The challenges of clinical trials in fragile X syndrome
Jacquemont, Sébastien, Berry-Kravis, Elizabeth, Hagerman, Randi, von Raison, Florian, Gasparini, Fabrizio, Apostol, George, Ufer, Mike, Des Portes, Vincent, Gomez-Mancilla, Baltazar
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Published in Psychopharmacology (01.03.2014)
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Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model
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Regional brain mGlu5 receptor occupancy following single oral doses of mavoglurant as measured by [11C]-ABP688 PET imaging in healthy volunteers
Streffer, Johannes, Treyer, Valerie, Buck, Alfred, Ametamey, Simon M., Blagoev, Milen, Maguire, Ralph P, Gautier, Aurélie, Auberson, Yves P., Schmidt, Mark E., Vranesic, Ivan-Toma, Gomez-Mancilla, Baltazar, Gasparini, Fabrizio
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Published in NeuroImage (Orlando, Fla.) (15.04.2021)
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Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity
Goniotaki, Despoina, Lakkaraju, Asvin K K, Shrivastava, Amulya N, Bakirci, Pamela, Sorce, Silvia, Senatore, Assunta, Marpakwar, Rajlakshmi, Hornemann, Simone, Gasparini, Fabrizio, Triller, Antoine, Aguzzi, Adriano
Published in PLoS pathogens (01.11.2017)
Published in PLoS pathogens (01.11.2017)
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In vivo variation in same-day estimates of metabotropic glutamate receptor subtype 5 binding using [11C]ABP688 and [18F]FPEB
DeLorenzo, Christine, Gallezot, Jean-Dominique, Gardus, John, Yang, Jie, Planeta, Beata, Nabulsi, Nabeel, Ogden, R Todd, Labaree, David C, Huang, Yiyun H, Mann, J John, Gasparini, Fabrizio, Lin, Xin, Javitch, Jonathan A, Parsey, Ramin V, Carson, Richard E, Esterlis, Irina
Published in Journal of cerebral blood flow and metabolism (01.08.2017)
Published in Journal of cerebral blood flow and metabolism (01.08.2017)
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AFQ056, a new mGluR5 antagonist for treatment of fragile X syndrome
Levenga, Josien, Hayashi, Shigemi, de Vrij, Femke M.S, Koekkoek, Sebastiaan K, van der Linde, Herma C, Nieuwenhuizen, Ingeborg, Song, Cheng, Buijsen, Ronald A.M, Pop, Andreea S, GomezMancilla, Baltazar, Nelson, David L, Willemsen, Rob, Gasparini, Fabrizio, Oostra, Ben A
Published in Neurobiology of disease (01.06.2011)
Published in Neurobiology of disease (01.06.2011)
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Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study
Abdallah, Chadi G., Hannestad, Jonas, Mason, Graeme F., Holmes, Sophie E., DellaGioia, Nicole, Sanacora, Gerard, Jiang, Lihong, Matuskey, David, Satodiya, Ritvij, Gasparini, Fabrizio, Lin, Xin, Javitch, Jonathan, Planeta, Beata, Nabulsi, Nabeel, Carson, Richard E., Esterlis, Irina
Published in Biological psychiatry : cognitive neuroscience and neuroimaging (01.07.2017)
Published in Biological psychiatry : cognitive neuroscience and neuroimaging (01.07.2017)
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Development of mavoglurant and its potential for the treatment of fragile X syndrome
Gomez-Mancilla, Baltazar, Berry-Kravis, Elizabeth, Hagerman, Randi, von Raison, Florian, Apostol, George, Ufer, Mike, Gasparini, Fabrizio, Jacquemont, Sébastien
Published in Expert opinion on investigational drugs (01.01.2014)
Published in Expert opinion on investigational drugs (01.01.2014)
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Metabotropic Glutamate Receptors for Parkinson's Disease Therapy
Gasparini, Fabrizio, Gomez-Mancilla, Baltazar, Di Paolo, Thérèse
Published in Parkinson's disease (01.01.2013)
Published in Parkinson's disease (01.01.2013)
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Potential anxiolytic‐ and antidepressant‐like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist
Tatarczyńska, Ewa, Kłodzińska, Aleksandra, Chojnacka‐Wójcik, Ewa, Pałucha, Agnieszka, Gasparini, Fabrizio, Kuhn, Rainer, Pilc, Andrzej
Published in British journal of pharmacology (01.04.2001)
Published in British journal of pharmacology (01.04.2001)
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ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: Identification, in vitro pharmacology, pharmacokinetic and biodistribution studies
Hintermann, Samuel, Vranesic, Ivo, Allgeier, Hans, Brülisauer, Armin, Hoyer, Daniel, Lemaire, Michel, Moenius, Thomas, Urwyler, Stephan, Whitebread, Steven, Gasparini, Fabrizio, Auberson, Yves P.
