Toward the Back-Up of Boceprevir (SCH 503034): Discovery of New Extended P-4-Capped Ketoamide Inhibitors of Hepatitis C Virus NS3 Serine Protease with Improved Potency and Pharmacokinetic Profiles
Bogen, Stephane L., Pan, Weidong, Ruan, Sumei, Nair, Latha G., Arasappan, Ashok, Bennett, Frank, Chen, Kevin X., Jao, Edwin, Venkatraman, Srikanth, Vibulbhan, Bancha, Liu, Rong, Cheng, Kuo-Chi, Guo, Zhuyan, Tong, Xiao, Saksena, Anil K., Girijavallabhan, Viyyoor, Njoroge, F. George
Published in Journal of medicinal chemistry (25.06.2009)
Published in Journal of medicinal chemistry (25.06.2009)
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Design and synthesis of novel fluoro amino acids: synthons for potent macrocyclic HCV NS3 protease inhibitors
Nair, Latha G., Bogen, Stephane, Bennett, Frank, Chen, Kevin, Vibulbhan, Bancha, Huang, Yuhua, Yang, Weing, Doll, Ronald J., Shih, N.-Y., Njoroge, F. George
Published in Tetrahedron letters (09.06.2010)
Published in Tetrahedron letters (09.06.2010)
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Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and Wap-ras transgenic mice
MING LIU, BRYANT, M. S, DELL, J, SINHA, D, SYED, J, KORFMACHER, W. A, NOMEIR, A. A, LIN, C.-C, WANG, L, TAVERAS, A. G, DOLL, R. J, NJOROGE, F. G, JIANPING CHEN, MALLAMS, A. K, REMISZEWSKI, S, CATINO, J. J, GIRIJAVALLABHAN, V. M, KIRSCHMEIER, P, BISHOP, W. R, SUINING LEE, YAREMKO, B, LIPARI, P, MALKOWSKI, M, FERRARI, E, NIELSEN, L, PRIOLI, N
Published in Cancer research (Chicago, Ill.) (01.11.1998)
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Published in Cancer research (Chicago, Ill.) (01.11.1998)
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Friedel-Crafts acylation with N-(trifluoroacetyl)-.alpha.-amino acid chlorides. Application to the preparation of .beta.-arylalkylamines and 3-substituted 1,2,3,4-tetrahydroisoquinolines
Nordlander, J. Eric, Payne, Mark J, Njoroge, F. George, Balk, Michael A, Laikos, George D, Vishwanath, Vasanth M
Published in Journal of organic chemistry (01.11.1984)
Published in Journal of organic chemistry (01.11.1984)
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A short enantiospecific synthesis of 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (ADTN)
Nordlander, J. Eric, Payne, Mark J, Njoroge, F. George, Vishwanath, Vasanth M, Han, Gi Rin, Laikos, George D, Balk, Michael A
Published in Journal of organic chemistry (01.09.1985)
Published in Journal of organic chemistry (01.09.1985)
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Depeptidization efforts on P[subscript 3]-P[prime subscript 2] [alpha]-ketoamide inhibitors of HCV NS3-4A serine protease: Effect on HCV replicon activity
Bogen, Stephane L., Ruan, Sumei, Liu, Rong, Agrawal, Sony, Pichardo, John, Prongay, Andrew, Baroudy, Bahige, Saksena, Anil K., Girijavallabhan, Viyyoor, Njoroge, F. George
Published in Bioorganic & medicinal chemistry letters (30.06.2008)
Published in Bioorganic & medicinal chemistry letters (30.06.2008)
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Mutations Conferring Resistance to SCH6, a Novel Hepatitis C Virus NS3/4A Protease Inhibitor: Reduced DNA Replication Fitness and Partial Rescue by Second-Site Mutations
Yi, MinKyung, Tong, Xiao, Skelton, Angela, Chase, Robert, Chen, Tong, Prongay, Andrew, Bogen, Stephane L., Saksena, Anil K., Njoroge, F. George, Veselenak, Ronald L., Pyles, Richard B., Bourne, Nigel, Malcolm, Bruce A., Lemon, Stanley M.
Published in The Journal of biological chemistry (30.06.2008)
Published in The Journal of biological chemistry (30.06.2008)
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Erratum to “Enhanced FTase activity achieved via piperazine interaction with catalytic zinc” [Bioorg. Med. Chem. Lett. 16 (2006) 984–988]
Njoroge, F. George, Vibulbhan, Bancha, Pinto, Patrick, Strickland, Corey, Bishop, W. Robert, Nomeir, Amin, Girijavallabhan, Vivyoor
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
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A Continuous Spectrophotometric Assay for the Hepatitis C Virus Serine Protease
Zhang, Rumin, Beyer, Brian M., Durkin, James, Ingram, Richard, Njoroge, F.George, Windsor, William T., Malcolm, Bruce A.
