Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes
Westra, Harm-Jan, Martínez-Bonet, Marta, Onengut-Gumuscu, Suna, Lee, Annette, Luo, Yang, Teslovich, Nikola, Worthington, Jane, Martin, Javier, Huizinga, Tom, Klareskog, Lars, Rantapaa-Dahlqvist, Solbritt, Chen, Wei-Min, Quinlan, Aaron, Todd, John A., Eyre, Steve, Nigrovic, Peter A., Gregersen, Peter K., Rich, Stephen S., Raychaudhuri, Soumya
Published in Nature genetics (01.10.2018)
Published in Nature genetics (01.10.2018)
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Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls
Fortune, Mary D, Guo, Hui, Burren, Oliver, Schofield, Ellen, Walker, Neil M, Ban, Maria, Sawcer, Stephen J, Bowes, John, Worthington, Jane, Barton, Anne, Eyre, Steve, Todd, John A, Wallace, Chris
Published in Nature genetics (01.07.2015)
Published in Nature genetics (01.07.2015)
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Evidence of NLRP3-inflammasome activation in rheumatoid arthritis (RA); genetic variants within the NLRP3-inflammasome complex in relation to susceptibility to RA and response to anti-TNF treatment
Mathews, Rebeccah J, Robinson, James I, Battellino, Michele, Wong, Chi, Taylor, John C, Eyre, Steve, Churchman, Sarah M, Wilson, Anthony G, Isaacs, John D, Hyrich, Kimme, Barton, Anne, Plant, Darren, Savic, Sinisa, Cook, Graham P, Sarzi-Puttini, Piercarlo, Emery, Paul, Barrett, Jennifer H, Morgan, Ann W, McDermott, Michael F
Published in Annals of the rheumatic diseases (01.06.2014)
Published in Annals of the rheumatic diseases (01.06.2014)
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Fine Mapping Seronegative and Seropositive Rheumatoid Arthritis to Shared and Distinct HLA Alleles by Adjusting for the Effects of Heterogeneity
Han, Buhm, Diogo, Dorothée, Eyre, Steve, Kallberg, Henrik, Zhernakova, Alexandra, Bowes, John, Padyukov, Leonid, Okada, Yukinori, González-Gay, Miguel A., Rantapää-Dahlqvist, Solbritt, Martin, Javier, Huizinga, Tom W.J., Plenge, Robert M., Worthington, Jane, Gregersen, Peter K., Klareskog, Lars, de Bakker, Paul I.W., Raychaudhuri, Soumya
Published in American journal of human genetics (03.04.2014)
Published in American journal of human genetics (03.04.2014)
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High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci
Kim, Kwangwoo, Bang, So-Young, Lee, Hye-Soon, Cho, Soo-Kyung, Choi, Chan-Bum, Sung, Yoon-Kyoung, Kim, Tae-Hwan, Jun, Jae-Bum, Yoo, Dae Hyun, Kang, Young Mo, Kim, Seong-Kyu, Suh, Chang-Hee, Shim, Seung-Cheol, Lee, Shin-Seok, Lee, Jisoo, Chung, Won Tae, Choe, Jung-Yoon, Shin, Hyoung Doo, Lee, Jong-Young, Han, Bok-Ghee, Nath, Swapan K, Eyre, Steve, Bowes, John, Pappas, Dimitrios A, Kremer, Joel M, Gonzalez-Gay, Miguel A, Rodriguez-Rodriguez, Luis, Ärlestig, Lisbeth, Okada, Yukinori, Diogo, Dorothée, Liao, Katherine P, Karlson, Elizabeth W, Raychaudhuri, Soumya, Rantapää-Dahlqvist, Solbritt, Martin, Javier, Klareskog, Lars, Padyukov, Leonid, Gregersen, Peter K, Worthington, Jane, Greenberg, Jeffrey D, Plenge, Robert M, Bae, Sang-Cheol
