Intravenous administration of retroviral replicating vector, Toca 511, demonstrates therapeutic efficacy in orthotopic immune-competent mouse glioma model
Huang, Tiffany T, Parab, Shraddha, Burnett, Ryan, Diago, Oscar, Ostertag, Derek, Hofman, Florence M, Espinoza, Fernando Lopez, Martin, Bryan, Ibañez, Carlos E, Kasahara, Noriyuki, Gruber, Harry E, Pertschuk, Daniel, Jolly, Douglas J, Robbins, Joan M
Published in Human gene therapy (01.02.2015)
Published in Human gene therapy (01.02.2015)
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Journal Article
A Retroviral Replicating Vector Encoding Cytosine Deaminase and 5-FC Induces Immune Memory in Metastatic Colorectal Cancer Models
Yagiz, Kader, Rodriguez-Aguirre, Maria E., Lopez Espinoza, Fernando, Montellano, Tiffany T., Mendoza, Daniel, Mitchell, Leah A., Ibanez, Carlos E., Kasahara, Noriyuki, Gruber, Harry E., Jolly, Douglas J., Robbins, Joan M.
Published in Molecular therapy. Oncolytics (30.03.2018)
Published in Molecular therapy. Oncolytics (30.03.2018)
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Journal Article
Toca 511 gene transfer and treatment with the prodrug, 5-fluorocytosine, promotes durable antitumor immunity in a mouse glioma model
Mitchell, Leah A, Lopez Espinoza, Fernando, Mendoza, Daniel, Kato, Yuki, Inagaki, Akihito, Hiraoka, Kei, Kasahara, Noriyuki, Gruber, Harry E, Jolly, Douglas J, Robbins, Joan M
Published in Neuro-oncology (Charlottesville, Va.) (01.07.2017)
Published in Neuro-oncology (Charlottesville, Va.) (01.07.2017)
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Journal Article
Efficient Therapeutic Protein Expression Using Retroviral Replicating Vector with 2A Peptide in Cancer Models
Hofacre, Andrew, Yagiz, Kader, Mendoza, Daniel, Lopez Espinoza, Fernando, Munday, Anthony W, Burrascano, Cynthia, Singer, Oded, Gruber, Harry E, Jolly, Douglas J, Lin, Amy H
Published in Human gene therapy (01.04.2018)
Published in Human gene therapy (01.04.2018)
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Journal Article
Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector
Ostertag, Derek, Amundson, Karin K, Lopez Espinoza, Fernando, Martin, Bryan, Buckley, Taylor, Galvão da Silva, Ana Paula, Lin, Amy H, Valenta, David T, Perez, Omar D, Ibañez, Carlos E, Chen, Ching-I, Pettersson, Pär L, Burnett, Ryan, Daublebsky, Veronika, Hlavaty, Juraj, Gunzburg, Walter, Kasahara, Noriyuki, Gruber, Harry E, Jolly, Douglas J, Robbins, Joan M
Published in Neuro-oncology (Charlottesville, Va.) (01.02.2012)
Published in Neuro-oncology (Charlottesville, Va.) (01.02.2012)
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Journal Article
Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models
Yagiz, Kader, Huang, Tiffany T, Lopez Espinoza, Fernando, Mendoza, Daniel, Ibañez, Carlos E, Gruber, Harry E, Jolly, Douglas J, Robbins, Joan M
Published in Neuro-oncology (Charlottesville, Va.) (01.10.2016)
Published in Neuro-oncology (Charlottesville, Va.) (01.10.2016)
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Journal Article
Retroviral Replicating Vector Delivery of miR-PDL1 Inhibits Immune Checkpoint PDL1 and Enhances Immune Responses In Vitro
Lin, Amy H., Twitty, Christopher G., Burnett, Ryan, Hofacre, Andrew, Mitchell, Leah A., Espinoza, Fernando Lopez, Gruber, Harry E., Jolly, Douglas J.
Published in Molecular therapy. Nucleic acids (17.03.2017)
Published in Molecular therapy. Nucleic acids (17.03.2017)
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Journal Article
PD-L1 checkpoint blockade delivered by retroviral replicating vector confers anti-tumor efficacy in murine tumor models
Mitchell, Leah A., Yagiz, Kader, Hofacre, Andrew, Viaud, Sophie, Munday, Anthony W., Espinoza, Fernando Lopez, Mendoza, Daniel, Rodriguez-Aguirre, Maria E., Bergqvist, Simon, Haghighi, Ali, Miner, Marin V., Accomando, William P., Burrascano, Cynthia, Gammon, Dawn, Gruber, Harry E., Jolly, Douglas J., Lin, Amy H.
