Inhibitors of sterol synthesis. Chemical synthesis and properties of 3-beta-hydroxy-25,26,26,26,27,27,27-heptafluoro-5-alpha-cholest-8(14)-en-15-one and 25,26,26,26,27,27,27-heptafluorocholesterol and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured mammalian cells
Swaminathan, S, Wilson, W.K, Pinkerton, F.D, Gerst, N, Ramser, M, Schroepfer, G.J. Jr
Published in Journal of lipid research (01.10.1993)
Published in Journal of lipid research (01.10.1993)
Get full text
Journal Article
INHIBITORS OF STEROL SYNTHESIS - METABOLISM-BASED DESIGN AND CONSTRUCTION OF A NEW ANALOG OF 3-BETA-HYDROXY-5-ALPHA-CHOLEST-8(14)-EN-15-ONE AND ITS EFFECTS IN CULTURED-MAMMALIAN-CELLS AND IN RATS
SWAMINATHAN, S, SIDDIQUI, AU, GERST, N, PINKERTON, FD, KISIC, A, KIM, LJ, WILSON, WK, SCHROEPFER, GJ
Published in Journal of lipid research (01.04.1995)
Published in Journal of lipid research (01.04.1995)
Get full text
Journal Article
INHIBITORS OF STEROL SYNTHESIS - CHEMICAL SYNTHESIS, STRUCTURE, AND BIOLOGICAL-ACTIVITIES OF (25R)-3-BETA,26-DIHYDROXY-5-ALPHA-CHOLEST-8(14)-EN-15-ONE, A METABOLITE OF 3-BETA-HYDROXY-5-ALPHA-CHOLEST-8(14)-EN-15-ONE
KIM, HS, WILSON, WK, NEEDLEMAN, DH, PINKERTON, FD, WILSON, DK, QUIOCHO, FA, SCHROEPFER, GJ
Published in Journal of lipid research (01.02.1989)
Published in Journal of lipid research (01.02.1989)
Get full text
Journal Article
Inhibitors of sterol synthesis. A highly efficient and specific side-chain oxidation of 3 beta-acetoxy-5 alpha-cholest-8(14)-en-15-one for construction of metabolites and analogs of the 15-ketosterol
Herz, JE, Swaminathan, S, Pinkerton, FD, Wilson, WK, Schroepfer, GJ
Published in Journal of lipid research (01.04.1992)
Published in Journal of lipid research (01.04.1992)
Get full text
Journal Article
Inhibitors of sterol synthesis. Chemical synthesis and spectral properties of 3 beta-hydroxy-5 alpha-cholesta-8(14),24-dien-15-one, 3 beta,25-dihydroxy-5 alpha-cholest-8(14)-en-15-one, and 3 beta,24-dihydroxy-5 alpha-cholest-8(14)-en-15-one and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in CHO-K1 cells
Swaminathan, S, Pinkerton, FD, Numazawa, S, Wilson, WK, Schroepfer, GJ
Published in Journal of lipid research (01.10.1992)
Published in Journal of lipid research (01.10.1992)
Get full text
Journal Article
Inhibitors of sterol synthesis. Characterization of beta,gamma-unsaturated analogs of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in CHO-K1 cells
Wilson, WK, Wheeler, ME, Pinkerton, FD, St Pyrek, J, Schroepfer, GJ
Published in Journal of lipid research (01.07.1991)
Published in Journal of lipid research (01.07.1991)
Get full text
Journal Article
Inhibitors of sterol synthesis. Effects of fluorine substitution at carbon atom 25 of cholesterol on its spectral and chromatographic properties and on 3-hydroxy-3-methylglutaryl coenzyme a reductase activity in CHO-K1 cells
Wilson, William K., Swaminathan, Shankar, Pinkerton, Frederick D., Gerst, Nicolas, Schroepfer, George J.
Published in Steroids (01.05.1994)
Published in Steroids (01.05.1994)
Get full text
Journal Article
Enzymatic formation and chemical synthesis of an active metabolite of 3β-hydroxy-5α-cholest-8(14)-en-15-one, a potent regulator of cholesterol metabolism
Schroepfer, George J., Kim, Hong-Seok, Vermilion, Janice L., Stephens, Thomas W., Pinkerton, Frederick D., Needleman, Dolores H., Wilson, William K., Pyrek, Jan St
Published in Biochemical and biophysical research communications (29.02.1988)
Published in Biochemical and biophysical research communications (29.02.1988)
Get full text
Journal Article
Inhibitors of sterol synthesis. Chemical syntheses and spectral properties of 26-oxygenated derivatives of 3β-hydroxy-5α-cholest-8(14)-en-15-one and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in CHO-K1 cells
Siddiqui, Abdul U., Wilson, William K., Ruecker, Karen E., Pinkerton, Frederick D., Schroepfer, George J.
Published in Chemistry and physics of lipids (01.11.1992)
Published in Chemistry and physics of lipids (01.11.1992)
Get full text
Journal Article
Inhibitors of sterol synthesis. Studies of the metabolism of 5α-cholest-8(14)-en-3β-ol-15-one in Chinese hamster ovary cells and its effects on activities of early enzymes in cholesterol biosynthesis
Pajewski, Thomas N., Pinkerton, Frederick D., Miller, Larry R., Schroepfer, George J.
Published in Chemistry and physics of lipids (01.10.1988)
Published in Chemistry and physics of lipids (01.10.1988)
Get full text
Journal Article
Sterols in blood of normal and Smith-Lemli-Opitz subjects
Ruan, B, Wilson, W K, Pang, J, Gerst, N, Pinkerton, F D, Tsai, J, Kelley, R I, Whitby, F G, Milewicz, D M, Garbern, J, Schroepfer, Jr, G J
Published in Journal of lipid research (01.05.2001)
Published in Journal of lipid research (01.05.2001)
Get full text
Journal Article
Inhibitors of sterol synthesis. Chemical synthesis of 5 beta-cholest-8-ene-3 beta,15 alpha-diol and its effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in CHO-K1 cells
Wilson, W K, Pinkerton, F D, Kirkpatrick, N D, Schroepfer, Jr, G J
Published in Journal of lipid research (01.06.1989)
Published in Journal of lipid research (01.06.1989)
Get full text
Journal Article
Inhibitors of sterol synthesis. Exogenous oleate reduces the inhibitory effect of 5α-Cholest-8(14)-en-3β-ol-15-one on the growth of CHO-K1 cells
Pinkerton, Frederick D., Kirkpatrick, Nanda Duhe, Schroepfer, George J.
Published in Biochemical and biophysical research communications (31.10.1988)
Published in Biochemical and biophysical research communications (31.10.1988)
Get full text
Journal Article
Sterol synthesis. Synthesis of 3 β-hydroxy-25,26,26,26,27,27,27-heptafluorocholest-5-en-7-one and its effects on HMG-CoA reductase activity in Chinese hamster ovary cells, on ACAT activity in rat jejunal microsomes, and serum cholesterol levels in rats
Carroll, Jeffery N, Pinkerton, Frederick D, Su, Xiangdong, Gerst, Nicolas, Wilson, William K, Schroepfer, George J
Published in Chemistry and physics of lipids (01.08.1998)
Published in Chemistry and physics of lipids (01.08.1998)
Get full text
Journal Article