GPx2 suppression of H2O2 stress links the formation of differentiated tumor mass to metastatic capacity in colorectal cancer
Emmink, Benjamin L, Laoukili, Jamila, Kipp, Anna P, Koster, Jan, Govaert, Klaas M, Fatrai, Szabolcs, Verheem, Andre, Steller, Ernst J A, Brigelius-Flohé, Regina, Jimenez, Connie R, Borel Rinkes, Inne H M, Kranenburg, Onno
Published in Cancer research (Chicago, Ill.) (15.11.2014)
Published in Cancer research (Chicago, Ill.) (15.11.2014)
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Journal Article
Maintenance of Clonogenic KIT+ Human Colon Tumor Cells Requires Secretion of Stem Cell Factor by Differentiated Tumor Cells
Fatrai, Szabolcs, van Schelven, Susanne J, Ubink, Inge, Govaert, Klaas M, Raats, Danielle, Koster, Jan, Verheem, Andre, Borel Rinkes, Inne H.M, Kranenburg, Onno
Published in Gastroenterology (New York, N.Y. 1943) (01.09.2015)
Published in Gastroenterology (New York, N.Y. 1943) (01.09.2015)
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Journal Article
Akt Induces β-Cell Proliferation by Regulating Cyclin D1, Cyclin D2, and p21 Levels and Cyclin-Dependent Kinase-4 Activity
Fatrai, Szabolcs, Elghazi, Lynda, Balcazar, Norman, Cras-Méneur, Corentin, Krits, Irina, Kiyokawa, Hiroaki, Bernal-Mizrachi, Ernesto
Published in Diabetes (New York, N.Y.) (01.02.2006)
Published in Diabetes (New York, N.Y.) (01.02.2006)
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Endoplasmic Reticulum Stress–Induced Apoptosis Is Partly Mediated by Reduced Insulin Signaling Through Phosphatidylinositol 3-Kinase/Akt and Increased Glycogen Synthase Kinase-3β in Mouse Insulinoma Cells
Srinivasan, Shanthi, Ohsugi, Mitsuru, Liu, Zhonghao, Fatrai, Szabolcs, Bernal-Mizrachi, Ernesto, Permutt, M. Alan
Published in Diabetes (New York, N.Y.) (01.04.2005)
Published in Diabetes (New York, N.Y.) (01.04.2005)
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Journal Article
Enhanced Polyamine Catabolism Alters Homeostatic Control of White Adipose Tissue Mass, Energy Expenditure, and Glucose Metabolism
Pirinen, Eija, Kuulasmaa, Teemu, Pietilä, Marko, Heikkinen, Sami, Tusa, Maija, Itkonen, Paula, Boman, Susanna, Skommer, Joanna, Virkamäki, Antti, Hohtola, Esa, Kettunen, Mikko, Fatrai, Szabolcs, Kansanen, Emilia, Koota, Suvi, Niiranen, Kirsi, Parkkinen, Jyrki, Levonen, Anna-Liisa, Ylä-Herttuala, Seppo, Hiltunen, J. Kalervo, Alhonen, Leena, Smith, Ulf, Jänne, Juhani, Laakso, Markku
Published in Molecular and Cellular Biology (01.07.2007)
Published in Molecular and Cellular Biology (01.07.2007)
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Journal Article
Malignant Transformation Involving CXXC4 Mutations Identified in a Leukemic Progression Model of Severe Congenital Neutropenia
Olofsen, Patricia A., Fatrai, Szabolcs, van Strien, Paulina M.H., Obenauer, Julia C., de Looper, Hans W.J., Hoogenboezem, Remco M., Erpelinck-Verschueren, Claudia A.J., Vermeulen, Michael P.W.M., Roovers, Onno, Haferlach, Torsten, Jansen, Joop H., Ghazvini, Mehrnaz, Bindels, Eric M.J., Schneider, Rebekka K., de Pater, Emma M., Touw, Ivo P.
