Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption
Pediaditakis, Iosif, Kodella, Konstantia R, Manatakis, Dimitris V, Le, Christopher Y, Hinojosa, Chris D, Tien-Street, William, Manolakos, Elias S, Vekrellis, Kostas, Hamilton, Geraldine A, Ewart, Lorna, Rubin, Lee L, Karalis, Katia
Published in Nature communications (08.10.2021)
Published in Nature communications (08.10.2021)
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Journal Article
Reproducing human and cross-species drug toxicities using a Liver-Chip
Jang, Kyung-Jin, Otieno, Monicah A, Ronxhi, Janey, Lim, Heng-Keang, Ewart, Lorna, Kodella, Konstantia R, Petropolis, Debora B, Kulkarni, Gauri, Rubins, Jonathan E, Conegliano, David, Nawroth, Janna, Simic, Damir, Lam, Wing, Singer, Monica, Barale, Erio, Singh, Bhanu, Sonee, Manisha, Streeter, Anthony J, Manthey, Carl, Jones, Barry, Srivastava, Abhishek, Andersson, Linda C, Williams, Dominic, Park, Hyoungshin, Barrile, Riccardo, Sliz, Josiah, Herland, Anna, Haney, Suzzette, Karalis, Katia, Ingber, Donald E, Hamilton, Geraldine A
Published in Science translational medicine (06.11.2019)
Published in Science translational medicine (06.11.2019)
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Journal Article
Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model
Bauer, Sophie, Wennberg Huldt, Charlotte, Kanebratt, Kajsa P, Durieux, Isabell, Gunne, Daniela, Andersson, Shalini, Ewart, Lorna, Haynes, William G, Maschmeyer, Ilka, Winter, Annika, Ämmälä, Carina, Marx, Uwe, Andersson, Tommy B
Published in Scientific reports (03.11.2017)
Published in Scientific reports (03.11.2017)
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Journal Article
Microphysiological lung models to evaluate the safety of new pharmaceutical modalities: a biopharmaceutical perspective
Ainslie, Garrett R, Davis, Myrtle, Ewart, Lorna, Lieberman, Linda A, Rowlands, David J, Thorley, Andrew J, Yoder, Gorm, Ryan, Anne M
Published in Lab on a chip (27.09.2019)
Published in Lab on a chip (27.09.2019)
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Journal Article
Introducing an automated high content confocal imaging approach for Organs-on-Chips
Peel, Samantha, Corrigan, Adam M, Ehrhardt, Beate, Jang, Kyung-Jin, Caetano-Pinto, Pedro, Boeckeler, Matthew, Rubins, Jonathan E, Kodella, Konstantia, Petropolis, Debora B, Ronxhi, Janey, Kulkarni, Gauri, Foster, Alison J, Williams, Dominic, Hamilton, Geraldine A, Ewart, Lorna
Published in Lab on a chip (29.01.2019)
Published in Lab on a chip (29.01.2019)
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Journal Article
Characterization of the Adenosine Pharmacology of Ticagrelor Reveals Therapeutically Relevant Inhibition of Equilibrative Nucleoside Transporter 1
Armstrong, Duncan, Summers, Claire, Ewart, Lorna, Nylander, Sven, Sidaway, James E., van Giezen, J. J. J.