Published in Bioorganic & medicinal chemistry (15.01.2007)
Published in Bioorganic & medicinal chemistry (15.01.2007)
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Anxiolytic-Like Effects of the Prototypical Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)pyridine in Rodents
Spooren, W P, Vassout, A, Neijt, H C, Kuhn, R, Gasparini, F, Roux, S, Porsolt, R D, Gentsch, C
Published in The Journal of pharmacology and experimental therapeutics (01.12.2000)
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Published in The Journal of pharmacology and experimental therapeutics (01.12.2000)
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The Non-competitive Antagonists 2-Methyl-6-(phenylethynyl)pyridine and 7-Hydroxyiminocyclopropan[b]chromen-1a-carboxylic Acid Ethyl Ester Interact with Overlapping Binding Pockets in the Transmembrane Region of Group I Metabotropic Glutamate Receptors
Pagano, Adriana, Rüegg, Doris, Litschig, Stephane, Stoehr, Natacha, Stierlin, Christine, Heinrich, Micheline, Floersheim, Philipp, Prezèau, Laurent, Carroll, Fiona, Pin, Jean-Philippe, Cambria, Antonio, Vranesic, Ivo, Flor, Peter Josef, Gasparini, Fabrizio, Kuhn, Rainer
Published in The Journal of biological chemistry (27.10.2000)
Published in The Journal of biological chemistry (27.10.2000)
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CPCCOEt, a Noncompetitive Metabotropic Glutamate Receptor 1 Antagonist, Inhibits Receptor Signaling Without Affecting Glutamate Binding
Litschig, S, Gasparini, F, Rueegg, D, Stoehr, N, Flor, P J, Vranesic, I, Prézeau, L, Pin, J P, Thomsen, C, Kuhn, R
Published in Molecular pharmacology (01.03.1999)
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Published in Molecular pharmacology (01.03.1999)
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Reciprocal changes in DNA methylation and hydroxymethylation and a broad repressive epigenetic switch characterize FMR1 transcriptional silencing in fragile X syndrome
Brasa, Sarah, Mueller, Arne, Jacquemont, Sébastien, Hahne, Florian, Rozenberg, Izabela, Peters, Thomas, He, Yunsheng, McCormack, Christine, Gasparini, Fabrizio, Chibout, Salah-Dine, Grenet, Olivier, Moggs, Jonathan, Gomez-Mancilla, Baltazar, Terranova, Rémi
Published in Clinical epigenetics (05.02.2016)
Published in Clinical epigenetics (05.02.2016)
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Effects of the prototypical mGlu5 receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine on rotarod, locomotor activity and rotational responses in unilateral 6-OHDA-lesioned rats
SPOOREN, Will P. J. M, GASPARINI, Fabrizio, BERGMANN, Reinhard, KUHN, Rainer
Published in European journal of pharmacology (01.10.2000)
Published in European journal of pharmacology (01.10.2000)
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