Published in Annals of the rheumatic diseases (01.03.2015)
Published in Annals of the rheumatic diseases (01.03.2015)
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Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus
Orozco, Gisela, Eyre, Steve, Hinks, Anne, Bowes, John, Morgan, Ann W, Wilson, Anthony G, Wordsworth, Paul, Steer, Sophia, Hocking, Lynne, Thomson, Wendy, Worthington, Jane, Barton, Anne
Published in Annals of the rheumatic diseases (01.03.2011)
Published in Annals of the rheumatic diseases (01.03.2011)
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A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases
Han, Buhm, Pouget, Jennie G, Slowikowski, Kamil, Stahl, Eli, Lee, Cue Hyunkyu, Diogo, Dorothee, Hu, Xinli, Park, Yu Rang, Kim, Eunji, Gregersen, Peter K, Dahlqvist, Solbritt Rantapää, Worthington, Jane, Martin, Javier, Eyre, Steve, Klareskog, Lars, Huizinga, Tom, Chen, Wei-Min, Onengut-Gumuscu, Suna, Rich, Stephen S, Wray, Naomi R, Raychaudhuri, Soumya
Published in Nature genetics (01.07.2016)
Published in Nature genetics (01.07.2016)
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Mapping DNA interaction landscapes in psoriasis susceptibility loci highlights KLF4 as a target gene in 9q31
Ray-Jones, Helen, Duffus, Kate, McGovern, Amanda, Martin, Paul, Shi, Chenfu, Hankinson, Jenny, Gough, Oliver, Yarwood, Annie, Morris, Andrew P, Adamson, Antony, Taylor, Christopher, Ding, James, Gaddi, Vasanthi Priyadarshini, Fu, Yao, Gaffney, Patrick, Orozco, Gisela, Warren, Richard B, Eyre, Steve
Published in BMC biology (04.05.2020)
Published in BMC biology (04.05.2020)
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Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility
Barton, Anne, Thomson, Wendy, Ke, Xiayi, Eyre, Steve, Hinks, Anne, Bowes, John, Gibbons, Laura, Plant, Darren, Wilson, Anthony G., Marinou, Ioanna, Morgan, Ann, Emery, Paul, Steer, Sophia, Hocking, Lynne, Reid, David M., Wordsworth, Paul, Harrison, Pille, Worthington, Jane
Published in Human molecular genetics (01.08.2008)
Published in Human molecular genetics (01.08.2008)
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Rare, Low-Frequency, and Common Variants in the Protein-Coding Sequence of Biological Candidate Genes from GWASs Contribute to Risk of Rheumatoid Arthritis
Diogo, Dorothée, Kurreeman, Fina, Stahl, Eli A., Liao, Katherine P., Gupta, Namrata, Greenberg, Jeffrey D., Rivas, Manuel A., Hickey, Brendan, Flannick, Jason, Thomson, Brian, Guiducci, Candace, Ripke, Stephan, Adzhubey, Ivan, Barton, Anne, Kremer, Joel M., Alfredsson, Lars, Sunyaev, Shamil, Martin, Javier, Zhernakova, Alexandra, Bowes, John, Eyre, Steve, Siminovitch, Katherine A., Gregersen, Peter K., Worthington, Jane, Klareskog, Lars, Padyukov, Leonid, Raychaudhuri, Soumya, Plenge, Robert M.
