Direct design of a potent non-peptide fibrinogen receptor antagonist based on the structure and conformation of a highly constrained cyclic RGD peptide
Ku, Thomas W, Ali, Fadia E, Barton, Linda S, Bean, John W, Bondinell, William E, Burgess, Joelle L, Callahan, James F, Calvo, Raul R, Chen, Lichong
Published in Journal of the American Chemical Society (01.09.1993)
Published in Journal of the American Chemical Society (01.09.1993)
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Discovery of Potent Nonpeptide Vitronectin Receptor (αVβ3) Antagonists
Keenan, Richard M, Miller, William H, Kwon, Chet, Ali, Fadia E, Callahan, James F, Calvo, Raul R, Hwang, Shing-Mei, Kopple, Kenneth D, Peishoff, Catherine E, Samanen, James M, Wong, Angela S, Yuan, Chuan-Kui, Huffman, William F
Published in Journal of medicinal chemistry (18.07.1997)
Published in Journal of medicinal chemistry (18.07.1997)
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Journal Article
Potent, Selective, Orally Active 3-Oxo-1,4-benzodiazepine GPIIb/IIIa Integrin Antagonists
Samanen, James M, Ali, Fadia E, Barton, Linda S, Bondinell, William E, Burgess, Joelle L, Callahan, James F, Calvo, Raul R, Chen, Wenting, Chen, Lichong, Erhard, Karl, Feuerstein, Giora, Heys, Richard, Hwang, Shing-Mei, Jakas, Dalia R, Keenan, Richard M, Ku, Thomas W, Kwon, Chet, Lee, Chao-Pin, Miller, William H, Newlander, Kenneth A, Nichols, Andrew, Parker, Michael, Peishoff, Catherine E, Rhodes, Gerald, Ross, Steven, Shu, Arthur, Simpson, Richard, Takata, Dennis, Yellin, Tobias O, Uzsinskas, Irene, Venslavsky, Joseph W, Yuan, Chuan-Kui, Huffman, William F
Published in Journal of medicinal chemistry (06.12.1996)
Published in Journal of medicinal chemistry (06.12.1996)
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Journal Article
Investigation of conformational specificity at GPIIb/IIIa: evaluation of conformationally constrained RGD peptides
Peishoff, Catherine E, Ali, Fadia E, Bean, John W, Calvo, Raul, D'Ambrosio, Cynthia A, Eggleston, Drake S, Kline, Tammy Page, Koster, Paul F, Hwang, S. M
Published in Journal of medicinal chemistry (01.10.1992)
Published in Journal of medicinal chemistry (01.10.1992)
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Journal Article
Conformationally Constrained Peptides and Semipeptides Derived from RGD as Potent Inhibitors of the Platelet Fibrinogen Receptor and Platelet Aggregation
Ali, Fadia E, Bennett, Donald B, Calvo, Raul R, Elliott, John D, Hwang, Shing-Mei, Ku, Thomas W, Lago, M. Amparo, Nichols, Andrew J, Romoff, Todd T
Published in Journal of medicinal chemistry (01.03.1994)
Published in Journal of medicinal chemistry (01.03.1994)
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Journal Article
Modulation of vitronectin receptor-mediated osteoclast adhesion by Arg-Gly-Asp peptide analogs: a structure-function analysis
Horton, M A, Dorey, E L, Nesbitt, S A, Samanen, J, Ali, F E, Stadel, J M, Nichols, A, Greig, R, Helfrich, M H
Published in Journal of bone and mineral research (01.02.1993)
Published in Journal of bone and mineral research (01.02.1993)
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Journal Article
Enantiospecific synthesis of SB 214857, a potent, orally active, nonpeptide fibrinogen receptor antagonist
Miller, William H., Ku, Thomas W., Ali, Fadia E., Bondinell, William E., Calvo, Raul R., Davis, Larry D., Erhard, Karl F., Hall, Leon B., Huffman, William F., Keenan, Richard M., Kwon, Chet, Newlander, Kenneth A., Ross, Stephen T., Samanen, James M., Takata, Dennis T., Yuan, Chuan-Kui
Published in Tetrahedron letters (25.12.1995)
Published in Tetrahedron letters (25.12.1995)
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Journal Article
An alternate enantiospecific synthesis of methyl (S)-7-tert-butoxycarbonyl-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetate
Ku, Thomas W., Ali, Fadia E., Bondinell, William E., Erhard, Karl F., Huffman, William F., Venslavsky, Joseph W., Yuan, Catherine C.-K.
Published in Tetrahedron letters (05.05.1997)
Published in Tetrahedron letters (05.05.1997)
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Journal Article
6-(Phenylthio)-substituted 2,3,4,5-tetrahydro-1H-3-benzazepines, a novel class of dopamine receptor antagonists and neuroleptics
Kaiser, Carl, Ali, Fadia E, Bondinell, William E, Brenner, Martin, Holden, Kenneth G, Ku, Thomas W, Oh, Hye-Ja, Ross, Stephen T, Yim, Nelson C. F
Published in Journal of medicinal chemistry (01.09.1980)
Published in Journal of medicinal chemistry (01.09.1980)
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Journal Article
Orally Active and Potent Inhibitors of γ-Aminobutyric Acid Uptake
Ali, Fadia E, Bondinell, William E, Dandridge, Penelope A, Frazee, James S, Garvey, Eleanor, Girard, Gerald R, Kaiser, Carl, Ku, Thomas W, Lafferty, John J, Moonsammy, George I, Oh, Hye-Ja, Rush, Julia A, Setler, Paulette E, Stringer, Orum D, Venslavsky, Joseph W, Volpe, Beth W, Yunger, Libby M, Zirkle, Charles L
Published in Journal of medicinal chemistry (01.05.1985)
Published in Journal of medicinal chemistry (01.05.1985)
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Journal Article
The in vitro pharmacological profile of SK&F 106760, a novel GPIIB/IIIA antagonist
Nichols, Andrew J., Vasko, Janice A., Valocik, Richard E., Kopaciewicz, Linda J., Storer, Barbara L., Ali, Fadia E., Romoff, Todd, Calvo, Raul, Samanen, James M.
