Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial
Pavord, Ian D, Prof, Korn, Stephanie, MD, Howarth, Peter, DM, Bleecker, Eugene R, Prof, Buhl, Roland, Prof, Keene, Oliver N, MSc, Ortega, Hector, MD, Chanez, Pascal, MD
Published in The Lancet (British edition) (18.08.2012)
Published in The Lancet (British edition) (18.08.2012)
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Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2 -agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial
Bleecker, Eugene R, Prof, FitzGerald, J Mark, Prof, Chanez, Pascal, Prof, Papi, Alberto, Prof, Weinstein, Steven F, Prof, Barker, Peter, PhD, Sproule, Stephanie, MMath, Gilmartin, Geoffrey, MD, Aurivillius, Magnus, MD, Werkström, Viktoria, MD, Goldman, Mitchell, MD
Published in The Lancet (British edition) (29.10.2016)
Published in The Lancet (British edition) (29.10.2016)
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Systematic Literature Review of Systemic Corticosteroid Use for Asthma Management
Bleecker, Eugene R, Menzies-Gow, Andrew N, Price, David B, Bourdin, Arnaud, Sweet, Stephen, Martin, Amber L, Alacqua, Marianna, Tran, Trung N
Published in American journal of respiratory and critical care medicine (01.02.2020)
Published in American journal of respiratory and critical care medicine (01.02.2020)
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Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial
FitzGerald, J Mark, Dr, Bleecker, Eugene R, Prof, Nair, Parameswaran, Prof, Korn, Stephanie, MD, Ohta, Ken, MD, Lommatzsch, Marek, Prof, Ferguson, Gary T, MD, Busse, William W, Prof, Barker, Peter, PhD, Sproule, Stephanie, MMath, Gilmartin, Geoffrey, MD, Werkström, Viktoria, MD, Aurivillius, Magnus, MD, Goldman, Mitchell, MD
Published in The Lancet (British edition) (29.10.2016)
Published in The Lancet (British edition) (29.10.2016)
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Journal Article
Baseline patient factors impact on the clinical efficacy of benralizumab for severe asthma
Bleecker, Eugene R, Wechsler, Michael E, FitzGerald, J Mark, Menzies-Gow, Andrew, Wu, Yanping, Hirsch, Ian, Goldman, Mitchell, Newbold, Paul, Zangrilli, James G
Published in The European respiratory journal (01.10.2018)
Published in The European respiratory journal (01.10.2018)
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Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline
Holguin, Fernando, Cardet, Juan Carlos, Chung, Kian Fan, Diver, Sarah, Ferreira, Diogenes S, Fitzpatrick, Anne, Gaga, Mina, Kellermeyer, Liz, Khurana, Sandhya, Knight, Shandra, McDonald, Vanessa M, Morgan, Rebecca L, Ortega, Victor E, Rigau, David, Subbarao, Padmaja, Tonia, Thomy, Adcock, Ian M, Bleecker, Eugene R, Brightling, Chris, Boulet, Louis-Philippe, Cabana, Michael, Castro, Mario, Chanez, Pascal, Custovic, Adnan, Djukanovic, Ratko, Frey, Urs, Frankemölle, Betty, Gibson, Peter, Hamerlijnck, Dominique, Jarjour, Nizar, Konno, Satoshi, Shen, Huahao, Vitary, Cathy, Bush, Andy
Published in The European respiratory journal (01.01.2020)
Published in The European respiratory journal (01.01.2020)
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Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts
Peters, Michael C, McGrath, Kelly Wong, Hawkins, Gregory A, Hastie, Annette T, Levy, Bruce D, Israel, Elliot, Phillips, Brenda R, Mauger, David T, Comhair, Suzy A, Erzurum, Serpil C, Johansson, Mats W, Jarjour, Nizar N, Coverstone, Andrea M, Castro, Mario, Holguin, Fernando, Wenzel, Sally E, Woodruff, Prescott G, Bleecker, Eugene R, Fahy, John V
Published in The lancet respiratory medicine (01.07.2016)
Published in The lancet respiratory medicine (01.07.2016)
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Severe eosinophilic asthma treated with mepolizumab stratified by baseline eosinophil thresholds: a secondary analysis of the DREAM and MENSA studies
Ortega, Hector G, Yancey, Steven W, Mayer, Bhabita, Gunsoy, Necdet B, Keene, Oliver N, Bleecker, Eugene R, Brightling, Christopher E, Pavord, Ian D
Published in The lancet respiratory medicine (01.07.2016)
Published in The lancet respiratory medicine (01.07.2016)
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Journal Article
Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis
Moore, Wendy C., MD, Hastie, Annette T., PhD, Li, Xingnan, PhD, MS, Li, Huashi, MS, Busse, William W., MD, Jarjour, Nizar N., MD, Wenzel, Sally E., MD, Peters, Stephen P., MD, PhD, Meyers, Deborah A., PhD, Bleecker, Eugene R., MD
Published in Journal of allergy and clinical immunology (01.06.2014)
Published in Journal of allergy and clinical immunology (01.06.2014)
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Blood eosinophil count and prospective annual asthma disease burden: a UK cohort study
Price, David B, Rigazio, Anna, Campbell, Jonathan D, Bleecker, Eugene R, Corrigan, Christopher J, Thomas, Mike, Wenzel, Sally E, Wilson, Andrew M, Small, Mary Buatti, Gopalan, Gokul, Ashton, Valerie L, Burden, Anne, Hillyer, Elizabeth V, Kerkhof, Marjan, Pavord, Ian D
Published in The lancet respiratory medicine (01.11.2015)
Published in The lancet respiratory medicine (01.11.2015)
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Airway Mucin Concentration as a Marker of Chronic Bronchitis