Published in Oncotarget (19.03.2019)
Published in Oncotarget (19.03.2019)
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Journal Article
Sustained Factor VIII Activity Following Single Dose of Non-Viral Integrating Gene Therapy
Truong, Brian, Nguyen, Giang N., Hajj, Khal, Lucas, Joseph, Schwerk, Johannes, Yen, James, Briseno, Kevin, Burrascano, Michelle, Smith, Daniel, Tamayo, Johnnatan, Lopez-Espinoza, Fernando, Bennett, Michael, Madison, Blair, Sabatino, Denise E., Rychak, Joshua
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
TMIC-42. TOCA 511 AND 5-FC INDUCES T CELL-MEDIATED ANTITUMOR IMMUNITY IN A MOUSE GLIOMA MODEL WHICH IS ENHANCED BY THE ADDITION OF A THERAPEUTIC ANTIBODY AGAINST CTLA-4 AND CORRELATIVE WITH A REDUCTION IN MEMORY T REGULATORY CELLS
Jolly, Douglas, Mitchell, Leah, Yagiz, Kader, Espinoza, Fernando Lopez, Mendoza, Daniel, Munday, Anthony, Gruber, Harry
Published in Neuro-oncology (Charlottesville, Va.) (06.11.2017)
Published in Neuro-oncology (Charlottesville, Va.) (06.11.2017)
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Journal Article
Temporal changes in tumor-associated immune cell populations in subcutaneous Tu-2449SC tumors transduced with Toca 511 following treatment with 5-fluorocytosine
Robbins, Joan, Mitchell, Leah, Yagiz, Kader, Espinoza, Fernando Lopez, Mendoza, Daniel, Jolly, Douglas J
Published in The Journal of immunology (1950) (01.05.2016)
Published in The Journal of immunology (1950) (01.05.2016)
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Journal Article
Abstract 3212: Combining Toca 511 and 5-fluorocytosine with αPD-1 or αCTLA-4 antibody significantly reduces tumor burden compared to either checkpoint inhibitor alone or in combination in a subcutaneous mouse glioma model
Mitchell, Leah, Lopez Espinoza, Fernando, Yagiz, Kader, Mendoza, Daniel, Rodriguez-Aguirre, Maria, Mitchell, Sean, Jolly, Douglas J., Robbins, Joan M.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract 3212: Combining Toca 511 and 5-fluorocytosine with PD-1 or CTLA-4 antibody significantly reduces tumor burden compared to either checkpoint inhibitor alone or in combination in a subcutaneous mouse glioma model
Mitchell, Leah, Lopez Espinoza, Fernando, Yagiz, Kader, Mendoza, Daniel, Rodriguez-Aguirre, Maria, Mitchell, Sean, Jolly, Douglas J, Robbins, Joan M
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
CADD-23. PD-L1 CHECKPOINT BLOCKADE USING A SINGLE-CHAIN VARIABLE FRAGMENT TARGETING PD-L1 DELIVERED BY RETROVIRAL REPLICATING VECTOR (TOCA 521) ENHANCES ANTI-TUMOR EFFECT IN CANCER MODELS
Lin, Amy, Yagiz, Kader, Hofacre, Andrew, Munday, Anthony, Espinoza, Fernando Lopez, Mendoza, Daniel, Burrascano, Cynthia, Gruber, Harry, Mitchell, Leah, Jolly, Douglas
Published in Neuro-oncology (Charlottesville, Va.) (05.11.2018)
Published in Neuro-oncology (Charlottesville, Va.) (05.11.2018)
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Journal Article
205. Cytotoxic and Immunotherapeutic Effects of Toca 511 and 5-Fluorocytosine in an Intraperitoneal Model of Metastatic Colorectal Cancer
Yagiz, Kader, Mendoza, Daniel, Rodriguez-Aguirre, Maria, Espinoza, Fernando Lopez, Ibañez, Carlos E., Gruber, Harry E., Jolly, Douglas J., Robbins, Joan M.
Published in Molecular therapy (01.05.2016)
Published in Molecular therapy (01.05.2016)
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Journal Article
Abstract 1413: Treatment of mouse liver and brain colon cancer metastases with Toca 511 and 5-fluorocytosine for intratumoral production of 5-fluorouracil leads to increased survival, induction of antitumor immune responses, and reduction of MDSC
Rodriguez-Aguirre, Maria, Yagiz, Kader, Lopez Espinoza, Fernando, Mendoza, Daniel, Huang, Tiffany T., Ibanez, Carlos, Gruber, Harry E., Jolly, Douglas J., Robbins, Joan
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Additive therapeutic effect of a non-lytic retroviral replicating vector (Toca 511) and 5-fluorocytosine in combination with lomustine in experimental glioma models
Robbins, Joan M., Huang, Tiffany T., Yagiz, Kader, Lopez Espinoza, Fernando, Martin, Bryan, Rodriguez-Aguirre, Maria, Ibanez, Carlos E., Gruber, Harry E., Jolly, Douglas J.
Published in Journal of clinical oncology (20.05.2015)
Published in Journal of clinical oncology (20.05.2015)
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Journal Article
Abstract 708: Toca 511 gene therapy in combination with 5-fluorocytosine for intratumoral production of 5-fluorouracil in a colon cancer metastasis model
Rodriguez-Aguirre, Maria E., Espinoza, Fernando Lopez, Martin, Bryan, Yadiz, Kader, Huang, Tiffany T., Ibanez, Carlos E., Ostertag, Derek G., Kasahara, Noriyuki, Gruber, Harry E., Jolly, Douglas J., Robbins, Joan M.
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
PD-L1 checkpoint blockade delivered by retroviral replicating vector confers anti-tumor efficacy in murine tumor models
Mitchell, Leah A, Yagiz, Kader, Hofacre, Andrew, Viaud, Sophie, Munday, Anthony W, Espinoza, Fernando Lopez, Mendoza, Daniel, Rodriguez-Aguirre, Maria E, Bergqvist, Simon, Haghighi, Ali, Miner, Marin V, Accomando, William P, Burrascano, Cynthia, Gammon, Dawn, Gruber, Harry E, Jolly, Douglas J, Lin, Amy H
Published in Oncotarget (19.03.2019)
Published in Oncotarget (19.03.2019)
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Journal Article