Published in Thrombosis research (15.07.1994)
Published in Thrombosis research (15.07.1994)
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Journal Article
Novel vasopressin analogs that help define a minimum effective antagonist pharmacophore
Huffman, William F, Ali, Fadia E, Bryan, William M, Callahan, James F, Moore, Michael L, Silvestri, Joanne S, Yim, Nelson C. F, Kinter, Lewis B, McDonald, Jeanne E
Published in Journal of medicinal chemistry (01.12.1985)
Published in Journal of medicinal chemistry (01.12.1985)
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Journal Article
Regioselective alkylation at the N4 positionof a 3-oxo-1,4-benzodiazepine on solid support
Ali, Fadia E, Yuan, Catherine Ck, Ross, Stephen T, Hall, Leon B
Published in Molecular diversity (01.03.2000)
Published in Molecular diversity (01.03.2000)
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Journal Article
Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (αvβ3) antagonists
Keenan, Richard M., Miller, William H., Lago, M.Amparo, Ali, Fadia E., Bondinell, William E., Callahan, James F., Calvo, Raul R., Cousins, Russell D., Hwang, Shing-Mei, Jakas, Dalia R., Ku, Thomas W., Kwon, Chet, Nguyen, Thomas T., Reader, Valerie A., Rieman, David J., Ross, Steven T., Takata, Dennis T., Uzinskas, Irene N., Yuan, Catherine C.K., Smith, Brian R.
Published in Bioorganic & medicinal chemistry letters (17.11.1998)
Published in Bioorganic & medicinal chemistry letters (17.11.1998)
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Journal Article
Discovery of an imidazopyridine-containing 1,4-benzodiazepine nonpeptide vitronectin receptor (αvβ3) antagonist with efficacy in a restenosis model
Keenan, Richard M., Lago, M.Amparo, Miller, William H., Ali, Fadia E., Cousins, Russell D., Hall, Leon B., Hwang, Shing-Mei, Jakas, Dalia R., Kwon, Chet, Louden, Calvert, Nguyen, Thomas T., Ohlstein, Eliot H., Rieman, David J., Ross, Steven T., Samanen, James M., Smith, Brian R., Stadel, Jeffrey, Takata, Dennis T., Vickery, Lynne, Yuan, Catherine C.K., Yue, Tian-Li
Published in Bioorganic & medicinal chemistry letters (17.11.1998)
Published in Bioorganic & medicinal chemistry letters (17.11.1998)
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Journal Article
Binding of [3H]-SK&F 107260 and [3H]-SB 214857 to Purified Integrin αIIbβ3: Evidence for a Common Binding Site for Cyclic Arginyl-Glycinyl-Aspartic Acid Peptides and Nonpeptides
Angela Wong, Shing Mei Hwang, Kyung Johanson, James Samanen, Donald Bennett, Scott W. Landvatter, Wenting Chen, J. Richard Heys, Fadia E. Ali, Thomas W. Ku, William Bondinell, Andrew J. Nichols, David A. Powers, Jeffrey M. Stadel
Published in The Journal of pharmacology and experimental therapeutics (01.04.1998)
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Published in The Journal of pharmacology and experimental therapeutics (01.04.1998)
Journal Article
Design of a potent and orally active nonpeptide platelet fibrinogen receptor (GPIIb/IIIa) antagonist
Bondinell, William E., Keenan, Richard M., Miller, William H., Ali, Fadia E., Allen, Andrew C., De Brosse, Charles W., Eggleston, Drake S., Erhard, Karl F., Haltiwanger, R.Curtis, Huffman, William F., Hwang, Shing-Mei, Jakas, Dalia R., Koster, Paul F., Ku, Thomas W., Lee, Chao Pin, Nichols, Andrew J., Ross, Stephen T., Samanen, James M., Valocik, Richard E., Vasko-Moser, Janice A., Venslavsky, Joseph W., Wong, Angela S., Yuan, Chuan-Kui
Published in Bioorganic & medicinal chemistry (01.09.1994)
Published in Bioorganic & medicinal chemistry (01.09.1994)
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Journal Article
Structure-activity relationships in 3-oxo-1,4-benzodiazepine-2-acetic acid GPIIb/IIIa antagonists. The 2-benzazepine series
Miller, William H., Ali, Fadia E., Bondinell, William E., Callahan, James F., Calvo, Raul R., Eggleston, Drake S., Curtis Haltiwanger, R., Huffman, William F., Hwang, Shing-Mei, Jakas, Dalia R., Keenan, Richard M., Koster, Paul F., Ku, Thomas W., Kwon, Chet, Newlander, Kenneth A., Nichols, Andrew J., Parker, Michael F., Samanen, James M., Southall, Linda S., Takata, Dennis T., Uzinskas, Irene N., Valocik, Richard E., Vasko-Moser, Janice A., Wong, Angela S., Yellin, Tobias O., Yuan, Catherine C.K.
Published in Bioorganic & medicinal chemistry letters (05.11.1996)
Published in Bioorganic & medicinal chemistry letters (05.11.1996)
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