Published in American journal of human genetics (10.01.2013)
Published in American journal of human genetics (10.01.2013)
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Journal Article
Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13
Barton, Anne, Thomson, Wendy, Ke, Xiayi, Eyre, Steve, Hinks, Anne, Bowes, John, Plant, Darren, Gibbons, Laura J, Wilson, Anthony G, Bax, Deborah E, Morgan, Ann W, Emery, Paul, Steer, Sophia, Hocking, Lynne, Reid, David M, Wordsworth, Paul, Harrison, Pille, Worthington, Jane
Published in Nature genetics (01.10.2008)
Published in Nature genetics (01.10.2008)
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Informed conditioning on clinical covariates increases power in case-control association studies
Zaitlen, Noah, Lindström, Sara, Pasaniuc, Bogdan, Cornelis, Marilyn, Genovese, Giulio, Pollack, Samuela, Barton, Anne, Bickeböller, Heike, Bowden, Donald W, Eyre, Steve, Freedman, Barry I, Friedman, David J, Field, John K, Groop, Leif, Haugen, Aage, Heinrich, Joachim, Henderson, Brian E, Hicks, Pamela J, Hocking, Lynne J, Kolonel, Laurence N, Landi, Maria Teresa, Langefeld, Carl D, Le Marchand, Loic, Meister, Michael, Morgan, Ann W, Raji, Olaide Y, Risch, Angela, Rosenberger, Albert, Scherf, David, Steer, Sophia, Walshaw, Martin, Waters, Kevin M, Wilson, Anthony G, Wordsworth, Paul, Zienolddiny, Shanbeh, Tchetgen, Eric Tchetgen, Haiman, Christopher, Hunter, David J, Plenge, Robert M, Worthington, Jane, Christiani, David C, Schaumberg, Debra A, Chasman, Daniel I, Altshuler, David, Voight, Benjamin, Kraft, Peter, Patterson, Nick, Price, Alkes L
Published in PLoS genetics (01.11.2012)
Published in PLoS genetics (01.11.2012)
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Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23
Orozco, Gisela, Hinks, Anne, Eyre, Steve, Ke, Xiayi, Gibbons, Laura J., Bowes, John, Flynn, Edward, Martin, Paul, Wilson, Anthony G., Bax, Deborah E., Morgan, Ann W., Emery, Paul, Steer, Sophia, Hocking, Lynne, Reid, David M., Wordsworth, Paul, Harrison, Pille, Thomson, Wendy, Barton, Anne, Worthington, Jane
Published in Human molecular genetics (15.07.2009)
Published in Human molecular genetics (15.07.2009)
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Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway
Li, Gang, Diogo, Dorothée, Wu, Di, Spoonamore, Jim, Dancik, Vlado, Franke, Lude, Kurreeman, Fina, Rossin, Elizabeth J, Duclos, Grant, Hartland, Cathy, Zhou, Xuezhong, Li, Kejie, Liu, Jun, De Jager, Philip L, Siminovitch, Katherine A, Zhernakova, Alexandra, Raychaudhuri, Soumya, Bowes, John, Eyre, Steve, Padyukov, Leonid, Gregersen, Peter K, Worthington, Jane, Gupta, Namrata, Clemons, Paul A, Stahl, Eli, Tolliday, Nicola, Plenge, Robert M
Published in PLoS genetics (01.05.2013)
Published in PLoS genetics (01.05.2013)
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Genetic analysis of the Trichuris muris-induced model of colitis reveals QTL overlap and a novel gene cluster for establishing colonic inflammation
Levison, Scott E, Fisher, Paul, Hankinson, Jenny, Zeef, Leo, Eyre, Steve, Ollier, William E, McLaughlin, John T, Brass, Andy, Grencis, Richard K, Pennock, Joanne L
Published in BMC genomics (26.02.2013)
Published in BMC genomics (26.02.2013)
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Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci
Martin, Paul, McGovern, Amanda, Orozco, Gisela, Duffus, Kate, Yarwood, Annie, Schoenfelder, Stefan, Cooper, Nicholas J., Barton, Anne, Wallace, Chris, Fraser, Peter, Worthington, Jane, Eyre, Steve
Published in Nature communications (30.11.2015)
Published in Nature communications (30.11.2015)
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P38 Integrating proteomics and genomics to investigate the mechanisms of paradoxical eczema developing in patients with psoriasis treated with biologics: a UK multicentre, longitudinal, cohort study
Al-Janabi, Ali, Martin, Paul, Khan, Adnan, Foulkes, Amy, Smith, Catherine, Griffiths, Christopher, Morris, Andrew, Eyre, Steve, Warren, Richard
Published in British journal of dermatology (1951) (26.06.2023)
Published in British journal of dermatology (1951) (26.06.2023)
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OA30 Identification of causal genes and mechanisms by which genetic variation mediates juvenile idiopathic arthritis susceptibility using functional genomics and CRISPR-Cas9
Frantzeskos, Antonios, Malysheva, Valeriya, Shi, Chenfu, Ding, James, Bowes, John, Thomson, Wendy, Eyre, Steve, Spivakov, Mikhail, Orozco, Gisela
Published in Rheumatology (Oxford, England) (23.04.2022)
Published in Rheumatology (Oxford, England) (23.04.2022)
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