Published in Journal of cardiovascular pharmacology and therapeutics (01.03.2014)
Published in Journal of cardiovascular pharmacology and therapeutics (01.03.2014)
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Journal Article
3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration
Wang, Hongbing, Brown, Paul C., Chow, Edwin C.Y., Ewart, Lorna, Ferguson, Stephen S., Fitzpatrick, Suzanne, Freedman, Benjamin S., Guo, Grace L., Hedrich, William, Heyward, Scott, Hickman, James, Isoherranen, Nina, Li, Albert P., Liu, Qi, Mumenthaler, Shannon M., Polli, James, Proctor, William R., Ribeiro, Alexandre, Wang, Jian‐Ying, Wange, Ronald L., Huang, Shiew‐Mei
Published in Clinical and translational science (01.09.2021)
Published in Clinical and translational science (01.09.2021)
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Journal Article
Integrated in vitro models for hepatic safety and metabolism: evaluation of a human Liver-Chip and liver spheroid
Foster, Alison J., Chouhan, Bhavik, Regan, Sophie L., Rollison, Helen, Amberntsson, Sara, Andersson, Linda C., Srivastava, Abhishek, Darnell, Malin, Cairns, Jonathan, Lazic, Stanley E., Jang, Kyung-Jin, Petropolis, Debora B., Kodella, Konstantia, Rubins, Jonathan E., Williams, Dominic, Hamilton, Geraldine A., Ewart, Lorna, Morgan, Paul
Published in Archives of toxicology (01.04.2019)
Published in Archives of toxicology (01.04.2019)
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Journal Article
Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology
Ewart, Lorna, Apostolou, Athanasia, Briggs, Skyler A, Carman, Christopher V, Chaff, Jake T, Heng, Anthony R, Jadalannagari, Sushma, Janardhanan, Jeshina, Jang, Kyung-Jin, Joshipura, Sannidhi R, Kadam, Mahika M, Kanellias, Marianne, Kujala, Ville J, Kulkarni, Gauri, Le, Christopher Y, Lucchesi, Carolina, Manatakis, Dimitris V, Maniar, Kairav K, Quinn, Meaghan E, Ravan, Joseph S, Rizos, Ann Catherine, Sauld, John F K, Sliz, Josiah D, Tien-Street, William, Trinidad, Dennis Ramos, Velez, James, Wendell, Max, Irrechukwu, Onyi, Mahalingaiah, Prathap Kumar, Ingber, Donald E, Scannell, Jack W, Levner, Daniel
Published in Communications medicine (06.12.2022)
Published in Communications medicine (06.12.2022)
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Journal Article
Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective
Ewart, Lorna, Fabre, Kristin, Chakilam, Ananthsrinivas, Dragan, Yvonne, Duignan, David B, Eswaraka, Jeetu, Gan, Jinping, Guzzie-Peck, Peggy, Otieno, Monicah, Jeong, Claire G, Keller, Douglas A, de Morais, Sonia M, Phillips, Jonathan A, Proctor, William, Sura, Radhakrishna, Van Vleet, Terry, Watson, David, Will, Yvonne, Tagle, Danilo, Berridge, Brian
Published in Experimental biology and medicine (Maywood, N.J.) (01.10.2017)
Published in Experimental biology and medicine (Maywood, N.J.) (01.10.2017)
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Journal Article
On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships
McAleer, Christopher W, Pointon, Amy, Long, Christopher J, Brighton, Rocky L, Wilkin, Benjamin D, Bridges, L Richard, Narasimhan Sriram, Narasimham, Fabre, Kristin, McDougall, Robin, Muse, Victorine P, Mettetal, Jerome T, Srivastava, Abhishek, Williams, Dominic, Schnepper, Mark T, Roles, Jeff L, Shuler, Michael L, Hickman, James J, Ewart, Lorna
Published in Scientific reports (03.07.2019)
Published in Scientific reports (03.07.2019)
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Journal Article
Optimal experimental design for efficient toxicity testing in microphysiological systems: A bone marrow application
Cairns, Jonathan, Leonard, Emilyanne, Khan, Kainat, Parks, Conor, Maglennon, Gareth, Zhang, Bairu, Lazic, Stanley E, Ewart, Lorna, David, Rhiannon
Published in Frontiers in pharmacology (31.03.2023)
Published in Frontiers in pharmacology (31.03.2023)
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Journal Article
Assessing the predictive value of the rodent neurofunctional assessment for commonly reported adverse events in phase I clinical trials
Mead, Andy N., Amouzadeh, Hamid R., Chapman, Kathryn, Ewart, Lorna, Giarola, Alessandra, Jackson, Samuel J., Jarvis, Philip, Jordaan, Pierre, Redfern, Will, Traebert, Martin, Valentin, Jean-Pierre, Vargas, Hugo M.
