The discovery of GSK221149A: A potent and selective oxytocin antagonist
Liddle, John, Allen, Michael J., Borthwick, Alan D., Brooks, David P., Davies, David E., Edwards, Richard M., Exall, Anne M., Hamlett, Chris, Irving, Wendy R., Mason, Andrew M., McCafferty, Gerald P., Nerozzi, Fabrizio, Peace, Simon, Philp, Joanne, Pollard, Derek, Pullen, Mark A., Shabbir, Shaila S., Sollis, Steve L., Westfall, Timothy D., Woollard, Pat M., Wu, Charlene, Hickey, Deirdre M.B.
Published in Bioorganic & medicinal chemistry (2008)
Published in Bioorganic & medicinal chemistry (2008)
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2,5-Diketopiperazines as Potent, Selective, and Orally Bioavailable Oxytocin Antagonists. 3. Synthesis, Pharmacokinetics, and in Vivo Potency
Borthwick, Alan D, Davies, Dave E, Exall, Anne M, Hatley, Richard J. D, Hughes, Jennifer A, Irving, Wendy R, Livermore, David G, Sollis, Steve L, Nerozzi, Fabrizio, Valko, Klara L, Allen, Michael J, Perren, Marion, Shabbir, Shalia S, Woollard, Patrick M, Price, Mark A
Published in Journal of medicinal chemistry (13.07.2006)
Published in Journal of medicinal chemistry (13.07.2006)
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Pyridyl-2,5-Diketopiperazines as Potent, Selective, and Orally Bioavailable Oxytocin Antagonists: Synthesis, Pharmacokinetics, and In Vivo Potency
Borthwick, Alan D, Liddle, John, Davies, Dave E, Exall, Anne M, Hamlett, Christopher, Hickey, Deirdre M, Mason, Andrew M, Smith, Ian E. D, Nerozzi, Fabrizio, Peace, Simon, Pollard, Derek, Sollis, Steve L, Allen, Michael J, Woollard, Patrick M, Pullen, Mark A, Westfall, Timothy D, Stanislaus, Dinesh J
Published in Journal of medicinal chemistry (26.01.2012)
Published in Journal of medicinal chemistry (26.01.2012)
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2,5-Diketopiperazines as potent and selective oxytocin antagonists 1: identification, stereochemistry and initial SAR
Wyatt, Paul G., Allen, Michael J., Borthwick, Alan D., Davies, Dave E., Exall, Anne M., Hatley, Richard J.D., Irving, Wendy R., Livermore, David G., Miller, Neil D., Nerozzi, Fabrizio, Sollis, Steve L., Szardenings, Anna Katrin
Published in Bioorganic & medicinal chemistry letters (16.05.2005)
Published in Bioorganic & medicinal chemistry letters (16.05.2005)
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2,5-Diketopiperazines as Potent, Selective, and Orally Bioavailable Oxytocin Antagonists. 2. Synthesis, Chirality, and Pharmacokinetics
Borthwick, Alan D, Davies, Dave E, Exall, Anne M, Livermore, David G, Sollis, Steve L, Nerozzi, Fabrizio, Allen, Michael J, Perren, Marion, Shabbir, Shalia S, Woollard, Patrick M, Wyatt, Paul G
Published in Journal of medicinal chemistry (03.11.2005)
Published in Journal of medicinal chemistry (03.11.2005)
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The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs
Watson, Nigel S., Adams, Carl, Belton, David, Brown, David, Burns-Kurtis, Cynthia L., Chaudry, Laiq, Chan, Chuen, Convery, Máire A., Davies, David E., Exall, Anne M., Harling, John D., Irvine, Stephanie, Irving, Wendy R., Kleanthous, Savvas, McLay, Iain M., Pateman, Anthony J., Patikis, Angela N., Roethke, Theresa J., Senger, Stefan, Stelman, Gary J., Toomey, John R., West, Robert I., Whittaker, Caroline, Zhou, Ping, Young, Robert J.
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
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Design and Synthesis of Pyrrolidine-5,5‘-trans-Lactams (5-Oxo-hexahydropyrrolo[3,2-b]pyrroles) as Novel Mechanism-Based Inhibitors of Human Cytomegalovirus Protease. 4. Antiviral Activity and Plasma Stability
Borthwick, Alan D, Davies, Dave E, Ertl, Peter F, Exall, Anne M, Haley, Terry M, Hart, Graham J, Jackson, Deborah L, Parry, Nigel R, Patikis, Angela, Trivedi, Naimisha, Weingarten, Gordon G, Woolven, James M
Published in Journal of medicinal chemistry (09.10.2003)
Published in Journal of medicinal chemistry (09.10.2003)
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Structure and property based design of factor Xa inhibitors: Pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs
Young, Robert J., Adams, Carl, Blows, Mike, Brown, David, Burns-Kurtis, Cynthia L., Chan, Chuen, Chaudry, Laiq, Convery, Máire A., Davies, David E., Exall, Anne M., Foster, Graham, Harling, John D., Hortense, Eric, Irvine, Stephanie, Irving, Wendy R., Jackson, Steve, Kleanthous, Savvas, Pateman, Anthony J., Patikis, Angela N., Roethka, Theresa J., Senger, Stefan, Stelman, Gary J., Toomey, John R., West, Robert I., Whittaker, Caroline, Zhou, Ping, Watson, Nigel S.
