Design and Synthesis of Pyrrolidine-5,5-trans-lactams (5-Oxo-hexahydro-pyrrolo[3,2-b]pyrroles) as Novel Mechanism-Based Inhibitors of Human Cytomegalovirus Protease. 1. The α-Methyl-trans-lactam Template
Borthwick, Alan D, Angier, S. Jane, Crame, Andrew J, Exall, Anne M, Haley, Terry M, Hart, Graham J, Mason, Andrew M, Pennell, Andrew M. K, Weingarten, Gordon G
Published in Journal of medicinal chemistry (16.11.2000)
Published in Journal of medicinal chemistry (16.11.2000)
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Design and Synthesis of Pyrrolidine-5,5-trans-lactams (5-Oxohexahydropyrrolo[3,2-b]pyrroles) as Novel Mechanism-Based Inhibitors of Human Cytomegalovirus Protease. 2. Potency and Chirality
Borthwick, Alan D, Crame, Andrew J, Ertl, Peter F, Exall, Anne M, Haley, Terry M, Hart, Graham J, Mason, Andrew M, Pennell, Andrew M. K, Singh, Onkar M. P, Weingarten, Gordon G, Woolven, James M
Published in Journal of medicinal chemistry (03.01.2002)
Published in Journal of medicinal chemistry (03.01.2002)
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Fluorocarbocyclic nucleosides : synthesis and antiviral activity of 2'- and 6'-fluorocarbocyclic 2'-deoxy guanosines
BORTHWICK, A. D, KIRK, B. E, BIGGADIKE, K, EXALL, A. M, BUTT, S, ROBERTS, S. M, KNIGHT, D. J, COATES, J. A. V, RYAN, D. M
Published in Journal of medicinal chemistry (01.03.1991)
Published in Journal of medicinal chemistry (01.03.1991)
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Fluoro carbocyclic nucleosides: synthesis and antiviral activity of 2'- and 6'-fluoro carbocyclic pyrimidine nucleosides including carbocyclic 1-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-5-methyluracil and carbocyclic 1-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-5-iodouracil
Borthwick, Alan D, Evans, Derek N, Kirk, Barrie E, Biggadike, Keith, Exall, Anne M, Youds, Peter, Roberts, Stanley M, Knight, David J, Coates, Jonathan A. V
Published in Journal of medicinal chemistry (01.01.1990)
Published in Journal of medicinal chemistry (01.01.1990)
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Use of diethylaminosulphur trifluoride (DAST) in the preparation of synthons of carbocyclic nucleosides
BIGGADIKE, K, BORTHWICK, A. D, EVANS, D, EXALL, A. M, KIRK, B. E, ROBERTS, S. M, STEPHENSON, L, YOUDS, P
Published in Journal of the Chemical Society, Perkin Transactions 1 (1988)
Published in Journal of the Chemical Society, Perkin Transactions 1 (1988)
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SYNTHESIS FROM (-)-ARISTEROMYCIN AND X-RAY STRUCTURE OF (-)-CARBOVIR
EXALL, AM, JONES, MF, MO, CL, MYERS, PL, PATERNOSTER, IL, SINGH, H, STORER, R, WEINGARTEN, GG, WILLIAMSON, C, BRODIE, AC, COOK, J, LAKE, DE, MEERHOLZ, CA, TURNBULL, PJ, HIGHCOCK, RM
Published in J. Chem. Soc., Perkin Trans. 1 (1991)
Published in J. Chem. Soc., Perkin Trans. 1 (1991)
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2,5-Diketopiperazines as potent and selective oxytocin antagonists 1: identification, stereochemistry and initial SAR
Wyatt, Paul G., Allen, Michael J., Borthwick, Alan D., Davies, Dave E., Exall, Anne M., Hatley, Richard J.D., Irving, Wendy R., Livermore, David G., Miller, Neil D., Nerozzi, Fabrizio, Sollis, Steve L., Szardenings, Anna Katrin
Published in Bioorganic & medicinal chemistry letters (16.05.2005)
Published in Bioorganic & medicinal chemistry letters (16.05.2005)
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2,5-Diketopiperazines as Potent, Selective, and Orally Bioavailable Oxytocin Antagonists. 2. Synthesis, Chirality, and Pharmacokinetics
Borthwick, Alan D, Davies, Dave E, Exall, Anne M, Livermore, David G, Sollis, Steve L, Nerozzi, Fabrizio, Allen, Michael J, Perren, Marion, Shabbir, Shalia S, Woollard, Patrick M, Wyatt, Paul G
Published in Journal of medicinal chemistry (03.11.2005)