Kesimer, Mehmet, Ford, Amina A, Ceppe, Agathe, Radicioni, Giorgia, Cao, Rui, Davis, C. William, Doerschuk, Claire M, Alexis, Neil E, Anderson, Wayne H, Henderson, Ashley G, Barr, R. Graham, Bleecker, Eugene R, Christenson, Stephanie A, Cooper, Christopher B, Han, MeiLan K, Hansel, Nadia N, Hastie, Annette T, Hoffman, Eric A, Kanner, Richard E, Martinez, Fernando, Paine, Robert, Woodruff, Prescott G, O’Neal, Wanda K, Boucher, Richard C
Published in The New England journal of medicine (07.09.2017)
Published in The New England journal of medicine (07.09.2017)
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Heterogeneity of severe asthma in childhood: Confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program
Fitzpatrick, Anne M., PhD, Teague, W. Gerald, MD, Meyers, Deborah A., PhD, Peters, Stephen P., MD, PhD, Li, Xingnan, PhD, Li, Huashi, MS, Wenzel, Sally E., MD, Aujla, Shean, MD, Castro, Mario, MD, Bacharier, Leonard B., MD, Gaston, Benjamin M., MD, Bleecker, Eugene R., MD, Moore, Wendy C., MD
Published in Journal of allergy and clinical immunology (01.02.2011)
Published in Journal of allergy and clinical immunology (01.02.2011)
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Journal Article
SPIROMICS Protocol for Multicenter Quantitative Computed Tomography to Phenotype the Lungs
Sieren, Jered P, Newell, Jr, John D, Barr, R Graham, Bleecker, Eugene R, Burnette, Nathan, Carretta, Elizabeth E, Couper, David, Goldin, Jonathan, Guo, Junfeng, Han, MeiLan K, Hansel, Nadia N, Kanner, Richard E, Kazerooni, Ella A, Martinez, Fernando J, Rennard, Stephen, Woodruff, Prescott G, Hoffman, Eric A
Published in American journal of respiratory and critical care medicine (01.10.2016)
Published in American journal of respiratory and critical care medicine (01.10.2016)
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Journal Article
Obesity and asthma: An association modified by age of asthma onset
Holguin, Fernando, MD, MPH, Bleecker, Eugene R., MD, Busse, William W., MD, Calhoun, William J., MD, Castro, Mario, MD, MPH, Erzurum, Serpil C., MD, Fitzpatrick, Anne M., PhD, RN, MS, Gaston, Benjamin, MD, Israel, Elliot, MD, Jarjour, Nizar N., MD, Moore, Wendy C., MD, Peters, Stephen P., MD, Yonas, Michael, DrPH, Teague, W. Gerald, MD, Wenzel, Sally E., MD
Published in Journal of allergy and clinical immunology (01.06.2011)
Published in Journal of allergy and clinical immunology (01.06.2011)
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Journal Article
Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions
Li, Xingnan, PhD, Howard, Timothy D., PhD, Zheng, Siqun L., MD, Haselkorn, Tmirah, PhD, Peters, Stephen P., MD, PhD, Meyers, Deborah A., PhD, Bleecker, Eugene R., MD
Published in Journal of allergy and clinical immunology (01.02.2010)
Published in Journal of allergy and clinical immunology (01.02.2010)
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Journal Article
Mixed Sputum Granulocyte Longitudinal Impact on Lung Function in the Severe Asthma Research Program
Hastie, Annette T, Mauger, David T, Denlinger, Loren C, Coverstone, Andrea, Castro, Mario, Erzurum, Serpil, Jarjour, Nizar, Levy, Bruce D, Meyers, Deborah A, Moore, Wendy C, Phillips, Brenda R, Wenzel, Sally E, Fahy, John V, Israel, Elliot, Bleecker, Eugene R
Published in American journal of respiratory and critical care medicine (01.04.2021)
Published in American journal of respiratory and critical care medicine (01.04.2021)
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Journal Article
Benralizumab for chronic obstructive pulmonary disease and sputum eosinophilia: a randomised, double-blind, placebo-controlled, phase 2a study
Brightling, Christopher E, Bleecker, Eugene R, Panettieri, Jr, Reynold A, Bafadhel, Mona, She, Dewei, Ward, Christine K, Xu, Xiao, Birrell, Claire, van der Merwe, René
Published in The lancet respiratory medicine (01.11.2014)
Published in The lancet respiratory medicine (01.11.2014)
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Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study
Castro, Mario, Wenzel, Sally E, Bleecker, Eugene R, Pizzichini, Emilio, Kuna, Piotr, Busse, William W, Gossage, David L, Ward, Christine K, Wu, Yanping, Wang, Bing, Khatry, Deepak B, van der Merwe, René, Kolbeck, Roland, Molfino, Nestor A, Raible, Donald G
Published in The lancet respiratory medicine (01.11.2014)
Published in The lancet respiratory medicine (01.11.2014)
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Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects
Hastie, Annette T., PhD, Moore, Wendy C., MD, Li, Huashi, MS, Rector, Brian M., MS, Ortega, Victor E., MD, Pascual, Rodolfo M., MD, Peters, Stephen P., MD, PhD, Meyers, Deborah A., PhD, Bleecker, Eugene R., MD
Published in Journal of allergy and clinical immunology (01.07.2013)
Published in Journal of allergy and clinical immunology (01.07.2013)
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Journal Article
Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes
Hastie, Annette T., PhD, Moore, Wendy C., MD, Meyers, Deborah A., PhD, Vestal, Penny L., MS, Li, Huashi, MS, Peters, Stephen P., MD, PhD, Bleecker, Eugene R., MD
Published in Journal of allergy and clinical immunology (01.05.2010)
Published in Journal of allergy and clinical immunology (01.05.2010)
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