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
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Journal Article
Design and Synthesis of Pyrrolidine-5,5-trans-lactams (5-Oxohexahydropyrrolo[3,2-b]pyrroles) as Novel Mechanism-Based Inhibitors of Human Cytomegalovirus Protease. 2. Potency and Chirality
Borthwick, Alan D, Crame, Andrew J, Ertl, Peter F, Exall, Anne M, Haley, Terry M, Hart, Graham J, Mason, Andrew M, Pennell, Andrew M. K, Singh, Onkar M. P, Weingarten, Gordon G, Woolven, James M
Published in Journal of medicinal chemistry (03.01.2002)
Published in Journal of medicinal chemistry (03.01.2002)
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Design and Synthesis of Pyrrolidine-5,5-trans-lactams (5-Oxo-hexahydro-pyrrolo[3,2-b]pyrroles) as Novel Mechanism-Based Inhibitors of Human Cytomegalovirus Protease. 1. The α-Methyl-trans-lactam Template
Borthwick, Alan D, Angier, S. Jane, Crame, Andrew J, Exall, Anne M, Haley, Terry M, Hart, Graham J, Mason, Andrew M, Pennell, Andrew M. K, Weingarten, Gordon G
Published in Journal of medicinal chemistry (16.11.2000)
Published in Journal of medicinal chemistry (16.11.2000)
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Pyrrolidine-5,5- trans-lactams as novel mechanism-based inhibitors of human cytomegalovirus protease. Part 3: potency and plasma stability
Borthwick, Alan D, Exall, Anne M, Haley, Terry M, Jackson, Deborah L, Mason, Andrew M, Weingarten, Gordon G
Published in Bioorganic & medicinal chemistry letters (08.07.2002)
Published in Bioorganic & medicinal chemistry letters (08.07.2002)
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Use of diethylaminosulphur trifluoride (DAST) in the preparation of synthons of carbocyclic nucleosides
BIGGADIKE, K, BORTHWICK, A. D, EVANS, D, EXALL, A. M, KIRK, B. E, ROBERTS, S. M, STEPHENSON, L, YOUDS, P
Published in Journal of the Chemical Society, Perkin Transactions 1 (1988)
Published in Journal of the Chemical Society, Perkin Transactions 1 (1988)
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Fluoro carbocyclic nucleosides: synthesis and antiviral activity of 2'- and 6'-fluoro carbocyclic pyrimidine nucleosides including carbocyclic 1-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-5-methyluracil and carbocyclic 1-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-5-iodouracil
Borthwick, Alan D, Evans, Derek N, Kirk, Barrie E, Biggadike, Keith, Exall, Anne M, Youds, Peter, Roberts, Stanley M, Knight, David J, Coates, Jonathan A. V
Published in Journal of medicinal chemistry (01.01.1990)
Published in Journal of medicinal chemistry (01.01.1990)
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An efficient synthesis of a chiral carbocyclic 2′-deoxyribonucleoside synthon by directed reduction
Borthwick, Alan D., Crame, Andrew J., Exall, Anne M., Weingarten, Gordon G.
Published in Tetrahedron letters (10.10.1994)
Published in Tetrahedron letters (10.10.1994)
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Fluorocarbocyclic nucleosides: synthesis and antiviral activity of 2'- and 6'-fluorocarbocyclic 2'-deoxyguanosines
Borthwick, Alan D, Kirk, Barrie E, Biggadike, Keith, Exall, Anne M, Butt, Suzanne, Roberts, Stanley M, Knight, David J, Coates, Jonathan A. V, Ryan, D. Michael
Published in Journal of medicinal chemistry (01.03.1991)
Published in Journal of medicinal chemistry (01.03.1991)
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SYNTHESIS FROM (-)-ARISTEROMYCIN AND X-RAY STRUCTURE OF (-)-CARBOVIR
EXALL, AM, JONES, MF, MO, CL, MYERS, PL, PATERNOSTER, IL, SINGH, H, STORER, R, WEINGARTEN, GG, WILLIAMSON, C, BRODIE, AC, COOK, J, LAKE, DE, MEERHOLZ, CA, TURNBULL, PJ, HIGHCOCK, RM
Published in J. Chem. Soc., Perkin Trans. 1 (1991)
Published in J. Chem. Soc., Perkin Trans. 1 (1991)
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2'-Deoxy-2'-fluoro-ara-aristeromycin, a new anti-herpes agent: the first direct introduction of a 2'-fluoro substituent into a carbocyclic nucleoside
BIGGADIKE, K, BORTHWICK, A. D, EXALL, A. M, KIRK, B. E, WARD, R. A
Published in Journal of the Chemical Society. Chemical communications (1988)
Published in Journal of the Chemical Society. Chemical communications (1988)
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