Published in Journal of medicinal chemistry (03.11.2005)
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Design and Synthesis of Pyrrolidine-5,5‘-trans-Lactams (5-Oxo-hexahydropyrrolo[3,2-b]pyrroles) as Novel Mechanism-Based Inhibitors of Human Cytomegalovirus Protease. 4. Antiviral Activity and Plasma Stability
Borthwick, Alan D, Davies, Dave E, Ertl, Peter F, Exall, Anne M, Haley, Terry M, Hart, Graham J, Jackson, Deborah L, Parry, Nigel R, Patikis, Angela, Trivedi, Naimisha, Weingarten, Gordon G, Woolven, James M
Published in Journal of medicinal chemistry (09.10.2003)
Published in Journal of medicinal chemistry (09.10.2003)
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SYNTHESIS AND ENZYMATIC RESOLUTION OF CARBOCYCLIC 2'-ARA-FLUORO-GUANOSINE - A POTENT NEW ANTI-HERPETIC AGENT
BORTHWICK, AD, BUTT, S, BIGGADIKE, K, EXALL, AM, ROBERTS, SM, YOUDS, PM, KIRK, BE, BOOTH, BR, CAMERON, JM, COX, SW, MARR, CLP, SHILL, MD
Published in Journal of the Chemical Society. Chemical communications (1988)
Published in Journal of the Chemical Society. Chemical communications (1988)
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Synthesis of fluorinated carbocyclic nucleosides: preparation of carbocyclic 1-(2'-deoxy-6'-fluororibofuranosyl)-5-iodouracils
BIGGADIKE, K, BORTHWICK, A. D, EXALL, A. M, KIRK, B. E, ROBERTS, S. M, YOUDS, P, SLAWIN, A. M. Z, WILLIAMS, D. J
Published in Journal of the Chemical Society. Chemical communications (1987)
Published in Journal of the Chemical Society. Chemical communications (1987)
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Pyrrolidine-5,5- trans-lactams as novel mechanism-based inhibitors of human cytomegalovirus protease. Part 3: potency and plasma stability
Borthwick, Alan D, Exall, Anne M, Haley, Terry M, Jackson, Deborah L, Mason, Andrew M, Weingarten, Gordon G
Published in Bioorganic & medicinal chemistry letters (08.07.2002)
Published in Bioorganic & medicinal chemistry letters (08.07.2002)
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Synthesis of fluorinated carbocyclic nucleosides: preparation of (±)-carbocyclic-FMAU and some congeners
BIGGADIKE, K, BORTHWICK, A. D, EVANS, D, EXALL, A. M, KIRK, B. E, ROBERTS, S. M, STEPHENSON, L, YOUDS, P, SLAWIN, A. M. Z, WILLIAMS, D. J
Published in Journal of the Chemical Society. Chemical communications (1987)
Published in Journal of the Chemical Society. Chemical communications (1987)
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Fluorocarbocyclic nucleosides: Synthesis and antiviral activity of 2'- and 6'-fluorocarbocyclic pyrimidine nucleosides including carbocyclic 1-(2-deoxy-2-fluoro- beta -D-arabinofuranosyl)-5-methyluracil and carbocyclic 1-(2-deoxy-2-fluoro- beta -D-arabinofuranosyl)-5-iodouracil
Borthwick, AD, Evans, D N, Kirk, B E, Biggadike, K, Exall, A M, Youds, P, Roberts, S M, Knight, D J, Coates, JAV
Published in Journal of medicinal chemistry (01.01.1990)
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Published in Journal of medicinal chemistry (01.01.1990)
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Stereoselective synthesis of alpha-methyl and beta-methyl pyrrolidine 5,5-trans-lactam (5-oxo-hexahydro-pyrrolo[3,2-b]pyrrole) and stereoselective alkylation of the strained pyrrolidine 5,5-trans-lactam ring system
Borthwick, AD, Crame, AJ, Davies, DE, Exall, AM, Jackson, DL, Mason, AM, Pennell, AMK, Weingarten, GG
Published in Synlett (2000)
Published in Synlett (2000)
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An efficient synthesis of a chiral carbocyclic 2′-deoxyribonucleoside synthon by directed reduction
Borthwick, Alan D., Crame, Andrew J., Exall, Anne M., Weingarten, Gordon G.
Published in Tetrahedron letters (10.10.1994)
Published in Tetrahedron letters (10.10.1994)
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