Published in Cell reports. Medicine (25.08.2020)
Published in Cell reports. Medicine (25.08.2020)
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Journal Article
Downregulation of Signal Transducer and Activator of Transcription 5 (STAT5) in CD34+ Cells Promotes Megakaryocytic Development, Whereas Activation of STAT5 Drives Erythropoiesis
Olthof, Sandra G., Fatrai, Szabolcs, Drayer, A. Lyndsay, Tyl, Monika R., Vellenga, Edo, Schuringa, Jan Jacob
Published in Stem cells (Dayton, Ohio) (01.07.2008)
Published in Stem cells (Dayton, Ohio) (01.07.2008)
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Journal Article
KRASG12V Enhances Proliferation and Initiates Myelomonocytic Differentiation in Human Stem/Progenitor Cells via Intrinsic and Extrinsic Pathways
Fatrai, Szabolcs, van Gosliga, Djoke, Han, Lina, Daenen, Simon M.G.J., Vellenga, Edo, Schuringa, Jan Jacob
Published in The Journal of biological chemistry (01.02.2011)
Published in The Journal of biological chemistry (01.02.2011)
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SIRT1/PGC1a-dependent increase in oxidative phosphorylation supports chemotherapy resistance of colon cancer
Vellinga, T.T, Borovski, T, Boer, V.C.J., de, Kranenburg, O
Published in Clinical cancer research (15.06.2015)
Published in Clinical cancer research (15.06.2015)
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Simple PCR heteroduplex, SSCP mutation screening methods for the detection of novel catalase mutations in Hungarian patients with type 2 diabetes mellitus
Vitai, Márta, Fátrai, Szabolcs, Rass, Péter, Csordás, Melinda, Tarnai, Ildikó
Published in Clinical chemistry and laboratory medicine (01.12.2005)
Published in Clinical chemistry and laboratory medicine (01.12.2005)
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Journal Article
SIRT1/PGC1α-Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer
Vellinga, Thomas T, Borovski, Tijana, de Boer, Vincent C J, Fatrai, Szabolcs, van Schelven, Susanne, Trumpi, Kari, Verheem, Andre, Snoeren, Nikol, Emmink, Benjamin L, Koster, Jan, Rinkes, Inne H M Borel, Kranenburg, Onno
Published in Clinical cancer research (15.06.2015)
Published in Clinical cancer research (15.06.2015)
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Journal Article
Combinatorial CSF3R and RUNX1 Mutations Involved in the Leukemic Progression of Severe Congenital Neutropenia Confer a G-CSF-Dependent Premalignant State in Mice
Fatrai, Szabolcs, van Strien, Paulette, Obenauer, Julia, Van den Heuvel-Eibrink, M.M., Touw, Ivo
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Journal Article
Phase I dose-escalation study of MCLA-158, a first-in-class bispecific antibody targeting EGFR and LGR5, in metastatic colorectal cancer (CRC)
Argiles, Guillem, Jungels, Christiane, Garcia-Carbonero, Rocio, Diez Garcia, Marc, Bendell, Johanna C., Tabernero, Josep, Bekradda, Mohamed, Lammerts van Bueren, Jeroen, Bol, Kees, Stalbovskaya, Viktoriya, Fatrai, Szabolcs, Brinkman, Arjen, Wasserman, Ernesto, Hollebecque, Antoine
Published in Journal of clinical oncology (20.01.2021)
Published in Journal of clinical oncology (20.01.2021)
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Journal Article
Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors
Herpers, Bram, Eppink, Berina, James, Mark I, Cortina, Carme, Cañellas-Socias, Adrià, Boj, Sylvia F, Hernando-Momblona, Xavier, Glodzik, Dominik, Roovers, Rob C, van de Wetering, Marc, Bartelink-Clements, Carina, Zondag-van der Zande, Vanessa, Mateos, Jara García, Yan, Kuan, Salinaro, Lucia, Basmeleh, Abdul, Fatrai, Szabolcs, Maussang, David, Lammerts van Bueren, Jeroen J, Chicote, Irene, Serna, Garazi, Cabellos, Laia, Ramírez, Lorena, Nuciforo, Paolo, Salazar, Ramon, Santos, Cristina, Villanueva, Alberto, Stephan-Otto Attolini, Camille, Sancho, Elena, Palmer, Hector G, Tabernero, Josep, Stratton, Michael R, de Kruif, John, Logtenberg, Ton, Clevers, Hans, Price, Leo S, Vries, Robert G J, Batlle, Eduard, Throsby, Mark
Published in Nature cancer (01.04.2022)
Published in Nature cancer (01.04.2022)
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A Leukemic Progression Model of Severe Congenital Neutropenia Uncovers a Novel Mechanism of AML Development Involving Elevated Inflammatory Responses, Mutation of CXXC4 and Decreased TET2 Levels
Olofsen, Patricia, Fatrai, Szabolcs, van Strien, Paulette, Obenauer, Julia, Hoogenboezem, Remco, Erpelinck-Verschueren, Claudia, Roovers, Onno, Haferlach, Torsten, Valk, Peter, Schneider, Rebekka, De Pater, Emma, Touw, Ivo
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Inhibition of RAF1 kinase activity restores apicobasal polarity and impairs tumour growth in human colorectal cancer
Borovski, Tijana, Vellinga, Thomas T, Laoukili, Jamila, Santo, Evan E, Fatrai, Szabolcs, van Schelven, Susanne, Verheem, Andre, Marvin, Dieuwke L, Ubink, Inge, Borel Rinkes, Inne H M, Kranenburg, Onno
Published in Gut (01.06.2017)
Published in Gut (01.06.2017)
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Journal Article
Abstract 1903: Zenocutuzumab, a HER2xHER3 bispecific antibody, is effective in cancer models with high NRG1 expression
O'Connor, Marie N., Schackmann, Ron C., Odintsov, Igor, Fatrai, Szabolcs, Brinkman, Arie B., Walker, Sidney, van Bueren, Jeroen J. Lammerts, Geuijen, Cecile A.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Hypoxia after liver surgery imposes an aggressive cancer stem cell phenotype on residual tumor cells
Govaert, Klaas M, Emmink, Benjamin L, Nijkamp, Maarten W, Cheung, Zing J, Steller, Ernst J A, Fatrai, Szabolcs, de Bruijn, Menno T, Kranenburg, Onno, Borel Rinkes, Inne H M
Published in Annals of surgery (01.04.2014)
Published in Annals of surgery (01.04.2014)
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Abstract 336: Mechanism of action of MCLA-129, a bispecific antibody that targets EGFR and c-MET and impairs growth of EGFR exon 20 insertion mutant non-small cell lung cancer
de Gorter, David J., O'Connor, Marie, Deshiere, Alexandre, van Rosmalen, Martijn, Fatrai, Szabolcs, van Bueren, Jeroen Lammerts, Geuijen, Cecile A.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Identification of HIF2α as an important STAT5 target gene in human hematopoietic stem cells
Fatrai, Szabolcs, Wierenga, Albertus T.J., Daenen, Simon M.G.J., Vellenga, Edo, Schuringa, Jan Jacob
Published in Blood (24.03.2011)
Published in Blood (24.03.2011)
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