Published in Analytical biochemistry (01.06.1999)
Published in Analytical biochemistry (01.06.1999)
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Depeptidization efforts on α-ketoamide inhibitors of HCV NS3-4A serine protease: Effect on HCV replicon activity
Bogen, Stéphane L., Ruan, Sumei, Liu, Rong, Agrawal, Sony, Pichardo, John, Prongay, Andrew, Baroudy, Bahige, Saksena, Anil K., Girijavallabhan, Viyyoor, Njoroge, F. George
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
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Bridgehead modification of trihalocycloheptabenzopyridine leads to a potent farnesyl protein transferase inhibitor with improved oral metabolic stability
Njoroge, F George, Vibulbhan, Bancha, Shi, Xiongwei, Strickland, Corey, Kirschmeier, Paul, Bishop, Robert, Nomeir, Amin, Girijavallabhan, Viyyoor
Published in Bioorganic & medicinal chemistry letters (06.12.2004)
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Published in Bioorganic & medicinal chemistry letters (06.12.2004)
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Tricyclic Farnesyl Protein Transferase Inhibitors: Crystallographic and Calorimetric Studies of Structure−Activity Relationships
Strickland, Corey L, Weber, Patricia C, Windsor, William T, Wu, Zhen, Le, Hung V, Albanese, Margaret M, Alvarez, Carmen S, Cesarz, David, del Rosario, Joycelyn, Deskus, Jeffrey, Mallams, Alan K, Njoroge, F. George, Piwinski, John J, Remiszewski, Stacy, Rossman, Randall R, Taveras, Arthur G, Vibulbhan, Bancha, Doll, Ronald J, Girijavallabhan, Viyyoor M, Ganguly, Ashit K
Published in Journal of medicinal chemistry (17.06.1999)
Published in Journal of medicinal chemistry (17.06.1999)
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Structural Interaction of Natural and Synthetic Inhibitors with the Venom Metalloproteinase, Atrolysin C (Form d)
Zhang, Dachuan, Botos, Istvan, Gomis-Rüth, Franz-Xaver, Doll, Ronald, Blood, Christine, Njoroge, F. George, Fox, Jay w., Bode, Wolfram, Meyer, Edgar F.
Published in Proceedings of the National Academy of Sciences - PNAS (30.08.1994)
Published in Proceedings of the National Academy of Sciences - PNAS (30.08.1994)
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Bridgehead modification of trihalocycloheptabenzopyridine lead to a potent farnesyl protein transferase inhibitor with improved oral metabolic stability
Njoroge, F. George, Vibulbhan, Bancha, Shi, Xiongwei, Strickland, Corey, Kirschmeier, Paul, Bishop, Robert, Nomeir, Amin, Girijavallabhan, Viyyoor
Published in Bioorganic & medicinal chemistry letters (06.12.2004)
Published in Bioorganic & medicinal chemistry letters (06.12.2004)
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The role of P-glycoprotein in the pharmacokinetics and tissue distribution of a hepatitis C virus protease inhibitor
Chen, Kevin X, Vibulbhan, Bancha, Liu, Tongtong, Broske, Lisa, Wang, Genfeng, Li, Cheng, Njoroge, F George, Uss, Annette S, Cheng, K-C
Published in Drug metabolism letters (01.12.2009)
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Published in Drug metabolism letters (01.12.2009)
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Lead Optimization in Discovery Drug Metabolism and Pharmacokinetics/Case study: The Hepatitis C Virus (HCV) Protease Inhibitor SCH 503034
Cheng, K.-C., Korfmacher, Walter A., White, Ronald E., Njoroge, F. George
Published in Perspectives in medicinal chemistry (01.01.2007)
Published in Perspectives in medicinal chemistry (01.01.2007)
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Potent, Selective, and Orally Bioavailable Tricyclic Pyridyl Acetamide N-Oxide Inhibitors of Farnesyl Protein Transferase with Enhanced in Vivo Antitumor Activity
Njoroge, F. George, Vibulbhan, Bancha, Pinto, Patrick, Bishop, W. Robert, Bryant, Mathew S, Nomeir, Amin A, Lin, C.-C, Liu, Ming, Doll, Ronald J, Girijavallabhan, V, Ganguly, Ashit K
Published in Journal of medicinal chemistry (07.05.1998)
Published in Journal of medicinal chemistry (07.05.1998)
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Discovery of novel nonpeptide tricyclic inhibitors of ras farnesyl protein transferase
Njoroge, F. George, Doll, Ronald J., Vibulbhan, Bancha, Alvarez, Carmen S., Bishop, W. Robert, Petrin, Joanne, Kirschmeier, Paul, Carruthers, Nicholas I., Wong, Jesse K., Albanese, Margaret M., Piwinski, John J., Catino, Joseph, Girijavallabhan, V., Ganguly, Ashit K.
Published in Bioorganic & medicinal chemistry (01.01.1997)
Published in Bioorganic & medicinal chemistry (01.01.1997)
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