Published in Regulatory toxicology and pharmacology (01.10.2016)
Published in Regulatory toxicology and pharmacology (01.10.2016)
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Journal Article
Physiological Replication of the Human Glomerulus Using a Triple Culture Microphysiological System
Pajoumshariati, Ramin, Ewart, Lorna, Kujala, Ville, Luc, Raymond, Peel, Samantha, Corrigan, Adam, Weber, Heather, Nugraha, Bramasta, Hansen, Pernille B. L., Williams, Julie
Published in Advanced science (01.11.2023)
Published in Advanced science (01.11.2023)
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Journal Article
Optimizing drug discovery by Investigative Toxicology: Current and future trends
Beilmann, Mario, Boonen, Harrie, Czich, Andreas, Dear, Gordon, Hewitt, Philip, Mow, Tomas, Newham, Peter, Oinonen, Teija, Pognan, Francois, Roth, Adrian, Valentin, Jean-Pierre, Van Goethem, Freddy, Weaver, Richard J, Birk, Barbara, Boyer, Scott, Caloni, Francesca, Chen, Alice E, Corvi, Raffaella, Cronin, Mark T D, Daneshian, Mardas, Ewart, Lorna C, Fitzgerald, Rex E, Hamilton, Geraldine A, Hartung, Thomas, Kangas, Joshua D, Kramer, Nynke I, Leist, Marcel, Marx, Uwe, Polak, Sebastian, Rovida, Costanza, Testai, Emanuela, Van der Water, Bob, Vulto, Paul, Steger-Hartmann, Thomas
Published in ALTEX, alternatives to animal experimentation (01.01.2019)
Published in ALTEX, alternatives to animal experimentation (01.01.2019)
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Journal Article
A microengineered Brain-Chip to model neuroinflammation in humans
Pediaditakis, Iosif, Kodella, Konstantia R., Manatakis, Dimitris V., Le, Christopher Y., Barthakur, Sonalee, Sorets, Alexander, Gravanis, Achille, Ewart, Lorna, Rubin, Lee L., Manolakos, Elias S., Hinojosa, Christopher D., Karalis, Katia
Published in iScience (19.08.2022)
Published in iScience (19.08.2022)
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Journal Article
Advancing nonclinical innovation and safety in pharmaceutical testing
Baker, Elizabeth J., Beck, Nancy A., Berg, Ellen L., Clayton-Jeter, Helene D., Chandrasekera, P. Charukeshi, Curley, J. Lowry, Donzanti, Bruce A., Ewart, Lorna C., Gunther, Jane M., Kenna, J. Gerry, LeCluyse, Edward L., Liebman, Michael N., Pugh, Catherine L., Watkins, Paul B., Sullivan, Kristie M.
Published in Drug discovery today (01.02.2019)
Published in Drug discovery today (01.02.2019)
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Journal Article
Safety Profiling of Tumor-targeted T Cell-Bispecific Antibodies with Alveolus Lung- and Colon-on-Chip
Kerns, Jordan S, Belgur, Chaitra, Kanellias, Marianne, Manatakis, Dimitris V, Barrile, Riccardo, Tien-Street, Will, Ewart, Lorna, Gjorevski, Nikolche, Cabon, Lauriane
Published in Bio-protocol (05.01.2023)
Published in Bio-protocol (05.01.2023)
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Journal Article
Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system
Kostrzewski, Tomasz, Snow, Sophie, Battle, Anya Lindström, Peel, Samantha, Ahmad, Zahida, Basak, Jayati, Surakala, Manasa, Bornot, Aurelie, Lindgren, Julia, Ryaboshapkina, Maria, Clausen, Maryam, Lindén, Daniel, Maass, Christian, Young, Lucy May, Corrigan, Adam, Ewart, Lorna, Hughes, David
Published in Communications biology (15.09.2021)
Published in Communications biology (15.09.2021)
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