Tiku, Coats, Caroline, Olivotto, Iacopo, Watkins, Hugh, Fifer, Michael A., Solomon, Scott D., Abraham, Theodore P., Heitner, Steve, Jacoby, Dan, Kupfer, Stuart, Malik, Fady I., Meng, Lisa, Sohn, Regina L., Wohltman, Amy, Maron, Martin S.
Published in Journal of the American College of Cardiology (07.03.2023)
Published in Journal of the American College of Cardiology (07.03.2023)
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Journal Article
LONG-TERM EFFICACY AND SAFETY OF AFICAMTEN IN PATIENTS WITH SYMPTOMATIC OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY
Saberi, Sara, Abraham, Theodore P., Choudhury, Lubna, Owens, Anjali Tiku, Tower-Rader, Albree, Rader, Florian, Pavia, Pablo Garcia, Olivotto, Iacopo, Coats, Caroline, Fifer, Michael A., Solomon, Scott D., Watkins, Hugh, Heitner, Steve, Jacoby, Dan, Kupfer, Stuart, Malik, Fady I., Meng, Lisa, Wohltman, Amy, Maron, Martin S., Masri, Ahmad
Published in Journal of the American College of Cardiology (07.03.2023)
Published in Journal of the American College of Cardiology (07.03.2023)
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Journal Article
THE EFFECT OF THE CARDIAC MYOSIN ACTIVATOR, MECAMTIV MECARBIL, ON RIGHT VENTRICULAR STRUCTURE AND FUNCTION IN CHRONIC SYSTOLIC HEART FAILURE (COSMIC-HF)
Biering-Sorensen, Tor, Papolos, Alexander, Teerlink, John, Felker, G. Michael, McMurray, John, Legg, Jason, Malik, Fady, Honarpour, Narimon, Kurtz, Christopher, Solomon, Scott D.
Published in Journal of the American College of Cardiology (24.03.2020)
Published in Journal of the American College of Cardiology (24.03.2020)
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